Il11 (interleukin 11) - Rat Genome Database

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Gene: Il11 (interleukin 11) Rattus norvegicus
Analyze
Symbol: Il11
Name: interleukin 11
RGD ID: 621475
Description: Predicted to enable cytokine activity; growth factor activity; and interleukin-11 receptor binding activity. Predicted to be involved in interleukin-11-mediated signaling pathway; positive regulation of MAPK cascade; and positive regulation of cell population proliferation. Predicted to act upstream of or within several processes, including negative regulation of hormone secretion; positive regulation of protein phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and extracellular space. Orthologous to human IL11 (interleukin 11); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2-amino-2-deoxy-D-glucopyranose; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-11; interleukin-11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,098,622 - 78,104,915 (+)NCBIGRCr8
mRatBN7.2169,069,829 - 69,076,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,068,137 - 69,076,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,414,863 - 74,421,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,979,176 - 82,985,471 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,127,995 - 76,134,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,636,959 - 72,643,255 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,635,267 - 72,643,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,891,524 - 75,902,590 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,784,584 - 67,795,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,862,694 - 68,157,244 (+)NCBI
Celera168,048,383 - 68,054,698 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
astaxanthin  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Brevianamide A  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
DDE  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ferulic acid  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
graphene oxide  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mycophenolic acid  (ISO)
naphthalene  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
pemetrexed  (ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Primycin  (ISO)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
PX-866  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
riddelliine  (EXP)
Ro 31-8220  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
extracellular space  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury. Kuenzler KA, etal., J Pediatr Surg 2002 Mar;37(3):457-9.
4. Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and analysis of their expression in rat uterus in the peri-implantation period. Li R, etal., Reproduction 2001 Oct;122(4):593-600.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2145578   PMID:7508917   PMID:7867561   PMID:7957045   PMID:11737071   PMID:16034134   PMID:18214944   PMID:20498256   PMID:31840157   PMID:36758859   PMID:38679415  


Genomics

Comparative Map Data
Il11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,098,622 - 78,104,915 (+)NCBIGRCr8
mRatBN7.2169,069,829 - 69,076,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,068,137 - 69,076,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,414,863 - 74,421,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,979,176 - 82,985,471 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,127,995 - 76,134,275 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,636,959 - 72,643,255 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,635,267 - 72,643,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,891,524 - 75,902,590 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,784,584 - 67,795,141 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,862,694 - 68,157,244 (+)NCBI
Celera168,048,383 - 68,054,698 (-)NCBICelera
Cytogenetic Map1q12NCBI
IL11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,364,382 - 55,370,463 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,364,382 - 55,370,463 (-)EnsemblGRCh38hg38GRCh38
GRCh371955,875,750 - 55,881,831 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,567,569 - 60,573,626 (-)NCBINCBI36Build 36hg18NCBI36
Build 341960,567,568 - 60,573,626NCBI
Celera1952,916,561 - 52,922,599 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1952,197,803 - 52,203,675 (-)NCBIHuRef
CHM1_11955,869,294 - 55,875,375 (-)NCBICHM1_1
T2T-CHM13v2.01958,459,867 - 58,465,950 (-)NCBIT2T-CHM13v2.0
Il11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,775,372 - 4,785,877 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,775,372 - 4,785,858 (-)EnsemblGRCm39 Ensembl
GRCm3874,772,373 - 4,782,907 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,772,373 - 4,782,859 (-)EnsemblGRCm38mm10GRCm38
MGSCv3774,724,657 - 4,729,743 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,376,142 - 4,381,118 (-)NCBIMGSCv36mm8
Celera74,502,811 - 4,507,897 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.76NCBI
Il11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955567871,489 - 883,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955567868,272 - 883,563 (+)NCBIChiLan1.0ChiLan1.0
IL11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,501,839 - 61,516,036 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11963,230,892 - 63,244,968 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,407,730 - 52,426,445 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11961,095,104 - 61,101,843 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1961,096,275 - 61,101,837 (-)Ensemblpanpan1.1panPan2
IL11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,311,960 - 102,319,102 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,316,105 - 102,318,653 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,368,701 - 102,375,810 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01102,965,197 - 102,972,306 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,965,691 - 102,972,548 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,602,478 - 102,609,587 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,314,584 - 102,321,607 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,077,747 - 103,084,856 (+)NCBIUU_Cfam_GSD_1.0
Il11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093491,937,446 - 1,941,716 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886618,419 - 621,772 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886617,531 - 620,661 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,541,213 - 59,544,896 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,540,482 - 59,544,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,967,245 - 47,972,557 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,967,680 - 47,971,316 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045601,368 - 607,368 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248321,933,179 - 1,935,971 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248321,932,959 - 1,936,937 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il11
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:72
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000023489
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
RH136727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,075,850 - 69,076,082 (+)MAPPERmRatBN7.2
Rnor_6.0172,642,977 - 72,643,208NCBIRnor6.0
Rnor_5.0175,891,571 - 75,891,802UniSTSRnor5.0
RGSC_v3.4167,792,293 - 67,792,524UniSTSRGSC3.4
Celera168,048,430 - 68,048,661UniSTS
Cytogenetic Map1q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 35 106 50 55 30 15 30 6 153 67 92 45 59 25

Sequence


Ensembl Acc Id: ENSRNOT00000023489   ⟹   ENSRNOP00000023489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,070,914 - 69,076,129 (+)Ensembl
Rnor_6.0 Ensembl172,636,959 - 72,643,255 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090636   ⟹   ENSRNOP00000073110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,068,137 - 69,075,505 (+)Ensembl
Rnor_6.0 Ensembl172,635,267 - 72,642,659 (+)Ensembl
RefSeq Acc Id: NM_133519   ⟹   NP_598203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,098,622 - 78,104,915 (+)NCBI
mRatBN7.2169,069,829 - 69,076,129 (+)NCBI
Rnor_6.0172,636,959 - 72,643,255 (+)NCBI
Rnor_5.0175,891,524 - 75,902,590 (-)NCBI
RGSC_v3.4167,784,584 - 67,795,141 (+)RGD
Celera168,048,383 - 68,054,698 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085515   ⟹   XP_038941443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,099,387 - 78,104,915 (+)NCBI
mRatBN7.2169,070,020 - 69,076,129 (+)NCBI
RefSeq Acc Id: XM_039085567   ⟹   XP_038941495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,099,551 - 78,104,915 (+)NCBI
mRatBN7.2169,070,743 - 69,076,129 (+)NCBI
Protein Sequences
Protein RefSeqs NP_598203 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941443 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941495 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK29623 (Get FASTA)   NCBI Sequence Viewer  
  EDL75855 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023489.4
  ENSRNOP00000073110.1
GenBank Protein Q99MF5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598203   ⟸   NM_133519
- Peptide Label: precursor
- UniProtKB: Q99MF5 (UniProtKB/Swiss-Prot),   A0A0G2K4N4 (UniProtKB/TrEMBL),   A6KNN6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023489   ⟸   ENSRNOT00000023489
Ensembl Acc Id: ENSRNOP00000073110   ⟸   ENSRNOT00000090636
RefSeq Acc Id: XP_038941443   ⟸   XM_039085515
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941495   ⟸   XM_039085567
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MF5-F1-model_v2 AlphaFold Q99MF5 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689696
Promoter ID:EPDNEW_R221
Type:single initiation site
Name:Il11_1
Description:interleukin 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,636,913 - 72,636,973EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621475 AgrOrtholog
BioCyc Gene G2FUF-60859 BioCyc
Ensembl Genes ENSRNOG00000017386 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023489.6 UniProtKB/TrEMBL
  ENSRNOT00000090636.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-11_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171040 UniProtKB/TrEMBL
NCBI Gene 171040 ENTREZGENE
PANTHER INTERLEUKIN-11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il11 PhenoGen
PRINTS INTLKN11MAML UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017386 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4N4 ENTREZGENE, UniProtKB/TrEMBL
  A6KNN6 ENTREZGENE, UniProtKB/TrEMBL
  G3V890_RAT UniProtKB/TrEMBL
  IL11_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Il11  interleukin 11      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Il11  interleukin 11      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process responsible for increasing the absorption of carbohydrate and amino acid in recovering rats which have undergone ischemia and reperfusion (IR) injury 633063