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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,6-diaminopurines
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Accession:CHEBI:38001 term browser browse the term
Definition:Any aminopurine that has amino substituents at positions 2 and 6, and their substituted derivatives.


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abacavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases export
decreases export		 ISO [Estradiol results in decreased activity of ABCG2 protein] which results in increased uptake of abacavir; [isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCG2 protein] which results in increased uptake of abacavir
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of abacavir]; Elacridar inhibits the reaction [ABCG2 protein results in decreased export of abacavir]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of abacavir]; Nelfinavir inhibits the reaction [ABCG2 protein results in increased export of abacavir]; pluronic block copolymer p85 inhibits the reaction [ABCG2 protein results in increased export of abacavir]		 CTD PMID:17437964 PMID:19056916 PMID:25844889 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Alb albumin affects binding
multiple interactions		 ISO abacavir binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]		 CTD PMID:15814459 PMID:16336266 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO abacavir results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Crp C-reactive protein increases expression ISO abacavir results in increased expression of CRP protein CTD PMID:19891054 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO abacavir results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO abacavir results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO abacavir results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO abacavir results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO abacavir results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO abacavir results in increased expression of GFAP protein CTD PMID:19358275 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Hoxb7 homeo box B7 increases expression ISO abacavir results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034 		JBrowse link
G Hoxb9 homeo box B9 increases expression ISO abacavir results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IFNG protein CTD PMID:23541086 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO [HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of IL13 protein CTD PMID:23541086 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il4 interleukin 4 affects response to substance ISO IL4 protein affects the susceptibility to abacavir CTD PMID:15867870 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO abacavir results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660 		JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 decreases expression ISO abacavir results in decreased expression of MESP2 mRNA CTD PMID:31711903 NCBI chr 1:133,756,601...133,759,207
Ensembl chr 1:133,756,601...133,759,198 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO abacavir results in increased expression of MMP9 protein CTD PMID:19891054 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase increases expression ISO abacavir results in increased expression of MPO protein CTD PMID:19891054 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Neurog2 neurogenin 2 increases expression ISO abacavir results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO abacavir results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149 		JBrowse link
G Pax3 paired box 3 decreases expression ISO abacavir results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042 		JBrowse link
G Pax6 paired box 6 increases expression ISO abacavir results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pdcd1 programmed cell death 1 multiple interactions ISO [HLA-B protein alternative form results in increased susceptibility to abacavir] which results in increased expression of PDCD1 CTD PMID:34606953 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO [Quinine results in decreased activity of SLC22A1] which results in decreased uptake of abacavir CTD PMID:25844889 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Syp synaptophysin increases expression ISO abacavir results in increased expression of SYP protein CTD PMID:19358275 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO abacavir results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO abacavir results in decreased activity of TERT protein CTD PMID:19358275 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [HLA-B protein polymorphism results in increased susceptibility to abacavir] which results in increased secretion of TNF protein CTD PMID:23541086 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO abacavir results in increased expression of UCP1 mRNA CTD PMID:14518702 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Uncx UNC homeobox decreases expression ISO abacavir results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300 		JBrowse link
olomoucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein] CTD PMID:16628227 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
multiple interactions		 ISO
EXP		 olomoucine results in decreased activity of CDK2 protein
olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein]		 CTD PMID:12387751 PMID:15026556 PMID:20149834 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression ISO olomoucine results in increased expression of RB1 mRNA; olomoucine results in increased expression of RB1 protein CTD PMID:14653808 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO olomoucine results in increased expression of SP1 mRNA; olomoucine results in increased expression of SP1 protein CTD PMID:14653808 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO olomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]; olomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein] CTD PMID:16628227 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpi1 triosephosphate isomerase 1 multiple interactions ISO olomoucine inhibits the reaction [CDK2 protein results in increased phosphorylation of TPI1 protein] CTD PMID:20149834 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
seliciclib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccng1 cyclin G1 decreases expression EXP roscovitine decreases expression of Ccng1 in rat brain injury lesions RGD PMID:18612315 RGD:151356935 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases activity EXP Roscovitine decreases activity of Cdk1 protein in oocytes RGD PMID:15695611 RGD:2301352 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP roscovitine (seliciclib) increases expression of mRNA inhibiting the reaction [camptothecin increases kinase activity] in rat cerebellar granule neurons RGD PMID:19151707 RGD:10053571 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression EXP roscovitine (seliciclib) increases expression of mRNA inhibiting the reaction [camptothecin increases kinase activity] in rat cerebellar granule neurons RGD PMID:19151707 RGD:10053571 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      atom 19839
        nonmetal atom 19777
          nitrogen atom 18962
            nitrogen molecular entity 18962
              organonitrogen compound 18812
                organonitrogen heterocyclic compound 18154
                  imidazopyrimidine 7714
                    purines 7713
                      aminopurine 6716
                        2,6-diaminopurines 39
                          (R)-DRF053 + 0
                          2-amino-6-hydroxyaminopurine 0
                          6-de(cyclopropylamino)-6-(2,2-dimethylazetidin-1-yl)abacavir 0
                          6-de(cyclopropylamino)-6-(2-methylazetidin-1-yl)abacavir 0
                          6-de(cyclopropylamino)-6-(3-cyclopropyl-3-fluoroazetidin-1-yl)abacavir 0
                          6-de(cyclopropylamino)-6-(3-fluoroazetidin-1-yl)abacavir 0
                          6-de(cyclopropylamino)-6-(3-isopropoxyazetidin-1-yl)abacavir 0
                          6-de(cyclopropylamino)-6-(3-methoxyazetidin-1-yl)abacavir 0
                          6-de(cyclopropylamino)-6-(azetidin-1-yl)abacavir 0
                          6-de(cyclopropylamino)-6-(isobutylamino)abacavir 0
                          6-de(cyclopropylamino)-6-(isopropylamino)abacavir 0
                          6-de(cyclopropylamino)-6-[(S)-sec-butylamino]abacavir 0
                          9H-purine-2,6-diamine + 0
                          abacavir + 31
                          abacavir monophosphate 0
                          olomoucine 6
                          purvalanol + 0
                          seliciclib 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  organic heteropolycyclic compound 18301
                                    organic heterobicyclic compound 17235
                                      imidazopyrimidine 7714
                                        purines 7713
                                          aminopurine 6716
                                            2,6-diaminopurines 39
                                              (R)-DRF053 + 0
                                              2-amino-6-hydroxyaminopurine 0
                                              6-de(cyclopropylamino)-6-(2,2-dimethylazetidin-1-yl)abacavir 0
                                              6-de(cyclopropylamino)-6-(2-methylazetidin-1-yl)abacavir 0
                                              6-de(cyclopropylamino)-6-(3-cyclopropyl-3-fluoroazetidin-1-yl)abacavir 0
                                              6-de(cyclopropylamino)-6-(3-fluoroazetidin-1-yl)abacavir 0
                                              6-de(cyclopropylamino)-6-(3-isopropoxyazetidin-1-yl)abacavir 0
                                              6-de(cyclopropylamino)-6-(3-methoxyazetidin-1-yl)abacavir 0
                                              6-de(cyclopropylamino)-6-(azetidin-1-yl)abacavir 0
                                              6-de(cyclopropylamino)-6-(isobutylamino)abacavir 0
                                              6-de(cyclopropylamino)-6-(isopropylamino)abacavir 0
                                              6-de(cyclopropylamino)-6-[(S)-sec-butylamino]abacavir 0
                                              9H-purine-2,6-diamine + 0
                                              abacavir + 31
                                              abacavir monophosphate 0
                                              olomoucine 6
                                              purvalanol + 0
                                              seliciclib 4
paths to the root