Cox7a2 (cytochrome c oxidase subunit 7A2) - Rat Genome Database

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Gene: Cox7a2 (cytochrome c oxidase subunit 7A2) Mus musculus
Analyze
Symbol: Cox7a2
Name: cytochrome c oxidase subunit 7A2
RGD ID: 68522
MGI Page MGI
Description: Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; heart; hemolymphoid system; integumental system; and nervous system. Orthologous to several human genes including COX7A2 (cytochrome c oxidase subunit 7A2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX; Cox7; Cox7a3; COX7AL; CoxVIIa-L; cytochrome c oxidase subunit 7A2, mitochondrial; cytochrome c oxidase subunit VIIa 2; cytochrome c oxidase subunit VIIa 3; cytochrome c oxidase subunit VIIa-L; cytochrome c oxidase subunit VIIa-liver/heart; cytochrome c oxidase, subunit VIIa 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm20206  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39979,662,523 - 79,667,135 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl979,662,643 - 79,667,160 (-)EnsemblGRCm39 Ensembl
GRCm38979,755,241 - 79,771,422 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl979,755,361 - 79,759,878 (-)EnsemblGRCm38mm10GRCm38
MGSCv37979,603,048 - 79,607,660 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36979,540,925 - 79,545,537 (-)NCBIMGSCv36mm8
Celera976,900,017 - 76,905,817 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
Benoxacor  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
clofibric acid  (ISO)
clotrimazole  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
gentamycin  (ISO)
isoniazide  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
maneb  (EXP)
methimazole  (ISO)
metronidazole  (ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (ISO)
oxybenzone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
PhIP  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (ISO)
tolcapone  (ISO)
toluene  (ISO)
Tributyltin oxide  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1659684   PMID:9615220   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12853116   PMID:12865426   PMID:14610273   PMID:14681479  
PMID:14691545   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16752004   PMID:18614015   PMID:18614564   PMID:21267068   PMID:21548202   PMID:21873635   PMID:25737280  
PMID:30550785   PMID:32325033  


Genomics

Comparative Map Data
Cox7a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39979,662,523 - 79,667,135 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl979,662,643 - 79,667,160 (-)EnsemblGRCm39 Ensembl
GRCm38979,755,241 - 79,771,422 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl979,755,361 - 79,759,878 (-)EnsemblGRCm38mm10GRCm38
MGSCv37979,603,048 - 79,607,660 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36979,540,925 - 79,545,537 (-)NCBIMGSCv36mm8
Celera976,900,017 - 76,905,817 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.82NCBI
COX7A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38675,237,675 - 75,250,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl675,237,675 - 75,250,323 (-)EnsemblGRCh38hg38GRCh38
GRCh37675,947,391 - 75,960,014 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36676,004,223 - 76,010,245 (-)NCBINCBI36Build 36hg18NCBI36
Build 34676,004,222 - 76,010,245NCBI
Celera676,341,126 - 76,347,377 (-)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef673,146,540 - 73,152,778 (-)NCBIHuRef
CHM1_1676,113,807 - 76,120,050 (-)NCBICHM1_1
T2T-CHM13v2.0676,414,841 - 76,427,128 (-)NCBIT2T-CHM13v2.0
Cox7a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8889,597,051 - 89,611,032 (-)NCBIGRCr8
mRatBN7.2880,716,824 - 80,720,922 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl880,716,825 - 80,720,264 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1451,301,168 - 51,301,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx886,243,328 - 86,247,447 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0884,520,473 - 84,524,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0882,343,104 - 82,347,224 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0887,209,529 - 87,213,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl887,209,530 - 87,213,627 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0886,753,411 - 86,757,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4884,813,292 - 84,817,390 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1884,832,748 - 84,836,813 (-)NCBI
Celera880,441,572 - 80,445,670 (-)NCBICelera
Cytogenetic Map8q31NCBI
LOC102029536
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555023,753,029 - 3,759,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555023,753,029 - 3,759,663 (-)NCBIChiLan1.0ChiLan1.0
LOC100981677
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2595,284,587 - 95,296,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1693,162,355 - 93,174,537 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0673,080,762 - 73,092,922 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1676,372,094 - 76,377,903 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl676,372,094 - 76,377,903 (-)Ensemblpanpan1.1panPan2
LOC100686500
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1829,140,982 - 29,142,680 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha828,886,608 - 28,886,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0829,305,305 - 29,305,793 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1828,982,787 - 28,983,079 (+)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.0829,383,827 - 29,384,119 (+)NCBIUU_Cfam_GSD_1.0
LOC101966864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494672,297,526 - 72,304,695 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936788679,717 - 686,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX7A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl190,696,698 - 90,703,409 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1190,696,746 - 90,703,407 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21101,816,761 - 101,823,433 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COX7A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11745,771 - 51,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1745,771 - 51,669 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660585,857,739 - 5,863,586 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101723434
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248192,248,826 - 2,256,080 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248192,249,831 - 2,255,915 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox7a2
182 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:79
Interacting mature miRNAs:86
Transcripts:ENSMUST00000034881
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95455996088559960Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95643910890439255Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95780504786121973Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95902438793024534Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95902438793024534Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95936994693370128Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95936994693370128Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95936994693370128Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959897283109089068Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96214976796149881Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
11081165Psl6_mpromotion susceptibility QTL 6 (mouse)96504119195522808Mouse
1301290Smgd1_msubmucosal gland distribution 1 (mouse)Not determined96583105686577967Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966089077100089175Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967006220101006220Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968779563102779705Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968779563102779705Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969121898103121973Mouse
10412174Habiir4_mhyperoxic acute lung injury imprinted region 4 (mouse)Not determined96926774798701707Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969428566103428698Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972859058106859205Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972859058106859205Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974250230108250378Mouse
1301914Ksc1_mkeratinocyte stem cell locus 1 (mouse)Not determined97540903779998332Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976024387101406120Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976417989110418183Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse

Markers in Region
Cox7a3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9E1UniSTS
cM Map942.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034881   ⟹   ENSMUSP00000034881
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl979,662,643 - 79,667,160 (-)Ensembl
GRCm38.p6 Ensembl979,755,361 - 79,759,878 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215452
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl979,665,589 - 79,666,992 (-)Ensembl
GRCm38.p6 Ensembl979,758,307 - 79,759,710 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215933
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl979,662,688 - 79,666,533 (-)Ensembl
GRCm38.p6 Ensembl979,755,406 - 79,759,251 (-)Ensembl
RefSeq Acc Id: NM_009945   ⟹   NP_034075
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39979,662,523 - 79,667,135 (-)NCBI
GRCm38979,755,241 - 79,759,853 (-)ENTREZGENE
MGSCv37979,603,048 - 79,607,660 (-)RGD
Celera976,900,017 - 76,905,817 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034075   ⟸   NM_009945
- Peptide Label: precursor
- UniProtKB: O54969 (UniProtKB/Swiss-Prot),   Q545J7 (UniProtKB/Swiss-Prot),   P48771 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034881   ⟸   ENSMUST00000034881

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48771-F1-model_v2 AlphaFold P48771 1-83 view protein structure

Promoters
RGD ID:6844354
Promoter ID:MM_KWN:58184
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009945
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36979,607,236 - 79,607,857 (-)MPROMDB
RGD ID:8670290
Promoter ID:EPDNEW_M13175
Type:initiation region
Name:Cox7a2_1
Description:Mus musculus cytochrome c oxidase subunit VIIa 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38979,759,712 - 79,759,772EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1316715 AgrOrtholog
Ensembl Genes ENSMUSG00000032330 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034881 ENTREZGENE
  ENSMUST00000034881.8 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.91.10 UniProtKB/Swiss-Prot
InterPro COX7a UniProtKB/Swiss-Prot
  Cyt_c_oxidase_su7a_sf UniProtKB/Swiss-Prot
  Cytc_oxidase_su7a_met UniProtKB/Swiss-Prot
KEGG Report mmu:12866 UniProtKB/Swiss-Prot
MGD MGI:1316715 ENTREZGENE
NCBI Gene 12866 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 7A2, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR10510 UniProtKB/Swiss-Prot
Pfam COX7a UniProtKB/Swiss-Prot
PhenoGen Cox7a2 PhenoGen
Superfamily-SCOP SSF81419 UniProtKB/Swiss-Prot
UniProt CX7A2_MOUSE UniProtKB/Swiss-Prot
  O54969 ENTREZGENE
  P48771 ENTREZGENE
  Q545J7 ENTREZGENE
UniProt Secondary O54969 UniProtKB/Swiss-Prot
  Q545J7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Cox7a2  cytochrome c oxidase subunit 7A2    cytochrome c oxidase subunit VIIa 2  Symbol and/or name change 5135510 APPROVED
2012-11-27 Cox7a2  cytochrome c oxidase subunit VIIa 2    cytochrome c oxidase, subunit VIIa 2  Symbol and/or name change 5135510 APPROVED