RGD Reference Report - Adipose tissue expression of IL-18 and HIV-associated lipodystrophy. - Rat Genome Database

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Adipose tissue expression of IL-18 and HIV-associated lipodystrophy.

Authors: Lindegaard, B  Hansen, AB  Pilegaard, H  Keller, P  Gerstoft, J  Pedersen, BK 
Citation: Lindegaard B, etal., AIDS. 2004 Sep 24;18(14):1956-8.
RGD ID: 8655934
Pubmed: PMID:15353983   (View Abstract at PubMed)

IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
HIV-Associated Lipodystrophy Syndrome  IEP 8655934 RGD 
HIV-Associated Lipodystrophy Syndrome  ISOIL18 (Homo sapiens)8655934; 8655934 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information