Akp3 (alkaline phosphatase 3, intestine, not Mn requiring) - Rat Genome Database

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Gene: Akp3 (alkaline phosphatase 3, intestine, not Mn requiring) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
RGD ID: 621650
Description: Enables alkaline phosphatase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in response to nutrient levels. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental); PARTICIPATES IN folate metabolic pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Alpi2; IAP-2; IAP-II; Intestinal alkaline phosphatase 2; Intestinal alkaline phosphatase II; intestinal alkaline phosphatase-II (IAP-II); intestinal alkaline phosphatase-II (IAP-II) gene; intestinal-type alkaline phosphatase; Intestinal-type alkaline phosphatase 2; putative alkaline phosphatase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,252,581 - 95,256,616 (+)NCBIGRCr8
mRatBN7.2987,804,680 - 87,808,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl987,804,749 - 87,807,913 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx996,229,049 - 96,233,083 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09101,364,679 - 101,368,710 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0999,732,935 - 99,736,974 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,228,960 - 94,232,001 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,228,960 - 94,232,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0993,954,155 - 93,957,145 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4985,924,232 - 85,927,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1986,107,650 - 86,110,746 (+)NCBI
Celera985,218,441 - 85,221,576 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Impaired mucosal barrier function in the small intestine of the cystic fibrosis mouse. De Lisle RC, etal., J Pediatr Gastroenterol Nutr. 2011 Oct;53(4):371-9. doi: 10.1097/MPG.0b013e318219c397.
2. Two rat intestinal alkaline phosphatase isoforms with different carboxyl-terminal peptides are both membrane-bound by a glycan phosphatidylinositol linkage. Engle MJ, etal., J Biol Chem. 1995 May 19;270(20):11935-40.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Expression of mRNA encoding intestinal type alkaline phosphatase in rat liver and its increase by fat-feeding. Goseki-Sone M, etal., Liver. 1996 Dec;16(6):358-64.
5. Characterization of structural and catalytic differences in rat intestinal alkaline phosphatase isozymes. Harada T, etal., FEBS J. 2005 May;272(10):2477-86.
6. Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Kaliannan K, etal., Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7003-8. doi: 10.1073/pnas.1220180110. Epub 2013 Apr 8.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis. Nakano T, etal., Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1439-49. doi: 10.1152/ajpgi.00331.2006. Epub 2007 Mar 1.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The two isozymes of rat intestinal alkaline phosphatase are products of two distinct genes. Xie Q and Alpers DH, Physiol Genomics 2000 Jun 29;3(1):1-8.
Additional References at PubMed
PMID:1458592   PMID:1654110   PMID:1954251  


Genomics

Variants

.
Variants in Akp3
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:93
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000026294, ENSRNOT00000073454
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

Markers in Region
D9Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2987,807,644 - 87,807,855 (+)MAPPERmRatBN7.2
Rnor_6.0994,231,780 - 94,231,990NCBIRnor6.0
Rnor_5.0993,956,919 - 93,957,134UniSTSRnor5.0
RGSC_v3.4985,927,106 - 85,927,316UniSTSRGSC3.4
Celera985,221,355 - 85,221,565UniSTS
Cytogenetic Map9q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 1 1 54 13 11 3 10 3 26 15 52 1 41 8

Sequence


Ensembl Acc Id: ENSRNOT00000080897   ⟹   ENSRNOP00000071091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl987,804,749 - 87,807,913 (+)Ensembl
Rnor_6.0 Ensembl994,228,960 - 94,232,001 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083137   ⟹   ENSRNOP00000070046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl994,228,960 - 94,231,966 (+)Ensembl
RefSeq Acc Id: NM_022680   ⟹   NP_073171
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,252,581 - 95,256,616 (+)NCBI
mRatBN7.2987,804,680 - 87,808,715 (+)NCBI
Rnor_6.0994,228,960 - 94,232,001 (+)NCBI
Rnor_5.0993,954,155 - 93,957,145 (+)NCBI
RGSC_v3.4985,924,232 - 85,927,327 (+)RGD
Celera985,218,441 - 85,221,576 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_073171 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB20378 (Get FASTA)   NCBI Sequence Viewer  
  AAF36718 (Get FASTA)   NCBI Sequence Viewer  
  EDL75615 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071091.1
GenBank Protein P51740 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_073171   ⟸   NM_022680
- Peptide Label: precursor
- UniProtKB: A0A0G2JZL2 (UniProtKB/TrEMBL),   A6JWK7 (UniProtKB/TrEMBL),   Q9JKS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071091   ⟸   ENSRNOT00000080897
Ensembl Acc Id: ENSRNOP00000070046   ⟸   ENSRNOT00000083137

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51740-F1-model_v2 AlphaFold P51740 1-551 view protein structure
AF-A0A0G2JZL2-F1-model_v2 AlphaFold A0A0G2JZL2 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696830
Promoter ID:EPDNEW_R7355
Type:multiple initiation site
Name:Akp3_1
Description:alkaline phosphatase 3, intestine, not Mn requiring
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0994,228,905 - 94,228,965EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621650 AgrOrtholog
BioCyc Gene G2FUF-26853 BioCyc
Ensembl Genes ENSRNOG00000058652 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080897.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64621 UniProtKB/TrEMBL
NCBI Gene 64621 ENTREZGENE
PANTHER INTESTINAL-TYPE ALKALINE PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11596 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akp3 PhenoGen
PRINTS ALKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058652 RatGTEx
SMART alkPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZL2 ENTREZGENE, UniProtKB/TrEMBL
  A6JWK7 ENTREZGENE, UniProtKB/TrEMBL
  P51740 ENTREZGENE, UniProtKB/Swiss-Prot
  Q9JKS8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Akp3  alkaline phosphatase 3, intestine, not Mn requiring  Alpi2  intestinal alkaline phosphatase-II (IAP-II) gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Alpi2  intestinal alkaline phosphatase-II (IAP-II) gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression increased by incubation with oleic acid when transfection of the promoter region (linked to luciferase as a reporter gene) into COS-7 632197
gene_transcript 5' region contains Sp1 and gut-enriched Kruppel-like factor (GKLF) binding sites and a TATA-box 55 bp upstream from the transcriptional start site 632197