alpha-carotene - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	alpha-carotene	go back to main search page
Accession:	CHEBI:28425	browse the term
Definition:	A cyclic carotene with a beta- and an epsilon-ring at opposite ends respectively.
Synonyms:	related_synonym:	Formula=C40H56; InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-23,25-28,37H,15-16,24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+; InChIKey=ANVAOWXLWRTKGA-JLTXGRSLSA-N; SMILES=CC(\\C=C\\C=C(C)\\C=C\\C1C(C)=CCCC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C; all-trans-alpha-carotene; beta,epsilon-Carotene
	alt_id:	CHEBI:10215; CHEBI:22447
	xref:	Beilstein:2067408; Beilstein:3227599; CAS:432-70-2; HMDB:HMDB0003993; KEGG:C05433; KNApSAcK:C00003765; LIPID_MAPS_instance:LMPR01070258
	xref_mesh:	MESH:C041635
	xref:	PMID:23620017; PMID:24169341; PMID:9408998; Reaxys:2682045

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Genes (62)

alpha-carotene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

O-6-methylguanine-DNA methyltransferase

affects response to substance

MGMT gene SNP affects the susceptibility to alpha-carotene

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

lutein

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alsin Rho guanine nucleotide exchange factor ALS2

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of ALS2 mRNA; [Cisplatin co-treated with Lutein] results in increased expression of ALS2 mRNA
Lutein results in decreased expression of ALS2 mRNA

NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737

G

APC regulator of WNT signaling pathway

multiple interactions

[Cisplatin co-treated with Lutein] results in increased expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

aquarius intron-binding spliceosomal factor

decreases expression
multiple interactions

Lutein results in decreased expression of AQR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of AQR mRNA

NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044

G

ATR serine/threonine kinase

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA
Lutein results in decreased expression of ATR mRNA

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

BCL2 associated X, apoptosis regulator

increases expression

Lutein results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Lutein results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

increases expression

Lutein results in increased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

beta-carotene oxygenase 2

increases metabolic processing
multiple interactions
affects metabolic processing

BCO2 protein results in increased metabolism of Lutein
[BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite

NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467

G

catalase

multiple interactions

Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression

Lutein results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

copper chaperone for superoxide dismutase

increases expression

Lutein results in increased expression of CCS mRNA

NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915

G

complement factor D

decreases expression
decreases secretion

Lutein results in decreased expression of CFD mRNA
Lutein results in decreased secretion of CFD protein

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

creatine kinase B

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased activity of CKB protein]

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

cathepsin B

increases expression
multiple interactions

Lutein results in increased expression of CTSB mRNA
Cisplatin inhibits the reaction [Lutein results in increased expression of CTSB mRNA]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cytochrome b-245 alpha chain

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA
Lutein results in decreased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

desmin

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression
multiple interactions

Lutein results in decreased expression of ERCC2 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 6, chromatin remodeling factor

decreases expression

Lutein results in decreased expression of ERCC6 mRNA

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

flavin containing dimethylaniline monoxygenase 2

decreases expression

Lutein results in decreased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

GRB2-associated binding protein 1

decreases expression
multiple interactions

Lutein results in decreased expression of GAB1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA

NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236

G

glutathione peroxidase 1

multiple interactions
increases expression

Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA]

PMID:22040935 PMID:24865317

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

multiple interactions

[Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione-disulfide reductase

increases expression
multiple interactions

Lutein results in increased expression of GSR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase kappa 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

heme oxygenase 1

multiple interactions
increases expression

arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Lutein results in increased expression of HMOX1 mRNA; Lutein results in increased expression of HMOX1 protein

PMID:25815309 PMID:26187899

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

isocitrate dehydrogenase (NADP(+)) 1

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of IDH1 mRNA
Lutein results in decreased expression of IDH1 mRNA

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

G

intraflagellar transport 172

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA
Lutein results in decreased expression of IFT172 mRNA

NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860

G

insulin 1

multiple interactions
decreases expression

[Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein; [Lutein co-treated with Ascorbic Acid] results in decreased expression of INS1 protein
Lutein results in decreased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

kinesin family member 9

multiple interactions
increases expression

Lutein promotes the reaction [Cisplatin results in decreased expression of KIF9 mRNA]
Lutein results in increased expression of KIF9 mRNA

NCBI chr 8:110,459,467...110,504,492
Ensembl chr 8:110,459,383...110,505,252

G

myoglobin

increases expression

Lutein results in increased expression of MB mRNA

NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383

G

microsomal glutathione S-transferase 1

multiple interactions
increases expression

arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA]

PMID:25815309 PMID:26187899

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

myocardial infarction associated transcript

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased expression of MIAT]

NCBI chr12:44,414,620...44,429,852

G

microRNA 200a

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of MIR200A mRNA]

NCBI chr 5:166,648,494...166,648,582

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein]; Lutein results in increased expression of and affects the localization of NFE2L2 protein
Lutein results in increased expression of NFE2L2 mRNA; Lutein results in increased expression of NFE2L2 protein
Lutein inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]

PMID:25815309 PMID:26187899 PMID:34435724

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

neuroglobin

increases expression

Lutein results in increased expression of NGB mRNA

NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830

G

NADPH oxidase 4

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of NOX4 mRNA
Lutein results in decreased expression of NOX4 mRNA

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NADPH oxidase organizer 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of NOXO1 mRNA

NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

[Cisplatin co-treated with Lutein] results in increased expression of NQO1 mRNA; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 protein]
Lutein results in increased expression of NQO1 mRNA; Lutein results in increased expression of NQO1 protein

PMID:24865317 PMID:25815309 PMID:26187899

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nudix hydrolase 15

decreases expression
multiple interactions

Lutein results in decreased expression of NUDT15 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of NUDT15 mRNA

NCBI chr15:48,707,776...48,713,847
Ensembl chr15:48,709,700...48,747,363

G

nucleoredoxin

increases expression
multiple interactions

Lutein results in increased expression of NXN mRNA
Lutein inhibits the reaction [Cisplatin results in increased expression of NXN mRNA]

NCBI chr10:61,109,322...61,247,578
Ensembl chr10:61,110,020...61,248,251

G

Parkinsonism associated deglycase

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

protein phosphatase 1, regulatory subunit 15B

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of PPP1R15B mRNA
Lutein results in decreased expression of PPP1R15B mRNA

NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737

G

peroxiredoxin 4

increases expression

Lutein results in increased expression of PRDX4 mRNA

NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066

G

peroxiredoxin 5

decreases expression

Lutein results in decreased expression of PRDX5 mRNA

NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268

G

peroxiredoxin 6

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of PRDX6 mRNA
Lutein results in decreased expression of PRDX6 mRNA

NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Lutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Lutein inhibits the reaction [deoxynivalenol affects the localization of RELA protein]; Lutein inhibits the reaction [deoxynivalenol results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

stearoyl-CoA desaturase

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SCD1 mRNA
Lutein results in decreased expression of SCD1 mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

superoxide dismutase 1

multiple interactions
increases expression

Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD1 mRNA]
Lutein results in increased expression of SOD1 mRNA

PMID:22040935 PMID:24865317

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SOD2 mRNA; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]
Lutein results in decreased expression of SOD2 mRNA

PMID:22040935 PMID:24865317

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA
Lutein results in decreased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

sulfiredoxin 1

multiple interactions
decreases expression

[Cisplatin co-treated with Lutein] results in decreased expression of SRXN1 mRNA
Lutein results in decreased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

troponin T2, cardiac type

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

thioredoxin 1

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in decreased expression of TXN protein]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin interacting protein

multiple interactions

Lutein inhibits the reaction [Isoproterenol results in increased expression of TXNIP protein]

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

decreases expression
multiple interactions

Lutein results in decreased expression of TXNRD1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

uncoupling protein 3

increases expression

Lutein results in increased expression of UCP3 mRNA

NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762

G

vimentin

increases expression

Lutein results in increased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

xin actin-binding repeat containing 1

increases expression

Lutein results in increased expression of XIRP1 mRNA

NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19838
role	19814
biological role	19812
provitamin	277
provitamin A	274
alpha-carotene	62
(6'R)-beta,epsilon-carotene +	61
(6'S)-beta,epsilon-carotene	0
Path 2
Term	Annotations
CHEBI ontology	19838
subatomic particle	19836
composite particle	19836
hadron	19836
baryon	19836
nucleon	19836
atomic nucleus	19836
atom	19836
main group element atom	19786
main group molecular entity	19786
s-block molecular entity	19624
hydrogen molecular entity	19611
hydrides	19117
organic hydride	18687
organic fundamental parent	18687
hydrocarbon	18432
terpene	14069
tetraterpene	595
carotene	595
carotenoid	595
carotenoid beta-end derivative	274
alpha-carotene	62
(6'R)-beta,epsilon-carotene +	61
(6'S)-beta,epsilon-carotene	0

paths to the root