1. |
Extracellular calcium modulates in vitro bone marrow-derived Flk-1+ CD34+ progenitor cell chemotaxis and differentiation through a calcium-sensing receptor. |
Aguirre A, etal., Biochem Biophys Res Commun. 2010 Feb 26;393(1):156-61. doi: 10.1016/j.bbrc.2010.01.109. Epub 2010 Feb 1.
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2. |
Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. |
Alam MU, etal., Cardiovasc Res. 2009 Feb 1;81(2):260-8. doi: 10.1093/cvr/cvn279. Epub 2008 Oct 13.
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3. |
Decrease in calcium-sensing receptor in the progress of diabetic cardiomyopathy. |
Bai SZ, etal., Diabetes Res Clin Pract. 2012 Mar;95(3):378-85. doi: 10.1016/j.diabres.2011.11.007. Epub 2011 Dec 3.
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4. |
Extracellular Calcium-sensing Receptor is Expressed in Rat Hepatocytes: Coupling to Intracellular Calcium Mobilization and Stimulation of Bile Flow. |
Canaff L, etal., J Biol Chem 2001 Feb 9;276(6):4070-9. Epub 2000 Nov 08.
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5. |
FGF23 fails to inhibit uremic parathyroid glands. |
Canalejo R, etal., J Am Soc Nephrol. 2010 Jul;21(7):1125-35. doi: 10.1681/ASN.2009040427. Epub 2010 Apr 29.
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6. |
Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1. |
Cha SK, etal., J Biol Chem. 2011 Jan 21;286(3):1828-35. doi: 10.1074/jbc.M110.160390. Epub 2010 Nov 17.
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7. |
Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. |
Chattopadhyay N, etal., Endocrinology 2004 Jul;145(7):3451-62. Epub 2004 Apr 7.
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8. |
Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system. |
Cheng SX Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G60-70. doi: 10.1152/ajpgi.00425.2011. Epub 2012 Apr 19.
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9. |
Expression of calcium-sensing receptor in rat colonic epithelium: evidence for modulation of fluid secretion. |
Cheng SX, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jul;283(1):G240-50.
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10. |
Cyclosporin A induces apoptosis in H9c2 cardiomyoblast cells through calcium-sensing receptor-mediated activation of the ERK MAPK and p38 MAPK pathways. |
Chi J, etal., Mol Cell Biochem. 2012 Aug;367(1-2):227-36. doi: 10.1007/s11010-012-1336-5. Epub 2012 Jun 8.
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11. |
Mutations in the human Ca(2+)-sensing-receptor gene that cause familial hypocalciuric hypercalcemia. |
Chou YH, etal., Am J Hum Genet. 1995 May;56(5):1075-9.
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12. |
A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis. |
Chou YH, etal., PLoS One. 2011;6(9):e25227. doi: 10.1371/journal.pone.0025227. Epub 2011 Sep 22.
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13. |
Post-conditioning protects cardiomyocytes from apoptosis via PKC(epsilon)-interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk. |
Dong S, etal., Mol Cell Biochem. 2010 Aug;341(1-2):195-206. doi: 10.1007/s11010-010-0450-5. Epub 2010 Apr 11.
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14. |
A novel mutation in the calcium-sensing receptor gene in an Irish pedigree showing familial hypocalciuric hypercalcemia: a case report. |
Elamin WF and de Buyl O, J Med Case Rep. 2010 Oct 29;4:349. doi: 10.1186/1752-1947-4-349.
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15. |
The clinical significance of parathyroid tissue calcium sensing receptor gene polymorphisms and expression levels in end-stage renal disease patients. |
Eren PA, etal., Clin Nephrol. 2009 Aug;72(2):114-21.
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16. |
Vitamin D receptor and calcium-sensing receptor gene polymorphisms in hypercalciuric stone-forming patients. |
Ferreira LG, etal., Nephron Clin Pract. 2010;114(2):c135-44. doi: 10.1159/000254386. Epub 2009 Nov 3.
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17. |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
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18. |
Rat ISS GO annotations from GOA human gene data--August 2006 |
GOA data from the GO Consortium
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19. |
Increased expression of calcium-sensing receptors induced by ox-LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia-reperfusion. |
Guo J, etal., Clin Exp Pharmacol Physiol. 2010 Mar;37(3):e128-35. doi: 10.1111/j.1440-1681.2010.05345.x.
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20. |
Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats. |
Guo J, etal., Mol Cell Biochem. 2012 Jul;366(1-2):345-54. doi: 10.1007/s11010-012-1312-0. Epub 2012 Apr 17.
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21. |
Early degenerative effects of diabetes mellitus on pancreas, liver, and kidney in rats: an immunohistochemical study. |
Haligur M, etal., Exp Diabetes Res. 2012;2012:120645. doi: 10.1155/2012/120645. Epub 2012 Jul 11.
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22. |
A homozygous inactivating calcium-sensing receptor mutation, Pro339Thr, is associated with isolated primary hyperparathyroidism: correlation between location of mutations and severity of hypercalcaemia. |
Hannan FM, etal., Clin Endocrinol (Oxf). 2010 Dec;73(6):715-22. doi: 10.1111/j.1365-2265.2010.03870.x.
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23. |
The calcium-sensing receptor affects fat accumulation via effects on antilipolytic pathways in adipose tissue of rats fed low-calcium diets. |
He YH, etal., J Nutr. 2011 Nov;141(11):1938-46. doi: 10.3945/jn.111.141762. Epub 2011 Sep 21.
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24. |
A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. |
Ho C, etal., Nat Genet. 1995 Dec;11(4):389-94.
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25. |
Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification. |
Hough TA, etal., Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13566-71. Epub 2004 Sep 3.
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26. |
Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function. |
Huang C, etal., Am J Physiol Renal Physiol. 2007 Mar;292(3):F1073-81. Epub 2006 Nov 22.
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27. |
Two novel missense mutations in calcium-sensing receptor gene associated with neonatal severe hyperparathyroidism. |
Kobayashi M, etal., J Clin Endocrinol Metab. 1997 Aug;82(8):2716-9.
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28. |
A calcimimetic (R-568), but not calcitriol, prevents vascular remodeling in uremia. |
Koleganova N, etal., Kidney Int. 2009 Jan;75(1):60-71. doi: 10.1038/ki.2008.490. Epub 2008 Oct 1.
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29. |
Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic. |
Koleganova N, etal., Lab Invest. 2009 May;89(5):520-30. doi: 10.1038/labinvest.2009.7. Epub 2009 Feb 2.
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30. |
The calcium-sensing receptor mediates hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells through MEK1/ERK1,2 and PI3K pathways. |
Li GW, etal., Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):185-93. doi: 10.1111/j.1742-7843.2010.00639.x. Epub 2010 Nov 12.
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31. |
Involvement of calcium-sensing receptor in oxLDL-induced MMP-2 production in vascular smooth muscle cells via PI3K/Akt pathway. |
Li HX, etal., Mol Cell Biochem. 2012 Mar;362(1-2):115-22. doi: 10.1007/s11010-011-1133-6. Epub 2011 Nov 15.
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32. |
Rat ISS GO annotations from MGI mouse gene data--August 2006 |
MGD data from the GO Consortium
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33. |
Extracellular calcium-sensing receptor is functionally expressed in human artery. |
Molostvov G, etal., Am J Physiol Renal Physiol. 2007 Sep;293(3):F946-55. Epub 2007 May 30.
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34. |
Electronic Transfer of LocusLink and RefSeq Data |
NCBI rat LocusLink and RefSeq merged data July 26, 2002
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35. |
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. |
O'Seaghdha CM, etal., Hum Mol Genet. 2010 Nov 1;19(21):4296-303. doi: 10.1093/hmg/ddq342. Epub 2010 Aug 12.
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36. |
Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes. |
Okamoto K, etal., Diabetes. 2012 Jul;61(7):1734-41. doi: 10.2337/db11-1201. Epub 2012 May 7.
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37. |
OMIM Disease Annotation Pipeline |
OMIM Disease Annotation Pipeline
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38. |
Glucose-mediated spatial interactions of voltage dependent calcium channels and calcium sensing receptor in insulin producing beta-cells. |
Parkash J Life Sci. 2011 Jan 31;88(5-6):257-64. doi: 10.1016/j.lfs.2010.12.002. Epub 2010 Dec 10.
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39. |
A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. |
Pearce SH, etal., N Engl J Med. 1996 Oct 10;335(15):1115-22.
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40. |
Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. |
Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
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41. |
Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. |
Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
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42. |
PID Annotation Import Pipeline |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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43. |
Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. |
Pollak MR, etal., Cell. 1993 Dec 31;75(7):1297-303.
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44. |
Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation. |
Pollak MR, etal., Nat Genet. 1994 Nov;8(3):303-7.
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45. |
GOA pipeline |
RGD automated data pipeline
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46. |
ClinVar Automated Import and Annotation Pipeline |
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
|
47. |
Data Import for Chemical-Gene Interactions |
RGD automated import pipeline for gene-chemical interactions
|
48. |
Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. |
Riccardi D, etal., Proc Natl Acad Sci U S A 1995 Jan 3;92(1):131-5.
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49. |
Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function. |
Ritter CS, etal., J Bone Miner Res 2002 Dec;17(12):2206-13.
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50. |
Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. |
Ruat M, etal., Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3161-5.
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51. |
Primary hyperparathyroidism and the presence of kidney stones are associated with different haplotypes of the calcium-sensing receptor. |
Scillitani A, etal., J Clin Endocrinol Metab. 2007 Jan;92(1):277-83. doi: 10.1210/jc.2006-0857. Epub 2006 Oct 3.
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52. |
A novel CASR mutation in a Tunisian FHH/NSHPT family associated with a mental retardation. |
Sfar S, etal., Mol Biol Rep. 2012 Mar;39(3):2395-400. doi: 10.1007/s11033-011-0990-0. Epub 2011 Jun 12.
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53. |
Association between calcium-sensing receptor gene polymorphisms and recurrent calcium kidney stone disease: a comprehensive gene analysis. |
Shakhssalim N, etal., Scand J Urol Nephrol. 2010 Dec;44(6):406-12. doi: 10.3109/00365599.2010.497770. Epub 2010 Jul 5.
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54. |
Phenotypic variation in a large family with autosomal dominant hypocalcaemia. |
Sorheim JI, etal., Horm Res Paediatr. 2010;74(6):399-405. doi: 10.1159/000303188. Epub 2010 May 26.
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55. |
Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. |
Tfelt-Hansen J, etal., Am J Physiol Endocrinol Metab 2003 Aug;285(2):E329-37. Epub 2003 Apr 15.
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56. |
Calcium-sensing receptor modulates cell adhesion and migration via integrins. |
Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3.
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57. |
Biased agonism of the calcium-sensing receptor. |
Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20.
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58. |
Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. |
Tu Q, etal., J Clin Invest 2003 Apr;111(7):1029-37.
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59. |
Polymorphisms at the regulatory regions of the CASR gene influence stone risk in primary hyperparathyroidism. |
Vezzoli G, etal., Eur J Endocrinol. 2011 Mar;164(3):421-7. doi: 10.1530/EJE-10-0915. Epub 2010 Dec 23.
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60. |
Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. |
Vezzoli G, etal., J Am Soc Nephrol. 2002 Oct;13(10):2517-23.
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61. |
Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region. |
Vezzoli G, etal., Nephrol Dial Transplant. 2010 Jul;25(7):2245-52. doi: 10.1093/ndt/gfp760. Epub 2010 Jan 12.
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62. |
Molecular cloning and characterization of a rat sensory nerve Ca2+-sensing receptor. |
Wang Y, etal., Am J Physiol Cell Physiol 2003 Jul;285(1):C64-75. Epub 2003 Mar 12.
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63. |
Association between activating mutations of calcium-sensing receptor and Bartter's syndrome. |
Watanabe S, etal., Lancet 2002 Aug 31;360(9334):692-4.
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64. |
Effect of silencing VDR gene in kidney on renal epithelial calcium transporter proteins and urinary calcium excretion in genetic hypercalciuric stone-forming rats. |
Xi QL, etal., Urology. 2011 Dec;78(6):1442.e1-7. doi: 10.1016/j.urology.2011.08.051.
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65. |
Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. |
Yamamura A, etal., Circ Res. 2012 Aug 3;111(4):469-81. doi: 10.1161/CIRCRESAHA.112.266361. Epub 2012 Jun 22.
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66. |
Inhibitory effect of hepatocyte growth factor on cardiomyocytes apoptosis is partly related to reduced calcium sensing receptor expression during a model of simulated ischemia/reperfusion. |
Yan L, etal., Mol Biol Rep. 2011 Apr;38(4):2695-701. doi: 10.1007/s11033-010-0412-8. Epub 2010 Nov 19.
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67. |
[Activation of calcium-sensing receptors is associated with apoptosis in cardiomyocytes under simulated ischemia/reperfusion]. |
Yan L, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Mar;40(2):207-12.
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68. |
Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism. |
Yano S, etal., Kidney Int. 2000 Nov;58(5):1980-6.
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69. |
Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction. |
Zhang J, etal., Antioxid Redox Signal. 2012 Aug 1;17(3):471-84. doi: 10.1089/ars.2011.4168. Epub 2012 Jan 25.
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70. |
Involvement of the calcium-sensing receptor in cyclosporin A-induced cardiomyocyte apoptosis in rats. |
Zhao Y, etal., Pharmazie. 2011 Dec;66(12):968-74.
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71. |
Calcium-sensing receptor activating phosphorylation of PKCdelta translocation on mitochondria to induce cardiomyocyte apoptosis during ischemia/reperfusion. |
Zheng H, etal., Mol Cell Biochem. 2011 Dec;358(1-2):335-43. doi: 10.1007/s11010-011-0984-1. Epub 2011 Jul 16.
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