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Gene: LZTS1 (leucine zipper tumor suppressor 1) Homo sapiens
Symbol: LZTS1
Name: leucine zipper tumor suppressor 1
Description: Predicted to have DNA-binding transcription factor activity. Involved in negative regulation of macroautophagy. Predicted to localize to several cellular components, including apical plasma membrane; dendrite; and postsynaptic density. Implicated in esophageal cancer and squamous cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: F37; F37/Esophageal cancer-related gene-coding leucine-zipper motif; FEZ1; leucine zipper putative tumor suppressor 1; leucine zipper, putative tumor suppressor 1; psd-zip70
Mus musculus (house mouse) : Lzts1 (leucine zipper, putative tumor suppressor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lzts1 (leucine zipper tumor suppressor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lzts1 (leucine zipper tumor suppressor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LZTS1 (leucine zipper tumor suppressor 1)
Canis lupus familiaris (dog) : LZTS1 (leucine zipper tumor suppressor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lzts1 (leucine zipper tumor suppressor 1)
Sus scrofa (pig) : LZTS1 (leucine zipper tumor suppressor 1)
Chlorocebus sabaeus (African green monkey) : LZTS1 (leucine zipper tumor suppressor 1)
Heterocephalus glaber (naked mole-rat) : Lzts1 (leucine zipper tumor suppressor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl820,246,165 - 20,303,963 (-)EnsemblGRCh38hg38GRCh38
GRCh38820,246,165 - 20,303,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37820,103,676 - 20,161,492 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36820,147,956 - 20,157,083 (-)NCBINCBI36hg18NCBI36
Build 34820,147,956 - 20,157,083NCBI
Celera819,066,273 - 19,075,376 (-)NCBI
Cytogenetic Map8p21.3NCBI
HuRef818,643,682 - 18,652,790 (-)NCBIHuRef
CHM1_1820,305,442 - 20,314,568 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LZTS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736900
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.