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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trimethylarsine oxide
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Accession:CHEBI:27131 term browser browse the term
Definition:An arsine oxide that has formula C3H9AsO.
Synonyms:exact_synonym: trimethylarsane oxide
 related_synonym: (CH3)3As=O;   Formula=C3H9AsO;   InChI=1S/C3H9AsO/c1-4(2,3)5/h1-3H3;   InChIKey=JWOWJQPAYGEFFK-UHFFFAOYSA-N;   SMILES=C[As](C)(C)=O
 xref: Beilstein:1734788;   CAS:4964-14-1;   Gmelin:164299
 xref_mesh: MESH:C052920
 xref: UM-BBD_compID:c0754


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trimethylarsine oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP trimethylarsine oxide results in increased expression of ABCB1A mRNA; trimethylarsine oxide results in increased expression of ABCB1A protein CTD PMID:16436460 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP trimethylarsine oxide results in increased expression of ABCC1 mRNA; trimethylarsine oxide results in increased expression of ABCC1 protein CTD PMID:16436460 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP trimethylarsine oxide results in increased expression of ABCC2 mRNA; trimethylarsine oxide results in increased expression of ABCC2 protein CTD PMID:16436460 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP trimethylarsine oxide results in increased expression of ABCC3 mRNA; trimethylarsine oxide results in increased expression of ABCC3 protein CTD PMID:16436460 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO trimethylarsine oxide affects the localization of and results in increased activity of AHR protein
AHR mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of CYP1A1 protein]; trimethylarsine oxide results in decreased expression of and affects the localization of AHR protein		 CTD PMID:24161444 PMID:26144063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP trimethylarsine oxide results in increased expression of ALDH1A1 mRNA CTD PMID:17481689 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G As3mt arsenite methyltransferase increases chemical synthesis
multiple interactions		 EXP AS3MT protein results in increased chemical synthesis of trimethylarsine oxide
Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]		 CTD PMID:15606138 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Casp3 caspase 3 increases expression EXP trimethylarsine oxide results in increased expression of CASP3 mRNA CTD PMID:17481689 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP trimethylarsine oxide results in increased expression of CCND1 mRNA CTD PMID:17481689 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression EXP trimethylarsine oxide results in increased expression of CCNE1 mRNA CTD PMID:17481689 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 increases expression EXP trimethylarsine oxide results in increased expression of CDH1 mRNA CTD PMID:17481689 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 increases expression EXP trimethylarsine oxide results in increased expression of CDH2 mRNA CTD PMID:17481689 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects expression
increases expression
multiple interactions		 EXP
ISO		 trimethylarsine oxide affects the expression of CYP1A1 mRNA
trimethylarsine oxide results in increased expression of CYP1A1 mRNA; trimethylarsine oxide results in increased expression of CYP1A1 protein
trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1A1 protein
AHR mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1A1 protein		 CTD PMID:17481689 PMID:24161444 PMID:26042454 PMID:26144063 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP
ISO		 trimethylarsine oxide results in increased expression of CYP1A2 mRNA
trimethylarsine oxide results in increased expression of CYP1A2 mRNA; trimethylarsine oxide results in increased expression of CYP1A2 protein		 CTD PMID:17481689 PMID:26144063 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1B1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]; trimethylarsine oxide results in increased expression of and results in increased activity of CYP1B1 protein
trimethylarsine oxide results in increased expression of CYP1B1 mRNA		 CTD PMID:26042454 PMID:26144063 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression		 EXP [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B1 mRNA; [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B1 protein
trimethylarsine oxide results in increased expression of CYP2B1 mRNA		 CTD PMID:12115560 PMID:17481689 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [trimethylarsine oxide co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA CTD PMID:12115560 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression EXP trimethylarsine oxide results in increased expression of CYP2C11 mRNA CTD PMID:17481689 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression EXP trimethylarsine oxide results in decreased expression of DNMT1 mRNA CTD PMID:17481689 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Faslg Fas ligand increases expression EXP trimethylarsine oxide results in increased expression of FASLG mRNA CTD PMID:17481689 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression EXP trimethylarsine oxide results in increased expression of GJB1 mRNA CTD PMID:17481689 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression
increases expression		 EXP trimethylarsine oxide results in decreased expression of GSTA2 mRNA; trimethylarsine oxide results in decreased expression of GSTA2 protein
trimethylarsine oxide results in increased expression of GSTA2 mRNA		 CTD PMID:16436460 PMID:17481689 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP trimethylarsine oxide results in increased expression of GSTM1 mRNA; trimethylarsine oxide results in increased expression of GSTM1 protein CTD PMID:16436460 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP trimethylarsine oxide results in increased expression of GSTP1 mRNA CTD PMID:17481689 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO trimethylarsine oxide results in increased expression of HMOX1 mRNA; trimethylarsine oxide results in increased expression of HMOX1 protein CTD PMID:26144063 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Itih3 inter-alpha trypsin inhibitor, heavy chain 3 increases expression EXP trimethylarsine oxide results in increased expression of ITIH3 mRNA CTD PMID:17481689 NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924 		JBrowse link
G Krt18 keratin 18 decreases expression EXP trimethylarsine oxide results in decreased expression of KRT18 mRNA CTD PMID:17481689 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP trimethylarsine oxide results in increased expression of MAPK14 mRNA CTD PMID:17481689 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression EXP trimethylarsine oxide results in decreased expression of MAPK8 mRNA CTD PMID:17481689 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of NQO1 protein]; trimethylarsine oxide results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:24161444 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression		 ISO NFE2L2 mutant form inhibits the reaction [trimethylarsine oxide results in increased expression of NQO1 protein]; trimethylarsine oxide promotes the reaction [sulforaphane results in increased expression of and results in increased activity of NQO1 protein]; trimethylarsine oxide promotes the reaction [sulforaphane results in increased expression of NQO1 mRNA]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of NQO1 protein]; trimethylarsine oxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; trimethylarsine oxide results in increased expression of and results in increased activity of NQO1 protein
trimethylarsine oxide results in increased expression of NQO1 mRNA; trimethylarsine oxide results in increased expression of NQO1 protein		 CTD PMID:24161444 PMID:26042454 PMID:26144063 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP trimethylarsine oxide results in increased expression of OGG1 mRNA CTD PMID:17481689 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP trimethylarsine oxide results in increased expression of PCNA mRNA CTD PMID:17481689 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Prkca protein kinase C, alpha increases expression EXP trimethylarsine oxide results in increased expression of PRKCA mRNA CTD PMID:17481689 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcg protein kinase C, gamma increases expression EXP trimethylarsine oxide results in increased expression of PRKCG mRNA CTD PMID:17481689 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO trimethylarsine oxide results in decreased secretion of TNF protein CTD PMID:9548797 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19839
      atom 19839
        metalloid atom 14322
          arsenic atom 13266
            arsenic molecular entity 13266
              arsine oxides 106
                trimethylarsine oxide 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      p-block molecular entity 19789
                        pnictogen molecular entity 19049
                          arsenic molecular entity 13266
                            arsine oxides 106
                              trimethylarsine oxide 36
paths to the root