Hpse (heparanase) - Rat Genome Database

Name: Hpse
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Hpse (heparanase) Rattus norvegicus

Analyze

Symbol:

Hpse

Name:

heparanase

RGD ID:

61969

Description:

Enables heparanase activity. Predicted to be involved in several processes, including heparan sulfate proteoglycan catabolic process; positive regulation of osteoblast proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in lysosome; membrane raft; and nucleoplasm. Predicted to be part of heparanase complex. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human HPSE (heparanase); PARTICIPATES IN syndecan signaling pathway; glycosaminoglycan degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

endo-glucoronidase; Hep; heparanase-like; Hpa; LOC100362546

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HPSE (heparanase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Hpse (heparanase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hpse (heparanase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HPSE (heparanase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HPSE (heparanase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hpse (heparanase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HPSE (heparanase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HPSE (heparanase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hpse (heparanase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Hpse (heparanase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HPSE (heparanase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hpse (heparanase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14309	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	hpse2	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hpse	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	9,200,971 - 9,241,377 (+)	NCBI		GRCr8
mRatBN7.2	14	8,896,593 - 8,937,011 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	8,896,593 - 8,937,010 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	8,870,273 - 8,910,720 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	10,170,116 - 10,210,568 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	8,866,737 - 8,907,192 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	10,534,358 - 10,576,686 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	10,534,423 - 10,575,224 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	10,483,116 - 10,523,890 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	10,144,322 - 10,185,115 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	10,144,321 - 10,185,115	NCBI
Celera	14	9,005,457 - 9,045,081 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

chromosome 4q21 deletion syndrome (ISO)

Experimental Liver Cirrhosis (ISO)

IgA glomerulonephritis (ISO)

melanoma (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

nephrosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-amygdalin (ISO)

1,1-dichloroethene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

7H-xanthine (EXP)

9H-xanthine (EXP)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

aldosterone (EXP)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitriptyline (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt dichloride (EXP,ISO)

Cuprizon (EXP)

dexamethasone (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

flavonoids (EXP)

folic acid (ISO)

genistein (EXP)

heparan sulfate (EXP,ISO)

heparin (ISO)

hydralazine (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

isoprenaline (EXP)

lipopolysaccharide (ISO)

lisinopril dihydrate (EXP)

methamphetamine (ISO)

methotrexate (ISO)

NAD zwitterion (EXP)

NAD(+) (EXP)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

propanal (ISO)

propofol (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 431542 (ISO)

sevoflurane (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

spironolactone (EXP)

sulforaphane (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP,ISO)

topotecan (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis involved in wound healing (IBA,ISO)

biological_process (ND)

cell-matrix adhesion (IBA,IEA,ISO)

establishment of endothelial barrier (IEA,ISO)

heparan sulfate proteoglycan catabolic process (IEA,ISO,ISS)

heparin metabolic process (IEA,ISO)

positive regulation of blood coagulation (IEA,ISO)

positive regulation of hair follicle development (IEA,ISO)

positive regulation of osteoblast proliferation (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

positive regulation of vascular endothelial growth factor production (IEA,ISO)

protein transmembrane transport (IEA,ISO)

regulation of hair follicle development (ISO)

vascular wound healing (IEA,ISO)

wound healing (ISO)

Cellular Component

extracellular matrix (IBA)

extracellular space (IBA,IEA,ISO)

heparanase complex (ISO)

intracellular membrane-bounded organelle (ISO)

lysosomal membrane (IEA)

lysosome (IEA,ISO)

membrane raft (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

Molecular Function

heparanase activity (IDA,IEA,ISO)

protein binding (ISO)

syndecan binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glycosaminoglycan degradation pathway (IEA)

syndecan signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Characterization of a novel intracellular heparanase that has a FERM domain.	Bame KJ, etal., Biochem J 2002 May 15;364(Pt 1):265-74.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	Characterization of heparanase from a rat parathyroid cell line.	Podyma-Inoue KA, etal., J Biol Chem 2002 Sep 6;277(36):32459-65.
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10395326	PMID:12213822	PMID:12773484	PMID:12927802	PMID:14522979	PMID:15044433	PMID:15126626	PMID:15292202	PMID:15728796	PMID:15793281	PMID:15877677	PMID:16320243
PMID:16452201	PMID:16899518	PMID:17051139	PMID:17368723	PMID:17689495	PMID:18095597	PMID:18222122	PMID:18278514	PMID:18557927	PMID:18589009	PMID:19096032	PMID:19218500
PMID:20130710	PMID:20309870	PMID:20634491	PMID:21424539	PMID:22339633	PMID:23063054	PMID:23471235	PMID:24115032	PMID:24608441	PMID:26638897	PMID:27979811	PMID:28720149
PMID:29581478

Genomics

Comparative Map Data

Hpse
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	9,200,971 - 9,241,377 (+)	NCBI		GRCr8
mRatBN7.2	14	8,896,593 - 8,937,011 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	8,896,593 - 8,937,010 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	8,870,273 - 8,910,720 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	10,170,116 - 10,210,568 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	8,866,737 - 8,907,192 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	10,534,358 - 10,576,686 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	10,534,423 - 10,575,224 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	10,483,116 - 10,523,890 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	10,144,322 - 10,185,115 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	10,144,321 - 10,185,115	NCBI
Celera	14	9,005,457 - 9,045,081 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

HPSE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	83,292,461 - 83,335,153 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	83,292,461 - 83,335,153 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	84,213,614 - 84,256,306 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	84,435,492 - 84,475,330 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	84,570,793 - 84,613,484	NCBI
Celera	4	81,506,894 - 81,546,444 (-)	NCBI		Celera
Cytogenetic Map	4	q21.23	NCBI
HuRef	4	79,956,669 - 79,999,104 (-)	NCBI		HuRef
CHM1_1	4	84,190,339 - 84,232,732 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	86,622,557 - 86,665,251 (-)	NCBI		T2T-CHM13v2.0

Hpse
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	100,827,350 - 100,867,582 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	100,827,350 - 100,867,582 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	100,679,484 - 100,719,716 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	100,679,484 - 100,719,716 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	101,108,505 - 101,148,702 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	100,920,698 - 100,959,985 (-)	NCBI		MGSCv36	mm8
Celera	5	98,006,862 - 98,047,031 (-)	NCBI		Celera
Cytogenetic Map	5	E4	NCBI
cM Map	5	48.51	NCBI

Hpse
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	6,367,467 - 6,394,395 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955474	6,367,467 - 6,394,395 (+)	NCBI	ChiLan1.0	ChiLan1.0

HPSE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	46,730,513 - 46,772,977 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	46,919,902 - 46,962,373 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	40,863,491 - 40,905,693 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	46,709,621 - 46,755,157 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	46,709,621 - 46,755,157 (+)	Ensembl	panpan1.1		panPan2

HPSE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	7,166,437 - 7,199,659 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	7,167,856 - 7,199,665 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	34,685,950 - 34,719,173 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	7,187,761 - 7,220,727 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	7,187,761 - 7,220,717 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	7,257,986 - 7,290,952 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	7,127,254 - 7,160,461 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	32,801,148 - 32,834,425 (+)	NCBI		UU_Cfam_GSD_1.0

Hpse
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	5,146,217 - 5,181,190 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936738	1,308,345 - 1,343,145 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936738	1,308,350 - 1,341,421 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HPSE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	135,097,725 - 135,120,887 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	135,082,199 - 135,120,887 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	144,378,429 - 144,417,256 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HPSE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	31,689,449 - 31,730,176 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	31,686,304 - 31,730,043 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	10,285,023 - 10,325,651 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hpse
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624900	296,676 - 335,570 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624900	296,626 - 335,624 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hpse
399 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	185
Count of miRNA genes:	124
Interacting mature miRNAs:	152
Transcripts:	ENSRNOT00000002983
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1217606	11030812	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1217606	16960180	Rat
724541	Niddm53	Non-insulin dependent diabetes mellitus QTL 53		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	3813074	9088978	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	3813074	18274691	Rat
2293089	Iddm31	Insulin dependent diabetes mellitus QTL 31	4.7		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	14	3813074	18274691	Rat
1300114	Srn2	Serum renin concentration QTL 2	3.27		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	3813074	21217635	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat

Markers in Region

AA690179

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	8,935,448 - 8,935,572 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	10,575,124 - 10,575,247	NCBI	Rnor6.0
Rnor_5.0	14	10,522,328 - 10,522,451	UniSTS	Rnor5.0
RGSC_v3.4	14	10,183,553 - 10,183,676	UniSTS	RGSC3.4
Celera	14	9,043,519 - 9,043,642	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH141764

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	8,935,636 - 8,935,856 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	10,575,312 - 10,575,531	NCBI	Rnor6.0
Rnor_5.0	14	10,522,516 - 10,522,735	UniSTS	Rnor5.0
RGSC_v3.4	14	10,183,741 - 10,183,960	UniSTS	RGSC3.4
Celera	14	9,043,707 - 9,043,926	UniSTS
RH 3.4 Map	14	152.28	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH141824

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	8,929,533 - 8,929,714 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	10,569,210 - 10,569,390	NCBI	Rnor6.0
Rnor_5.0	14	10,516,414 - 10,516,594	UniSTS	Rnor5.0
RGSC_v3.4	14	10,177,639 - 10,177,819	UniSTS	RGSC3.4
Celera	14	9,037,605 - 9,037,785	UniSTS
RH 3.4 Map	14	130.19	UniSTS
Cytogenetic Map	14	p22	UniSTS

RH128886

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	8,936,736 - 8,936,926 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	10,576,412 - 10,576,601	NCBI	Rnor6.0
Rnor_5.0	14	10,523,616 - 10,523,805	UniSTS	Rnor5.0
RGSC_v3.4	14	10,184,841 - 10,185,030	UniSTS	RGSC3.4
Celera	14	9,044,807 - 9,044,996	UniSTS
RH 3.4 Map	1	1174.7	UniSTS
Cytogenetic Map	14	p22	UniSTS

BE115323

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	8,925,000 - 8,925,150 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	10,563,209 - 10,563,358	NCBI	Rnor6.0
Rnor_5.0	14	10,511,684 - 10,511,833	UniSTS	Rnor5.0
Celera	14	9,033,270 - 9,033,419	UniSTS
RH 3.4 Map	14	152.88	UniSTS
Cytogenetic Map	14	p22	UniSTS

D21S1270

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	8,911,269 - 8,912,431 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	10,549,451 - 10,550,610	NCBI	Rnor6.0
Rnor_5.0	14	10,498,209 - 10,499,368	UniSTS	Rnor5.0
Celera	14	9,019,591 - 9,020,750	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	4	12	4	19	4					3	11
Low		39	45	37		37	8	11	74	35	38		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF184967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF359508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002983 ⟹ ENSRNOP00000002983

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	8,896,593 - 8,937,010 (+)	Ensembl
Rnor_6.0 Ensembl	14	10,534,423 - 10,575,224 (+)	Ensembl

RefSeq Acc Id:

NM_022605 ⟹ NP_072127

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	9,200,971 - 9,241,377 (+)	NCBI
mRatBN7.2	14	8,896,593 - 8,937,011 (+)	NCBI
Rnor_6.0	14	10,534,358 - 10,576,686 (+)	NCBI
Rnor_5.0	14	10,483,116 - 10,523,890 (+)	NCBI
RGSC_v3.4	14	10,144,322 - 10,185,115 (+)	RGD
Celera	14	9,005,457 - 9,045,081 (+)	RGD

Sequence:

show sequence

GGGACCTTGAGCCAGCGCGCCGGCTGCCCCAGCTCTCACGGCCGCTGGCGGTCCAGCCAGGTAG
GATGCTGCGGCCGCTGCTGCTGCTGTGGCTCTGGGGGCGGCTCCGTGCCCTGACCCAAGGCACT
CCGGCGGGGACCGCGCCGACCAAGGACGTGGTGGACTTGGAGTTTTACACCAAGAGGCTATTCC
AAAGCGTGAGTCCCTCGTTCCTGTCCATCACCATCGACGCCAGCCTGGCCACCGACCCTCGGTT
CCTCACCTTCCTGGGCTCTCCACGGCTTCGAGCCCTGGCTAGAGGCTTATCTCCTGCGTACTTG
AGATTTGGCGGCACCAAGACTGACTTCCTTATTTTTGATCCCAACAAGGAACCCACCTCTGAAG
AAAGAAGTTACTGGCAATCTCAAGACAACAATGATATTTGCGGGTCTGAGCGGGTCTCTGCTGA
CGTGTTGAGGAAACTCCAGATGGAGTGGCCCTTCCAGGAGCTGCTGCTGCTCCGAGAACAGTAC
CAAAGAGAATTCAAGAACAGCACCTACTCACGAAGCTCGGTGGACATGCTCTACAGTTTTGCTA
AGTGCTCGAGGTTAGACCTGATCTTTGGTCTAAATGCGTTACTAAGAACCCCAGACTTGCGGTG
GAACAGCTCCAACGCCCAGCTTCTCCTCAACTACTGCTCTTCCAAGGGTTATAACATCTCCTGG
GAACTGGGCAACGAGCCCAACAGTTTCTGGAAGAAAGCTCAGATTTCCATCGATGGGTTGCAGC
TAGGAGAAGACTTTGTGGAGTTGCATAAACTTCTACAAAAGTCAGCTTTCCAAAACGCAAAACT
CTATGGTCCTGACATTGGTCAGCCTCGAGGGAAGACAGTTAAGCTGCTGAGAAGCTTCCTGAAG
GCTGGTGGAGAAGTGATTGACTCTCTCACCTGGCATCACTACTACTTGAATGGACGAGTTGCGA
CCAAAGAAGATTTTCTGAGCTCTGATGTCCTGGACACTTTTATCCTATCTGTGCAAAAAATTCT
GAAGGTGACTAAGGAGATGACACCTGGCAAGAAGGTCTGGTTGGGAGAGACGAGCTCTGCCTAC
GGCGGCGGAGCGCCCTTGCTGTCCAATACCTTTGCAGCTGGCTTTATGTGGCTGGATAAATTGG
GCCTGTCAGCCCAGCTGGGGATAGAAGTCGTGATGAGGCAGGTGTTTTTCGGAGCAGGCAACTA
CCACTTAGTGGACGAAAACTTCGAGCCCTTGCCCGATTACTGGCTCTCTCTCCTGTTCAAGAAA
CTGGTAGGTCCCAAGGTGTTAATGTCAAGAGTGAAAGGCCCAGACAGAAGCAAACTCCGAGTGT
ACCTCCACTGCACGAACGTCTATCACCCAAGGTATCGGGAAGGAGATTTAACTCTGTACGTCCT
GAACCTCCATAATGTCACCAAGCACTTGAAGCTGCCGCCTCCGATGTTCAGCAGACCGGTGGAT
AAGTACCTGCTGAAGCCTTTCGGTTCTGACGGACTGCTTTCCAAATCCGTCCAACTGAACGGTC
AAACCCTGAAGATGGTCGATGAGCAGACCCTGCCAGCTCTAACAGAAAAACCTCTCCCCGCAGG
AAGCTCACTAAGCGTGCCCGCCTTTTCCTATGGGTTTTTTGTCATAAGAAATGCCAAAATCGCA
GCTTGTATATGAAAATAAAAGGCATTACAGTACCCCTGAGACGAAAGCGGTCAGGGGTGTCATT
CATAAGAATAAAGCAAAACCCCAGCGGTAGGGAGCGGACTCCTTAGCAAGCTCCAGAGCCTCGG
GAGGGCGGGGCATGCTCCAGTGCTGGATCCAGAGCCTCGGGAGGGCGGGGCAAGCTTCAACGCT
GGATCCAGAGCCTCGGGAGGGCGGGGCACGCGCTTCAGTGTTAACATCCAGTGCGGTGTTCTCT
AAGTAGACCACTGCAGGTGGTGACAGTTAATGGCACCATGTGGCAAATGACGCTTAGCACTTTG
CATGCACTATTTTGAGGGTTATTAAAAATGAATACAAATGCCTCCAATATGACCAAGAGGCAAA
TAAGTGAAGGATATGTCCTGATTTAAAAAAAAAAAAAAACAACAAACTTTGTTTTTATTTTATT
GTTATTATTTTGTTAGGAAGATTGTCAAATACGACCTCCAGTAGCCTCTCTGTAGCTCCAATGG
GGGAAAGGCCCATTGCCTTAACGCCACACTGGCTGTAAGAAGACACCTGCTCACCCTGAGAGGA
ACTAAAACAGAGAAACAGCCCCTGTGCCTCTCTTCGTTCTTCTTGAGTCTGTGAAAGGACAGGT
GGCTGGGTGGAGTAATACTAAACAAAAGCAAGAGACCGTCACAGTTGAGAGGGAAGGGAAATGA
CTGTAAAGGAGATGGTTGGTTGCTAGGGAGCTGTTTCCGGGAACACCTGACATGCCATCATTGG
GGTTTATGGTTTCTACACCTGTAGTTCTTGCTTTGCTGGGAAAGCTTTGGCCTGTGAGTAACAG
AAATCTTTAATGAGGACATTTGTAACCCCACATAAGTTGTTGAAGTGAGGTAGAGCCTGACAGC
TGGGCACATCAGCAGGACACGTCATCATCAGGAGTCTACCTTCTTTCTCCCTCTCTGTCCTGCT
GTCTGTAGTGCTGGCTCCCTTCTGGGCCTGGTCATGTGATGGCTGCAACTGGTCTACAGATCCA
TTGAGATCTGGCAGTGAGCAGAGGAAGAGATGAGTGGTTTCTTCACAGACCTGAAGAGCTCTTT
CTTGGAGGCTCTCCCAGCAAGCCTTTCCTCAAGTCTCAAGTCTTACTGGCTAGGAATAGGTCTG
TGGTCATTCTCAATGCCCATAACTGTCTTCACACAGTACTCCTTTGGGGAAGAGAGGTTTGGTG
GAGTCCACAGCCCTAGACATTTGCTTTCGGTCTGTGCTTTTGATCAAGCAACAAAGTGTAATTC
TCCCCCCCACCCCGGGATTTTAATATTAAGGATCGCAATTCTATATGTTTGTGCCTGCTATGAA
TATTATCTCGAGTGAATTTAGCATGCCGATGAAGCTAGAACGTAAAGTTTGTATGCCTAGATAT
TTTCAATTTTTATGCAAGTAGGTTTTATATTTTCACATTCGAAATAAACTAATTTTATAGCCTC
GAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_072127	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF04563	(Get FASTA)	NCBI Sequence Viewer
	AAQ15189	(Get FASTA)	NCBI Sequence Viewer
	EDL99556	(Get FASTA)	NCBI Sequence Viewer
	EDL99557	(Get FASTA)	NCBI Sequence Viewer
	EDL99558	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002983
	ENSRNOP00000002983.8
GenBank Protein	Q71RP1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_072127 ⟸ NM_022605
- Peptide Label:	precursor
- UniProtKB:	F1M581 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLRPLLLLWLWGRLRALTQGTPAGTAPTKDVVDLEFYTKRLFQSVSPSFLSITIDASLATDPRF LTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPNKEPTSEERSYWQSQDNNDICGSERVSAD VLRKLQMEWPFQELLLLREQYQREFKNSTYSRSSVDMLYSFAKCSRLDLIFGLNALLRTPDLRW NSSNAQLLLNYCSSKGYNISWELGNEPNSFWKKAQISIDGLQLGEDFVELHKLLQKSAFQNAKL YGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRVATKEDFLSSDVLDTFILSVQKIL KVTKEMTPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQLGIEVVMRQVFFGAGNY HLVDENFEPLPDYWLSLLFKKLVGPKVLMSRVKGPDRSKLRVYLHCTNVYHPRYREGDLTLYVL NLHNVTKHLKLPPPMFSRPVDKYLLKPFGSDGLLSKSVQLNGQTLKMVDEQTLPALTEKPLPAG SSLSVPAFSYGFFVIRNAKIAACI hide sequence

RefSeq Acc Id:

ENSRNOP00000002983 ⟸ ENSRNOT00000002983

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q71RP1-F1-model_v2	AlphaFold	Q71RP1	1-536	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699192

Promoter ID:

EPDNEW_R9716

Type:

initiation region

Name:

Hpse_1

Description:

heparanase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	10,534,328 - 10,534,388	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61969	AgrOrtholog
BioCyc Gene	G2FUF-16414	BioCyc
Ensembl Genes	ENSRNOG00000002188	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002983	ENTREZGENE
	ENSRNOT00000002983.8	UniProtKB/TrEMBL
Gene3D-CATH	Glycosidases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Glyco_hydro_79	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Glycoside_hydrolase_SF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64537	UniProtKB/Swiss-Prot
NCBI Gene	Hpse	ENTREZGENE
PANTHER	HEPARANASE	UniProtKB/Swiss-Prot
	HEPARANASE	UniProtKB/Swiss-Prot
	HEPARANASE	UniProtKB/TrEMBL
	HEPARANASE	UniProtKB/TrEMBL
Pfam	Glyco_hydro_79n	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hpse	PhenoGen
RatGTEx	ENSRNOG00000002188	RatGTEx
Superfamily-SCOP	SSF51445	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC230485
UniProt	A6K5Y6_RAT	UniProtKB/TrEMBL
	A6K5Y7_RAT	UniProtKB/TrEMBL
	A6K5Y8_RAT	UniProtKB/TrEMBL
	F1M581	ENTREZGENE, UniProtKB/TrEMBL
	HPSE_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q9QZF8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-04-17	Hpse	heparanase	LOC100362546	heparanase-like	Data merged from RGD:2324508	737654	PROVISIONAL
2010-05-06	LOC100362546	heparanase-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Hpse	heparanase			Name updated	70584	APPROVED
2001-12-06	Hpse	heparanase			Symbol updated to reflect Human and Mouse nomenclature	69665	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	activity suggests function in extralysosomal compartments	632901

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)