RGD Reference Report - Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. - Rat Genome Database

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Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

Authors: Ruat, M  Molliver, ME  Snowman, AM  Snyder, SH 
Citation: Ruat M, etal., Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3161-5.
RGD ID: 1298726
Pubmed: PMID:7724534   (View Abstract at PubMed)
PMCID: PMC42125   (View Article at PubMed Central)

We have molecularly cloned a calcium sensing receptor (CaSR) from a rat striatal cDNA library. Rat CaSR displays 92% overall homology to its bovine counterpart with seven putative transmembrane domains characteristic of the superfamily of guanine nucleotide-binding proteins and significant homology with the metabotropic glutamate receptors. Northern blot analysis reveals two transcripts in thyroid, kidney, lung, ileum, and pituitary. In brain highest regional expression of the RNA occurs in the hypothalamus and the corpus striatum. Immunohistochemistry reveals discrete punctate localizations throughout the brain that appear to be associated with nerve terminals. No staining is evident in cell bodies of neurons or glia. Cerebral arteries display an intense network of CaSR immunoreactive fibers associated with vessel innervation. CaSR on nerve terminal membranes may regulate neurotransmitter disposition in response to Ca2+ levels in the synaptic space.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon terminus  IDA 1298726 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casr  (calcium-sensing receptor)


Additional Information