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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-taxifolin | increases expression | ISO | RGD:731288 | 6480464 | taxifolin results in increased expression of DCC mRNA | CTD | PMID:17541156 | (S)-amphetamine | multiple interactions | EXP | | 6480464 | SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of DCC mRNA] | CTD | PMID:12205029 | (S)-amphetamine | increases expression | EXP | | 6480464 | Dextroamphetamine results in increased expression of DCC mRNA | CTD | PMID:12205029 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:731288 | 6480464 | decitabine results in increased expression of DCC mRNA | CTD | PMID:19329758 | 5-fluorouracil | multiple interactions | ISO | RGD:731288 | 6480464 | DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole] | CTD | PMID:15148649 | 6-propyl-2-thiouracil | increases expression | ISO | RGD:2492 | 6480464 | Propylthiouracil results in increased expression of DCC protein | CTD | PMID:22504374 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of DCC mRNA | CTD | PMID:21715664 | bis(2-chloroethyl) sulfide | increases expression | EXP | | 6480464 | Mustard Gas results in increased expression of DCC mRNA | CTD | PMID:15674843 | ciguatoxin CTX1B | affects expression | EXP | | 6480464 | Ciguatoxins affects the expression of DCC mRNA | CTD | PMID:18353800 | copper(2+) sulfate | affects expression | ISO | RGD:731288 | 6480464 | Copper Sulfate affects the expression of DCC mRNA | CTD | PMID:19549813 | Delta(9)-tetrahydrocannabinol | increases expression | ISO | RGD:2492 | 6480464 | Tetrahydrocannabinol results in increased expression of DCC mRNA | CTD | PMID:17578508 | diarsenic trioxide | increases expression | ISO | RGD:731288 | 6480464 | arsenic trioxide results in increased expression of DCC mRNA | CTD | PMID:11940349 | dibutyl phthalate | increases expression | ISO | RGD:2492 | 6480464 | Dibutyl Phthalate results in increased expression of DCC mRNA | CTD | PMID:21266533 | diethylstilbestrol | increases expression | ISO | RGD:731288 | 6480464 | Diethylstilbestrol results in increased expression of DCC mRNA | CTD | PMID:15766595 | dioxygen | increases expression | ISO | RGD:731288 | 6480464 | Oxygen deficiency results in increased expression of DCC mRNA | CTD | PMID:17914565 | fonofos | increases methylation | ISO | RGD:731288 | 6480464 | Fonofos results in increased methylation of DCC promoter | CTD | PMID:22847954 | formaldehyde | increases expression | ISO | RGD:2492 | 6480464 | Formaldehyde results in increased expression of DCC mRNA | CTD | PMID:12679049 | methimazole | increases expression | ISO | RGD:2492 | 6480464 | Methimazole results in increased expression of DCC protein | CTD | PMID:22504374 | nickel atom | affects expression | ISO | RGD:731288 | 6480464 | Nickel affects the expression of DCC mRNA | CTD | PMID:14575637 | nickel atom | multiple interactions | ISO | RGD:731288 | 6480464 | trichostatin A inhibits the reaction [Nickel affects the expression of DCC mRNA] | CTD | PMID:14575637 | parathion | increases methylation | ISO | RGD:731288 | 6480464 | Parathion results in increased methylation of DCC promoter | CTD | PMID:22847954 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of DCC mRNA | CTD | PMID:20813756 | terbufos | increases methylation | ISO | RGD:731288 | 6480464 | terbufos results in increased methylation of DCC promoter | CTD | PMID:22847954 | trichostatin A | multiple interactions | ISO | RGD:731288 | 6480464 | trichostatin A inhibits the reaction [Nickel affects the expression of DCC mRNA] | CTD | PMID:14575637 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Axon guidance |
| Colorectal cancer | |
| Pathways in cancer | |
| Pathway Interaction Database | Netrin-mediated signaling events (PID:200088) |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Axon guidance |
| Colorectal cancer | |
| Pathways in cancer | |
| Pathway Interaction Database | Netrin-mediated signaling events (PID:200088) |
Phenotype Annotations
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References - curated| 1. |
Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55. |
| 2. |
Manitt C, etal., J Neurosci Res. 2006 Dec;84(8):1808-20. |
| 3. |
MGD and Homologene mouse data transfer |
| 4. |
MGD data from the GO Consortium |
| 5. |
MGD IEA |
| 6. |
Moon C, etal., J Neuroimmunol. 2006 Mar;172(1-2):66-72. Epub 2005 Dec 6. |
| 7. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 8. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 9. |
RGD automated import pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD Automated Pipelines |
| 12. |
Tsuchiya A, etal., Brain Res. 2007 Jul 23;1159:1-7. Epub 2007 Jan 20. |
References - uncurated| PubMed | 10049565 |
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RGD Disease Portals| Dcc has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Dcc (Mus musculus) |
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| DCC (Homo sapiens) |
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| Dcc (Rattus norvegicus) |
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Position Markers| Dcc |
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| D18Mit186 |
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| UniSTS:237840 |
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| D18Mit141 |
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| GDB:201899 |
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| GDB:201912 |
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| D18Abb2e |
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| Dcc |
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| Dcc |
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| Dcc |
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| Dcc |
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| Dcc |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_007831 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01139983 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01139984 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139985 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139986 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139987 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139988 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139989 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139990 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139991 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139992 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139993 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139994 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139995 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139996 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139997 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139998 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01139999 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140000 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140001 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140002 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140003 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140004 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140005 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140006 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140007 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140008 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140009 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140010 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140011 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140012 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140013 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140014 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140015 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140016 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140017 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140018 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140019 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140020 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140021 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140022 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140023 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140024 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140025 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140026 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140027 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140028 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140029 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140030 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140031 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140032 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01140033 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC105957 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC107230 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC109179 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC109499 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC121523 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC136637 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC161177 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC163492 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC167547 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC167548 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC167549 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK021125 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK043657 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK048768 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK090377 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK157715 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BQ550935 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466528 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CN665025 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X85788 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_007831 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_031857 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_031857 | (Get FASTA) |
| GenBank Protein | AAI72616 | (Get FASTA) |
| AAI72723 | (Get FASTA) | |
| BAE34163 | (Get FASTA) | |
| CAA59786 | (Get FASTA) | |
| EDL09563 | (Get FASTA) | |
| P70211 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000060534 | |
| Entrez Gene | 13176 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| Germonline | ENSMUSG00000060534 | |
| HomoloGene Group ID | 21081 | ENTREZGENE |
| InterPro | Fibronectin_type3 | UniProtKB/Swiss-Prot |
| Ig-like | UniProtKB/Swiss-Prot | |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig_I-set | UniProtKB/Swiss-Prot | |
| Ig_sub | UniProtKB/Swiss-Prot | |
| Ig_sub2 | UniProtKB/Swiss-Prot | |
| Neogenin_C | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:13176 | ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| MGD | MGI:94869 | ENTREZGENE |
| Pfam | fn3 | UniProtKB/Swiss-Prot |
| I-set | UniProtKB/Swiss-Prot | |
| Neogenin_C | UniProtKB/Swiss-Prot | |
| PROSITE | FN3 | UniProtKB/Swiss-Prot |
| IG_LIKE | UniProtKB/Swiss-Prot | |
| SMART | FN3 | UniProtKB/Swiss-Prot |
| IGc2 | UniProtKB/Swiss-Prot | |
| SM00409 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | FN_III-like | UniProtKB/Swiss-Prot |
| UniGene | Mm.167882 | ENTREZGENE |
| UniProt | DCC_MOUSE | UniProtKB/Swiss-Prot |
| Q3TZP5_MOUSE | UniProtKB/TrEMBL |
| More on Dcc | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 10465 |
| Created: | 2000-05-25 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




