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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Carnosol
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Accession:CHEBI:3429 term browser browse the term
Definition:A diterpenoid that has formula C20H26O4.
Synonyms:related_synonym: Formula=C20H26O4;   InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1;   InChIKey=XUSYGBPHQBWGAD-PJSUUKDQSA-N;   SMILES=CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
 xref: CAS:5957-80-2;   HMDB:HMDB0002121;   KEGG:C09069;   KNApSAcK:C00003410;   LINCS:LSM-37166
 xref_mesh: MESH:C068623


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Carnosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in increased expression of BAX protein]; carnosol inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]] CTD PMID:34678374 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in decreased expression of BCL2 protein]; carnosol inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]] CTD PMID:34678374 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in increased expression of CASP3 protein modified form]; carnosol inhibits the reaction [Rotenone results in increased activity of CASP3 protein] CTD PMID:17047462 PMID:34678374 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO carnosol results in decreased activity of CYP1A2 protein CTD PMID:34592323 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO carnosol results in decreased activity of CYP2C19 protein CTD PMID:34592323 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO carnosol results in decreased activity of CYP2D6 protein CTD PMID:34592323 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO carnosol results in decreased activity of CYP3A4 protein CTD PMID:34592323 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in increased expression of DNM1L protein]; carnosol inhibits the reaction [Palmitic Acid results in increased expression of DNM1L protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of DNM1L protein]] CTD PMID:34678374 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in increased expression of FIS1 protein]; carnosol inhibits the reaction [Palmitic Acid results in increased expression of FIS1 protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of FIS1 protein]] CTD PMID:34678374 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO carnosol results in increased expression of GCLC mRNA CTD PMID:20116392 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO carnosol results in increased expression of GCLM mRNA CTD PMID:20116392 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO carnosol results in increased expression of HMOX1 protein
[HMOX1 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [carnosol results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
carnosol results in increased expression of HMOX1 mRNA; carnosol results in increased expression of HMOX1 protein		 CTD PMID:20116392 PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [HMOX1 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] CTD PMID:20116392 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO carnosol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] CTD PMID:23942037 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO carnosol inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein] CTD PMID:20116392 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP carnosol inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA] CTD PMID:15252869 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in increased expression of MAP3K5 protein]; carnosol inhibits the reaction [Palmitic Acid results in increased expression of MAP3K5 protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of MAP3K5 protein]] CTD PMID:34678374 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO carnosol results in increased phosphorylation of MAPK1 protein CTD PMID:17047462 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO carnosol results in increased phosphorylation of MAPK3 protein CTD PMID:17047462 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in increased expression of MAPK8 protein modified form]; carnosol inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein]] CTD PMID:34678374 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in increased expression of MAPK9 protein modified form]; carnosol inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK9 protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK9 protein]] CTD PMID:34678374 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in decreased expression of MFN2 protein]; carnosol inhibits the reaction [Palmitic Acid results in decreased expression of MFN2 protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in decreased expression of MFN2 protein]] CTD PMID:34678374 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases localization
multiple interactions		 ISO carnosol results in increased localization of NFE2L2 protein
[NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]
NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]		 CTD PMID:20116392 PMID:23942037 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO carnosol inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:20116392 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO carnosol results in increased expression of NR4A2 protein CTD PMID:17047462 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO carnosol inhibits the reaction [Dietary Fats results in increased expression of PARP1 protein modified form]; carnosol inhibits the reaction [Palmitic Acid results in increased expression of PARP1 protein modified form]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of PARP1 protein modified form]] CTD PMID:34678374 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO carnosol binds to and results in increased expression of PRDX3 protein; carnosol inhibits the reaction [Dietary Fats results in decreased expression of PRDX3 mRNA]; carnosol inhibits the reaction [Dietary Fats results in decreased expression of PRDX3 protein]; carnosol inhibits the reaction [Palmitic Acid results in decreased expression of PRDX3 protein]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in decreased expression of MFN2 protein]]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of DNM1L protein]]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of FIS1 protein]]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of MAP3K5 protein]]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased expression of PARP1 protein modified form]]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein]]; PRDX3 protein promotes the reaction [carnosol inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK9 protein]] CTD PMID:34678374 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases glutathionylation		 ISO [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein] CTD PMID:20116392 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression		 ISO 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [carnosol results in increased expression of TH protein]; carnosol inhibits the reaction [Rotenone results in decreased expression of TH protein]; U 0126 inhibits the reaction [carnosol results in increased expression of TH protein] CTD PMID:17047462 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; carnosol inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; carnosol inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
carnosol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:20116392 PMID:23942037 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyr tyrosinase decreases expression ISO carnosol results in decreased expression of TYR mRNA; carnosol results in decreased expression of TYR protein CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          carbon atom 19702
            organic molecular entity 19702
              isoprenoid 14057
                terpenoid 13755
                  diterpenoid 13024
                    Carnosol 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  terpene 14057
                                    diterpene 13024
                                      diterpenoid 13024
                                        Carnosol 31
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