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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(+)-taxifolin
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Accession:CHEBI:17948 term browser browse the term
Definition:A taxifolin that has (2R,3R)-configuration.
Synonyms:exact_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one
 related_synonym: (2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;   (2R,3R)-dihydroquercetin;   (2R-trans)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone;   Dihydroquercetin;   Formula=C15H12O7;   InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1;   InChIKey=CXQWRCVTCMQVQX-LSDHHAIUSA-N;   SMILES=O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1ccc(O)c(O)c1;   trans-Dihydroquercetin
 alt_id: CHEBI:15206;   CHEBI:23764;   CHEBI:42225;   CHEBI:9415
 xref: Beilstein:93548;   CAS:480-18-2;   DrugBank:DB02224;   KEGG:C01617;   KNApSAcK:C00000677;   LINCS:LSM-5990
 xref_mesh: MESH:C003377
 xref: PDBeChem:DQH;   Wikipedia:Taxifolin
 cyclic_relationship: is_conjugate_acid_of CHEBI:58329;   is_enantiomer_of CHEBI:41963


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(+)-taxifolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] CTD PMID:34217736 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 multiple interactions
decreases activity		 ISO taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
taxifolin results in decreased activity of ABCC1 protein		 CTD PMID:15041478 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO taxifolin inhibits the reaction [Rotenone results in decreased activity of ACHE protein] CTD PMID:35187747 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions ISO taxifolin binds to and results in increased activity of ADIPOR2 protein CTD PMID:23691032 NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665 		JBrowse link
G Afp alpha fetoprotein affects binding ISO taxifolin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766 		JBrowse link
G Agt angiotensinogen decreases expression EXP taxifolin results in decreased expression of AGT protein modified form CTD PMID:24269735 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions ISO AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA] CTD PMID:29584932 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein]; taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]] CTD PMID:32828744 PMID:35465754 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Apoa1 apolipoprotein A-I increases expression ISO taxifolin results in increased expression of APOA1 protein CTD PMID:11108730 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apob apolipoprotein B decreases secretion
decreases expression		 ISO taxifolin results in decreased secretion of APOB protein
taxifolin results in decreased expression of APOB protein		 CTD PMID:11108730 PMID:15380446 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]] CTD PMID:35465754 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of BCL2 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]] CTD PMID:32525071 PMID:35465754 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]] CTD PMID:35465754 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions		 ISO taxifolin results in decreased activity of CASP3 protein
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]; taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]		 CTD PMID:24269735 PMID:32828744 PMID:35465754 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 decreases activity ISO taxifolin results in decreased activity of CASP9 protein CTD PMID:24269735 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]; taxifolin analog inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; taxifolin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT mRNA]; taxifolin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased activity of CAT protein]
taxifolin results in decreased activity of CAT protein		 CTD PMID:30372826 PMID:32525071 PMID:33741339 PMID:35187747 PMID:35465754 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccna1 cyclin A1 decreases expression ISO taxifolin results in decreased expression of CCNA1 mRNA CTD PMID:17541156 NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO taxifolin results in decreased expression of CDC25A mRNA CTD PMID:17541156 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:30372826 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO taxifolin affects the localization of CYCS protein CTD PMID:24269735 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein] CTD PMID:32525071 PMID:36198370 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO taxifolin results in increased expression of CYP1A1 mRNA; taxifolin results in increased expression of CYP1A1 protein
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]		 CTD PMID:22422552 PMID:29584932 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO taxifolin results in decreased expression of CYP2E1 mRNA CTD PMID:17541156 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dcc DCC netrin 1 receptor increases expression ISO taxifolin results in increased expression of DCC mRNA CTD PMID:17541156 NCBI chr18:71,386,703...72,484,299
Ensembl chr18:71,386,705...72,484,140 		JBrowse link
G Egf epidermal growth factor decreases expression ISO taxifolin results in decreased expression of EGF mRNA CTD PMID:17541156 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Fgf18 fibroblast growth factor 18 decreases expression ISO taxifolin results in decreased expression of FGF18 mRNA CTD PMID:17541156 NCBI chr11:33,066,970...33,097,400
Ensembl chr11:33,067,430...33,097,400 		JBrowse link
G Fgf3 fibroblast growth factor 3 decreases expression ISO taxifolin results in decreased expression of FGF3 mRNA CTD PMID:17541156 NCBI chr 7:144,392,349...144,397,085
Ensembl chr 7:144,391,820...144,398,173 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:32828744 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]] CTD PMID:35465754 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]] CTD PMID:35465754 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gas6 growth arrest specific 6 increases expression ISO taxifolin results in increased expression of GAS6 mRNA CTD PMID:17541156 NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO taxifolin results in increased expression of GDF15 mRNA CTD PMID:17541156 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions ISO taxifolin inhibits the reaction [Rotenone results in decreased activity of GLUL protein] CTD PMID:35187747 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] CTD PMID:32828744 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 protein] CTD PMID:32525071 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]] CTD PMID:35465754 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 increases expression ISO taxifolin results in increased expression of GSTM1 mRNA CTD PMID:17541156 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
decreases expression		 ISO
EXP		 taxifolin results in increased expression of HMOX1 protein
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]
taxifolin results in decreased expression of HMOX1 protein
Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein]		 CTD PMID:16799064 PMID:31152760 PMID:35465754 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]] CTD PMID:35465754 NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD17B3 protein] CTD PMID:32525071 PMID:36198370 NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]] CTD PMID:35465754 PMID:36198370 NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein] CTD PMID:12044887 PMID:19103272 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]
taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of IFNG protein]		 CTD PMID:12044887 PMID:19103272 PMID:31152760 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma multiple interactions ISO taxifolin inhibits the reaction [Rotenone results in increased expression of IKBKG mRNA] CTD PMID:35187747 NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]] CTD PMID:35465754 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein]; taxifolin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein]		 CTD PMID:32828744 PMID:35187747 PMID:38574953 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein]		 CTD PMID:32828744 PMID:38574953 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSL3 protein] CTD PMID:32525071 PMID:36198370 NCBI chr 8:72,141,896...72,143,221
Ensembl chr 8:72,141,858...72,143,219 		JBrowse link
G Jun jun proto-oncogene decreases expression ISO taxifolin results in decreased expression of JUN mRNA CTD PMID:17541156 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]] CTD PMID:35465754 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein] CTD PMID:12044887 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]] CTD PMID:35465754 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO taxifolin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; taxifolin inhibits the reaction [Rotenone results in increased activity of MPO protein] CTD PMID:33741339 PMID:35187747 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]; taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]] CTD PMID:35465754 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Mttp microsomal triglyceride transfer protein decreases activity ISO taxifolin results in decreased activity of MTTP protein CTD PMID:15380446 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
decreases expression		 ISO
EXP		 taxifolin results in increased expression of NFE2L2 protein
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]
Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein]		 CTD PMID:16799064 PMID:31152760 PMID:35465754 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO taxifolin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA] CTD PMID:35187747 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]] CTD PMID:35465754 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases activity
increases expression		 ISO taxifolin results in increased activity of NQO1 protein
taxifolin results in increased expression of NQO1 mRNA		 CTD PMID:17541156 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein CTD PMID:32828744 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide decreases expression ISO taxifolin results in decreased expression of PDGFB mRNA CTD PMID:17541156 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha multiple interactions ISO taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein] CTD PMID:32828744 NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases phosphorylation ISO taxifolin results in increased phosphorylation of PPARA protein CTD PMID:23691032 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein] CTD PMID:32525071 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit decreases phosphorylation ISO taxifolin results in decreased phosphorylation of PRKAA1 protein CTD PMID:23691032 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit decreases phosphorylation ISO taxifolin results in decreased phosphorylation of PRKAA2 protein CTD PMID:23691032 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP taxifolin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21341175 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rasa1 RAS p21 protein activator 1 decreases expression ISO taxifolin results in decreased expression of RASA1 mRNA CTD PMID:17541156 NCBI chr13:85,362,893...85,437,487
Ensembl chr13:85,362,899...85,437,249 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 protein] CTD PMID:36198370 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] CTD PMID:32525071 PMID:36198370 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein] CTD PMID:32525071 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA] CTD PMID:32525071 PMID:36198370 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 multiple interactions ISO taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOX9 mRNA] CTD PMID:32525071 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein] CTD PMID:12044887 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]] CTD PMID:35465754 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO taxifolin inhibits the reaction [Rotenone results in decreased activity of TH protein] CTD PMID:35187747 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]		 CTD PMID:31152760 PMID:32828744 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Traf3 TNF receptor-associated factor 3 increases expression ISO taxifolin results in increased expression of TRAF3 mRNA CTD PMID:17541156 NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
decreases activity		 ISO taxifolin results in increased expression of TXNRD1 mRNA
taxifolin results in decreased activity of TXNRD1 protein modified form		 CTD PMID:16618767 PMID:17541156 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) multiple interactions ISO taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] CTD PMID:30372826 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression
multiple interactions		 ISO taxifolin results in increased expression of UGT1A1 mRNA
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]		 CTD PMID:29584932 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides]
taxifolin inhibits the reaction [Rotenone results in increased activity of XDH protein]		 CTD PMID:19555678 PMID:35187747 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
G Xpa xeroderma pigmentosum, complementation group A increases expression ISO taxifolin results in increased expression of XPA mRNA CTD PMID:17541156 NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311 		JBrowse link
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 increases expression ISO taxifolin results in increased expression of XRCC4 mRNA CTD PMID:17541156 NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727 		JBrowse link
astilbin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c20 aldo-keto reductase family 1, member C20 multiple interactions ISO [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] CTD PMID:29471006 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:29471006 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:29471006 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:29471006 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] CTD PMID:29471006 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:29471006 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] CTD PMID:29471006 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA] CTD PMID:29471006 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:29471006 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein] CTD PMID:29471006 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] CTD PMID:29471006 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] CTD PMID:29471006 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP
ISO		 astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein]		 CTD PMID:29471006 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] CTD PMID:29471006 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:29471006 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:29471006 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] CTD PMID:29471006 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] CTD PMID:29471006 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:29471006 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]		 CTD PMID:29471006 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] CTD PMID:29471006 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22205
    role 22190
      biological role 22189
        biochemical role 21465
          metabolite 21413
            (+)-taxifolin 94
              (+)-taxifolin 3-O-acetate 0
              (+)-taxifolin 3-O-alpha-D-arabinopyranoside 0
              (+)-taxifolin 3-O-alpha-L-arabinofuranoside 0
              (+)-taxifolin 3-O-alpha-L-arabinopyranoside 0
              (+)-taxifolin 3-O-beta-D-arabinopyranoside 0
              (+)-taxifolin 3-O-beta-D-xylopyranoside 0
              6-methoxytaxifolin 0
              astilbin 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    p-block element atom 22131
                      carbon group element atom 21928
                        carbon atom 21854
                          organic molecular entity 21854
                            organic molecule 21671
                              organic cyclic compound 21276
                                organic heterocyclic compound 20346
                                  oxacycle 18876
                                    benzopyran 12219
                                      1-benzopyran 11978
                                        flavonoid 7275
                                          anthoxanthin 4596
                                            flavones 4596
                                              hydroxyflavone 4567
                                                flavonols 4462
                                                  7-hydroxyflavonol 4406
                                                    quercetin 4349
                                                      taxifolin 94
                                                        (+)-taxifolin 94
                                                          (+)-taxifolin 3-O-acetate 0
                                                          (+)-taxifolin 3-O-alpha-D-arabinopyranoside 0
                                                          (+)-taxifolin 3-O-alpha-L-arabinofuranoside 0
                                                          (+)-taxifolin 3-O-alpha-L-arabinopyranoside 0
                                                          (+)-taxifolin 3-O-beta-D-arabinopyranoside 0
                                                          (+)-taxifolin 3-O-beta-D-xylopyranoside 0
                                                          6-methoxytaxifolin 0
                                                          astilbin 22
paths to the root