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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2277
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casr
Name: calcium-sensing receptor
Acc ID: CHEBI:28112
Term: nickel atom
Definition: Chemical element (nickel group element atom) with atomic number 28.
Chemical ID: MESH:D009532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casrincreases activityISOCASR (Homo sapiens)6480464CTDNickel results in increased activity of CASR proteinPMID:19781536
Casrmultiple interactionsISOCASR (Homo sapiens)6480464CTD[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased abundance of Calcium]; [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ACTA2 mRNA]; [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of COL1A1 mRNA]; [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ICAM1 mRNA]; [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of IL1B mRNA]; [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of TNF mRNA]; [2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] which results in decreased susceptibility to Nickel; CASR protein affects the reaction [Nickel results in increased abundance of Calcium]PMID:19781536
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