TWIST1 (twist family bHLH transcription factor 1) - Rat Genome Database

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Gene: TWIST1 (twist family bHLH transcription factor 1) Sus scrofa
Analyze
Symbol: TWIST1
Name: twist family bHLH transcription factor 1
RGD ID: 13983046
Description: ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN aortic valve morphogenesis (ortholog); bone development (ortholog); cardiac neural crest cell development involved in outflow tract morphogenesis (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acrocephalosyndactylia (ortholog); anaplastic large cell lymphoma (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: twist basic helix-loop-helix transcription factor 1; twist-related protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1988,286,911 - 88,290,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2997,326,044 - 97,329,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (ISO)
bone development  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell differentiation  (ISO)
cell proliferation involved in heart valve development  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cranial suture morphogenesis  (ISO)
embryonic camera-type eye formation  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
embryonic skeletal system morphogenesis  (ISO)
endocardial cushion morphogenesis  (ISO)
eyelid development in camera-type eye  (ISO)
hindlimb morphogenesis  (ISO)
in utero embryonic development  (ISO)
mitral valve morphogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of double-strand break repair  (ISO)
negative regulation of histone acetylation  (ISO)
negative regulation of histone phosphorylation  (ISO)
negative regulation of molecular function  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of oxidative phosphorylation uncoupler activity  (ISO)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
negative regulation of phosphatidylinositol 3-kinase signaling  (ISO)
negative regulation of skeletal muscle tissue development  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
neural tube closure  (ISO)
neuron migration  (ISO)
odontogenesis  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
positive regulation of cell motility  (ISO)
positive regulation of DNA-templated transcription, initiation  (ISO)
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of fatty acid beta-oxidation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of bone mineralization  (ISO)
roof of mouth development  (ISO)

Cellular Component
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
TWIST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1988,286,911 - 88,290,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2997,326,044 - 97,329,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWIST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl719,020,991 - 19,117,636 (-)EnsemblGRCh38hg38GRCh38
GRCh38719,113,047 - 19,117,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37719,152,670 - 19,157,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36719,121,616 - 19,123,820 (-)NCBINCBI36hg18NCBI36
Build 34718,928,330 - 18,930,265NCBI
Celera719,134,693 - 19,136,894 (-)NCBI
Cytogenetic Map7p21.1NCBI
HuRef719,039,766 - 19,041,695 (-)NCBIHuRef
CHM1_1719,155,871 - 19,158,073 (-)NCBICHM1_1
CRA_TCAGchr7v2719,206,542 - 19,208,746 (-)NCBI
Twist1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391234,007,670 - 34,009,830 (+)NCBIGRCm39mm39
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)Ensembl
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIGRCm37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBImm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
Twist1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2650,674,910 - 50,676,904 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl650,674,678 - 50,677,653 (+)Ensembl
Rnor_6.0653,401,241 - 53,403,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl653,401,109 - 53,403,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0663,023,523 - 63,025,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4652,605,869 - 52,607,863 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1652,609,172 - 52,609,784 (+)NCBI
Celera649,841,416 - 49,843,227 (+)NCBICelera
Cytogenetic Map6q16NCBI
Twist1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541022,003,981 - 22,005,483 (-)NCBIChiLan1.0ChiLan1.0
TWIST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1719,086,842 - 19,088,398 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0719,761,041 - 19,765,665 (-)NCBIMhudiblu_PPA_v0panPan3
TWIST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1432,910,643 - 32,912,659 (-)NCBI
ROS_Cfam_1.01433,303,139 - 33,305,160 (-)NCBI
UMICH_Zoey_3.11433,412,240 - 33,414,258 (-)NCBI
UNSW_CanFamBas_1.01433,113,407 - 33,115,426 (-)NCBI
UU_Cfam_GSD_1.01433,429,893 - 33,431,914 (-)NCBI
Twist1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBI
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWIST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12139,040,178 - 39,042,384 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2139,040,547 - 39,041,146 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604265,498,692 - 65,500,893 (-)NCBIVero_WHO_p1.0
Twist1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473911,352,040 - 11,354,019 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_003130192   ⟹   XP_003130240
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1988,286,911 - 88,290,131 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003130240 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003130240   ⟸   XM_003130192
- UniProtKB: F1SEI1 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00070008259 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00070013161 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00070015920 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Twist-related UniProtKB/TrEMBL
KEGG Report ssc:100516456 UniProtKB/TrEMBL
NCBI Gene TWIST1 ENTREZGENE
PANTHER PTHR23349:SF64 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A4X1TEI0_PIG UniProtKB/TrEMBL
  F1SEI1 ENTREZGENE