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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2277 Species: Rattus norvegicus RGD Object: Gene Symbol: Casr Name: calcium-sensing receptor

Acc ID: CHEBI:28112 Term: nickel atom Definition: Chemical element with atomic number 28. CasRN: 7440-02-0 Chemical ID: MESH:D009532

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10291	6480464	CTD	[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of COL1A1 mRNA] [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ACTA2 mRNA] [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased abundance of Calcium] [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of IL1B mRNA] [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ICAM1 mRNA] [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of TNF mRNA] [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] which results in decreased susceptibility to Nickel CASR protein affects the reaction [Nickel results in increased abundance of Calcium]	PMID:19781536
increases activity	ISO	RGD:10291	6480464	CTD	Nickel results in increased activity of CASR protein	PMID:19781536