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G |
A2m |
alpha-2-macroglobulin |
increases expression |
ISO |
Isoniazid results in increased expression of A2M mRNA |
CTD |
PMID:12883083 |
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NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186
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G |
Abcb11 |
ATP-binding cassette, sub-family B member 11 |
multiple interactions decreases expression |
ISO EXP |
[Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCB11 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCB11 mRNA] Isoniazid results in decreased expression of ABCB11 protein [Rifampin co-treated with Isoniazid] results in decreased expression of ABCB11 protein [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCB11 protein |
CTD |
PMID:25331106 PMID:25886055 PMID:32673658 PMID:35835356 |
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NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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G |
Abcc1 |
ATP-binding cassette, sub-family C member 1 |
increases expression |
ISO |
Isoniazid results in increased expression of ABCC1 mRNA |
CTD |
PMID:11752103 |
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NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601
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G |
Abcc2 |
ATP-binding cassette, sub-family member 2 |
multiple interactions decreases expression |
ISO |
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCC2 protein; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCC2 mRNA Isoniazid results in decreased expression of ABCC2 mRNA |
CTD |
PMID:25331106 PMID:32673658 PMID:35835356 |
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NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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G |
Abcc3 |
ATP-binding cassette, sub-family C member 3 |
multiple interactions decreases expression |
ISO |
[Lipopolysaccharides co-treated with Isoniazid] results in increased expression of ABCC3 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCC3 mRNA] |
CTD |
PMID:25331106 PMID:32673658 |
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NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
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G |
Abcc4 |
ATP-binding cassette, sub-family C member 4 |
decreases expression |
ISO |
Isoniazid results in decreased expression of ABCC4 mRNA |
CTD |
PMID:32673658 |
|
NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631
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G |
Abcc6 |
ATP-binding cassette, sub-family C member 6 |
decreases expression |
ISO |
Isoniazid results in decreased expression of ABCC6 mRNA |
CTD |
PMID:16260000 |
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NCBI chr 7:45,625,804...45,679,915
Ensembl chr 7:45,616,979...45,679,726
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G |
Ace2 |
angiotensin converting enzyme 2 |
decreases expression |
ISO |
Isoniazid results in decreased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
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NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
multiple interactions |
ISO |
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of ACSL4 protein |
CTD |
PMID:36878459 |
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NCBI chr X:141,100,989...141,173,792
Ensembl chr X:141,100,989...141,173,531
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G |
Afp |
alpha fetoprotein |
decreases expression |
ISO |
Isoniazid results in decreased expression of AFP mRNA |
CTD |
PMID:30008028 |
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NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
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G |
Agpat3 |
1-acylglycerol-3-phosphate O-acyltransferase 3 |
multiple interactions increases expression |
ISO |
[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA] Isoniazid results in increased expression of AGPAT3 mRNA |
CTD |
PMID:28619387 |
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NCBI chr10:78,105,008...78,188,335
Ensembl chr10:78,105,012...78,188,323
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G |
Akr1b10 |
aldo-keto reductase family 1, member B10 |
increases expression |
ISO |
Isoniazid results in increased expression of AKR1B10 mRNA |
CTD |
PMID:28444390 |
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NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
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G |
Alas1 |
aminolevulinic acid synthase 1 |
increases expression |
EXP ISO |
Isoniazid results in increased expression of ALAS1 protein |
CTD |
PMID:27438535 PMID:30517741 |
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NCBI chr 9:106,110,654...106,125,153
Ensembl chr 9:106,110,654...106,125,853
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G |
Alb |
albumin |
affects binding |
ISO |
Isoniazid binds to ALB protein |
CTD |
PMID:25489718 |
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NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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G |
Alpl |
alkaline phosphatase, liver/bone/kidney |
increases activity multiple interactions |
EXP |
Isoniazid results in increased activity of ALPL protein [Rifampin co-treated with Isoniazid] results in increased activity of ALPL protein |
CTD |
PMID:25886055 |
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NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
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G |
Apoa4 |
apolipoprotein A-IV |
affects response to substance |
EXP |
APOA4 affects the susceptibility to Isoniazid |
CTD |
PMID:24848797 |
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NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757
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G |
Apoa5 |
apolipoprotein A-V |
decreases expression multiple interactions |
ISO |
Isoniazid results in decreased expression of APOA5 mRNA [Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA] |
CTD |
PMID:28619387 |
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NCBI chr 9:46,179,906...46,183,219
Ensembl chr 9:46,179,931...46,183,217
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G |
App |
amyloid beta precursor protein |
increases expression |
ISO |
Isoniazid results in increased expression of APP mRNA |
CTD |
PMID:30008028 |
|
NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
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G |
Asl |
argininosuccinate lyase |
increases activity multiple interactions |
ISO |
Isoniazid results in increased activity of ASL protein [Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein] |
CTD |
PMID:28619387 |
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NCBI chr 5:130,040,099...130,053,222
Ensembl chr 5:130,040,099...130,058,088
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G |
Atp1b1 |
ATPase, Na+/K+ transporting, beta 1 polypeptide |
increases expression |
ISO |
Isoniazid results in increased expression of ATP1B1 mRNA |
CTD |
PMID:30008028 |
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NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924
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G |
Atp5f1b |
ATP synthase F1 subunit beta |
affects expression |
EXP |
Isoniazid affects the expression of ATP5F1B mRNA |
CTD |
PMID:24848797 |
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NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260
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G |
Atp5mc1 |
ATP synthase membrane subunit c locus 1 |
affects expression |
EXP |
Isoniazid affects the expression of ATP5MC1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr11:95,963,619...95,966,520
Ensembl chr11:95,959,678...95,966,496
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G |
Atp5mc3 |
ATP synthase membrane subunit c locus 3 |
affects expression |
EXP |
Isoniazid affects the expression of ATP5MC3 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 2:73,738,791...73,742,793
Ensembl chr 2:73,738,791...73,741,670
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G |
Atp5pb |
ATP synthase peripheral stalk-membrane subunit b |
affects expression |
EXP |
Isoniazid affects the expression of ATP5PB mRNA |
CTD |
PMID:24848797 |
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NCBI chr 3:105,850,014...105,866,579
Ensembl chr 3:105,850,014...105,867,415
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G |
Atp5pf |
ATP synthase peripheral stalk subunit F6 |
affects expression |
EXP |
Isoniazid affects the expression of ATP5PF mRNA |
CTD |
PMID:24848797 |
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NCBI chr16:84,624,754...84,632,495
Ensembl chr16:84,624,754...84,632,513
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G |
Bax |
BCL2-associated X protein |
multiple interactions increases expression affects expression |
EXP ISO |
[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein] Isoniazid results in increased expression of BAX protein Quercetin inhibits the reaction [Isoniazid results in increased expression of BAX protein] chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein] Isoniazid results in increased expression of BAX mRNA Isoniazid affects the expression of BAX protein |
CTD |
PMID:20433247 PMID:21419764 PMID:31332904 PMID:33121995 PMID:33771660 |
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NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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G |
Bbox1 |
gamma-butyrobetaine hydroxylase 1 |
increases expression |
ISO |
Isoniazid results in increased expression of BBOX1 mRNA |
CTD |
PMID:30008028 |
|
NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions decreases expression |
EXP ISO |
[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein] Isoniazid results in decreased expression of BCL2 protein Quercetin inhibits the reaction [Isoniazid results in decreased expression of BCL2 protein] Isoniazid results in decreased expression of BCL2 mRNA |
CTD |
PMID:20433247 PMID:21419764 PMID:31332904 PMID:33771660 |
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage increases expression increases activity |
EXP ISO |
[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein] acadesine promotes the reaction [Isoniazid results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP3 protein] Isoniazid results in increased expression of CASP3 mRNA [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CASP3 Isoniazid results in increased activity of CASP3 protein |
CTD |
PMID:20433247 PMID:21419764 PMID:23764483 PMID:28556920 PMID:31332904 PMID:33771660 PMID:35835356 More...
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Casp9 |
caspase 9 |
increases cleavage increases activity multiple interactions |
ISO |
Isoniazid results in increased cleavage of CASP9 protein Isoniazid results in increased activity of CASP9 protein Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP9 protein] |
CTD |
PMID:20433247 PMID:31332904 |
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NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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G |
Casr |
calcium-sensing receptor |
affects expression |
ISO |
Isoniazid affects the expression of CASR mRNA |
CTD |
PMID:20623750 |
|
NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503
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G |
Cat |
catalase |
decreases activity multiple interactions |
ISO EXP |
Isoniazid results in decreased activity of CAT protein [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CAT protein; chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein] |
CTD |
PMID:20433247 PMID:33121995 PMID:33771660 PMID:36878459 |
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
decreases expression |
ISO |
Isoniazid results in decreased expression of CCR2 mRNA |
CTD |
PMID:20623750 |
|
NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
EXP |
Isoniazid results in decreased expression of CEBPA mRNA; Isoniazid results in decreased expression of CEBPA protein |
CTD |
PMID:24128855 |
|
NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
decreases expression |
EXP |
Isoniazid results in decreased expression of CEBPB protein |
CTD |
PMID:24128855 |
|
NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338
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G |
Cebpd |
CCAAT/enhancer binding protein delta |
decreases expression |
EXP |
Isoniazid results in decreased expression of CEBPD mRNA; Isoniazid results in decreased expression of CEBPD protein |
CTD |
PMID:24128855 |
|
NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895
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G |
Chpt1 |
choline phosphotransferase 1 |
affects response to substance |
EXP |
CHPT1 affects the susceptibility to Isoniazid |
CTD |
PMID:24848797 |
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NCBI chr10:88,305,376...88,339,855
Ensembl chr10:88,288,607...88,339,935
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G |
Cldn2 |
claudin 2 |
increases expression |
ISO |
Isoniazid results in increased expression of CLDN2 mRNA |
CTD |
PMID:30008028 |
|
NCBI chr X:138,701,552...138,712,135
Ensembl chr X:138,701,577...138,712,135
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G |
Cox11 |
cytochrome c oxidase assembly protein 11, copper chaperone |
affects expression |
EXP |
Isoniazid affects the expression of COX11 mRNA |
CTD |
PMID:24848797 |
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NCBI chr11:90,529,010...90,536,803
Ensembl chr11:90,528,999...90,535,757
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G |
Cox17 |
cytochrome c oxidase assembly protein 17, copper chaperone |
affects expression |
EXP |
Isoniazid affects the expression of COX17 mRNA |
CTD |
PMID:24848797 |
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NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659
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G |
Cox5b |
cytochrome c oxidase subunit 5B |
affects expression |
EXP |
Isoniazid affects the expression of COX5B mRNA |
CTD |
PMID:24848797 |
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NCBI chr 1:36,730,568...36,732,469
Ensembl chr 1:36,730,530...36,732,762
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G |
Cox6a1 |
cytochrome c oxidase subunit 6A1 |
affects expression |
EXP |
Isoniazid affects the expression of COX6A1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 5:115,483,711...115,487,017
Ensembl chr 5:115,483,701...115,487,040
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G |
Cox6b1 |
cytochrome c oxidase, subunit 6B1 |
affects expression |
EXP |
Isoniazid affects the expression of COX6B1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 7:30,316,396...30,325,539
Ensembl chr 7:30,316,286...30,325,576
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G |
Cox7a2 |
cytochrome c oxidase subunit 7A2 |
affects expression |
EXP |
Isoniazid affects the expression of COX7A2 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 9:79,662,523...79,667,135
Ensembl chr 9:79,662,643...79,667,160
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G |
Cpt1a |
carnitine palmitoyltransferase 1a, liver |
affects expression |
EXP |
Isoniazid affects the expression of CPT1A mRNA |
CTD |
PMID:24848797 |
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NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases secretion |
ISO |
Isoniazid results in increased secretion of CXCL10 protein |
CTD |
PMID:28444390 |
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NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
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G |
Cxcl15 |
C-X-C motif chemokine ligand 15 |
multiple interactions |
ISO |
[Isoniazid co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA |
CTD |
PMID:29594315 |
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NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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G |
Cyb5a |
cytochrome b5 type A (microsomal) |
multiple interactions decreases expression |
ISO |
[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA; Silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA] Isoniazid results in decreased expression of CYB5A mRNA |
CTD |
PMID:28619387 |
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NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
increases expression |
ISO |
Isoniazid results in increased expression of CYP27A1 mRNA |
CTD |
PMID:32673658 |
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NCBI chr 1:74,752,311...74,777,056
Ensembl chr 1:74,752,733...74,777,051
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G |
Cyp2c29 |
cytochrome P450, family 2, subfamily c, polypeptide 29 |
decreases activity multiple interactions |
ISO |
Isoniazid results in decreased activity of CYP2C8 protein torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein] |
CTD |
PMID:15304522 |
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NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects response to substance increases metabolic processing multiple interactions increases expression increases activity increases response to substance |
ISO EXP |
CYP2E1 gene polymorphism affects the susceptibility to Isoniazid; CYP2E1 gene SNP affects the susceptibility to Isoniazid CYP2E1 protein results in increased metabolism of Isoniazid 2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene; [Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]; Isoniazid results in increased expression of and results in increased activity of CYP2E1 protein; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein] Isoniazid results in increased expression of CYP2E1; Isoniazid results in increased expression of CYP2E1 mRNA; Isoniazid results in increased expression of CYP2E1 protein Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA] GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid] |
CTD |
PMID:3113478 PMID:7710944 PMID:8074729 PMID:9051121 PMID:9065729 PMID:9129171 PMID:11752103 PMID:12458634 PMID:12668988 PMID:15132840 PMID:15205388 PMID:15763544 PMID:17950035 PMID:18754103 PMID:19683030 PMID:20485159 PMID:20566340 PMID:22342832 PMID:23211455 PMID:24929095 PMID:25683034 PMID:26880746 PMID:27919644 PMID:28762043 More...
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NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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G |
Cyp7a1 |
cytochrome P450, family 7, subfamily a, polypeptide 1 |
multiple interactions increases expression |
ISO |
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CYP7A1 protein; [Lipopolysaccharides co-treated with Isoniazid] results in increased expression of CYP7A1 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in increased expression of CYP7A1 mRNA] [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CYP7A1 protein; [Isoniazid co-treated with Vitamin B 6] results in increased expression of CYP7A1 mRNA |
CTD |
PMID:25331106 PMID:32673658 PMID:35835356 |
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NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression decreases expression |
ISO |
Isoniazid results in increased expression of DDIT3 mRNA Isoniazid results in decreased expression of DDIT3 mRNA |
CTD |
PMID:12883083 PMID:30008028 |
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NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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G |
Depp1 |
DEPP1 autophagy regulator |
increases expression |
ISO |
Isoniazid results in increased expression of DEPP1 mRNA |
CTD |
PMID:17175557 |
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NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755
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G |
Epx |
eosinophil peroxidase |
increases oxidation multiple interactions |
ISO |
EPX protein results in increased oxidation of Isoniazid [EPX protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of isonicotinyl-NAD |
CTD |
PMID:30922765 |
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NCBI chr11:87,754,824...87,766,362
Ensembl chr11:87,754,826...87,766,362
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G |
Fech |
ferrochelatase |
decreases expression |
EXP ISO |
Isoniazid results in decreased expression of FECH protein |
CTD |
PMID:27438535 PMID:30517741 |
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NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322
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G |
G6pdx |
glucose-6-phosphate dehydrogenase X-linked |
decreases activity |
ISO |
Isoniazid results in decreased activity of G6PD protein |
CTD |
PMID:20433247 |
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NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
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G |
Gadd45a |
growth arrest and DNA-damage-inducible 45 alpha |
decreases expression |
ISO |
Isoniazid results in decreased expression of GADD45A mRNA |
CTD |
PMID:20623750 |
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NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
ISO |
Isoniazid results in increased expression of GAPDH mRNA |
CTD |
PMID:12883083 |
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NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions decreases expression increases expression |
EXP ISO |
Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA] Isoniazid results in decreased expression of GCLC mRNA Isoniazid results in increased expression of GCLC mRNA chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA] |
CTD |
PMID:24128855 PMID:33121995 PMID:33771660 |
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NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
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G |
Gclm |
glutamate-cysteine ligase, modifier subunit |
decreases expression increases expression multiple interactions |
ISO EXP |
Isoniazid results in decreased expression of GCLM mRNA Isoniazid results in increased expression of GCLM mRNA chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA] |
CTD |
PMID:30008028 PMID:33121995 PMID:33771660 |
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NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions increases expression |
ISO |
chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein] Isoniazid results in increased expression of GFAP mRNA; Isoniazid results in increased expression of GFAP protein |
CTD |
PMID:33121995 |
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NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
[Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GGT1 protein |
CTD |
PMID:25331106 |
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NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034
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G |
Got1 |
glutamic-oxaloacetic transaminase 1, soluble |
multiple interactions increases activity |
EXP |
[Rifampin co-treated with Isoniazid] results in increased activity of GOT1 protein Isoniazid results in increased activity of GOT1 protein |
CTD |
PMID:25886055 |
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NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044
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G |
Gpt |
glutamic pyruvic transaminase, soluble |
increases activity multiple interactions increases expression |
ISO EXP |
Isoniazid results in increased activity of GPT protein [Rifampin co-treated with Isoniazid] results in increased activity of GPT protein Quercetin inhibits the reaction [Isoniazid results in increased expression of GPT protein] [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPT protein; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein; [Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GPT protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein]; Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]] |
CTD |
PMID:25331106 PMID:25886055 PMID:28619387 PMID:31332904 PMID:35835356 PMID:36878459 More...
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NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein] |
CTD |
PMID:36878459 |
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NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
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G |
Gsta2 |
glutathione S-transferase, alpha 2 (Yc2) |
increases expression |
ISO |
Isoniazid results in increased expression of GSTA2 mRNA |
CTD |
PMID:12883083 |
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NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070
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G |
Gstm1 |
glutathione S-transferase, mu 1 |
multiple interactions decreases response to substance |
ISO |
GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid] GSTM1 protein results in decreased susceptibility to Isoniazid |
CTD |
PMID:28762043 |
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NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
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G |
Gstp1 |
glutathione S-transferase, pi 1 |
decreases expression |
ISO |
Isoniazid results in decreased expression of GSTP1 mRNA |
CTD |
PMID:20623750 |
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NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
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G |
Gstt1 |
glutathione S-transferase, theta 1 |
multiple interactions |
ISO |
GSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]; GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide] |
CTD |
PMID:18397238 PMID:20485159 |
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NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
affects expression |
ISO |
Isoniazid affects the expression of HAVCR1 mRNA |
CTD |
PMID:20623750 |
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NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
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G |
Hgf |
hepatocyte growth factor |
multiple interactions |
EXP |
HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein] |
CTD |
PMID:23764483 |
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NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150
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G |
Hif1a |
hypoxia inducible factor 1, alpha subunit |
multiple interactions |
ISO |
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein] |
CTD |
PMID:36878459 |
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NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA] Isoniazid results in decreased expression of HMOX1 mRNA Isoniazid results in increased expression of HMOX1 mRNA chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA] |
CTD |
PMID:24128855 PMID:33121995 PMID:33771660 |
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NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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G |
Hmox2 |
heme oxygenase 2 |
increases expression |
ISO |
Isoniazid results in increased expression of HMOX2 mRNA |
CTD |
PMID:12883083 |
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NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
increases expression |
ISO |
Isoniazid results in increased expression of HPRT1 mRNA |
CTD |
PMID:12883083 |
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NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536
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G |
Ifng |
interferon gamma |
increases secretion |
ISO |
Isoniazid results in increased secretion of IFNG protein |
CTD |
PMID:28444390 |
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NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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G |
Il10 |
interleukin 10 |
increases secretion |
ISO |
Isoniazid results in increased secretion of IL10 protein |
CTD |
PMID:28444390 |
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NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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G |
Il12a |
interleukin 12a |
increases secretion |
ISO |
Isoniazid results in increased secretion of IL12A protein |
CTD |
PMID:28444390 |
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NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
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G |
Il12b |
interleukin 12b |
increases secretion |
ISO |
Isoniazid results in increased secretion of IL12B protein |
CTD |
PMID:28444390 |
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NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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G |
Il17a |
interleukin 17A |
increases secretion |
ISO |
Isoniazid results in increased secretion of IL17A protein |
CTD |
PMID:28444390 |
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NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
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G |
Il1a |
interleukin 1 alpha |
increases secretion increases expression |
ISO |
Isoniazid results in increased secretion of IL1A protein Isoniazid results in increased expression of IL1A mRNA |
CTD |
PMID:28444390 PMID:32816093 |
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NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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G |
Il1b |
interleukin 1 beta |
increases secretion increases expression multiple interactions |
ISO |
Isoniazid results in increased secretion of IL1B protein Isoniazid results in increased expression of IL1B mRNA chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA] |
CTD |
PMID:28444390 PMID:32816093 PMID:33121995 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
[Isoniazid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA |
CTD |
PMID:29594315 |
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NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
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G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Isoniazid results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
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NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
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G |
Il6 |
interleukin 6 |
increases expression increases secretion multiple interactions |
EXP ISO |
Isoniazid results in increased expression of IL6 protein Isoniazid results in increased secretion of IL6 protein Isoniazid results in increased expression of IL6 mRNA chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA] |
CTD |
PMID:19575532 PMID:28444390 PMID:33121995 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Inhbe |
inhibin beta-E |
increases expression |
ISO |
Isoniazid results in increased expression of INHBE mRNA |
CTD |
PMID:17175557 |
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NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280
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G |
Izumo1r |
IZUMO1 receptor, JUNO |
decreases expression |
EXP |
Isoniazid results in decreased expression of IZUMO1R protein |
CTD |
PMID:33771660 |
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NCBI chr 9:14,797,110...14,815,247
Ensembl chr 9:14,797,110...14,815,245
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G |
Keap1 |
kelch-like ECH-associated protein 1 |
decreases expression |
EXP |
Isoniazid results in decreased expression of KEAP1 mRNA |
CTD |
PMID:33771660 |
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NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
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G |
Lamp1 |
lysosomal-associated membrane protein 1 |
affects response to substance |
EXP |
LAMP1 affects the susceptibility to Isoniazid |
CTD |
PMID:24848797 |
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NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338
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G |
Lcn2 |
lipocalin 2 |
increases expression |
ISO |
Isoniazid results in increased expression of LCN2 mRNA |
CTD |
PMID:20623750 |
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NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
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G |
Map2 |
microtubule-associated protein 2 |
affects expression |
EXP |
Isoniazid affects the expression of MAP2 mRNA |
CTD |
PMID:22131109 |
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NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
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G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein]]; Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:31332904 |
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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G |
Mapk3 |
mitogen-activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein]]; Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein] |
CTD |
PMID:31332904 |
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NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
EXP |
Isoniazid results in increased expression of MGST1 mRNA |
CTD |
PMID:33771660 |
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NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
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G |
Mir106b |
microRNA 106b |
decreases expression |
EXP |
Isoniazide decreased expression of miR106b miRNA in the liver |
RGD |
PMID:29554950 |
RGD:15042854 |
NCBI chr 5:138,163,999...138,164,080
Ensembl chr 5:138,163,999...138,164,080
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G |
Mpo |
myeloperoxidase |
multiple interactions increases oxidation |
ISO |
[[MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of Free Radicals] which results in increased chemical synthesis of isonicotinyl-NAD; [MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of Free Radicals; [MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of isonicotinyl-NAD |
CTD |
PMID:26867495 |
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NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
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G |
mt-Co3 |
cytochrome c oxidase III, mitochondrial |
increases expression |
ISO |
Isoniazid results in increased expression of COX3 mRNA |
CTD |
PMID:12883083 |
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NCBI chr MT:8,607...9,390
Ensembl chr MT:8,607...9,390
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G |
Muc1 |
mucin 1, transmembrane |
increases expression |
ISO |
Isoniazid results in increased expression of MUC1 mRNA |
CTD |
PMID:30008028 |
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NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688
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G |
Nat2 |
N-acetyltransferase 2 (arylamine N-acetyltransferase) |
increases acetylation affects acetylation decreases expression multiple interactions decreases acetylation increases metabolic processing affects metabolic processing affects response to substance |
ISO |
NAT2 protein polymorphism results in increased acetylation of Isoniazid; NAT2 protein results in increased acetylation of Isoniazid NAT2 protein polymorphism affects the acetylation of Isoniazid Isoniazid results in decreased expression of NAT2 mRNA [Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA] [NAT2 gene polymorphism results in decreased acetylation of Isoniazid] which results in decreased abundance of acetylisoniazid; [NAT2 gene polymorphism results in decreased metabolism of Isoniazid] which results in increased abundance of hydrazine NAT2 protein results in increased metabolism of Isoniazid NAT2 protein affects the metabolism of Isoniazid; NAT2 protein polymorphism affects the metabolism of Isoniazid NAT2 gene polymorphism affects the susceptibility to Isoniazid; NAT2 gene SNP affects the susceptibility to Isoniazid |
CTD |
PMID:11379777 PMID:11915035 PMID:15546075 PMID:15565348 PMID:15618686 PMID:15627487 PMID:15908628 PMID:16531626 PMID:16847467 PMID:17509624 PMID:17973219 PMID:18544910 PMID:20485159 PMID:25794903 PMID:28619387 PMID:30358977 PMID:36040704 More...
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NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236
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G |
Ndufa1 |
NADH:ubiquinone oxidoreductase subunit A1 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFA1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr X:36,451,241...36,454,891
Ensembl chr X:36,451,241...36,454,816
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G |
Ndufa10 |
NADH:ubiquinone oxidoreductase subunit A10 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFA10 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 1:92,367,208...92,401,547
Ensembl chr 1:92,366,732...92,401,582
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G |
Ndufa12 |
NADH:ubiquinone oxidoreductase subunit A12 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFA12 mRNA |
CTD |
PMID:24848797 |
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NCBI chr10:94,034,897...94,057,302
Ensembl chr10:94,034,582...94,057,305
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G |
Ndufa13 |
NADH:ubiquinone oxidoreductase subunit A13 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFA13 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 8:70,346,813...70,355,208
Ensembl chr 8:70,346,830...70,355,208
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G |
Ndufa4 |
Ndufa4, mitochondrial complex associated |
affects expression |
EXP |
Isoniazid affects the expression of NDUFA4 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 6:11,900,371...11,907,449
Ensembl chr 6:11,900,291...11,907,496
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G |
Ndufa5 |
NADH:ubiquinone oxidoreductase subunit A5 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFA5 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 6:24,518,661...24,527,689
Ensembl chr 6:24,518,665...24,528,012
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G |
Ndufa8 |
NADH:ubiquinone oxidoreductase subunit A8 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFA8 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 2:35,926,336...35,939,350
Ensembl chr 2:35,926,338...35,939,418
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G |
Ndufa9 |
NADH:ubiquinone oxidoreductase subunit A9 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFA9 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 6:126,798,826...126,826,107
Ensembl chr 6:126,798,684...126,826,099
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G |
Ndufab1 |
NADH:ubiquinone oxidoreductase subunit AB1 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFAB1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 7:121,686,038...121,701,071
Ensembl chr 7:121,684,626...121,701,109
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G |
Ndufb10 |
NADH:ubiquinone oxidoreductase subunit B10 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFB10 mRNA |
CTD |
PMID:24848797 |
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NCBI chr17:24,941,034...24,943,397
Ensembl chr17:24,941,034...24,943,452
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G |
Ndufb2 |
NADH:ubiquinone oxidoreductase subunit B2 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFB2 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 6:39,569,499...39,576,777
Ensembl chr 6:39,569,508...39,580,316
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G |
Ndufb3 |
NADH:ubiquinone oxidoreductase subunit B3 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFB3 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 1:58,625,556...58,635,123
Ensembl chr 1:58,625,543...58,635,123
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G |
Ndufb5 |
NADH:ubiquinone oxidoreductase subunit B5 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFB5 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 3:32,791,206...32,805,708
Ensembl chr 3:32,791,139...32,805,715
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G |
Ndufb6 |
NADH:ubiquinone oxidoreductase subunit B6 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFB6 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 4:40,270,591...40,279,421
Ensembl chr 4:40,270,591...40,279,421
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G |
Ndufb7 |
NADH:ubiquinone oxidoreductase subunit B7 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFB7 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 8:84,293,387...84,298,252
Ensembl chr 8:84,293,300...84,298,255
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Ndufs1 |
NADH:ubiquinone oxidoreductase core subunit S1 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFS1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 1:63,182,751...63,215,981
Ensembl chr 1:63,182,755...63,215,992
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G |
Ndufs2 |
NADH:ubiquinone oxidoreductase core subunit S2 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFS2 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 1:171,062,426...171,078,956
Ensembl chr 1:171,062,422...171,078,957
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G |
Ndufs3 |
NADH:ubiquinone oxidoreductase core subunit S3 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFS3 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 2:90,724,971...90,735,065
Ensembl chr 2:90,724,978...90,735,171
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G |
Ndufs4 |
NADH:ubiquinone oxidoreductase core subunit S4 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFS4 mRNA |
CTD |
PMID:24848797 |
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NCBI chr13:114,424,331...114,524,630
Ensembl chr13:114,424,331...114,524,794
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G |
Ndufs8 |
NADH:ubiquinone oxidoreductase core subunit S8 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFS8 mRNA |
CTD |
PMID:24848797 |
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NCBI chr19:3,958,863...3,962,774
Ensembl chr19:3,958,863...3,962,774
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G |
Ndufv1 |
NADH:ubiquinone oxidoreductase core subunit V1 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFV1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr19:4,057,499...4,062,755
Ensembl chr19:4,057,384...4,062,806
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G |
Ndufv2 |
NADH:ubiquinone oxidoreductase core subunit V2 |
affects expression |
EXP |
Isoniazid affects the expression of NDUFV2 mRNA |
CTD |
PMID:24848797 |
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NCBI chr17:66,385,790...66,408,554
Ensembl chr17:66,385,633...66,408,554
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G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
increases activity increases expression multiple interactions |
EXP ISO |
Isoniazid results in increased activity of NFE2L2 protein Isoniazid results in increased expression of NFE2L2 mRNA chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:30203046 PMID:33121995 PMID:33771660 |
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NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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G |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
multiple interactions increases expression |
ISO |
chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA] |
CTD |
PMID:33121995 |
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NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
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G |
Nqo1 |
NAD(P)H dehydrogenase, quinone 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA] Isoniazid results in decreased expression of NQO1 mRNA Isoniazid results in increased expression of NQO1 mRNA chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA] |
CTD |
PMID:24128855 PMID:28444390 PMID:33121995 PMID:33771660 |
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NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
multiple interactions decreases expression |
ISO |
obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR0B2 mRNA] [Isoniazid co-treated with Vitamin B 6] results in decreased expression of NR0B2 mRNA |
CTD |
PMID:32673658 |
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NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions decreases expression |
ISO |
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of NR1H4 mRNA; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA] [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4; [Isoniazid co-treated with Vitamin B 6] results in decreased expression of NR1H4 mRNA isoniazide decreases expression of nr1h4 protein in rat liver |
CTD RGD |
PMID:25331106 PMID:32673658 PMID:35835356 PMID:30068870 |
RGD:15042870 |
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
EXP |
Isoniazid results in increased activity of NR1I3 protein |
CTD |
PMID:30203046 |
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NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270
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G |
Nrf1 |
nuclear respiratory factor 1 |
decreases expression multiple interactions |
ISO |
Isoniazid results in decreased expression of NRF1 protein acadesine inhibits the reaction [Isoniazid results in decreased expression of NRF1 protein] |
CTD |
PMID:28556920 |
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NCBI chr 6:30,047,984...30,153,462
Ensembl chr 6:30,047,987...30,153,457
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G |
Nupr1 |
nuclear protein transcription regulator 1 |
increases expression |
ISO |
Isoniazid results in increased expression of NUPR1 mRNA |
CTD |
PMID:17175557 |
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NCBI chr 7:126,222,418...126,224,642
Ensembl chr 7:126,222,421...126,230,033
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G |
Ogdh |
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
affects expression |
EXP |
Isoniazid affects the expression of OGDH mRNA |
CTD |
PMID:24848797 |
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NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642
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G |
Park7 |
Parkinson disease (autosomal recessive, early onset) 7 |
affects expression |
EXP |
Isoniazid affects the expression of PARK7 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894
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G |
Pid1 |
phosphotyrosine interaction domain containing 1 |
increases expression |
ISO |
Isoniazid results in increased expression of PID1 mRNA |
CTD |
PMID:32816093 |
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NCBI chr 1:84,014,014...84,317,550
Ensembl chr 1:84,014,017...84,341,901
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G |
Plod2 |
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 |
increases expression |
ISO |
Isoniazid results in increased expression of PLOD2 mRNA |
CTD |
PMID:15997088 |
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NCBI chr 9:92,421,828...92,490,481
Ensembl chr 9:92,424,276...92,490,481
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G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions decreases expression |
ISO |
[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA] Isoniazid results in decreased expression of POR mRNA |
CTD |
PMID:28619387 |
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NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases activity multiple interactions |
EXP |
Isoniazid results in increased activity of PPARA protein [Isoniazid co-treated with Rifampin] results in decreased expression of PPARA protein |
CTD |
PMID:30203046 PMID:36347327 |
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NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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G |
Pparg |
peroxisome proliferator activated receptor gamma |
decreases expression multiple interactions |
ISO EXP |
Isoniazid results in decreased expression of PPARG mRNA [Isoniazid co-treated with Rifampin] results in decreased expression of PPARG protein Isoniazid results in decreased expression of PPARG mRNA; Isoniazid results in decreased expression of PPARG protein |
CTD |
PMID:24128855 PMID:36347327 |
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NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
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G |
Ppargc1a |
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
multiple interactions decreases expression |
ISO |
acadesine inhibits the reaction [Isoniazid results in decreased expression of PPARGC1A protein] |
CTD |
PMID:28556920 |
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NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
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G |
Psen1 |
presenilin 1 |
affects expression |
EXP |
Isoniazid affects the expression of PSEN1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
Isoniazid results in increased expression of PTGS2 mRNA |
CTD |
PMID:32816093 |
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NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Sdha |
succinate dehydrogenase complex, subunit A, flavoprotein (Fp) |
affects expression |
EXP |
Isoniazid affects the expression of SDHA mRNA |
CTD |
PMID:24848797 |
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NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399
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G |
Sdhb |
succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
affects expression |
EXP |
Isoniazid affects the expression of SDHB mRNA |
CTD |
PMID:24848797 |
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NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504
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G |
Sdhd |
succinate dehydrogenase complex, subunit D, integral membrane protein |
affects expression |
EXP |
Isoniazid affects the expression of SDHD mRNA |
CTD |
PMID:24848797 |
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NCBI chr 9:50,507,640...50,515,149
Ensembl chr 9:50,507,657...50,515,112
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G |
Sfn |
stratifin |
decreases expression |
ISO |
Isoniazid results in decreased expression of SFN mRNA |
CTD |
PMID:30008028 |
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NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479
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G |
Sirt1 |
sirtuin 1 |
multiple interactions decreases expression |
ISO |
acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein]; Quercetin inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] |
CTD |
PMID:28556920 PMID:31332904 |
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NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
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G |
Slc10a1 |
solute carrier family 10 (sodium/bile acid cotransporter family), member 1 |
multiple interactions decreases expression |
ISO EXP |
obeticholic acid promotes the reaction [Isoniazid results in decreased expression of SLC10A1 mRNA] Isoniazid results in decreased expression of SLC10A1 protein [Rifampin co-treated with Isoniazid] results in decreased expression of SLC10A1 protein [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of SLC10A1 |
CTD |
PMID:25886055 PMID:32673658 PMID:35835356 |
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NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
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G |
Slc11a1 |
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 |
affects expression |
ISO |
Isoniazid affects the expression of SLC11A1 mRNA |
CTD |
PMID:20623750 |
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NCBI chr 1:74,414,318...74,429,974
Ensembl chr 1:74,414,354...74,425,221
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G |
Slc7a11 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 |
multiple interactions |
ISO |
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein] |
CTD |
PMID:36878459 |
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NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
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G |
Slc7a5 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 |
decreases expression |
ISO |
Isoniazid results in decreased expression of SLC7A5 mRNA |
CTD |
PMID:30008028 |
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NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433
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G |
Slco1c1 |
solute carrier organic anion transporter family, member 1c1 |
decreases expression |
ISO |
Isoniazid results in decreased expression of SLCO1B1 mRNA |
CTD |
PMID:32673658 |
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NCBI chr 6:141,470,080...141,515,903
Ensembl chr 6:141,470,094...141,515,903
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
increases expression |
ISO |
Isoniazid results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 |
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NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015
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G |
Sod1 |
superoxide dismutase 1, soluble |
increases expression |
EXP |
Isoniazid results in increased expression of SOD1 mRNA |
CTD |
PMID:33771660 |
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NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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G |
Sod2 |
superoxide dismutase 2, mitochondrial |
multiple interactions affects expression |
ISO EXP |
[SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid Isoniazid affects the expression of SOD2 mRNA |
CTD |
PMID:19501153 PMID:24848797 |
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NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
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G |
Spp1 |
secreted phosphoprotein 1 |
affects expression decreases expression |
ISO |
Isoniazid affects the expression of SPP1 mRNA Isoniazid results in decreased expression of SPP1 mRNA |
CTD |
PMID:20623750 PMID:30008028 |
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NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916
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G |
Srxn1 |
sulfiredoxin 1 homolog (S. cerevisiae) |
increases expression |
ISO |
Isoniazid results in increased expression of SRXN1 mRNA |
CTD |
PMID:28444390 |
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NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
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G |
Surf1 |
surfeit gene 1 |
affects expression |
EXP |
Isoniazid affects the expression of SURF1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 2:26,803,390...26,806,667
Ensembl chr 2:26,803,393...26,806,542
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G |
Tnf |
tumor necrosis factor |
increases secretion multiple interactions increases expression |
ISO |
Isoniazid results in increased secretion of TNF protein [Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; Isoniazid promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein] |
CTD |
PMID:25331106 PMID:28444390 PMID:28619387 PMID:33121995 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Tpo |
thyroid peroxidase |
decreases activity |
ISO |
Isoniazid results in decreased activity of TPO protein |
CTD |
PMID:26884060 |
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NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623
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G |
Trak1 |
trafficking protein, kinesin binding 1 |
affects expression |
EXP |
Isoniazid affects the expression of TRAK1 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 9:121,126,568...121,303,985
Ensembl chr 9:121,126,568...121,303,984
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G |
Trf |
transferrin |
increases expression |
ISO |
Isoniazid results in increased expression of TF mRNA |
CTD |
PMID:12883083 |
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NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643
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G |
Trib3 |
tribbles pseudokinase 3 |
increases expression |
ISO |
Isoniazid results in increased expression of TRIB3 mRNA |
CTD |
PMID:30008028 |
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NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952
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G |
Txn2 |
thioredoxin 2 |
affects expression |
EXP |
Isoniazid affects the expression of TXN2 mRNA |
CTD |
PMID:24848797 |
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NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
Isoniazid results in increased expression of TXNRD1 mRNA |
CTD |
PMID:28444390 |
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NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
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G |
Txnrd2 |
thioredoxin reductase 2 |
affects expression |
EXP |
Isoniazid affects the expression of TXNRD2 mRNA |
CTD |
PMID:24848797 |
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NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823
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G |
Uqcrb |
ubiquinol-cytochrome c reductase binding protein |
affects expression |
EXP |
Isoniazid affects the expression of UQCRB mRNA |
CTD |
PMID:24848797 |
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NCBI chr13:67,048,640...67,053,414
Ensembl chr13:67,048,681...67,053,442
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G |
Uqcrc2 |
ubiquinol cytochrome c reductase core protein 2 |
affects expression |
EXP |
Isoniazid affects the expression of UQCRC2 mRNA |
CTD |
PMID:24848797 |
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NCBI chr 7:120,234,412...120,258,746
Ensembl chr 7:120,234,399...120,258,747
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G |
Mpo |
myeloperoxidase |
increases oxidation |
ISO |
MPO protein results in increased oxidation of (N)1-acetylisoniazid |
CTD |
PMID:26867495 |
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NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
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