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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:betulinic acid
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Accession:CHEBI:3087 term browser browse the term
Definition:A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.
Synonyms:exact_synonym: 3beta-hydroxylup-20(29)-en-28-oic acid
 related_synonym: Formula=C30H48O3;   InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1;   InChIKey=QGJZLNKBHJESQX-FZFNOLFKSA-N;   Mairin;   SMILES=[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@]1(CC[C@@H](C(C)=C)[C@]21[H])C(O)=O
 alt_id: CHEBI:65491
 xref: CAS:472-15-1;   HMDB:HMDB0030094;   KEGG:C08619;   KNApSAcK:C00003741;   LIPID_MAPS_instance:LMPR0106140004
 xref_mesh: MESH:C002070
 xref: PMID:14595673;   PMID:15083202;   PMID:20075711;   PMID:7489361;   PMID:8176401;   Patent:RU2445317;   Patent:RU2458933;   Patent:US2012237629;   Reaxys:2711110;   Wikipedia:Betulinic_acid


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betulinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; Betulinic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2] CTD PMID:21172400 PMID:22285267 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO Betulinic Acid results in increased phosphorylation of AKT1 protein
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of AKT1 protein]		 CTD PMID:16077934 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions		 ISO Betulinic Acid results in increased expression of BAK1 protein
[Betulinic Acid co-treated with Oxygen deficiency] results in increased expression of BAK1 protein		 CTD PMID:33181113 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Betulinic Acid analog] results in increased activity of BAX protein; CA 074 methyl ester inhibits the reaction [[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Betulinic Acid analog] results in increased activity of BAX protein] CTD PMID:23000516 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO Betulinic Acid results in decreased expression of BCL2 protein
[Betulinic Acid co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein		 CTD PMID:30136359 PMID:33181113 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
increases expression
decreases expression
decreases response to substance		 ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased expression of BIRC5]; Betulinic Acid promotes the reaction [Oxygen deficiency results in decreased expression of BIRC5 protein]; Erlotinib Hydrochloride inhibits the reaction [Betulinic Acid results in decreased expression of BIRC5 protein]
BIRC5 protein results in decreased susceptibility to Betulinic Acid		 CTD PMID:16077934 PMID:26540049 PMID:30136359 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression
decreases expression		 ISO Betulinic Acid results in increased expression of BMI1 protein
Betulinic Acid results in decreased expression of BMI1 protein		 CTD PMID:33157086 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G Car9 carbonic anhydrase 9 decreases activity
multiple interactions		 ISO Betulinic Acid analog results in decreased activity of CA9 protein
Betulinic Acid inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]		 CTD PMID:26540049 PMID:29454615 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Betulinic Acid analog results in increased cleavage of CASP3 protein]; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Betulinic Acid inhibits the reaction [Bortezomib results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [Betulinic Acid analog results in increased cleavage of CASP3 protein]]; VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP3 protein modified form]
Betulinic Acid analog results in increased activity of CASP3 protein; Betulinic Acid results in increased activity of CASP3 protein
Betulinic Acid analog results in increased cleavage of CASP3 protein; Betulinic Acid results in increased cleavage of CASP3 protein		 CTD PMID:22260869 PMID:23000516 PMID:26772157 PMID:28578903 PMID:29454615 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP7 protein modified form]
Betulinic Acid results in increased activity of CASP7 protein		 CTD PMID:22260869 PMID:30136359 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Betulinic Acid results in increased activity of CASP8 protein CTD PMID:26772157 PMID:29454615 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Betulinic Acid analog results in increased activity of CASP9 protein; Betulinic Acid results in increased activity of CASP9 protein CTD PMID:26772157 PMID:29454615 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP Betulinic Acid inhibits the reaction [Dimethylnitrosamine results in decreased activity of CAT protein] CTD PMID:34472159 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Betulinic Acid results in decreased expression of CCNB1 protein CTD PMID:33181113 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO Betulinic Acid analog results in decreased expression of CCND1 protein; Betulinic Acid results in decreased expression of CCND1 protein
[Betulinic Acid co-treated with Oxygen deficiency] results in decreased expression of CCND1 protein		 CTD PMID:28254521 PMID:33181113 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions ISO Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of CDK6 protein]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of CDK6 protein] CTD PMID:30136359 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Betulinic Acid analog results in increased expression of CDKN1A protein CTD PMID:28254521 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
decreases expression		 ISO Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Betulinic Acid inhibits the reaction [Bortezomib results in increased expression of CEBPB protein alternative form]
Betulinic Acid results in decreased expression of CEBPB protein modified form		 CTD PMID:30482226 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO [Betulinic Acid co-treated with Erlotinib Hydrochloride] results in decreased expression of CTNNB1 protein; [Betulinic Acid co-treated with Oxygen deficiency] results in decreased expression of CTNNB1 protein
Betulinic Acid results in decreased expression of CTNNB1 protein		 CTD PMID:30136359 PMID:33181113 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein] CTD PMID:24463094 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Betulinic Acid inhibits the reaction [Bortezomib results in increased expression of DDIT3 protein] CTD PMID:30482226 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation		 ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of EGFR protein]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of EGFR protein modified form] CTD PMID:16077934 PMID:30136359 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 ISO Betulinic Acid results in increased phosphorylation of GSK3B protein
[Betulinic Acid co-treated with Oxygen deficiency] results in increased phosphorylation of GSK3B protein		 CTD PMID:33181113 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions		 ISO Betulinic Acid results in decreased expression of HIF1A protein
[Betulinic Acid co-treated with Oxygen deficiency] affects the expression of HIF1A protein		 CTD PMID:26540049 PMID:33181113 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [VDAC1 protein results in decreased susceptibility to Betulinic Acid] which results in increased expression of HK2 protein CTD PMID:30136359 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Betulinic Acid inhibits the reaction [Dimethylnitrosamine results in increased expression of IL6 protein] CTD PMID:34472159 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:30136359 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of MAPK1 protein]; [Betulinic Acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein CTD PMID:16077934 PMID:33181113 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Betulinic Acid results in increased phosphorylation of MAPK3 protein
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of MAPK3 protein]; [Betulinic Acid co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein		 CTD PMID:16077934 PMID:33181113 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir24-2 microRNA 24-2 multiple interactions
affects response to substance		 ISO MIR24-2 mRNA affects the susceptibility to [Betulinic Acid co-treated with Gemcitabine]
MIR24-2 mRNA affects the susceptibility to Betulinic Acid		 CTD PMID:25841339 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO		 Betulinic Acid inhibits the reaction [Ethanol results in increased expression of MMP2 protein]
Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]
Betulinic Acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]		 CTD PMID:21172400 PMID:24463094 PMID:28578903 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein] CTD PMID:24463094 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Betulinic Acid co-treated with Oxygen deficiency] results in decreased expression of MYC protein CTD PMID:33181113 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased phosphorylation of NFKBIA protein] CTD PMID:21172400 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Betulinic Acid inhibits the reaction [Bortezomib results in increased expression of NOS1 protein] CTD PMID:30482226 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
increases expression
multiple interactions		 ISO Betulinic Acid results in increased cleavage of PARP1 protein
Betulinic Acid results in increased expression of PARP1 protein modified form
[Betulinic Acid co-treated with Oxygen] results in increased cleavage of PARP1 protein; Betulinic Acid promotes the reaction [Gefitinib results in increased cleavage of PARP1 protein]		 CTD PMID:26540049 PMID:30136359 PMID:33181113 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression		 EXP
ISO		 Betulinic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]
Betulinic Acid analog results in decreased expression of PCNA protein		 CTD PMID:28254521 PMID:34541749 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pla2g2a phospholipase A2 group IIA affects binding ISO Betulinic Acid binds to PLA2G2A protein CTD PMID:29391000 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Betulinic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein] CTD PMID:34541749 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions
decreases expression
decreases secretion
decreases response to substance		 ISO Betulinic Acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
Betulinic Acid results in decreased expression of PTHLH mRNA
Betulinic Acid results in decreased secretion of PTHLH protein
Betulinic Acid results in decreased susceptibility to PTHLH protein		 CTD PMID:24463094 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression
multiple interactions		 ISO Betulinic Acid results in decreased expression of RB1 protein modified form
Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of RB1 protein modified form]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of RB1 protein modified form]; Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in decreased expression of RB1 protein modified form]; Gefitinib promotes the reaction [Betulinic Acid results in decreased expression of RB1 protein modified form]		 CTD PMID:30136359 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein] CTD PMID:21172400 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Betulinic Acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form CTD PMID:30136359 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO		 Betulinic Acid inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]
Betulinic Acid affects the reaction [TGFB1 protein affects the expression of and affects the secretion of MMP2 protein]		 CTD PMID:21172400 PMID:28578903 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased expression of TIMP1 protein] CTD PMID:21172400 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Betulinic Acid inhibits the reaction [Ethanol results in increased expression of TIMP2 protein] CTD PMID:21172400 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Betulinic Acid inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF protein] CTD PMID:34472159 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance		 ISO Betulinic Acid inhibits the reaction [PTHLH protein results in increased expression of TNFSF11 protein]
Betulinic Acid results in decreased susceptibility to TNFSF11 protein
Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of CTSK protein]; Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP2 protein]; Betulinic Acid inhibits the reaction [TNFSF11 protein results in increased secretion of MMP9 protein]		 CTD PMID:24463094 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO Betulinic Acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO Betulinic Acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Betulinic Acid results in increased expression of TP53 protein
[Betulinic Acid co-treated with Oxygen deficiency] results in increased expression of TP53 protein		 CTD PMID:33181113 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions ISO Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Betulinic Acid inhibits the reaction [Bortezomib results in increased expression of TRIB3 protein] CTD PMID:30482226 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Tyms thymidylate synthetase multiple interactions
decreases expression		 ISO Betulinic Acid promotes the reaction [Erlotinib Hydrochloride results in decreased expression of TYMS protein]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of TYMS protein]; Erlotinib Hydrochloride promotes the reaction [Betulinic Acid results in decreased expression of TYMS protein]; Gefitinib promotes the reaction [Betulinic Acid results in decreased expression of TYMS protein] CTD PMID:30136359 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases response to substance
multiple interactions
increases expression		 ISO VDAC1 protein results in decreased susceptibility to Betulinic Acid
[VDAC1 protein results in decreased susceptibility to Betulinic Acid] which results in increased expression of HK2 protein; VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP3 protein modified form]; VDAC1 protein inhibits the reaction [Betulinic Acid results in increased expression of CASP7 protein modified form]
Betulinic Acid results in increased expression of VDAC1 protein		 CTD PMID:30136359 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        anti-inflammatory agent 16580
          betulinic acid 55
            2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid 0
            bevirimat 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  terpene 14057
                                    terpenoid 13755
                                      triterpenoid 1202
                                        pentacyclic triterpenoid 467
                                          betulinic acid 55
                                            2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid 0
                                            bevirimat 0
paths to the root