Twist1 (twist family bHLH transcription factor 1) - Rat Genome Database

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Pathways
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Gene: Twist1 (twist family bHLH transcription factor 1) Ictidomys tridecemlineatus
Analyze
Symbol: Twist1
Name: twist family bHLH transcription factor 1
RGD ID: 12612342
Description: ENCODES a protein that exhibits bHLH transcription factor binding (inferred); cis-regulatory region sequence-specific DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN bone development (ortholog); cardiac neural crest cell development involved in outflow tract morphogenesis (ortholog); cardiac neural crest cell migration involved in outflow tract morphogenesis (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acrocephalosyndactylia (ortholog); anaplastic large cell lymphoma (ortholog); breast cancer (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: twist basic helix-loop-helix transcription factor 1; twist-related protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365465,331,863 - 5,332,555 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IEA)
bone development  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (IEA,ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA,ISO)
cell proliferation involved in heart valve development  (IEA)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (IEA)
cranial suture morphogenesis  (IEA,ISO)
developmental process  (IEA)
embryonic camera-type eye formation  (IEA)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic forelimb morphogenesis  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA)
embryonic limb morphogenesis  (IEA,ISO)
embryonic skeletal system morphogenesis  (IEA,ISO)
endocardial cushion morphogenesis  (IEA,ISO)
energy homeostasis  (IEA,ISO)
eyelid development in camera-type eye  (IEA)
hindlimb morphogenesis  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
mitral valve morphogenesis  (IEA)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cell differentiation  (IEA)
negative regulation of cellular senescence  (IEA)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of double-strand break repair  (IEA)
negative regulation of macrophage cytokine production  (IEA,ISO)
negative regulation of miRNA transcription  (IEA)
negative regulation of osteoblast differentiation  (IEA,ISO)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (IEA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
negative regulation of skeletal muscle tissue development  (IEA,ISO)
negative regulation of striated muscle tissue development  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
neural tube closure  (IEA,ISO)
neuron migration  (IEA,ISO)
ossification  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell motility  (IEA)
positive regulation of DNA-templated transcription initiation  (IEA)
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation  (IEA)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of fatty acid beta-oxidation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of monocyte chemotactic protein-1 production  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA)
regulation of bone mineralization  (IEA)
roof of mouth development  (ISO)
stem cell differentiation  (IEA,ISO)

Cellular Component
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Twist1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365465,331,863 - 5,332,555 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWIST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38719,113,047 - 19,117,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl719,020,991 - 19,117,636 (-)EnsemblGRCh38hg38GRCh38
GRCh37719,152,670 - 19,157,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36719,121,616 - 19,123,820 (-)NCBINCBI36Build 36hg18NCBI36
Build 34718,928,330 - 18,930,265NCBI
Celera719,134,693 - 19,136,894 (-)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef719,039,766 - 19,041,695 (-)NCBIHuRef
CHM1_1719,155,871 - 19,158,073 (-)NCBICHM1_1
T2T-CHM13v2.0719,242,984 - 19,247,572 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2719,206,542 - 19,208,746 (-)NCBI
Twist1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391234,007,670 - 34,009,830 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)EnsemblGRCm39 Ensembl
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBIMGSCv36mm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
Twist1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8656,402,309 - 56,404,303 (+)NCBIGRCr8
mRatBN7.2650,674,910 - 50,676,904 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl650,674,678 - 50,677,653 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx650,955,709 - 50,957,706 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0651,270,651 - 51,272,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0650,726,837 - 50,728,832 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0653,401,241 - 53,403,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl653,401,109 - 53,403,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0663,023,523 - 63,025,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4652,605,869 - 52,607,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1652,609,172 - 52,609,784 (+)NCBI
Celera649,841,416 - 49,843,227 (+)NCBICelera
Cytogenetic Map6q16NCBI
Twist1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541022,003,981 - 22,005,483 (-)NCBIChiLan1.0ChiLan1.0
TWIST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2623,940,627 - 23,944,192 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1772,265,343 - 72,268,909 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0719,761,041 - 19,765,665 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1719,086,842 - 19,088,398 (-)NCBIpanpan1.1PanPan1.1panPan2
TWIST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1432,910,643 - 32,912,659 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01433,303,139 - 33,305,160 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1433,304,421 - 33,305,047 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11433,412,240 - 33,414,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01433,113,407 - 33,115,426 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01433,429,893 - 33,431,914 (-)NCBIUU_Cfam_GSD_1.0
TWIST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl988,289,407 - 88,290,015 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1988,286,911 - 88,290,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2997,326,044 - 97,329,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWIST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12139,040,178 - 39,042,384 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2139,040,547 - 39,041,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604265,498,692 - 65,500,893 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Twist1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473911,352,141 - 11,352,809 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473911,352,040 - 11,354,019 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005328806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000039136   ⟹   ENSSTOP00000025119
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365465,331,863 - 5,332,555 (-)Ensembl
RefSeq Acc Id: XM_005328806   ⟹   XP_005328863
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBI
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005328863 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000025119.1
GenBank Protein KAG3277955 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005328863   ⟸   XM_005328806
- UniProtKB: A0A287CV12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000025119   ⟸   ENSSTOT00000039136
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000032264 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000039136.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  TWIST1_bHLH UniProtKB/TrEMBL
NCBI Gene Twist1 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/TrEMBL
  PTHR23349:SF64 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0A287CV12 ENTREZGENE, UniProtKB/TrEMBL