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Gene:
A2m ( Rattus norvegicus )
alpha-2-macroglobulin
Description:plays a role in acute phase response; activated form induces a decrease in N-methyl-D-aspartate (NMDA) mediated calcium signaling
Synonyms:A2m; alpha-2-macroglobulin; A2MAC1; A2maa; RATA2MAC1; A2m1; AI893533; MGC114358; Mam;  (details...)
ArrayIDs:6181248; 6622350; 5638271; 6389216; 6687263; 5673845; 6612009; 5976615; 6049292; X13983mRNA_at; 5810896; 5795135; 6325264; M22670cds_g_at; 5720405; 5945193; 6270624; rc_AA900582_at; 6215953; 5677744; 5839062; 5755022; M22670cds_at; 5698333; 6403323; 6537074; 5980127; 5635982; 6359547; 6254071; 6351094; 6173395; 1367794_at; 6547414; 5859870; 6173516; 6425018; 5877355; 6170521; 6718098; 5897530; 6343305; 6271157; rc_AI113046_at; 6322240; 6038308; 6379689; 6080333; 5872908; 5714458; 6601749; M23566exon_s_at; 6111521; 5781084; 6426696;  (details...)
Gene Type:protein-coding
 
Additional Data
Candidate gene for: Plsm2 - Polydactyly-luxate syndrome (PLS) morphotypes QTL 2
Markers: D4Arb15 D4Mit20 D4Wox16
 
Homologs
Homo sapiens: A2M     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: A2m     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusA2mgenome assembly 3.14158348624 - 158398358
  Rat Celera Assembly4143730173 - 143781189
  RGSC genome assembly v3.44158103689 - 158153422
  Cytogenetic4q42
Mus musculusA2mMouse genome assembly build 36.16121577973 - 121629245
  Cytogenetic66 F1
Homo sapiensA2Mhuman genome assembly129111576 - 9159754
  Human genome assembly build 36.2129111571 - 9159825
  Cytogenetic12p13.3-p12.3
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
Other Map Data:
Associated SSLP Map Locations
STSD4Arb15genome assembly 3.14158346684 - 158346899
  SHRSP x BN475.9499
  RH 3.44997.5
  Rat cytogenetic map4
  RGSC genome assembly v3.44158101748 - 158101963
  RH 2.0 4989.4
STSD4Mit20genome assembly 3.14158353240 - 158353464
  RH 3.44997.54
  RGSC genome assembly v3.44158108304 - 158108528
  RH 2.0 41012.9
STSD4Wox16genome assembly 3.14158346766 - 158346909
  RH 3.44997.91
  RGSC genome assembly v3.44158101830 - 158101973
 
 Annotation
Molecular Function
Gene Ontology
interleukin-1 binding,  receptor binding,  interleukin-8 binding ...  (details...)
Biological Process
NoteReference
has a role in the acute-phase response to tissue damage and infection67925, 70249
inhibits proteinases67925, 70249
Gene Ontology
response to glucocorticoid stimulus,  response to nutrient,  negative regulation of complement activation, lectin pathway ...  (details...)
Cellular Component
Gene Ontology
extracellular space,  platelet alpha granule lumen,  extracellular region (details...)
Disease
Ontology
Carcinoma, Hepatocellular,  Cardiomegaly,  Burns ...  (details...)
Phenotype
Ontology
abnormal erythrocyte cell number,  cardiac hypertrophy,  abnormal hippocampus function (details...)
Expression
NoteReference
may be induced during the regeneration of hepatocytes after liver damage67925, 70249
Pathway
Ontology
transforming growth factor-beta Smad dependent signaling pathway,  immune response pathway,  inflammatory response pathway ...  (details...)
 
 External Links
Databases
DATABASEIDSOURCE
PROSITE:ALPHA_2_MACROGLOBULINIPI
UNIPARC:UPI000050336AIPI
KEGG Report:rno:24153ENTREZGENE
HomoloGene Group ID:37248ENTREZGENE
Germonline:2004
Pfam:A2M_recepIPI
Pfam:A2M_NIPI
Pfam:A2M_compIPI
Pfam:A2MIPI
Pfam:A2M_N_2IPI
Pfam:Thiol-ester_clIPI
KEGG Pathway:05010ENTREZGENE
KEGG Pathway:04610ENTREZGENE
InterPro:Terpenoid_cyclase/PrenylTrfase.IPI
InterPro:MacrogloblnA2_thiol-ester-bond.IPI
InterPro:MacrogloblnA2_CS.IPI
InterPro:A-macroglobulin_rcpt-bd.IPI
InterPro:A2M_comp.IPI
InterPro:A2M_N.IPI
InterPro:A2M_N_2.IPI
InterPro:MacrogloblnA2.IPI
Ensembl Protein:ENSRNOP00000019346IPI
IPI:IPI00559074IPI
Gene3D-CATH:A-macroglobulin_rcpt-bdIPI
Entrez Gene:A2mENTREZGENE
IMAGE_CLONE:IMAGE:7458629IMAGE-MGC_LOAD
MGC_CLONE:MGC:114358IMAGE-MGC_LOAD
TIGR:TC229016
TIGR:TC239648
UniProt:Q6L4_RATIPI
UniProt:Q6LDG8_RATIPI
UniProt:Q63335_RATIPI
UniProt:Q5FX35_RATIPI
UniProt:Q5D1M8_RATIPI
UniProt:Q5D178_RATIPI
UniProt:A2MG_RATIPI
Ensembl Genes:ENSRNOG00000028896IPI
RatMap:5ENTREZGENE
Superfamily-SCOP:AM_receptor_bindIPI
Superfamily-SCOP:Terp_cyc_toroidIPI
Sequences
Nucleotide:NM_012488Get FASTASearch GEO Profiles
Nucleotide:M84370Get FASTASearch GEO Profiles
Nucleotide:M11793Get FASTASearch GEO Profiles
Nucleotide:J02635Get FASTASearch GEO Profiles
Nucleotide:BC098922Get FASTASearch GEO Profiles
Nucleotide:AY921651Get FASTASearch GEO Profiles
Nucleotide:AY919611Get FASTASearch GEO Profiles
Nucleotide:AY887133Get FASTASearch GEO Profiles
Nucleotide:M23567Get FASTASearch GEO Profiles
Nucleotide:M22670Get FASTASearch GEO Profiles
Nucleotide:CH473964Get FASTASearch GEO Profiles
(View all 11 Nucleotide Accessions)
Protein:Q5FX35Get FASTA
Protein:Q5D1M8Get FASTA
Protein:Q5D178Get FASTA
Protein:P06238Get FASTA
Protein:AAA41595Get FASTA
Protein:AAA40638Get FASTA
Protein:AAA40636Get FASTA
Protein:AAH98922Get FASTA
Protein:AAX11376Get FASTA
Protein:AAX12488Get FASTA
Protein:AAW65786Get FASTA
Protein:AAA77658Get FASTA
Protein:AAA41592Get FASTA
Protein:EDM02009Get FASTA
Protein:EDM02008Get FASTA
Protein:EDM02007Get FASTA
Protein:NP_036620Get FASTA
Protein:Q6LDR4Get FASTA
Protein:Q6LDG8Get FASTA
Protein:Q63335Get FASTA
(View all 20 Protein Accessions)
Clusters
UniGene:109457
 
 References
Curated References
30 references in RGD related to A2m
Other References
29 other references at PubMed related to A2m
 
 Database Information
RGD ID2004
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
16-NOV-06: A2m A2m1 alpha-2-macroglobulin APPROVED Symbol updated to reflect Human and Mouse nomenclature 1299863
10-JUN-02: A2m alpha-2-macroglobulin APPROVED Symbol and Name status set to approved 70586

       

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