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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Aloe emodin
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Accession:CHEBI:2607 term browser browse the term
Definition:A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.
Synonyms:exact_synonym: 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
 related_synonym: 1,8-Dihydroxy-3-hydroxymethylanthraquinone;   3-(Hydroxymethyl)chrysazin;   Aloeemodin;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2;   InChIKey=YDQWDHRMZQUTBA-UHFFFAOYSA-N;   Rhabarberone;   SMILES=OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
 alt_id: MESH:C518327
 xref: CAS:481-72-1;   HMDB:HMDB0030829;   KEGG:C10294;   KNApSAcK:C00002789;   LIPID_MAPS_instance:LMPK13040002
 xref_mesh: MESH:C518327
 xref: PMID:22931417;   PMID:24685589;   PMID:24707862;   Patent:US4670265;   Reaxys:2059062;   Wikipedia:Aloe_emodin


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Aloe emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA] CTD PMID:22645054 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases activity ISO aloe emodin results in decreased activity of AKR1B10 protein CTD PMID:35065925 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO aloe emodin results in decreased activity of AKR1C3 protein CTD PMID:35065925 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO aloe emodin results in increased expression of ATF3 mRNA CTD PMID:22210228 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO aloe emodin results in increased expression of BAX protein CTD PMID:19928967 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein CTD PMID:19928967 PMID:22210228 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression
increases cleavage
multiple interactions		 ISO aloe emodin results in increased activity of CASP3 protein
aloe emodin results in increased expression of CASP3 protein modified form
aloe emodin results in increased cleavage of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]		 CTD PMID:19928967 PMID:22210228 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
increases expression
multiple interactions		 ISO aloe emodin results in increased activity of CASP8 protein
aloe emodin results in increased expression of CASP8 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]		 CTD PMID:19928967 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases expression		 ISO aloe emodin results in increased activity of CASP9 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]		 CTD PMID:19928967 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cbr1 carbonyl reductase 1 decreases activity ISO aloe emodin results in decreased activity of CBR1 protein CTD PMID:35065925 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO aloe emodin results in increased expression of CYCS protein CTD PMID:19928967 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO aloe emodin results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO aloe emodin results in decreased activity of CYP1A2 protein CTD PMID:27633141 PMID:33438235 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO aloe emodin results in decreased activity of CYP1B1 protein CTD PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases chemical synthesis		 ISO [CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin		 CTD PMID:29698620 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO aloe emodin results in decreased activity of CYP2C19 protein CTD PMID:33438235 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions		 ISO CYP3A4 protein results in increased chemical synthesis of aloe emodin
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin		 CTD PMID:29698620 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein CTD PMID:22210228 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO aloe emodin results in increased phosphorylation of EIF2S1 protein CTD PMID:22210228 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA] CTD PMID:22645054 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO aloe emodin results in increased expression of and affects the localization of FADD protein CTD PMID:19928967 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO aloe emodin results in increased expression of FAS protein CTD PMID:19928967 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO aloe emodin results in increased expression of FASLG protein CTD PMID:19928967 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein CTD PMID:22210228 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA] CTD PMID:22645054 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
decreases expression		 ISO aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA		 CTD PMID:16314733 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:19352036 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA] CTD PMID:22645054 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA] CTD PMID:19352036 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Retn resistin multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA] CTD PMID:22645054 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO aloe emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO aloe emodin results in decreased activity of SULT1E1 protein CTD PMID:27633141 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein		 CTD PMID:19928967 PMID:22645054 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO aloe emodin results in increased expression of TNFRSF1A protein CTD PMID:19928967 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO aloe emodin results in increased expression of TNFRSF1B protein CTD PMID:19928967 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO aloe emodin results in increased expression of TP53 protein CTD PMID:19928967 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO aloe emodin results in increased expression of and affects the localization of TRADD protein CTD PMID:19928967 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of aloe emodin CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO aloe emodin results in increased splicing of XBP1 mRNA CTD PMID:22210228 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
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    role 19784
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              Aloe emodin 39
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                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    ketone 17165
                                      cyclic ketone 15685
                                        quinone 8644
                                          acenoquinone 7719
                                            anthraquinone 514
                                              hydroxyanthraquinones 502
                                                dihydroxyanthraquinone 350
                                                  chrysazin 73
                                                    Aloe emodin 39
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