Gnl3 (G protein nucleolar 3) - Rat Genome Database

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Gene: Gnl3 (G protein nucleolar 3) Rattus norvegicus
Analyze
Symbol: Gnl3
Name: G protein nucleolar 3
RGD ID: 631354
Description: Enables GTP binding activity. Involved in regulation of cell population proliferation. Located in nucleolus. Orthologous to human GNL3 (G protein nucleolar 3); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanine nucleotide binding protein-like 3 (nucleolar); guanine nucleotide-binding protein-like 3; Ns; nucleolar GTP-binding protein 3; nucleostemin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gnl3-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,213,844 - 6,220,029 (-)NCBIGRCr8
mRatBN7.2166,207,402 - 6,213,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,207,402 - 6,213,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,219,249 - 6,225,194 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,364,713 - 7,370,658 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,226,411 - 6,232,353 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,097,580 - 7,103,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,097,507 - 7,103,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,026,164 - 7,032,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,444,437 - 6,450,375 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,444,434 - 6,450,373 (-)NCBI
Celera168,975,971 - 8,981,909 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phorone  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA,ISO)
midbody  (IEA,ISO)
nuclear body  (IEA,ISO)
nucleolus  (IBA,IDA,ISO)
nucleoplasm  (ISO)
nucleus  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
7. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Tsai RY and McKay RD, Genes Dev 2002 Dec 1;16(23):2991-3003.
8. A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin. Tsai RY and McKay RD, J Cell Biol. 2005 Jan 17;168(2):179-84.
Additional References at PubMed
PMID:15857956   PMID:16139428   PMID:16213212   PMID:17158916   PMID:18211284   PMID:18519946   PMID:19946888   PMID:22641345   PMID:22658674   PMID:22664934   PMID:22681889   PMID:25522312  
PMID:25569094   PMID:26138242   PMID:34785448  


Genomics

Comparative Map Data
Gnl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,213,844 - 6,220,029 (-)NCBIGRCr8
mRatBN7.2166,207,402 - 6,213,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,207,402 - 6,213,392 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,219,249 - 6,225,194 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,364,713 - 7,370,658 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,226,411 - 6,232,353 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,097,580 - 7,103,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,097,507 - 7,103,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,026,164 - 7,032,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,444,437 - 6,450,375 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,444,434 - 6,450,373 (-)NCBI
Celera168,975,971 - 8,981,909 (+)NCBICelera
Cytogenetic Map16p16NCBI
GNL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,685,920 - 52,694,497 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,681,156 - 52,694,497 (+)EnsemblGRCh38hg38GRCh38
GRCh37352,719,936 - 52,728,513 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,694,976 - 52,703,553 (+)NCBINCBI36Build 36hg18NCBI36
Celera352,698,648 - 52,707,224 (+)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,781,776 - 52,790,367 (+)NCBIHuRef
CHM1_1352,672,005 - 52,680,589 (+)NCBICHM1_1
T2T-CHM13v2.0352,718,831 - 52,727,408 (+)NCBIT2T-CHM13v2.0
Gnl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,734,390 - 30,741,088 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,734,390 - 30,741,109 (-)EnsemblGRCm39 Ensembl
GRCm381431,012,433 - 31,019,131 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,012,433 - 31,019,152 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,825,619 - 31,832,275 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361429,841,442 - 29,848,070 (-)NCBIMGSCv36mm8
Celera1427,270,250 - 27,276,906 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Gnl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554302,675,477 - 2,678,113 (+)NCBIChiLan1.0ChiLan1.0
GNL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,679,394 - 52,688,116 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,684,359 - 52,694,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,626,424 - 52,635,009 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,854,257 - 53,862,823 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,854,257 - 53,862,818 (+)Ensemblpanpan1.1panPan2
GNL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,103,298 - 37,110,350 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,103,320 - 37,110,207 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,085,316 - 37,092,373 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,454,085 - 37,461,144 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,453,398 - 37,461,079 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12036,817,632 - 36,824,634 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,226,252 - 37,233,270 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,503,889 - 37,510,799 (-)NCBIUU_Cfam_GSD_1.0
Gnl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,337,889 - 170,345,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,476,392 - 3,483,615 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,476,436 - 3,483,868 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,814,901 - 34,828,517 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,820,243 - 34,828,523 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,020,526 - 38,028,557 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,059,191 - 14,068,388 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2214,059,204 - 14,068,155 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041152,831,706 - 152,840,905 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,519,324 - 4,528,802 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,519,172 - 4,529,241 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnl3
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000033677
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
RH143485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2166,209,352 - 6,209,550 (+)MAPPERmRatBN7.2
Rnor_6.0167,099,531 - 7,099,728NCBIRnor6.0
Rnor_5.0167,028,115 - 7,028,312UniSTSRnor5.0
RGSC_v3.4166,446,388 - 6,446,585UniSTSRGSC3.4
Celera168,979,761 - 8,979,958UniSTS
RH 3.4 Map1644.7UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000033677   ⟹   ENSRNOP00000035860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,207,402 - 6,213,392 (-)Ensembl
Rnor_6.0 Ensembl167,097,507 - 7,103,604 (-)Ensembl
RefSeq Acc Id: NM_175580   ⟹   NP_783170
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,213,844 - 6,219,782 (-)NCBI
mRatBN7.2166,207,402 - 6,213,340 (-)NCBI
Rnor_6.0167,097,580 - 7,103,518 (-)NCBI
Rnor_5.0167,026,164 - 7,032,102 (-)NCBI
RGSC_v3.4166,444,437 - 6,450,375 (-)RGD
Celera168,975,971 - 8,981,909 (+)RGD
Sequence:
RefSeq Acc Id: XM_063275134   ⟹   XP_063131204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,214,689 - 6,220,029 (-)NCBI
RefSeq Acc Id: NP_783170   ⟸   NM_175580
- UniProtKB: Q566E0 (UniProtKB/Swiss-Prot),   Q811S9 (UniProtKB/Swiss-Prot),   A6KG10 (UniProtKB/TrEMBL),   A6KG11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035860   ⟸   ENSRNOT00000033677
RefSeq Acc Id: XP_063131204   ⟸   XM_063275134
- Peptide Label: isoform X1
Protein Domains
CP-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811S9-F1-model_v2 AlphaFold Q811S9 1-538 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699922
Promoter ID:EPDNEW_R10445
Type:initiation region
Name:Gnl3_1
Description:G protein nucleolar 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0167,103,549 - 7,103,609EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631354 AgrOrtholog
BioCyc Gene G2FUF-12170 BioCyc
Ensembl Genes ENSRNOG00000028461 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055021726 UniProtKB/Swiss-Prot
  ENSRNOG00060014569 UniProtKB/Swiss-Prot
  ENSRNOG00065015428 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033677.6 UniProtKB/Swiss-Prot
  ENSRNOT00055037213 UniProtKB/Swiss-Prot
  ENSRNOT00060024915 UniProtKB/Swiss-Prot
  ENSRNOT00065025623 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1580.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099304 IMAGE-MGC_LOAD
  IMAGE:7316170 IMAGE-MGC_LOAD
InterPro G_CP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gnl3_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTP-bd UniProtKB/TrEMBL
  GTP-bd_ortho_bundle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTP_binding_domain UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAFAC_YlqF/YawG_RiboMat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105287 IMAGE-MGC_LOAD
  MGC:91414 IMAGE-MGC_LOAD
NCBI Gene 290556 ENTREZGENE
PANTHER GTP-BINDING PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GN3L_Grn1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MMR_HSR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnl3 PhenoGen
PRINTS GTP1OBG UniProtKB/TrEMBL
PROSITE G_CP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028461 RatGTEx
  ENSRNOG00055021726 RatGTEx
  ENSRNOG00060014569 RatGTEx
  ENSRNOG00065015428 RatGTEx
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KG10 ENTREZGENE, UniProtKB/TrEMBL
  A6KG11 ENTREZGENE, UniProtKB/TrEMBL
  A6KG12_RAT UniProtKB/TrEMBL
  GNL3_RAT UniProtKB/Swiss-Prot
  Q566E0 ENTREZGENE
  Q811S9 ENTREZGENE
UniProt Secondary Q566E0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnl3  G protein nucleolar 3  Gnl3  guanine nucleotide binding protein-like 3 (nucleolar)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-03-14 Gnl3  guanine nucleotide binding protein-like 3 (nucleolar)  Ns  nucleostemin  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-02-11 Ns  nucleostemin      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleoli of CNS stem cells, embryonic stem cells, and several cancer cell lines 633365