Lzts1 (leucine zipper tumor suppressor 1) - Rat Genome Database

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Gene: Lzts1 (leucine zipper tumor suppressor 1) Rattus norvegicus
Analyze
Symbol: Lzts1
Name: leucine zipper tumor suppressor 1
RGD ID: 708565
Description: Involved in regulation of dendrite morphogenesis and regulation of synaptic plasticity. Located in several cellular components, including apical plasma membrane; dendrite; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in breast carcinoma; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leucine zipper putative tumor suppressor 1; leucine zipper, putative tumor suppressor 1; PSD-Zip70; Psdzip70; similar to leucine zipper putative tumor suppressor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81625,309,502 - 25,364,942 (+)NCBIGRCr8
mRatBN7.21620,542,756 - 20,598,204 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1620,542,809 - 20,598,203 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1623,910,466 - 23,965,921 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01627,341,958 - 27,397,438 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01623,275,771 - 23,331,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01622,250,452 - 22,306,667 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,250,470 - 22,306,662 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01622,147,127 - 22,202,136 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,243,137 - 22,300,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11622,243,134 - 22,300,975 (+)NCBI
Celera1620,519,932 - 20,575,243 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. Apperson ML, etal., J Neurosci 1996 Nov 1;16(21):6839-52.
2. Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis. Chen L, etal., Breast Cancer Res Treat. 2009 Aug;116(3):471-8. doi: 10.1007/s10549-008-0147-6. Epub 2008 Aug 7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Ishii H, etal., Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33.
6. The postsynaptic density and dendritic raft localization of PSD-Zip70, which contains an N-myristoylation sequence and leucine-zipper motifs. Konno D, etal., J Cell Sci 2002 Dec 1;115(Pt 23):4695-706.
7. Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendritic spine maturity. Maruoka H, etal., J Neurosci. 2005 Feb 9;25(6):1421-30.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22354037  


Genomics

Comparative Map Data
Lzts1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81625,309,502 - 25,364,942 (+)NCBIGRCr8
mRatBN7.21620,542,756 - 20,598,204 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1620,542,809 - 20,598,203 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1623,910,466 - 23,965,921 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01627,341,958 - 27,397,438 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01623,275,771 - 23,331,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01622,250,452 - 22,306,667 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1622,250,470 - 22,306,662 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01622,147,127 - 22,202,136 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41622,243,137 - 22,300,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11622,243,134 - 22,300,975 (+)NCBI
Celera1620,519,932 - 20,575,243 (+)NCBICelera
Cytogenetic Map16p14NCBI
LZTS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38820,246,165 - 20,303,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl820,246,165 - 20,303,963 (-)EnsemblGRCh38hg38GRCh38
GRCh37820,103,676 - 20,161,474 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36820,147,956 - 20,157,083 (-)NCBINCBI36Build 36hg18NCBI36
Build 34820,147,956 - 20,157,083NCBI
Celera819,066,273 - 19,075,376 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef818,643,682 - 18,652,790 (-)NCBIHuRef
CHM1_1820,305,442 - 20,314,568 (-)NCBICHM1_1
T2T-CHM13v2.0820,511,247 - 20,569,040 (-)NCBIT2T-CHM13v2.0
Lzts1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39869,585,311 - 69,636,901 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl869,585,321 - 69,636,877 (-)EnsemblGRCm39 Ensembl
GRCm38869,132,659 - 69,184,249 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,132,669 - 69,184,225 (-)EnsemblGRCm38mm10GRCm38
MGSCv37871,659,402 - 71,664,852 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36872,064,492 - 72,069,942 (-)NCBIMGSCv36mm8
Celera871,685,839 - 71,691,289 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.88NCBI
Lzts1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540343,909,681 - 43,962,971 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540343,909,722 - 43,962,965 (-)NCBIChiLan1.0ChiLan1.0
LZTS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2738,727,693 - 38,785,761 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1814,453,283 - 14,511,350 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0819,471,361 - 19,529,437 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1816,418,501 - 16,476,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl816,418,496 - 16,476,111 (-)Ensemblpanpan1.1panPan2
LZTS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12536,764,235 - 36,814,204 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2536,744,061 - 36,811,972 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2537,357,148 - 37,408,722 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02536,989,870 - 37,041,266 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2536,989,853 - 37,042,926 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12536,925,719 - 36,977,061 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02536,773,887 - 36,825,207 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02536,942,939 - 36,994,282 (+)NCBIUU_Cfam_GSD_1.0
Lzts1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494314,185,606 - 14,239,234 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365554,330,787 - 4,384,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365554,330,878 - 4,384,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LZTS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl144,346,480 - 4,404,168 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1144,344,496 - 4,404,208 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2144,633,021 - 4,693,042 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LZTS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1818,315,243 - 18,377,492 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl818,315,130 - 18,324,345 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605223,878,741 - 23,937,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lzts1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475815,956,236 - 16,006,192 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475815,956,300 - 16,006,174 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lzts1
208 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:396
Count of miRNA genes:215
Interacting mature miRNAs:285
Transcripts:ENSRNOT00000015799
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat

Markers in Region
D16Rat47  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,591,591 - 20,591,821 (+)MAPPERmRatBN7.2
Rnor_6.01622,299,348 - 22,299,577NCBIRnor6.0
Rnor_5.01622,195,975 - 22,196,204UniSTSRnor5.0
RGSC_v3.41622,293,370 - 22,293,600RGDRGSC3.4
RGSC_v3.41622,293,371 - 22,293,600UniSTSRGSC3.4
RGSC_v3.11622,293,368 - 22,293,598RGD
Celera1620,568,683 - 20,568,912UniSTS
SHRSP x BN Map167.88UniSTS
SHRSP x BN Map167.88RGD
FHH x ACI Map1612.1799RGD
Cytogenetic Map16p14UniSTS
D16Rat77  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,568,335 - 20,568,510 (+)MAPPERmRatBN7.2
mRatBN7.21620,568,335 - 20,568,727 (+)MAPPERmRatBN7.2
Rnor_6.01622,276,339 - 22,276,761NCBIRnor6.0
Rnor_6.01622,276,339 - 22,276,513NCBIRnor6.0
Rnor_5.01622,172,966 - 22,173,388UniSTSRnor5.0
Rnor_5.01622,172,966 - 22,173,140UniSTSRnor5.0
RGSC_v3.41622,270,122 - 22,270,297RGDRGSC3.4
RGSC_v3.41622,270,123 - 22,270,297UniSTSRGSC3.4
RGSC_v3.11622,270,120 - 22,270,295RGD
Celera1620,545,421 - 20,545,595UniSTS
RH 2.0 Map16289.2RGD
SHRSP x BN Map167.88RGD
Cytogenetic Map16p14UniSTS
RH129739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21620,597,966 - 20,598,146 (+)MAPPERmRatBN7.2
Rnor_6.01622,306,430 - 22,306,609NCBIRnor6.0
Rnor_5.01622,201,899 - 22,202,078UniSTSRnor5.0
RGSC_v3.41622,300,741 - 22,300,920UniSTSRGSC3.4
Celera1620,575,006 - 20,575,185UniSTS
Cytogenetic Map16p14UniSTS
AU049658  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04227,443,857 - 227,444,176NCBIRnor5.0
Rnor_5.01622,173,039 - 22,173,212NCBIRnor5.0
RGSC_v3.41622,270,197 - 22,270,370UniSTSRGSC3.4
RGSC_v3.44165,944,416 - 165,944,734UniSTSRGSC3.4
Celera1620,545,495 - 20,545,667UniSTS
Celera4150,880,136 - 150,880,454UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68 24
Low 2 43 34 18 19 18 7 9 6 28 17 11 7
Below cutoff 1 23 23 23 1 2 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015799   ⟹   ENSRNOP00000015800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1620,542,809 - 20,598,203 (+)Ensembl
Rnor_6.0 Ensembl1622,250,470 - 22,306,662 (+)Ensembl
RefSeq Acc Id: NM_153470   ⟹   NP_703200
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,309,553 - 25,364,942 (+)NCBI
mRatBN7.21620,542,809 - 20,598,204 (+)NCBI
Rnor_6.01622,250,500 - 22,306,667 (+)NCBI
Rnor_5.01622,147,127 - 22,202,136 (+)NCBI
RGSC_v3.41622,243,137 - 22,300,978 (+)RGD
Celera1620,519,932 - 20,575,243 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094242   ⟹   XP_038950170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81625,309,502 - 25,364,942 (+)NCBI
mRatBN7.21620,542,756 - 20,598,204 (+)NCBI
Protein Sequences
Protein RefSeqs NP_703200 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950170 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC16535 (Get FASTA)   NCBI Sequence Viewer  
  EDL84665 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015800
  ENSRNOP00000015800.2
  ENSRNOP00055004903
  ENSRNOP00060023184
  ENSRNOP00065005135
GenBank Protein Q8CFC9 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_703200   ⟸   NM_153470
- UniProtKB: Q8CFC9 (UniProtKB/Swiss-Prot),   A6KU68 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015800   ⟸   ENSRNOT00000015799
RefSeq Acc Id: XP_038950170   ⟸   XM_039094242
- Peptide Label: isoform X1
- UniProtKB: Q8CFC9 (UniProtKB/Swiss-Prot),   A6KU68 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CFC9-F1-model_v2 AlphaFold Q8CFC9 1-601 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700055
Promoter ID:EPDNEW_R10579
Type:initiation region
Name:Lzts1_1
Description:leucine zipper tumor suppressor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01622,250,477 - 22,250,537EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708565 AgrOrtholog
BioCyc Gene G2FUF-11708 BioCyc
Ensembl Genes ENSRNOG00000011826 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055004022 UniProtKB/Swiss-Prot
  ENSRNOG00060016849 UniProtKB/Swiss-Prot
  ENSRNOG00065005040 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015799 ENTREZGENE
  ENSRNOT00000015799.5 UniProtKB/Swiss-Prot
  ENSRNOT00055006410 UniProtKB/Swiss-Prot
  ENSRNOT00060028811 UniProtKB/Swiss-Prot
  ENSRNOT00065007385 UniProtKB/Swiss-Prot
InterPro LZTS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 266711 ENTREZGENE
PANTHER PTHR19354 UniProtKB/Swiss-Prot
  PTHR19354:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED UniProtKB/TrEMBL
Pfam Fez1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lzts1 PhenoGen
RatGTEx ENSRNOG00000011826 RatGTEx
  ENSRNOG00055004022 RatGTEx
  ENSRNOG00060016849 RatGTEx
  ENSRNOG00065005040 RatGTEx
UniProt A6KU68 ENTREZGENE, UniProtKB/TrEMBL
  LZTS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-27 Lzts1  leucine zipper tumor suppressor 1  Lzts1  leucine zipper, putative tumor suppressor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Lzts1  leucine zipper, putative tumor suppressor 1  Psdzip70  PSD-Zip70  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to dendritic spines of the postsynaptic density and postsynaptic membrane 1299532