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Strain Registration

Strain: SD-Tg(Ren2)27

Symbol: SD-Tg(Ren2)27
Strain: SD
RGD ID: 629501
Citation ID: RRID:RGD_629501
Ontology ID: RS:0000687
Alleles: Ace;   Agtr1b
Also Known As: TGRmRen2L27; TGR+/-; TGRmRen2
Type: transgenic
Available Source: Not Available
Origination: Center for Genome Research, University of Edinburgh, UK
Description: This is a hypertensive rat strain in which the mouse Ren2 renin gene along with its 5' and 3' flanking sequences were microinjected into fertilized eggs from a Hannover Sprague-Dawley (SD) background.
Last Known Status: Unknown





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Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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References

References - curated
# Reference Title Reference Citation
1. Transcriptional alterations in the left ventricle of three hypertensive rat models. Cerutti C, etal., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1.
2. Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats. Kantachuvesiri S, etal., Kidney Int 1999 Aug;56(2):414-20.
3. Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. Liu X, etal., J Biol Chem. 2009 Jun 5;284(23):15564-72. Epub 2009 Mar 23.
4. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Mullins JJ, etal., Nature 1990 Apr 5;344(6266):541-4.
5. Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney. Ohta KY, etal., Drug Metab Dispos. 2006 Nov;34(11):1868-74. Epub 2006 Aug 23.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. A genetic model of malignant phase hypertension in rats. Whitworth CE, etal., Kidney Int 1995 Feb;47(2):529-35.

Region

Strain QTL Data
Symbol Name Trait
Bp342 Blood pressure QTL 342 life span trait   (VT:0005372)    
Bp343 Blood pressure QTL 343 life span trait   (VT:0005372)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics A good model for low-renin hypertension, their blood pressure is elevated which leads to cardiovascular diseases and death due to cerebral haemorrhage. Both male and female of line 27 developed hypertension. 619627
strain_characteristics A good model for low-renin hypertension, their blood pressure is elevated which leads to cardiovascular diseases and death due to cerebral haemorrhage. Both male and female of line 27 developed hypertension. 628589
strain_drgs_chems Captopril a conversion of angiotensin I to angiotensin II this is sufficient to reduce the blood pressure of hypertensive rat 619627
strain_drgs_chems Captopril a conversion of angiotensin I to angiotensin II this is sufficient to reduce the blood pressure of hypertensive rat 628589
strain_life_disease suspectible to malignant hypertension and higher plasma angiotensin-converting enzyme activity in progeny receiving the Fischer allele than in progeny receiving the Lewis allele 619627
strain_life_disease suspectible to malignant hypertension and higher plasma angiotensin-converting enzyme activity in progeny receiving the Fischer allele than in progeny receiving the Lewis allele 628589
strain_phys_biochem Overexpression of active renin is not seen in the kidneys but they have low levels of active renin in their plasma. 619627
strain_phys_biochem Overexpression of active renin is not seen in the kidneys but they have low levels of active renin in their plasma. 628589