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ONTOLOGY REPORT - ANNOTATIONS

Term:lung cell differentiation
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Accession:GO:0060479 term browser browse the term
Definition:The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.
Synonyms:exact_synonym: pulmonary cell differentiation


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lung cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO MGI:2148569 (PMID:19805295) RGD PMID:19805295 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
club cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:108067 (PMID:17164424)		 Ensembl
RGD		 PMID:17164424 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Nfib nuclear factor I/B involved_in ISS
ISO		 GO_REF:0000024
(MGI:5049839|PMID:21513708)		 UniProt
RGD		 PMID:21513708 GO_REF:0000024 MGI:5049839 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:107516 (PMID:17164424)		 Ensembl
RGD		 PMID:17164424 GO_REF:0000107 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO MGI:3583755 (PMID:22797898) RGD PMID:22797898 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
lung ciliated cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfib nuclear factor I/B involved_in ISS
ISO		 GO_REF:0000024
(MGI:5049839|PMID:21513708)		 UniProt
RGD		 PMID:21513708 GO_REF:0000024 MGI:5049839 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
lung epithelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO MGI:2153356 (PMID:31837950) RGD PMID:31837950 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:1858008|MGI:2445707|MGI:2679524 (PMID:16040629)		 Ensembl
RGD		 PMID:16040629 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase acts_upstream_of_or_within ISO MGI:2387406 (PMID:15005800) RGD PMID:15005800 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 acts_upstream_of_or_within ISO MGI:107423|MGI:1917942|MGI:1923373|MGI:2443665 (PMID:21385765) RGD PMID:21385765 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Foxa1 forkhead box A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1347476 (PMID:15668254)		 Ensembl
RGD		 PMID:15668254 GO_REF:0000107 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188 		JBrowse link
G Foxa2 forkhead box A2 acts_upstream_of_or_within ISO MGI:1347472 (PMID:15668254) RGD PMID:15668254 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326 		JBrowse link
G Gpsm2 G-protein signaling modulator 2 acts_upstream_of_or_within ISO (PMID:21385765) RGD PMID:21385765 NCBI chr 2:196,327,149...196,375,322
Ensembl chr 2:196,327,149...196,375,154 		JBrowse link
G Grhl2 grainyhead-like transcription factor 2 involved_in ISO (MGI:5613464|PMID:22955271) RGD PMID:22955271 MGI:5613464 NCBI chr 7:68,400,287...68,530,269
Ensembl chr 7:68,400,477...68,530,258 		JBrowse link
G Insc INSC, spindle orientation adaptor protein acts_upstream_of_or_within ISO (PMID:21385765) RGD PMID:21385765 NCBI chr 1:168,993,032...169,100,438
Ensembl chr 1:168,993,032...169,100,433 		JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 acts_upstream_of_or_within ISO (PMID:21385765) RGD PMID:21385765 NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855 		JBrowse link
G Numb NUMB, endocytic adaptor protein acts_upstream_of_or_within ISO (PMID:21385765) RGD PMID:21385765 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha acts_upstream_of_or_within ISO MGI:3044031 (PMID:16998587) RGD PMID:16998587 NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907 		JBrowse link
G Pthlh parathyroid hormone-like hormone acts_upstream_of_or_within ISO MGI:2154515 (PMID:15162506) RGD PMID:15162506 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Sav1 salvador family WW domain containing protein 1 acts_upstream_of_or_within ISO MGI:3790763 (PMID:18369314) RGD PMID:18369314 NCBI chr 6:88,478,536...88,500,121
Ensembl chr 6:88,478,539...88,499,968 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of_or_within ISO (PMID:24191021) RGD PMID:24191021 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within ISO MGI:3716065 (PMID:19515693) RGD PMID:19515693 NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3053959|MGI:5316446 (PMID:25043473)		 Ensembl
RGD		 PMID:25043473 GO_REF:0000107 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
lung goblet cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member acts_upstream_of_or_within ISO (PMID:22675208) RGD PMID:22675208 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Hoxa5 homeo box A5 acts_upstream_of_or_within ISO MGI:2150397 (PMID:17003488) RGD PMID:17003488 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234 		JBrowse link
G Spdef SAM pointed domain containing ets transcription factor acts_upstream_of_or_within ISO (PMID:17347682) RGD PMID:17347682 NCBI chr20:5,771,440...5,785,893
Ensembl chr20:5,771,441...5,785,893 		JBrowse link
lung neuroendocrine cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:1857470 (PMID:9126746) RGD PMID:9126746 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
lung secretory cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:1921373 (PMID:22675208) RGD PMID:22675208 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Foxp4 forkhead box P4 acts_upstream_of_or_within ISO MGI:1914004 (PMID:22675208) RGD PMID:22675208 NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879 		JBrowse link
negative regulation of lung goblet cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:1921373 (PMID:22675208) RGD PMID:22675208 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Foxp4 forkhead box P4 acts_upstream_of_or_within ISO MGI:1914004 (PMID:22675208) RGD PMID:22675208 NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879 		JBrowse link
positive regulation of lung ciliated cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj1 forkhead box J1 involved_in ISO
IEA		 (PMID:20539013)
GO_REF:0000107		 RGD
Ensembl		 PMID:20539013 GO_REF:0000107 NCBI chr10:101,566,299...101,570,370
Ensembl chr10:101,566,304...101,570,237 		JBrowse link
G Tp73 tumor protein p73 involved_in ISO (PMID:34077761) RGD PMID:34077761 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
regulation of lung goblet cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp1 forkhead box P1 acts_upstream_of_or_within ISO MGI:1344405|MGI:1921373 (PMID:22675208) RGD PMID:22675208 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Foxp4 forkhead box P4 acts_upstream_of_or_within ISO MGI:1344405|MGI:1914004 (PMID:22675208) RGD PMID:22675208 NCBI chr 9:13,058,506...13,115,406
Ensembl chr 9:13,058,476...13,114,879 		JBrowse link
type I pneumocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 acts_upstream_of_or_within ISO MGI:4999627 (PMID:21408140) RGD PMID:21408140 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO MGI:1926485 (PMID:16691571) RGD PMID:16691571 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Klf2 KLF transcription factor 2 acts_upstream_of_or_within ISO (PMID:22001906) RGD PMID:22001906 NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Kras KRAS proto-oncogene, GTPase acts_upstream_of ISO (PMID:24058167) RGD PMID:24058167 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lta4h leukotriene A4 hydrolase IEP RGD PMID:15805137 RGD:2316585 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 acts_upstream_of_or_within ISO MGI:3829987|MGI:98742|MGI:98743 (PMID:22001906) RGD PMID:22001906 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nfib nuclear factor I/B involved_in ISS
ISO		 GO_REF:0000024
(MGI:5049839|PMID:21513708)		 UniProt
RGD		 PMID:21513708 GO_REF:0000024 MGI:5049839 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
G Sox9 SRY-box transcription factor 9 acts_upstream_of ISO MGI:2385468 (PMID:24058167) RGD PMID:24058167 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Thra thyroid hormone receptor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1337080|MGI:98743 (PMID:22001906)		 Ensembl
RGD		 PMID:22001906 GO_REF:0000107 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1337080|MGI:98742 (PMID:22001906)		 Ensembl
RGD		 PMID:22001906 GO_REF:0000107 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
type II pneumocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3497919 (PMID:12819782)		 Ensembl
RGD		 PMID:12819782 GO_REF:0000107 NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769 		JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO (PMID:15531758) RGD PMID:15531758 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fndc3b fibronectin type III domain containing 3B acts_upstream_of_or_within ISO MGI:4822558 (PMID:21704616) RGD PMID:21704616 NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830 		JBrowse link
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:108067 (PMID:17164424)		 Ensembl
RGD		 PMID:17164424 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Igf1 insulin-like growth factor 1 acts_upstream_of_or_within ISO MGI:1926485 (PMID:16691571) RGD PMID:16691571 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Nfib nuclear factor I/B involved_in ISS
ISO		 GO_REF:0000024
(MGI:5049839|PMID:21513708)		 UniProt
RGD		 PMID:21513708 GO_REF:0000024 MGI:5049839 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479 		JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:107516 (PMID:17164424)		 Ensembl
RGD		 PMID:17164424 GO_REF:0000107 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Rbbp9 RB binding protein 9, serine hydrolase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:32484881)		 Ensembl
RGD		 PMID:32484881 GO_REF:0000107 NCBI chr 3:131,925,095...131,939,042
Ensembl chr 3:131,925,341...131,932,156 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    cellular process 18195
      cellular developmental process 4695
        cell differentiation 4694
          lung cell differentiation 41
            lung basal cell differentiation 0
            lung epithelial cell differentiation + 41
Path 2
Term Annotations click to browse term
  biological_process 19692
    developmental process 6963
      anatomical structure development 6486
        multicellular organism development 5239
          system development 4526
            respiratory system development 321
              lung development 285
                lung cell differentiation 41
                  lung basal cell differentiation 0
                  lung epithelial cell differentiation + 41
paths to the root