Gene: Egf (epidermal growth factor)  Mus musculus Symbol: Egf Name: epidermal growth factor Description: ENCODES a protein that exhibits epidermal growth factor receptor binding; growth factor activity (ortholog); INVOLVED IN activation of MAPKK activity; branching morphogenesis of an epithelial tube; epidermal growth factor receptor signaling pathway; PARTICIPATES IN altered epidermal growth factor/neuregulin signaling pathway; ceramide signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH abnormal branching of the mammary ductal tree; abnormal ileum morphology; abnormal intestinal goblet cell morphology; ASSOCIATED WITH Pneumonia; Acute Kidney Injury (ortholog); AIDS-Associated Nephropathy (ortholog); FOUND IN extracellular space; plasma membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5-triiodo-L-thyronine; 3,4-dihydrocoumarin Type: protein-coding RefSeq Status: VALIDATED Also known as: AI790464; pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF) Orthologs: Homo sapiens : EGF (epidermal growth factor)  HGNC Rattus norvegicus : Egf (epidermal growth factor) Related Pseudogenes: Gm18238   Latest Assembly: Mouse Genome Assembly Build 37 Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 129,677,575 - 129,755,322 - NCBI Mouse cM Map 3 58.5   NCBI Mouse Celera Assembly 3 136,187,440 - 136,268,006 - NCBI Mouse Genome Assembly Build 37 3 129,380,493 - 129,458,240 - NCBI Mouse Genome Assembly Build 36.1 3 129,380,496 - 129,458,234 - NCBI Mouse Cytogenetic Map 3 G3   NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   ISS RGD:736832 6906908   RGD   AIDS-Associated Nephropathy   ISS RGD:736832 6906909   RGD   Carcinoma, Pancreatic Ductal Disease_progression ISS RGD:736832 2317644 protein:increased expression: : RGD   Diabetic Nephropathies   ISS RGD:736832 6906912   RGD   Enterocolitis, Necrotizing   ISS RGD:2542 2317627   RGD   Gallbladder Neoplasms Susceptibility ISS RGD:736832 2317641 DNA:SNP: :+61A>G (rs4444903)(human) RGD   Gallbladder Neoplasms   ISS RGD:736832 2317646   RGD   Hypomagnesemia 4, Renal   ISS RGD:736832 7240710   OMIM   Hypomagnesemia primary   ISS RGD:736832 6906911   RGD   Lupus Nephritis   ISS RGD:736832 5688301   RGD   Pancreatic Neoplasms   ISS RGD:736832 5490965   RGD   Pancreatic Neoplasms Disease_progression ISS RGD:736832 2317650 protein:increased expression:pancreas RGD   Pancreatitis   ISS RGD:736832 2317638 protein:decreased expression:serum RGD   Pneumonia Resistance IED   6906904   RGD   Reperfusion Injury Resistance ISS RGD:736832 6906916   RGD   Wounds and Injuries   ISS RGD:2542 6906918   RGD   Zollinger-Ellison Syndrome   ISS RGD:736832 2317668 protein:increased expression:saliva RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-taxifolin decreases expression ISO RGD:736832 6480464 taxifolin results in decreased expression of EGF mRNA CTD PMID:17541156 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:736832 6480464 epigallocatechin gallate inhibits the reaction [EGF protein binds to EGFR protein]; more ... CTD PMID:17616711 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:736832 6480464 epigallocatechin gallate results in decreased expression of EGF mRNA CTD PMID:20346928 PMID:20706672 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:736832 6480464 epigallocatechin gallate results in decreased expression of EGF mRNA CTD PMID:20346928 (R)-noradrenaline multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Norepinephrine] results in increased expression of MYC mRNA CTD PMID:12632255 1-chloro-2,4-dinitrobenzene decreases expression ISO RGD:736832 6480464 Dinitrochlorobenzene results in decreased expression of EGF mRNA CTD PMID:20146380 11-deoxycorticosterone multiple interactions ISO RGD:2542 6480464 4,5-dianilinophthalimide inhibits the reaction [EGF protein results in increased susceptibility to Desoxycorticosterone]; more ... CTD PMID:11751714 11-deoxycorticosterone increases response to substance ISO RGD:2542 6480464 EGF protein results in increased susceptibility to Desoxycorticosterone CTD PMID:11751714 17alpha-ethynylestradiol increases response to substance ISO RGD:2542 6480464 Ethinyl Estradiol results in increased susceptibility to EGF protein CTD PMID:2786453 17beta-estradiol multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]; more ... CTD PMID:18629630 17beta-estradiol multiple interactions ISO RGD:736832 6480464 Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; more ... CTD PMID:21185374 17beta-estradiol multiple interactions ISO RGD:2542 6480464 Cycloheximide promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; more ... CTD PMID:12632255 17beta-estradiol multiple interactions ISO RGD:736832 6480464 Estradiol inhibits the reaction [EGF protein results in increased expression of PLAUR protein] CTD PMID:19395996 17beta-estradiol multiple interactions ISO RGD:736832 6480464 Estradiol promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:16901965 17beta-estradiol affects activity ISO RGD:736832 6480464 Estradiol affects the activity of EGF protein CTD PMID:19395996 17beta-estradiol multiple interactions ISO RGD:736832 6480464 EGF protein promotes the reaction [Estradiol results in increased phosphorylation of EGFR protein] CTD PMID:20005069 17beta-estradiol multiple interactions ISO RGD:736832 6480464 EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]; more ... CTD PMID:21048224 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736832 6480464 Tetrachlorodibenzodioxin results in increased expression of EGF mRNA CTD PMID:20044593 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:2542 6480464 geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 [TGFA protein co-treated with EGF protein] affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:12520078 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF protein CTD PMID:2260090 PMID:9787404 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:6309801 PMID:9664232 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736832 6480464 Tetrachlorodibenzodioxin results in increased expression of EGF protein CTD PMID:9787404 2,3,7,8-tetrachlorodibenzodioxine affects response to substance EXP   6480464 EGF protein affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:12520078 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 CSK protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]; more ... CTD PMID:9664232 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of EGF protein] CTD PMID:2260090 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:736832 6480464 Tetrachlorodibenzodioxin results in increased expression of EGF mRNA CTD PMID:20044593 PMID:9787404 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:2542 6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA CTD PMID:18796159 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:6309801 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:2542 6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA CTD PMID:18796159 PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736832 6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:2033054 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 AG 1879 inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]]; more ... CTD PMID:16971554 2,3,7,8-tetrachlorodibenzodioxine affects response to substance EXP   6480464 EGF gene mutant form affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:11399798 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA CTD PMID:19759094 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA] CTD PMID:19759094 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:2542 6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA CTD PMID:18796159 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of EGF mRNA CTD PMID:20044593 2,3,7,8-tetrachlorodibenzodioxine decreases activity EXP   6480464 Tetrachlorodibenzodioxin results in decreased activity of EGF protein CTD PMID:20486776 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of AQP1 mRNA]; more ... CTD PMID:15667827 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 [Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of CDKN1B protein; more ... CTD PMID:20486776 2,3,7,8-tetrachlorodibenzodioxine decreases response to substance EXP   6480464 EGF protein results in decreased susceptibility to Tetrachlorodibenzodioxin CTD PMID:14514962 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of AHR mRNA]; more ... CTD PMID:16054899 2,4-dinitrotoluene affects expression ISO RGD:2542 6480464 2,4-dinitrotoluene affects the expression of EGF mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:2542 6480464 2,6-dinitrotoluene affects the expression of EGF mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions ISO RGD:2542 6480464 2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:10900465 2-acetamidofluorene decreases localization ISO RGD:2542 6480464 2-Acetylaminofluorene results in decreased localization of EGF protein CTD PMID:10900465 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:2542 6480464 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EGF mRNA CTD PMID:20959002 3,3',5-triiodo-L-thyronine multiple interactions EXP   6480464 Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; more ... CTD PMID:16150908 3,4-dihydrocoumarin increases expression EXP   6480464 3,4-dihydrocoumarin results in increased expression of EGF mRNA CTD PMID:22016648 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 AG 1879 inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]]; more ... CTD PMID:16971554 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:2542 6480464 1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [EGF results in increased phosphorylation of MAPK3 protein]]; more ... CTD PMID:21177760 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CALML4 mRNA]; more ... CTD PMID:16054899 4,4'-diaminodiphenylmethane decreases expression EXP   6480464 4,4'-diaminodiphenylmethane results in decreased expression of EGF mRNA CTD PMID:18648102 4,4'-diaminodiphenylmethane decreases expression ISO RGD:2542 6480464 4,4'-diaminodiphenylmethane results in decreased expression of EGF mRNA CTD PMID:18289764 4,5-dianilinophthalimide multiple interactions ISO RGD:2542 6480464 4,5-dianilinophthalimide inhibits the reaction [EGF protein results in increased susceptibility to Desoxycorticosterone] CTD PMID:11751714 acetaldehyde multiple interactions ISO RGD:736832 6480464 chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]; more ... CTD PMID:17991733 acetaldehyde decreases response to substance ISO RGD:736832 6480464 EGF protein results in decreased susceptibility to Acetaldehyde CTD PMID:17991733 actinomycin D multiple interactions ISO RGD:2542 6480464 Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 afimoxifene multiple interactions ISO RGD:736832 6480464 [4-hydroxytamoxifen co-treated with EGF protein] results in increased expression of CDH1 mRNA; more ... CTD PMID:19593637 aflatoxin B1 affects expression ISO RGD:736832 6480464 Aflatoxin B1 affects the expression of EGF protein CTD PMID:20106945 aflatoxin B1 increases expression EXP   6480464 Aflatoxin B1 results in increased expression of EGF mRNA CTD PMID:19770486 all-trans-retinoic acid decreases activity ISO RGD:736832 6480464 EGF protein results in decreased activity of Tretinoin CTD PMID:11171635 all-trans-retinoic acid multiple interactions EXP   6480464 Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of EGF protein] CTD PMID:2260090 all-trans-retinoic acid multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein] CTD PMID:11171635 all-trans-retinoic acid multiple interactions ISO RGD:736832 6480464 [Tretinoin co-treated with EGF protein co-treated with NOG protein] results in increased expression of SOX10 mRNA; more ... CTD PMID:17196394 alpha-hexachlorocyclohexane multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA CTD PMID:12632255 ammonium chloride affects expression ISO RGD:2542 6480464 Ammonium Chloride affects the expression of EGF mRNA CTD PMID:16483693 ammonium chloride multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Ammonium Chloride] results in increased expression of MYC mRNA CTD PMID:12632255 amsacrine multiple interactions ISO RGD:736832 6480464 [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine CTD PMID:16969495 arsenite(3-) multiple interactions ISO RGD:2542 6480464 SB 203580 results in decreased activity of [arsenite co-treated with EGF protein] CTD PMID:9733710 bacitracin decreases expression ISO RGD:2542 6480464 Bacitracin results in decreased expression of EGF mRNA CTD PMID:18289764 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of EGF mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions EXP   6480464 Benzo(a)pyrene inhibits the reaction [EGF protein binds to EGFR protein]; more ... CTD PMID:6309801 bicalutamide multiple interactions ISO RGD:736832 6480464 bicalutamide inhibits the reaction [FOS protein results in increased expression of EGF mRNA] CTD PMID:15466214 bis(2-chloroethyl) sulfide increases expression ISO RGD:736832 6480464 Mustard Gas results in increased expression of EGF protein CTD PMID:17266442 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of EGF mRNA CTD PMID:11011959 butan-1-ol multiple interactions ISO RGD:2542 6480464 1-Butanol inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein]; more ... CTD PMID:11134345 calcitriol increases expression ISO RGD:736832 6480464 Calcitriol results in increased expression of EGF mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:2542 6480464 [Calcium co-treated with Calcitriol] affects the expression of EGF mRNA CTD PMID:15913539 calcitriol multiple interactions ISO RGD:736832 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of EGF mRNA CTD PMID:21592394 calcium atom increases abundance ISO RGD:736832 6480464 EGF protein results in increased abundance of Calcium CTD PMID:11527950 calcium atom multiple interactions ISO RGD:2542 6480464 [Calcium co-treated with Calcitriol] affects the expression of EGF mRNA CTD PMID:15913539 calcium atom affects expression ISO RGD:2542 6480464 Calcium affects the expression of EGF mRNA CTD PMID:15913539 calcium atom multiple interactions EXP   6480464 [IGF2 protein co-treated with EGF protein] results in increased import of Calcium CTD PMID:2442157 calcium atom multiple interactions ISO RGD:736832 6480464 tyrphostin AG 1478 inhibits the reaction [EGF protein results in increased abundance of Calcium] CTD PMID:11527950 calcium(0) increases abundance ISO RGD:736832 6480464 EGF protein results in increased abundance of Calcium CTD PMID:11527950 calcium(0) multiple interactions ISO RGD:2542 6480464 [Calcium co-treated with Calcitriol] affects the expression of EGF mRNA CTD PMID:15913539 calcium(0) affects expression ISO RGD:2542 6480464 Calcium affects the expression of EGF mRNA CTD PMID:15913539 calcium(0) multiple interactions EXP   6480464 [IGF2 protein co-treated with EGF protein] results in increased import of Calcium CTD PMID:2442157 calcium(0) multiple interactions ISO RGD:736832 6480464 tyrphostin AG 1478 inhibits the reaction [EGF protein results in increased abundance of Calcium] CTD PMID:11527950 capsaicin multiple interactions ISO RGD:736832 6480464 Capsaicin inhibits the reaction [EGF results in increased activity of MMP9 protein]; more ... CTD PMID:21462327 capsaicin decreases expression ISO RGD:2542 6480464 Capsaicin results in decreased expression of EGF protein CTD PMID:14521749 capsaicin decreases activity ISO RGD:2542 6480464 Capsaicin results in decreased activity of EGF protein CTD PMID:9324159 chlorogenic acid decreases expression ISO RGD:736832 6480464 Chlorogenic Acid results in decreased expression of EGF mRNA CTD PMID:20706672 chloroquine multiple interactions ISO RGD:736832 6480464 Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein] CTD PMID:20332299 ciguatoxin CTX1B affects expression EXP   6480464 Ciguatoxins affects the expression of EGF mRNA CTD PMID:18353800 cisplatin multiple interactions ISO RGD:736832 6480464 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; more ... CTD PMID:21613822 cisplatin decreases expression ISO RGD:2542 6480464 Cisplatin results in decreased expression of EGF protein CTD PMID:15033597 cisplatin decreases expression ISO RGD:2542 6480464 Cisplatin results in decreased expression of EGF mRNA CTD PMID:18289764 copper atom multiple interactions ISO RGD:736832 6480464 [NSC 689534 binds to Copper] which results in increased expression of EGF mRNA CTD PMID:20971185 copper atom decreases expression ISO RGD:2542 6480464 Copper results in decreased expression of EGF mRNA CTD PMID:22465980 copper(0) multiple interactions ISO RGD:736832 6480464 [NSC 689534 binds to Copper] which results in increased expression of EGF mRNA CTD PMID:20971185 copper(0) decreases expression ISO RGD:2542 6480464 Copper results in decreased expression of EGF mRNA CTD PMID:22465980 cortisol multiple interactions ISO RGD:736832 6480464 gefitinib promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]]; more ... CTD PMID:17805209 crocidolite asbestos affects expression ISO RGD:736832 6480464 Asbestos, Crocidolite affects the expression of EGF mRNA CTD PMID:17331233 curcumin multiple interactions ISO RGD:736832 6480464 Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; more ... CTD PMID:18214481 curcumin multiple interactions ISO RGD:736832 6480464 Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:10851300 more ... curcumin multiple interactions ISO RGD:736832 6480464 Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18214481 more ... curcumin multiple interactions ISO RGD:736832 6480464 Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:15129424 more ... curcumin multiple interactions ISO RGD:2542 6480464 Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]; more ... CTD PMID:17372590 curcumin decreases activity ISO RGD:736832 6480464 Curcumin results in decreased activity of EGF protein CTD PMID:15486348 curcumin multiple interactions ISO RGD:736832 6480464 Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein] CTD PMID:15129424 curcumin multiple interactions ISO RGD:736832 6480464 Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:15129424 more ... cycloheximide multiple interactions ISO RGD:2542 6480464 Cycloheximide promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 cyclosporin A increases expression ISO RGD:736832 6480464 Cyclosporine results in increased expression of EGF mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:2542 6480464 Cyclosporine results in decreased expression of EGF mRNA CTD PMID:21865292 cyproterone acetate multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Cyproterone Acetate] results in increased expression of MYC mRNA CTD PMID:12632255 cytochalasin D multiple interactions EXP   6480464 EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 D-glucose multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA] CTD PMID:19816600 D-glucose multiple interactions ISO RGD:736832 6480464 EGF protein promotes the reaction [Glucose results in increased expression of TGFA mRNA]; more ... CTD PMID:8638660 dasatinib (anhydrous) multiple interactions ISO RGD:736832 6480464 dasatinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:20664932 daunorubicin multiple interactions ISO RGD:736832 6480464 Daunorubicin inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 DDT multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with DDT] results in increased expression of MYC mRNA CTD PMID:12632255 dexamethasone multiple interactions EXP   6480464 AG 1879 inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]]; more ... CTD PMID:16971554 dexamethasone multiple interactions ISO RGD:2542 6480464 Dexamethasone promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 dexamethasone multiple interactions EXP   6480464 EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]; more ... CTD PMID:16054899 dexamethasone multiple interactions ISO RGD:736832 6480464 Dexamethasone inhibits the reaction [EGF protein results in increased expression of MAPK1 protein modified form]; more ... CTD PMID:17077316 dexamethasone multiple interactions ISO RGD:736832 6480464 Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to ARAF protein]]; more ... CTD PMID:10807665 dexamethasone multiple interactions ISO RGD:2542 6480464 Dexamethasone inhibits the reaction [EGF protein results in increased expression of FOS mRNA]; more ... CTD PMID:7705776 diarsenic trioxide increases expression EXP   6480464 arsenic trioxide results in increased expression of EGF mRNA CTD PMID:15073043 diethylstilbestrol increases expression EXP   6480464 Diethylstilbestrol results in increased expression of EGF mRNA CTD PMID:15336711 diethylstilbestrol increases expression EXP   6480464 Diethylstilbestrol results in increased expression of EGF mRNA CTD PMID:11011959 PMID:15336711 diethylstilbestrol multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Diethylstilbestrol] results in increased expression of MYC mRNA CTD PMID:12632255 diethylstilbestrol increases expression ISO RGD:2542 6480464 Diethylstilbestrol results in increased expression of EGF mRNA CTD PMID:17011747 disodium selenite multiple interactions EXP   6480464 Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of EGF mRNA] CTD PMID:17997286 doxorubicin multiple interactions ISO RGD:736832 6480464 [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Doxorubicin CTD PMID:16969495 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of EGF mRNA CTD PMID:22016648 elemental selenium multiple interactions ISO RGD:2542 6480464 Selenium inhibits the reaction [EGF protein results in increased abundance of Peroxides]; more ... CTD PMID:11158190 ethanolamine increases activity ISO RGD:736832 6480464 Ethanolamine results in increased activity of EGF protein CTD PMID:15802876 etoposide multiple interactions ISO RGD:736832 6480464 [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Etoposide CTD PMID:16969495 flurbiprofen increases expression EXP   6480464 Flurbiprofen results in increased expression of EGF mRNA CTD PMID:16949054 fructose increases uptake ISO RGD:2542 6480464 EGF protein results in increased uptake of Fructose CTD PMID:15691865 fructose multiple interactions ISO RGD:2542 6480464 wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose] CTD PMID:15691865 fulvestrant affects activity ISO RGD:736832 6480464 fulvestrant affects the activity of EGF protein CTD PMID:19395996 fulvestrant multiple interactions ISO RGD:736832 6480464 fulvestrant inhibits the reaction [EGF protein results in increased expression of TFF1 mRNA] CTD PMID:20206645 fulvestrant multiple interactions ISO RGD:736832 6480464 fulvestrant inhibits the reaction [EGF protein results in increased expression of PLAUR protein] CTD PMID:19395996 fulvestrant multiple interactions ISO RGD:736832 6480464 fulvestrant inhibits the reaction [[4-hydroxytamoxifen co-treated with EGF protein] results in increased expression of CDH1 protein] CTD PMID:19593637 gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF affects the localization of MAPK1]; more ... CTD PMID:20088784 gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:19318490 more ... gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:19318490 more ... gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; more ... CTD PMID:18927496 more ... gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19233551 more ... gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:16243822 more ... gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:15841081 gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] CTD PMID:17805209 gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF results in increased activity of MAPK1 protein]; more ... CTD PMID:21787763 gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; more ... CTD PMID:19318490 gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19318490 more ... gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:16243822 more ... gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:18927496 more ... gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein]; more ... CTD PMID:17898861 gefitinib multiple interactions ISO RGD:736832 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:19233551 geldanamycin multiple interactions EXP   6480464 geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9664232 geldanamycin multiple interactions ISO RGD:2542 6480464 geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431 genistein multiple interactions ISO RGD:736832 6480464 Genistein inhibits the reaction [EGF protein results in increased activity of AKT1 protein] CTD PMID:18431742 genistein decreases expression ISO RGD:736832 6480464 Genistein results in decreased expression of EGF mRNA CTD PMID:20706672 genistein multiple interactions ISO RGD:2542 6480464 [Genistein co-treated with vinclozolin] results in decreased expression of EGF mRNA CTD PMID:22317923 glucose multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA] CTD PMID:19816600 glucose multiple interactions ISO RGD:736832 6480464 EGF protein promotes the reaction [Glucose results in increased expression of TGFA mRNA]; more ... CTD PMID:8638660 glutathione affects abundance ISO RGD:2542 6480464 EGF protein affects the abundance of Glutathione CTD PMID:10544272 Goe 6976 multiple interactions ISO RGD:2542 6480464 Go 6976 inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein] CTD PMID:11134345 heparin decreases activity ISO RGD:736832 6480464 Heparin results in decreased activity of EGF protein CTD PMID:12714831 hydrogen peroxide decreases expression EXP   6480464 Hydrogen Peroxide results in decreased expression of EGF mRNA CTD PMID:17997286 hydrogen peroxide multiple interactions EXP   6480464 Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of EGF mRNA] CTD PMID:17997286 ibuprofen multiple interactions ISO RGD:736832 6480464 Ibuprofen inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; more ... CTD PMID:16340751 indomethacin multiple interactions EXP   6480464 allylpyrocatechol promotes the reaction [Indomethacin results in increased expression of EGF protein]; more ... CTD PMID:18431645 indomethacin increases expression EXP   6480464 Indomethacin results in increased expression of EGF protein CTD PMID:18431645 PMID:18237397 indomethacin multiple interactions EXP   6480464 Plant Extracts promotes the reaction [Indomethacin results in increased expression of EGF protein] CTD PMID:18237397 indomethacin increases expression EXP   6480464 Indomethacin results in increased expression of EGF protein CTD PMID:18237397 PMID:18431645 indomethacin multiple interactions ISO RGD:736832 6480464 Indomethacin promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] CTD PMID:17805209 indomethacin multiple interactions ISO RGD:736832 6480464 Indomethacin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; more ... CTD PMID:12037131 inulin multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]; more ... CTD PMID:17991733 ionomycin multiple interactions ISO RGD:736832 6480464 [Ionomycin co-treated with EGF protein] results in increased phosphorylation of MAPK1 protein; more ... CTD PMID:22317921 lovastatin multiple interactions ISO RGD:736832 6480464 Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]] CTD PMID:12942316 lovastatin multiple interactions ISO RGD:736832 6480464 Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:19760159 luteolin multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of PTK2 protein]; more ... CTD PMID:15135307 luteolin multiple interactions ISO RGD:736832 6480464 Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; more ... CTD PMID:22926442 LY294002 multiple interactions ISO RGD:736832 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of VEGFA mRNA] CTD PMID:15040022 LY294002 multiple interactions ISO RGD:736832 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16343977 more ... LY294002 multiple interactions ISO RGD:736832 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16472761 more ... LY294002 multiple interactions ISO RGD:736832 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein] CTD PMID:16848764 PMID:18214481 LY294002 multiple interactions ISO RGD:736832 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]; more ... CTD PMID:16472761 LY294002 multiple interactions ISO RGD:736832 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16343977 more ... mestranol multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Mestranol] results in increased expression of MYC mRNA CTD PMID:12632255 midostaurin multiple interactions ISO RGD:736832 6480464 4'-N-benzoylstaurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 mifepristone multiple interactions ISO RGD:736832 6480464 Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]]; more ... CTD PMID:10807665 mifepristone multiple interactions ISO RGD:736832 6480464 Mifepristone inhibits the reaction [Progesterone promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]]; more ... CTD PMID:16175315 mitomycin C multiple interactions ISO RGD:736832 6480464 Mitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc] CTD PMID:1502195 monensin A multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 mono(2-ethylhexyl) phthalate decreases expression EXP   6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of EGF mRNA CTD PMID:22401849 myricetin multiple interactions EXP   6480464 myricetin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:17693661 N-acetyl-L-cysteine multiple interactions ISO RGD:2542 6480464 Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine]; more ... CTD PMID:11158190 N-methyl-N'-nitro-N-nitrosoguanidine affects activity ISO RGD:736832 6480464 Methylnitronitrosoguanidine affects the activity of EGF protein CTD PMID:15708576 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:736832 6480464 Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein]; more ... CTD PMID:15708576 N-nitrosodiethylamine decreases expression ISO RGD:2542 6480464 Diethylnitrosamine results in decreased expression of EGF mRNA CTD PMID:19638242 N-nitrosodimethylamine increases expression ISO RGD:2542 6480464 Dimethylnitrosamine results in increased expression of EGF mRNA CTD PMID:17203207 nevirapine decreases expression ISO RGD:736832 6480464 Nevirapine results in decreased expression of EGF mRNA CTD PMID:19152342 nickel dichloride multiple interactions ISO RGD:736832 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of EGF protein CTD PMID:18437699 nocodazole multiple interactions ISO RGD:736832 6480464 Nocodazole inhibits the reaction [EGF protein results in increased expression of PSA mRNA] CTD PMID:20807808 omeprazole multiple interactions EXP   6480464 Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein] CTD PMID:18431645 paclitaxel decreases expression ISO RGD:736832 6480464 Paclitaxel results in decreased expression of EGF mRNA CTD PMID:18058816 paclitaxel multiple interactions ISO RGD:736832 6480464 Paclitaxel inhibits the reaction [EGF protein results in increased expression of PSA mRNA] CTD PMID:20807808 paracetamol multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with HGF protein] promotes the reaction [Acetaminophen results in decreased expression of CYP1A2 mRNA] CTD PMID:12969438 perfluorooctanoic acid affects expression EXP   6480464 perfluorooctanoic acid affects the expression of EGF mRNA CTD PMID:17132714 perfluorooctanoic acid decreases expression ISO RGD:2542 6480464 perfluorooctanoic acid results in decreased expression of EGF mRNA CTD PMID:19162173 permethrin multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA] CTD PMID:14722249 PMID:11377398 permethrin multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA] CTD PMID:11377398 PMID:14722249 permethrin multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Permethrin results in increased expression of CYP3A1 mRNA] CTD PMID:11377398 phencyclidine increases expression EXP   6480464 Phencyclidine results in increased expression of EGF mRNA CTD PMID:12105081 phenobarbital multiple interactions ISO RGD:2542 6480464 Phenobarbital inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:10828207 phenobarbital multiple interactions EXP   6480464 Phenobarbital inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:6309801 phenobarbital multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:14722249 PMID:11377398 phenobarbital multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:11377398 PMID:14722249 phenylephrine multiple interactions ISO RGD:2542 6480464 ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; more ... CTD PMID:16760267 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 Tetradecanoylphorbol Acetate inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:6309801 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:2542 6480464 bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein]; more ... CTD PMID:12947092 phorbol 13-acetate 12-myristate increases expression ISO RGD:736832 6480464 Tetradecanoylphorbol Acetate results in increased expression of EGF protein CTD PMID:19447859 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736832 6480464 pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein] CTD PMID:19447859 piperonyl butoxide decreases expression ISO RGD:2542 6480464 Piperonyl Butoxide results in decreased expression of EGF mRNA CTD PMID:22484513 pirinixic acid multiple interactions EXP   6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EGF mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:2542 6480464 pirinixic acid results in decreased expression of EGF mRNA CTD PMID:19162173 progesterone multiple interactions ISO RGD:736832 6480464 Mifepristone inhibits the reaction [Progesterone promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]]; more ... CTD PMID:16175315 prostaglandin D2 multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Prostaglandin D2] results in increased expression of MYC mRNA CTD PMID:12632255 prostaglandin E2 multiple interactions ISO RGD:736832 6480464 gefitinib promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]]; more ... CTD PMID:17805209 prostaglandin E2 increases abundance ISO RGD:736832 6480464 EGF protein results in increased abundance of Dinoprostone CTD PMID:17805209 pterostilbene multiple interactions ISO RGD:736832 6480464 pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein] CTD PMID:19447859 quercetin multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [Quercetin results in decreased phosphorylation of PTK2 protein]; more ... CTD PMID:15135307 quercetin decreases expression ISO RGD:736832 6480464 Quercetin results in decreased expression of EGF protein CTD PMID:12469199 quercetin multiple interactions ISO RGD:736832 6480464 Quercetin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16619521 resveratrol multiple interactions ISO RGD:736832 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; more ... CTD PMID:14739659 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased expression of MUC5AC protein]; more ... CTD PMID:22213337 resveratrol multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [resveratrol results in decreased phosphorylation of EGFR protein]; more ... CTD PMID:20729295 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:15849355 PMID:16626303 resveratrol decreases activity ISO RGD:736832 6480464 resveratrol results in decreased activity of EGF protein CTD PMID:16343977 resveratrol multiple interactions ISO RGD:736832 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; more ... CTD PMID:16343977 resveratrol multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [resveratrol results in increased expression of FOS mRNA]; more ... CTD PMID:15542774 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16626303 PMID:15849355 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased localization of GAB1 protein] CTD PMID:15849355 resveratrol multiple interactions EXP   6480464 PTPN11 protein affects the reaction [resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]] CTD PMID:15849355 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:16626303 Ro 31-8220 multiple interactions ISO RGD:2542 6480464 Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; more ... CTD PMID:16877402 Ro 31-8220 multiple interactions ISO RGD:2542 6480464 Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein] CTD PMID:12947092 rosiglitazone multiple interactions EXP   6480464 EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CALML4 mRNA]; more ... CTD PMID:16054899 selenium atom multiple interactions ISO RGD:2542 6480464 Selenium inhibits the reaction [EGF protein results in increased abundance of Peroxides]; more ... CTD PMID:11158190 sirolimus multiple interactions ISO RGD:736832 6480464 Sirolimus inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein] CTD PMID:21187475 sirolimus decreases activity EXP   6480464 Sirolimus analog results in decreased activity of EGF protein CTD PMID:12406821 staurosporine multiple interactions ISO RGD:736832 6480464 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; more ... CTD PMID:15542774 staurosporine multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; more ... CTD PMID:19406941 sulfasalazine increases expression EXP   6480464 Sulfasalazine results in increased expression of EGF mRNA CTD PMID:22016648 sulindac multiple interactions ISO RGD:736832 6480464 Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of BAD protein]; more ... CTD PMID:12566304 tamoxifen affects activity ISO RGD:736832 6480464 Tamoxifen affects the activity of EGF protein CTD PMID:19395996 testosterone multiple interactions ISO RGD:736832 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of EGF mRNA CTD PMID:21592394 testosterone decreases secretion ISO RGD:2542 6480464 EGF protein results in decreased secretion of Testosterone CTD PMID:19059320 testosterone multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [AG 1879 inhibits the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]; more ... CTD PMID:17272394 testosterone increases expression ISO RGD:736832 6480464 Testosterone results in increased expression of EGF mRNA CTD PMID:21592394 tetrachloromethane increases expression ISO RGD:2542 6480464 Carbon Tetrachloride results in increased expression of EGF mRNA CTD PMID:17631135 PMID:16097045 tetrachloromethane increases expression ISO RGD:2542 6480464 Carbon Tetrachloride results in increased expression of EGF mRNA CTD PMID:16097045 PMID:17631135 tetrachloromethane multiple interactions ISO RGD:2542 6480464 IL10 protein affects the reaction [Carbon Tetrachloride results in increased expression of EGF mRNA]; more ... CTD PMID:16097045 tetraphene multiple interactions EXP   6480464 benz(a)anthracene inhibits the reaction [EGF protein binds to EGFR protein]; more ... CTD PMID:6309801 tetrathiomolybdate(2-) multiple interactions ISO RGD:736832 6480464 tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]; more ... CTD PMID:18480265 thapsigargin multiple interactions ISO RGD:736832 6480464 Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein] CTD PMID:17991733 trans-resveratrol multiple interactions ISO RGD:736832 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; more ... CTD PMID:14739659 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased expression of MUC5AC protein]; more ... CTD PMID:22213337 trans-resveratrol multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [resveratrol results in decreased phosphorylation of EGFR protein]; more ... CTD PMID:20729295 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:15849355 PMID:16626303 trans-resveratrol decreases activity ISO RGD:736832 6480464 resveratrol results in decreased activity of EGF protein CTD PMID:16343977 trans-resveratrol multiple interactions ISO RGD:736832 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; more ... CTD PMID:16343977 trans-resveratrol multiple interactions ISO RGD:736832 6480464 EGF protein inhibits the reaction [resveratrol results in increased expression of FOS mRNA]; more ... CTD PMID:15542774 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16626303 PMID:15849355 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased localization of GAB1 protein] CTD PMID:15849355 trans-resveratrol multiple interactions EXP   6480464 PTPN11 protein affects the reaction [resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]] CTD PMID:15849355 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:16626303 urethane multiple interactions EXP   6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of EGF mRNA CTD PMID:12400877 urethane increases expression EXP   6480464 Urethane results in increased expression of EGF mRNA CTD PMID:12400877 valproic acid multiple interactions ISO RGD:736832 6480464 U 0126 inhibits the reaction [Valproic Acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]] CTD PMID:15103026 vancomycin increases expression EXP   6480464 Vancomycin results in increased expression of EGF mRNA CTD PMID:18930951 vancomycin decreases expression ISO RGD:2542 6480464 Vancomycin results in decreased expression of EGF mRNA CTD PMID:18289764 wortmannin multiple interactions ISO RGD:2542 6480464 wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:15849355 wortmannin multiple interactions ISO RGD:2542 6480464 wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose] CTD PMID:15691865 zinc atom increases import EXP   6480464 EGF protein results in increased import of Zinc CTD PMID:16443356 zinc atom increases uptake ISO RGD:736832 6480464 EGF protein results in increased uptake of Zinc CTD PMID:1502195 zinc atom multiple interactions ISO RGD:736832 6480464 Mitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc] CTD PMID:1502195 zinc atom multiple interactions ISO RGD:2542 6480464 Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]] CTD PMID:12947092 zinc atom increases expression ISO RGD:2542 6480464 Zinc deficiency results in increased expression of EGF mRNA CTD PMID:19111725 zinc sulfate multiple interactions ISO RGD:2542 6480464 [Zinc Sulfate co-treated with EGF protein] results in increased expression of MT1A mRNA CTD PMID:7705776 zinc(0) increases import EXP   6480464 EGF protein results in increased import of Zinc CTD PMID:16443356 zinc(0) increases expression ISO RGD:2542 6480464 Zinc deficiency results in increased expression of EGF mRNA CTD PMID:19111725 zinc(0) multiple interactions ISO RGD:2542 6480464 Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]] CTD PMID:12947092 zinc(0) increases uptake ISO RGD:736832 6480464 EGF protein results in increased uptake of Zinc CTD PMID:1502195 zinc(0) multiple interactions ISO RGD:736832 6480464 Mitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc] CTD PMID:1502195 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) activation of MAPKK activity   IDA   2290270 MGI:MGI:3614383|PMID:16339969 MGI MGI:MGI:3614383 PMID:16339969 angiogenesis   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 branching morphogenesis of an epithelial tube   IDA   2290270 MGI:MGI:3575981|PMID:15831470 MGI MGI:MGI:3575981 PMID:15831470 epidermal growth factor receptor signaling pathway   IDA   2290270 MGI:MGI:3531070|PMID:15695332 MGI MGI:MGI:3531070 PMID:15695332 epidermal growth factor receptor signaling pathway   ISO UniProtKB:P07522 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 epidermal growth factor receptor signaling pathway   IDA   2290270 MGI:MGI:63909|PMID:6315706 MGI MGI:MGI:63909 PMID:6315706 epidermal growth factor receptor signaling pathway   IGI MGI:MGI:95294 2290270 MGI:MGI:75839|PMID:7641815 MGI MGI:MGI:75839 PMID:7641815 ERK1 and ERK2 cascade   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 mammary gland alveolus development   IGI MGI:MGI:98724|MGI:MGI:88068 2290270 MGI:MGI:1336843|PMID:10331984 MGI MGI:MGI:1336843 PMID:10331984 negative regulation of cholesterol efflux   IDA   2290270 MGI:MGI:4460848|PMID:20037141 BHF-UCL MGI:MGI:4460848 PMID:20037141 negative regulation of secretion   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 peptidyl-tyrosine phosphorylation   IDA   2290270 MGI:MGI:2683380|PMID:14561752 MGI MGI:MGI:2683380 PMID:14561752 positive regulation of catenin import into nucleus   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of cell proliferation   IGI MGI:MGI:96522 2290270 MGI:MGI:3521553|PMID:15509736 MGI MGI:MGI:3521553 PMID:15509736 positive regulation of cell proliferation   IGI MGI:MGI:95516 2290270 MGI:MGI:3039221|PMID:15051883 MGI MGI:MGI:3039221 PMID:15051883 positive regulation of cell proliferation   IGI MGI:MGI:95705|MGI:MGI:95294 2290270 MGI:MGI:75839|PMID:7641815 MGI MGI:MGI:75839 PMID:7641815 positive regulation of cell proliferation   IDA   2290270 MGI:MGI:3531070|PMID:15695332 MGI MGI:MGI:3531070 PMID:15695332 positive regulation of cell proliferation   IDA   2290270 MGI:MGI:3032880|PMID:14712229 MGI MGI:MGI:3032880 PMID:14712229 positive regulation of cell proliferation   ISO UniProtKB:P01133 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 positive regulation of cerebellar granule cell precursor proliferation   IDA   2290270 MGI:MGI:1329746|PMID:10027293 MGI MGI:MGI:1329746 PMID:10027293 positive regulation of DNA binding   IDA   2290270 MGI:MGI:5284803|PMID:15156153 UniProtKB MGI:MGI:5284803 PMID:15156153 positive regulation of epidermal growth factor-activated receptor activity   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of hyaluronan biosynthetic process   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of MAP kinase activity   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of mitosis   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of peptidyl-threonine phosphorylation   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of phosphorylation   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process   IDA   2290270 MGI:MGI:4887523|PMID:20208556 BHF-UCL MGI:MGI:4887523 PMID:20208556 positive regulation of transcription, DNA-dependent   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of calcium ion import   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of peptidyl-tyrosine phosphorylation   IDA   2290270 MGI:MGI:2182234|PMID:11940581 MGI MGI:MGI:2182234 PMID:11940581 regulation of protein localization to cell surface   ISO UniProtKB:P01133 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of protein secretion   ISO UniProtKB:P07522 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 regulation of protein transport   ISO UniProtKB:P07522 2290270 MGI:MGI:4420359|PMID:19723622 MGI MGI:MGI:4420359 PMID:19723622 STAT protein import into nucleus   IDA   2290270 MGI:MGI:5284803|PMID:15156153 UniProtKB MGI:MGI:5284803 PMID:15156153 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular space   IDA   2290270 MGI:MGI:63540|PMID:8240367 MGI MGI:MGI:63540 PMID:8240367 extracellular space   IDA   2290270 MGI:MGI:75839|PMID:7641815 MGI MGI:MGI:75839 PMID:7641815 integral to membrane   IEA UniProtKB-KW:KW-0812 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 membrane   IEA UniProtKB-KW:KW-0472 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 plasma membrane   IDA   2290270 MGI:MGI:4887327|PMID:17626015 UniProtKB MGI:MGI:4887327 PMID:17626015 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) calcium ion binding   IEA InterPro:IPR001881|InterPro:IPR018097 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 epidermal growth factor receptor binding   IDA   2290270 MGI:MGI:63909|PMID:6315706 MGI MGI:MGI:63909 PMID:6315706 epidermal growth factor receptor binding   ISO UniProtKB:P07522 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 growth factor activity   ISO UniProtKB:P01133 2290270 MGI:MGI:2154458 MGI MGI:MGI:2154458 protein binding   IPI UniProtKB:Q8VD37 2290270 MGI:MGI:4887327|PMID:17626015 UniProtKB MGI:MGI:4887327 PMID:17626015 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) altered epidermal growth factor/neuregulin signaling pathway   ISS RGD:736832 5490965   RGD   bladder cancer pathway   IEA RGD:10510 6907045   KEGG mmu:05219 ceramide signaling pathway   ISO RGD:736832 6484113   PID PID:200119 ceramide signaling pathway   IEA RGD:10510 6907045   KEGG mmu:05212 E-cadherin signaling pathway   ISO RGD:736832 6484113   PID PID:200182 eicosanoid signaling pathway   ISO RGD:736832 6484113   PID PID:200082 endocytosis pathway   IEA RGD:10510 6907045   KEGG mmu:04144 endometrial cancer pathway   IEA RGD:10510 6907045   KEGG mmu:05213 epidermal growth factor/neuregulin signaling pathway   ISS RGD:2542 1626483   RGD   epidermal growth factor/neuregulin signaling pathway   IEA RGD:10510 6907045   KEGG mmu:04012 epidermal growth factor/neuregulin signaling pathway   ISO RGD:736832 6484113   PID PID:200159 epidermal growth factor/neuregulin signaling pathway   ISO RGD:736832 6484113   PID PID:200101 epidermal growth factor/neuregulin signaling pathway   ISS RGD:736832 2317963   RGD   glioma pathway   IEA RGD:10510 6907045   KEGG mmu:05214 hepatitis C virus infection pathway   IEA RGD:10510 6907045   KEGG mmu:05160 melanoma pathway   IEA RGD:10510 6907045   KEGG mmu:05218 mitogen activated protein kinase signaling pathway   IEA RGD:10510 6907045   KEGG mmu:04010 non-small cell lung cancer pathway   IEA RGD:10510 6907045   KEGG mmu:05223 pancreatic cancer pathway   ISS RGD:736832 5490965   RGD   pancreatic cancer pathway   IEA RGD:10510 6907045   KEGG mmu:05212 prostate cancer pathway   IEA RGD:10510 6907045   KEGG mmu:05215 External Database Links KEGG Pathway Bladder cancer Cytokine-cytokine receptor interaction Endocytosis Endometrial cancer ErbB signaling pathway Focal adhesion Gap junction Glioma Hepatitis C HIF-1 signaling pathway MAPK signaling pathway Melanoma Non-small cell lung cancer Pancreatic cancer Pathways in cancer PI3K-Akt signaling pathway Prostate cancer Regulation of actin cytoskeleton Pathway Interaction Database a6b1 and a6b4 Integrin signaling (PID:200190) Arf6 signaling events (PID:200073) Ceramide signaling pathway (PID:200119) EGF receptor (ErbB1) signaling pathway (PID:200101) EGFR-dependent Endothelin signaling events (PID:200112) ErbB receptor signaling network (PID:200159) ErbB1 downstream signaling (PID:200133) Internalization of ErbB1 (PID:200171) Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) Regulation of Telomerase (PID:200086) SHP2 signaling (PID:200083) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by TCPTP (PID:200078) Stabilization and expansion of the E-cadherin adherens junction (PID:200182) Thromboxane A2 receptor signaling (PID:200082) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal branching of the mammary ductal tree   IAGP   5509061   MGI PMID:10331984 abnormal ileum morphology   IAGP   5509061   MGI PMID:11438495 abnormal intestinal goblet cell morphology   IAGP   5509061   MGI PMID:11438495 abnormal lactation   IAGP   5509061   MGI PMID:10331984 abnormal mammary gland growth during pregnancy   IAGP   5509061   MGI PMID:10331984 abnormal small intestine crypts of Lieberkuhn morphology   IAGP   5509061   MGI PMID:11438495 abnormal small intestine morphology   IAGP   5509061   MGI PMID:11438495 alopecia   IAGP   5509061   MGI PMID:10331984 corneal opacity   IAGP   5509061   MGI PMID:10331984 curly vibrissae   IAGP   5509061   MGI PMID:10331984 decreased body weight   IAGP   5509061   MGI PMID:11438495 dermatitis   IAGP   5509061   MGI PMID:10331984 duodenal lesions   IAGP   5509061   MGI PMID:11438495 eyelids open at birth   IAGP   5509061   MGI PMID:10331984 eyelids open at birth   IAGP   5509061   MGI PMID:15456865 microphthalmia   IAGP   5509061   MGI PMID:10331984 no abnormal phenotype detected   IAGP   5509061   MGI PMID:10331984 postnatal growth retardation   IAGP   5509061   MGI PMID:10331984 spontaneous skin ulceration   IAGP   5509061   MGI PMID:10331984 waved hair   IAGP   5509061   MGI PMID:10331984 waved hair   IAGP   5509061   MGI PMID:15456865 weight loss   IAGP   5509061   MGI PMID:10331984 Disease Annotations Acute Kidney Injury  (ISS) AIDS-Associated Nephropathy  (ISS) Carcinoma, Pancreatic Ductal  (ISS) Diabetic Nephropathies  (ISS) Enterocolitis, Necrotizing  (ISS) Gallbladder Neoplasms  (ISS) Hypomagnesemia 4, Renal  (ISS) Hypomagnesemia primary  (ISS) Lupus Nephritis  (ISS) Pancreatic Neoplasms  (ISS) Pancreatitis  (ISS) Pneumonia  (IED) Reperfusion Injury  (ISS) Wounds and Injuries  (ISS) Zollinger-Ellison Syndrome  (ISS) Gene-Chemical Interaction Annotations (+)-taxifolin  (ISO) (-)-epigallocatechin 3-gallate  (ISO) (R)-noradrenaline  (ISO) 1-chloro-2,4-dinitrobenzene  (ISO) 11-deoxycorticosterone  (ISO) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,4-dinitrotoluene  (ISO) 2,6-dinitrotoluene  (ISO) 2-acetamidofluorene  (ISO) 3,3',4,4',5-pentachlorobiphenyl  (ISO) 3,3',5-triiodo-L-thyronine  (EXP) 3,4-dihydrocoumarin  (EXP) 3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO) 4,4'-diaminodiphenylmethane  (EXP,ISO) 4,5-dianilinophthalimide  (ISO) acetaldehyde  (ISO) actinomycin D  (ISO) afimoxifene  (ISO) aflatoxin B1  (EXP,ISO) all-trans-retinoic acid  (EXP,ISO) alpha-hexachlorocyclohexane  (ISO) ammonium chloride  (ISO) amsacrine  (ISO) arsenite(3-)  (ISO) bacitracin  (ISO) benzo[a]pyrene  (EXP) bicalutamide  (ISO) bis(2-chloroethyl) sulfide  (ISO) bisphenol A  (EXP) butan-1-ol  (ISO) calcitriol  (ISO) calcium atom  (EXP,ISO) calcium(0)  (EXP,ISO) capsaicin  (ISO) chlorogenic acid  (ISO) chloroquine  (ISO) ciguatoxin CTX1B  (EXP) cisplatin  (ISO) copper atom  (ISO) copper(0)  (ISO) cortisol  (ISO) crocidolite asbestos  (ISO) curcumin  (ISO) cycloheximide  (ISO) cyclosporin A  (ISO) cyproterone acetate  (ISO) cytochalasin D  (EXP) D-glucose  (ISO) dasatinib (anhydrous)  (ISO) daunorubicin  (ISO) DDT  (ISO) dexamethasone  (EXP,ISO) diarsenic trioxide  (EXP) diethylstilbestrol  (EXP,ISO) disodium selenite  (EXP) doxorubicin  (EXP,ISO) elemental selenium  (ISO) ethanolamine  (ISO) etoposide  (ISO) flurbiprofen  (EXP) fructose  (ISO) fulvestrant  (ISO) gefitinib  (EXP,ISO) geldanamycin  (EXP,ISO) genistein  (ISO) glucose  (ISO) glutathione  (ISO) Goe 6976  (ISO) heparin  (ISO) hydrogen peroxide  (EXP) ibuprofen  (ISO) indomethacin  (EXP,ISO) inulin  (ISO) ionomycin  (ISO) lovastatin  (ISO) luteolin  (ISO) LY294002  (ISO) mestranol  (ISO) midostaurin  (ISO) mifepristone  (ISO) mitomycin C  (ISO) monensin A  (ISO) mono(2-ethylhexyl) phthalate  (EXP) myricetin  (EXP) N-acetyl-L-cysteine  (ISO) N-methyl-N'-nitro-N-nitrosoguanidine  (ISO) N-nitrosodiethylamine  (ISO) N-nitrosodimethylamine  (ISO) nevirapine  (ISO) nickel dichloride  (ISO) nocodazole  (ISO) omeprazole  (EXP) paclitaxel  (ISO) paracetamol  (ISO) perfluorooctanoic acid  (EXP,ISO) permethrin  (ISO) phencyclidine  (EXP) phenobarbital  (EXP,ISO) phenylephrine  (ISO) phorbol 13-acetate 12-myristate  (EXP,ISO) piperonyl butoxide  (ISO) pirinixic acid  (EXP,ISO) progesterone  (ISO) prostaglandin D2  (ISO) prostaglandin E2  (ISO) pterostilbene  (ISO) quercetin  (ISO) resveratrol  (EXP,ISO) Ro 31-8220  (ISO) rosiglitazone  (EXP) selenium atom  (ISO) sirolimus  (EXP,ISO) staurosporine  (ISO) sulfasalazine  (EXP) sulindac  (ISO) tamoxifen  (ISO) testosterone  (ISO) tetrachloromethane  (ISO) tetraphene  (EXP) tetrathiomolybdate(2-)  (ISO) thapsigargin  (ISO) trans-resveratrol  (EXP,ISO) urethane  (EXP) valproic acid  (ISO) vancomycin  (EXP,ISO) wortmannin  (ISO) zinc atom  (EXP,ISO) zinc sulfate  (ISO) zinc(0)  (EXP,ISO) Gene Ontology Annotations Biological Process activation of MAPKK activity  (IDA) angiogenesis  (ISO) branching morphogenesis of an epithelial tube  (IDA) epidermal growth factor receptor signaling pathway  (IDA,IGI,ISO) ERK1 and ERK2 cascade  (ISO) mammary gland alveolus development  (IGI) negative regulation of cholesterol efflux  (IDA) negative regulation of secretion  (ISO) peptidyl-tyrosine phosphorylation  (IDA) positive regulation of catenin import into nucleus  (ISO) positive regulation of cell proliferation  (IDA,IGI,ISO) positive regulation of cerebellar granule cell precursor proliferation  (IDA) positive regulation of DNA binding  (IDA) positive regulation of epidermal growth factor-activated receptor activity  (ISO) positive regulation of hyaluronan biosynthetic process  (ISO) positive regulation of MAP kinase activity  (ISO) positive regulation of mitosis  (ISO) positive regulation of peptidyl-threonine phosphorylation  (ISO) positive regulation of phosphorylation  (ISO) positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  (IDA) positive regulation of transcription, DNA-dependent  (ISO) regulation of calcium ion import  (ISO) regulation of peptidyl-tyrosine phosphorylation  (IDA) regulation of protein localization to cell surface  (ISO) regulation of protein secretion  (ISO) regulation of protein transport  (ISO) STAT protein import into nucleus  (IDA) Cellular Component extracellular space  (IDA) integral to membrane  (IEA) membrane  (IEA) plasma membrane  (IDA) Molecular Function calcium ion binding  (IEA) epidermal growth factor receptor binding  (IDA,ISO) growth factor activity  (ISO) protein binding  (IPI) Molecular Pathway Annotations altered epidermal growth factor/neuregulin signaling pathway  (ISS) bladder cancer pathway  (IEA) ceramide signaling pathway  (IEA,ISO) E-cadherin signaling pathway  (ISO) eicosanoid signaling pathway  (ISO) endocytosis pathway  (IEA) endometrial cancer pathway  (IEA) epidermal growth factor/neuregulin signaling pathway  (IEA,ISO,ISS) glioma pathway  (IEA) hepatitis C virus infection pathway  (IEA) melanoma pathway  (IEA) mitogen activated protein kinase signaling pathway  (IEA) non-small cell lung cancer pathway  (IEA) pancreatic cancer pathway  (IEA,ISS) prostate cancer pathway  (IEA) External Database Links KEGG Pathway Bladder cancer Cytokine-cytokine receptor interaction Endocytosis Endometrial cancer ErbB signaling pathway Focal adhesion Gap junction Glioma Hepatitis C HIF-1 signaling pathway MAPK signaling pathway Melanoma Non-small cell lung cancer Pancreatic cancer Pathways in cancer PI3K-Akt signaling pathway Prostate cancer Regulation of actin cytoskeleton Pathway Interaction Database a6b1 and a6b4 Integrin signaling (PID:200190) Arf6 signaling events (PID:200073) Ceramide signaling pathway (PID:200119) EGF receptor (ErbB1) signaling pathway (PID:200101) EGFR-dependent Endothelin signaling events (PID:200112) ErbB receptor signaling network (PID:200159) ErbB1 downstream signaling (PID:200133) Internalization of ErbB1 (PID:200171) Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) Regulation of Telomerase (PID:200086) SHP2 signaling (PID:200083) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by TCPTP (PID:200078) Stabilization and expansion of the E-cadherin adherens junction (PID:200182) Thromboxane A2 receptor signaling (PID:200082) Phenotype Annotations abnormal branching of the mammary ductal tree  (IAGP) abnormal ileum morphology  (IAGP) abnormal intestinal goblet cell morphology  (IAGP) abnormal lactation  (IAGP) abnormal mammary gland growth during pregnancy  (IAGP) abnormal small intestine crypts of Lieberkuhn morphology  (IAGP) abnormal small intestine morphology  (IAGP) alopecia  (IAGP) corneal opacity  (IAGP) curly vibrissae  (IAGP) decreased body weight  (IAGP) dermatitis  (IAGP) duodenal lesions  (IAGP) eyelids open at birth  (IAGP) microphthalmia  (IAGP) no abnormal phenotype detected  (IAGP) postnatal growth retardation  (IAGP) spontaneous skin ulceration  (IAGP) waved hair  (IAGP) weight loss  (IAGP) References - curated 1. Abraham JA, etal., Biochem Biophys Res Commun 1993 Jan 15;190(1):125-33. 2. Cao YQ, etal., Zhong Xi Yi Jie He Xue Bao. 2005 May;3(3):220-4. 3. Cibrian D, etal., Clin Sci (Lond). 2006 May;110(5):563-73. 4. Dominguez JA, etal., Shock. 2011 Oct;36(4):381-9. 5. Groenestege WM, etal., J Clin Invest. 2007 Aug;117(8):2260-7. 6. Khailova L, etal., Pediatr Res. 2009 Aug;66(2):140-4. 7. Liangos O, etal., Biomarkers. 2010 Aug;15(5):436-45. 8. Lindenmeyer MT, etal., J Am Soc Nephrol. 2007 Jun;18(6):1765-76. Epub 2007 May 2. 9. MGD and Homologene mouse data transfer 10. MGD data from the GO Consortium 11. MGD IEA 12. Papachristou GI, etal., Dig Dis Sci. 2010 Feb 3. 13. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 14. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 15. Pryczynicz A, etal., Anticancer Res. 2008 Mar-Apr;28(2B):1399-404. 16. Reich HN, etal., J Mol Diagn. 2011 Mar;13(2):143-51. 17. RGD automated import pipeline 18. RGD automated import pipeline for gene-chemical interactions 19. RGD Automated Pipelines 20. Sarosiek J, etal., Am J Gastroenterol. 2000 May;95(5):1158-65. 21. Schaudies RP, etal., Am J Physiol. 1990 Dec;259(6 Pt 1):G1056-61. 22. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93. 23. Soler-Garcia AA, etal., Kidney Int. 2009 Jul;76(2):207-14. Epub 2009 Apr 8. 24. Vishnoi M, etal., Hum Immunol. 2008 Jun;69(6):360-7. Epub 2008 May 6. 25. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9. 26. Yamanaka Y Nippon Ika Daigaku Zasshi. 1992 Feb;59(1):51-61. 27. Yukawa M, etal., Hum Pathol. 1993 Jan;24(1):37-40. References - uncurated PubMed 10027293   10082370   10331984   10349636   10441734   10521784   10700187   10753509   10926756   10964941   11042159   11076861   11217851   11387238   11399798   11438495   11518516   11553295   11707574   11773073   11822870   11825889   11841993   11884396   11909964   11940581   11956170   12162747   12372343   12399441   12426576   12466851   12477932   12495619   12520078   12700634   12714603   12761849   12837294   12878679   12880367   12919676   12960147   12967642   1349842   1426645   1445923   14514757   14514962   14561752   14643177   14662770   14668448   14712229   14747473   14964469   15051883   15103386   15149844   15156153   15314086   15375216   15380929   15456865   15489334   15509736   15522985   15525267   15572151   15633125   15652340   15695332   1577403   1578263   15790735   15799028   15811345   15831470   15987744   16014027   16019431   16054021   16141072   16141073   1617215   16339969   16400024   16517600   16574995   16675530   16727441   1676977   16773716   1716634   17223098   1726866   1728582   1731873   17626015   1764058   17673689   1783375   17991704   18069687   18165319   18287559   18441095   18691227   18838072   1898268   19081071   19196031   19218245   19273609   19328792   19330341   19341767   19474150   19500387   19571236   19629819   1968405   19710174   19723622   20032199   20037141   20080754   20087964   20095053   20133770   20208556   20371608   20392696   20444693   20462955   20472833   20606012   20705924   20714325   20843830   20870721   20878766   20881363   21098035   21186272   21209099   21293035   21350188   21464922   21512138   21624348   21660950   21666233   21767580   22035642   22160594   22294205   22493503   22514047   22682244   22798669   23135700   23168795   23377280   2542863   2574151   2663575   2676841   2885848   2897103   3076779   3871506   3871525   4636327   4750422   6248866   6304537   6315413   6315706   6602382   7523515   7538664   7544156   7588322   7590736   7595133   7608209   7640657   7641815   7724532   7743917   7751935   7781894   7819439   7881126   7910583   7932371   7951532   7956906   8013342   8026321   8034329   8036006   8063822   8071311   8076525   8086337   8231109   8240367   8266997   8292539   8344470   8349621   8364887   8378774   8395365   8419117   8449508   8504737   8565823   8593821   8600155   8604219   8660964   8661727   8706788   8770913   8800404   8833158   8901048   8901633   8906120   8937653   8940071   9022052   9165054   9261927   9264259   9275222   9281334   9285326   9305636   9305638   9367891   9367982   9390635   9403069   9504046   9832315   9890455 RGD Disease Portals Egf has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Biological Process Diabetes Diseases Diabetes Pathways Immune and Inflammatory Diseases Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Biological Process Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Obesity Phenotypes Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data Egf   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 129,677,575 - 129,755,322 - NCBI Mouse cM Map 3 58.5   NCBI Mouse Celera Assembly 3 136,187,440 - 136,268,006 - NCBI Mouse Genome Assembly Build 37 3 129,380,493 - 129,458,240 - NCBI Mouse Genome Assembly Build 36.1 3 129,380,496 - 129,458,234 - NCBI Mouse Cytogenetic Map 3 G3   NCBI EGF   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 110,628,399 - 110,728,472 + NCBI Human Genome Assembly HuRef 4 106,566,131 - 106,666,223 + NCBI Human Genome Assembly GRCh37 4 110,834,040 - 110,934,118 + NCBI Human Genome Assembly Build 36 4 111,053,499 - 111,152,868 + NCBI Human Cytogenetic Map 4 q25   NCBI Human Genome Assembly 4 111,191,653 - 111,291,023   NCBI Egf   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 2 q42-q43   NCBI RGSC Genome Assembly v5.0 2 253,481,574 - 253,482,579 - NCBI RGSC Genome Assembly v5.0 2 74,746,757 - 74,782,858 + NCBI RGSC Genome Assembly v5.0 2 88,549,762 - 88,621,573 + NCBI RGSC Genome Assembly v3.4 2 227,103,900 - 227,195,062 - NCBI Rat Celera Assembly 2 210,511,076 - 210,588,041 - NCBI Genome Assembly 3.1 2 227,090,579 - 227,181,742 - NCBI RH 3.4 2 1556.7   RGD Position Markers J00380   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 129,678,023 - 129,678,214   UniSTS Mouse Whitehead_YAC 1     UniSTS Mouse cM Map 3 65.2   UniSTS Mouse Celera Assembly 3 136,187,888 - 136,188,079   UniSTS Mouse Genome Assembly Build 37 3 129,380,941 - 129,381,132   UniSTS Mouse Cytogenetic Map 3 G3   UniSTS Egf   Map Chr Position Strand Source Mouse cM Map 3 65.2   UniSTS Mouse Celera Assembly 3 136,187,549 - 136,187,738   UniSTS Mouse Genome Assembly Build 37 3 129,380,602 - 129,380,791   UniSTS Mouse Cytogenetic Map 3 G3   UniSTS AI790464   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 129,677,917 - 129,678,004   UniSTS Mouse Whitehead/MRC_RH 3 1469.31   UniSTS Mouse Whitehead/MRC_RH 3 1468.75   UniSTS Mouse cM Map 3 65.2   UniSTS Mouse Celera Assembly 3 136,187,782 - 136,187,869   UniSTS Mouse Genome Assembly Build 37 3 129,380,835 - 129,380,922   UniSTS Mouse Cytogenetic Map 3 G3   UniSTS Egf   Map Chr Position Strand Source Mouse cM Map 3 65.2   UniSTS Mouse Cytogenetic Map 3 G3   UniSTS Egf   Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 129,677,684 - 129,677,873   UniSTS Mouse cM Map 3 65.2   UniSTS Mouse Celera Assembly 3 136,187,549 - 136,187,738   UniSTS Mouse Genome Assembly Build 37 3 129,380,602 - 129,380,791   UniSTS Mouse Cytogenetic Map 3 G3   UniSTS Egf   Map Chr Position Strand Source Mouse Cytogenetic Map 3 G3   UniSTS Egf   Map Chr Position Strand Source Mouse Cytogenetic Map 3 G3   UniSTS QTLs in Region (Mouse Genome Assembly Build 37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1301347 Fpli_m fasting plasma insulin (mouse) Not determined 3 126417717 160417883 Mouse 1300753 Eae10_m susceptibility to experimental allergic encephalomyelitis 10 (mouse) Not determined 3 126310189 160310386 Mouse 1301218 Letohc1_m low ethanol consumption 1 (mouse) Not determined 3 126310189 160310386 Mouse 4142245 Pstc1_m periosteal circumference 1 (mouse) Not determined 3 126227451 160227570 Mouse 4141737 Brml4_m bone response to mechanical loading 4 (mouse) Not determined 3 126227451 160227570 Mouse 4141995 Elorr2_m ethanol induced loss of righting response 2 (mouse) Not determined 3 125848413 159848587 Mouse 1357863 Thyct2_m thymocyte count 2 (mouse) Not determined 3 125848413 159848587 Mouse 4142355 Chlq3_m circulating hormone level QTL 3 (mouse) Not determined 3 125848413 159848587 Mouse 1302151 Lprm2_m lymphoproliferation modifier 2 (mouse) Not determined 3 119736060 153736247 Mouse 1558868 Ses9_m salmonella enteritidis susceptibility 9 (mouse) Not determined 3 119014535 153014659 Mouse 1301100 Bdt2_m bone density traits 2 (mouse) Not determined 3 114693820 148693987 Mouse 1558950 Nsila3_m novelty/stress induced locomotor activation 3 (mouse) Not determined 3 114569282 148569425 Mouse 1301381 Bomb1_m bone marrow pre-B 1 (mouse) Not determined 3 111042512 145042686 Mouse 4141268 Raml2_m radiation induced acute myeloid leukemia 2 (mouse) Not determined 3 111042512 145042686 Mouse 1301791 Char4_m P. chabaudi malaria resistance QTL 4 (mouse) Not determined 3 110399252 144399483 Mouse 1357495 Gpdc1_m G protein deficiency-induced colitis 1 (mouse) Not determined 3 109744151 143744274 Mouse 1300619 Cdcs1_m cytokine deficiency colitis susceptibility 1 (mouse) Not determined 3 109744151 143744274 Mouse 1301805 Mors2_m modifier of obesity related sterility 2 (mouse) Not determined 3 103391928 137392052 Mouse 4142363 Wbcq2_m white blood cell quantitative locus 2 (mouse) Not determined 3 101145575 135145718 Mouse 1302114 Tbs1_m tuberculosis severity 1 (mouse) Not determined 3 98833374 132833519 Mouse 4141299 Ascla4_m atherosclerotic lesion area 4 (mouse) Not determined 3 98533310 132533466 Mouse 4142178 Ctrq2_m C. trachomatis resistance QTL 2 (mouse) Not determined 3 89036582 137410211 Mouse Sequence Nucleotide Sequences Nucleotide RefSeqs NM_010113 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AAHY01031870 (Get FASTA) Search GEO for Microarray Profiles   AAHY01031871 (Get FASTA) Search GEO for Microarray Profiles   AAHY01031872 (Get FASTA) Search GEO for Microarray Profiles   AAHY01031873 (Get FASTA) Search GEO for Microarray Profiles   AAHY01031874 (Get FASTA) Search GEO for Microarray Profiles   AC098732 (Get FASTA) Search GEO for Microarray Profiles   AK084927 (Get FASTA) Search GEO for Microarray Profiles   AK085707 (Get FASTA) Search GEO for Microarray Profiles   AK088408 (Get FASTA) Search GEO for Microarray Profiles   AK136439 (Get FASTA) Search GEO for Microarray Profiles   AK142666 (Get FASTA) Search GEO for Microarray Profiles   AK157778 (Get FASTA) Search GEO for Microarray Profiles   BC017681 (Get FASTA) Search GEO for Microarray Profiles   BC060741 (Get FASTA) Search GEO for Microarray Profiles   BC092277 (Get FASTA) Search GEO for Microarray Profiles   CH466532 (Get FASTA) Search GEO for Microarray Profiles   J00380 (Get FASTA) Search GEO for Microarray Profiles   U69534 (Get FASTA) Search GEO for Microarray Profiles   V00741 (Get FASTA) Search GEO for Microarray Profiles   X08047 (Get FASTA) Search GEO for Microarray Profiles   X74038 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_010113 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_034243 Peptide Label: precursor Position: Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 129,677,575 - 129,755,322 - ENTREZGENE Mouse cM Map 3   - ENTREZGENE Mouse Celera Assembly 3 136,187,440 - 136,268,006 - RGD Mouse Genome Assembly Build 37 3 129,380,493 - 129,458,240 - RGD Protein Sequences Protein RefSeqs NP_034243 (Get FASTA) GenBank Protein AAA37539 (Get FASTA)   AAH17681 (Get FASTA)   AAH60741 (Get FASTA)   AAH92277 (Get FASTA)   BAE22978 (Get FASTA)   CAA24115 (Get FASTA)   EDL12237 (Get FASTA)   EDL12238 (Get FASTA)   P01132 (Get FASTA) Promoters RGD ID: 6833679 Promoter ID: MM_KWN:36075 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: 3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen Transcripts: UC008RIG.1,   UC008RII.1 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 3 129,427,936 - 129,428,502 - MPROMDB RGD ID: 6833681 Promoter ID: MM_KWN:36077 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: Kidney Transcripts: NM_010113,   UC008RIJ.1 Position: Map Chr Position Strand Source Mouse Genome Assembly Build 36.1 3 129,458,036 - 129,458,536 - MPROMDB Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSMUSG00000028017 ENTREZGENE Ensembl Protein ENSMUSP00000029653 ENTREZGENE Ensembl Transcript ENSMUST00000029653 ENTREZGENE Entrez Gene 13645 ENTREZGENE Gene3D-CATH 55.10 UniProtKB/TrEMBL   6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot Germonline ENSMUSG00000028017 HomoloGene Group ID 1483 ENTREZGENE InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot   EGF-like_Ca-bd UniProtKB/Swiss-Prot   EGF-like_reg_CS UniProtKB/Swiss-Prot   EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot   EGF_3 UniProtKB/Swiss-Prot   EGF_Ca-bd_CS UniProtKB/Swiss-Prot   GFP_like UniProtKB/TrEMBL   LDLR_classB_rpt UniProtKB/Swiss-Prot   Pro-epidermal_GF UniProtKB/Swiss-Prot IPI IPI00132121 UniProtKB/Swiss-Prot   IPI00987371 UniProtKB/TrEMBL KEGG Report mmu:13645 ENTREZGENE, UniProtKB/Swiss-Prot MGD MGI:95290 ENTREZGENE Pfam EGF UniProtKB/Swiss-Prot   EGF_CA UniProtKB/Swiss-Prot   Ldl_recept_b UniProtKB/Swiss-Prot PharmGKB EGF RGD PIRSF Pro-epidermal_growth_factor UniProtKB/Swiss-Prot PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot   EGF_1 UniProtKB/Swiss-Prot   EGF_2 UniProtKB/Swiss-Prot   EGF_3 UniProtKB/Swiss-Prot   EGF_CA UniProtKB/Swiss-Prot   LDLRB UniProtKB/Swiss-Prot SMART EGF UniProtKB/Swiss-Prot   EGF_CA UniProtKB/Swiss-Prot   SM00135 UniProtKB/Swiss-Prot UniGene Mm.252481 ENTREZGENE UniProt EGF_MOUSE UniProtKB/Swiss-Prot   Q3UWD7_MOUSE UniProtKB/TrEMBL   Q8VD07_MOUSE UniProtKB/TrEMBL

More on Egf Entrez Gene Ensembl Gene Genome Browser MGI Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 10510 Created: 2000-05-25 Species: Mus musculus Last Modified: 2013-05-14 Status: ACTIVE