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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2277 Species: Rattus norvegicus RGD Object: Gene Symbol: Casr Name: calcium-sensing receptor

Acc ID: CHEBI:29320 Term: calcium(0) Definition: An elemental calcium that has formula Ca. CasRN: 7440-70-2 Chemical ID: MESH:D002118

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10291	6480464	CTD	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CASR protein results in increased uptake of Calcium] 2-aminoethoxydiphenyl borate inhibits the reaction [CASR protein results in increased uptake of Calcium] 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [CASR protein results in increased uptake of Calcium] chelerythrine inhibits the reaction [CASR protein results in increased uptake of Calcium] CASR protein promotes the reaction [TRPC6 protein results in increased uptake of Calcium] Flufenamic Acid promotes the reaction [CASR protein results in increased uptake of Calcium] methyl-beta-cyclodextrin inhibits the reaction [CASR protein results in increased uptake of Calcium] Lanthanum inhibits the reaction [CASR protein results in increased uptake of Calcium] Pertussis Toxin inhibits the reaction [CASR protein results in increased uptake of Calcium]	PMID:21562303
increases activity	ISO	RGD:10291	6480464	CTD	Calcium results in increased activity of CASR protein	PMID:17041782
multiple interactions	ISO	RGD:10291	6480464	CTD	[Calcium binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium 2-aminoethoxydiphenyl borate inhibits the reaction [Calcium binds to and results in increased activity of CASR protein] Lanthanum inhibits the reaction [Calcium binds to and results in increased activity of CASR protein] [Spermine binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium	PMID:17041782
increases uptake	ISO	RGD:10291	6480464	CTD	CASR protein results in increased uptake of Calcium	PMID:21562303
multiple interactions	ISO	RGD:10291	6480464	CTD	bisindolylmaleimide I inhibits the reaction [NPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]] Calcium Chloride promotes the reaction [Calcium results in increased phosphorylation of CASR protein]	PMID:17376781
increases phosphorylation	ISO	RGD:10291	6480464	CTD	Calcium results in increased phosphorylation of CASR protein	PMID:17376781
increases response to substance	ISO	RGD:10291	6480464	CTD	CASR gene mutant form results in increased susceptibility to Calcium	PMID:11089548
decreases response to substance	ISO	RGD:10291	6480464	CTD	CASR protein mutant form results in decreased susceptibility to Calcium	PMID:9011580
increases response to substance	ISO	RGD:10291	6480464	CTD	CASR protein mutant form results in increased susceptibility to Calcium	PMID:7874174 PMID:11701698
multiple interactions	ISO	RGD:10291	6480464	CTD	N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine affects the reaction [CASR gene mutant form results in increased susceptibility to Calcium] N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine promotes the reaction [CASR protein results in increased susceptibility to Calcium]	PMID:11089548
multiple interactions	ISO	RGD:10291	6480464	CTD	[CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate	PMID:7874174
affects expression	EXP		6480464	CTD	Calcium affects the expression of CASR mRNA Calcium affects the expression of CASR protein	PMID:15788476
multiple interactions	EXP		6480464	CTD	Calcium binds to and results in increased activity of CASR protein	PMID:11071898
multiple interactions	ISO	RGD:10291	6480464	CTD	[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased abundance of Calcium] CASR protein affects the reaction [Nickel results in increased abundance of Calcium]	PMID:19781536
increases response to substance	ISO	RGD:10291	6480464	CTD	CASR protein mutant form results in increased susceptibility to Calcium	PMID:11701698 PMID:7874174
multiple interactions	EXP		6480464	CTD	[Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium [Calcium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates [Calcium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium [Gadolinium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium Gadolinium inhibits the reaction [Calcium binds to and results in increased activity of CASR protein] [Magnesium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium [Neomycin binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium	PMID:10231437
multiple interactions	EXP		6480464	CTD	Calcium binds to and results in increased activity of CASR protein	PMID:10231437 PMID:11071898