TWIST1 (twist family bHLH transcription factor 1) - Rat Genome Database

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Gene: TWIST1 (twist family bHLH transcription factor 1) Canis lupus familiaris
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Symbol: TWIST1
Name: twist family bHLH transcription factor 1
RGD ID: 40909211
Description: ENCODES a protein that exhibits bHLH transcription factor binding (inferred); cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); INVOLVED IN bone development (ortholog); cardiac neural crest cell development involved in outflow tract morphogenesis (ortholog); cardiac neural crest cell migration involved in outflow tract morphogenesis (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acrocephalosyndactylia (ortholog); anaplastic large cell lymphoma (ortholog); breast cancer (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: twist-related protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1432,910,643 - 32,912,659 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01433,303,139 - 33,305,160 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1433,304,421 - 33,305,047 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11433,412,240 - 33,414,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01433,113,407 - 33,115,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01433,429,893 - 33,431,914 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0



Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IEA)
bone development  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell differentiation  (IEA,ISO)
cell proliferation involved in heart valve development  (IEA)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (IEA)
cranial suture morphogenesis  (IEA,ISO)
developmental process  (IBA)
DNA-templated transcription  (IEA)
embryonic camera-type eye formation  (IEA)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (IEA)
embryonic limb morphogenesis  (ISO)
embryonic skeletal system morphogenesis  (ISO)
endocardial cushion morphogenesis  (ISO)
energy homeostasis  (ISO)
eyelid development in camera-type eye  (IEA)
hindlimb morphogenesis  (ISO)
in utero embryonic development  (ISO)
mitral valve morphogenesis  (IEA)
muscle organ development  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell differentiation  (IEA)
negative regulation of cellular senescence  (IEA)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of double-strand break repair  (IEA)
negative regulation of miRNA transcription  (IEA)
negative regulation of osteoblast differentiation  (IEA,ISO)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
negative regulation of skeletal muscle tissue development  (ISO)
negative regulation of striated muscle tissue development  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of tumor necrosis factor production  (ISO)
neural tube closure  (ISO)
neuron migration  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell motility  (IEA)
positive regulation of DNA-templated transcription initiation  (IEA)
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation  (IEA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of fatty acid beta-oxidation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA)
regulation of bone mineralization  (IEA)
regulation of transcription by RNA polymerase II  (IBA,IEA)
rhythmic process  (IEA)
roof of mouth development  (ISO)

Cellular Component
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TWIST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1432,910,643 - 32,912,659 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01433,303,139 - 33,305,160 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1433,304,421 - 33,305,047 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11433,412,240 - 33,414,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01433,113,407 - 33,115,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01433,429,893 - 33,431,914 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TWIST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38719,113,047 - 19,117,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl719,020,991 - 19,117,636 (-)Ensemblhg38GRCh38
GRCh37719,152,670 - 19,157,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36719,121,616 - 19,123,820 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34718,928,330 - 18,930,265NCBI
Celera719,134,693 - 19,136,894 (-)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef719,039,766 - 19,041,695 (-)NCBIHuRef
CHM1_1719,155,871 - 19,158,073 (-)NCBICHM1_1
T2T-CHM13v2.0719,242,984 - 19,247,572 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2719,206,542 - 19,208,746 (-)NCBI
Twist1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391234,007,670 - 34,009,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)Ensemblmm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBIMGSCv36mm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
Twist1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8656,402,309 - 56,404,303 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl656,398,061 - 56,404,965 (+)EnsemblGRCr8
mRatBN7.2650,674,910 - 50,676,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl650,674,678 - 50,677,653 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx650,955,709 - 50,957,706 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0651,270,651 - 51,272,648 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0650,726,837 - 50,728,832 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd657,818,654 - 57,820,651 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive657,232,694 - 57,234,691 (+)NCBILyon_Normotensive
Lyon_Hypertensive655,028,021 - 55,030,018 (+)NCBILyon_Hypertensive
F344_StmMcwi654,266,537 - 54,268,532 (+)NCBIF344_StmMcwi
Rnor_6.0653,401,241 - 53,403,235 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl653,401,109 - 53,403,214 (+)Ensemblrn6Rnor6.0
Rnor_5.0663,023,523 - 63,025,517 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4652,605,869 - 52,607,863 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera649,841,416 - 49,843,227 (+)NCBICelera
RGSC_v3.1652,609,172 - 52,609,784 (+)NCBI
Cytogenetic Map6q16NCBI
Twist1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541022,003,981 - 22,005,483 (-)NCBIChiLan1.0ChiLan1.0
TWIST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2623,940,627 - 23,944,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1772,265,343 - 72,268,909 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0719,761,041 - 19,765,665 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1719,086,842 - 19,088,398 (-)NCBIPanPan1.1PanPan1.1panPan2
Twist1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365465,331,863 - 5,332,555 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWIST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl988,289,407 - 88,290,015 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1988,286,911 - 88,290,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2997,326,044 - 97,329,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWIST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12139,040,178 - 39,042,384 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2139,040,547 - 39,041,146 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604265,498,692 - 65,500,893 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Twist1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473911,352,141 - 11,352,809 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473911,352,040 - 11,354,019 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Twist1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1747,301,838 - 47,302,508 (+)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00845012550   ⟹   ENSCAFP00845009804
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1433,304,421 - 33,305,047 (-)Ensembl
RefSeq Acc Id: XM_038440859   ⟹   XP_038296787
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1432,910,643 - 32,912,659 (-)NCBI
RefSeq Acc Id: XM_038495287   ⟹   XP_038351215
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11433,412,240 - 33,414,258 (-)NCBI
RefSeq Acc Id: XM_038556383   ⟹   XP_038412311
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01433,429,893 - 33,431,914 (-)NCBI
RefSeq Acc Id: XM_038620306   ⟹   XP_038476234
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01433,113,407 - 33,115,426 (-)NCBI
RefSeq Acc Id: XM_038685985   ⟹   XP_038541913
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01433,303,139 - 33,305,160 (-)NCBI
RefSeq Acc Id: XP_038351215   ⟸   XM_038495287
RefSeq Acc Id: XP_038476234   ⟸   XM_038620306
RefSeq Acc Id: XP_038541913   ⟸   XM_038685985
- UniProtKB: A0A8C0JKV7 (UniProtKB/TrEMBL),   A0A8C0RY00 (UniProtKB/TrEMBL),   A0A8I3N2Z5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038296787   ⟸   XM_038440859
- UniProtKB: A0A8P0PLX1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412311   ⟸   XM_038556383
- UniProtKB: A0A8C0JKV7 (UniProtKB/TrEMBL),   A0A8C0RY00 (UniProtKB/TrEMBL),   A0A8I3N2Z5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845009804   ⟸   ENSCAFT00845012550
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000057471 UniProtKB/TrEMBL
  ENSCAFG00040004960 UniProtKB/TrEMBL
  ENSCAFG00845007076 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000106295.1 UniProtKB/TrEMBL
  ENSCAFT00040009324.1 UniProtKB/TrEMBL
  ENSCAFT00845012550 ENTREZGENE
  ENSCAFT00845012550.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  E-box_TF_Regulators UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  TWIST1_bHLH UniProtKB/TrEMBL
NCBI Gene TWIST1 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/TrEMBL
  PTHR23349:SF64 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A8C0JKV7 ENTREZGENE
  A0A8C0RY00 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2Z5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PLX1 ENTREZGENE, UniProtKB/TrEMBL