Twist1 (twist family bHLH transcription factor 1) - Rat Genome Database

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Gene: Twist1 (twist family bHLH transcription factor 1) Ictidomys tridecemlineatus
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Symbol: Twist1
Name: twist family bHLH transcription factor 1
RGD ID: 12612342
Description: ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN aortic valve morphogenesis (ortholog); bone development (ortholog); cardiac neural crest cell development involved in outflow tract morphogenesis (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acrocephalosyndactylia (ortholog); anaplastic large cell lymphoma (ortholog); craniosynostosis (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: twist basic helix-loop-helix transcription factor 1; twist-related protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBI
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (ISO)
bone development  (ISO)
cardiac neural crest cell development involved in outflow tract morphogenesis  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell differentiation  (ISO)
cell proliferation involved in heart valve development  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hypoxia  (ISO)
cranial suture morphogenesis  (ISO)
embryonic camera-type eye formation  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
embryonic skeletal system morphogenesis  (ISO)
endocardial cushion morphogenesis  (ISO)
eyelid development in camera-type eye  (ISO)
hindlimb morphogenesis  (ISO)
in utero embryonic development  (ISO)
mitral valve morphogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of double-strand break repair  (ISO)
negative regulation of histone acetylation  (ISO)
negative regulation of histone phosphorylation  (ISO)
negative regulation of molecular function  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of oxidative phosphorylation uncoupler activity  (ISO)
negative regulation of peroxisome proliferator activated receptor signaling pathway  (ISO)
negative regulation of phosphatidylinositol 3-kinase signaling  (ISO)
negative regulation of skeletal muscle tissue development  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
neural tube closure  (ISO)
neuron migration  (ISO)
odontogenesis  (ISO)
ossification  (ISO)
osteoblast differentiation  (ISO)
positive regulation of cell motility  (ISO)
positive regulation of DNA-templated transcription, initiation  (ISO)
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of fatty acid beta-oxidation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of bone mineralization  (ISO)
roof of mouth development  (ISO)

Cellular Component
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Twist1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBI
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWIST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl719,020,991 - 19,117,636 (-)EnsemblGRCh38hg38GRCh38
GRCh38719,113,047 - 19,117,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37719,152,670 - 19,157,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36719,121,616 - 19,123,820 (-)NCBINCBI36hg18NCBI36
Build 34718,928,330 - 18,930,265NCBI
Celera719,134,693 - 19,136,894 (-)NCBI
Cytogenetic Map7p21.1NCBI
HuRef719,039,766 - 19,041,695 (-)NCBIHuRef
CHM1_1719,155,871 - 19,158,073 (-)NCBICHM1_1
CRA_TCAGchr7v2719,206,542 - 19,208,746 (-)NCBI
Twist1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391234,007,670 - 34,009,830 (+)NCBIGRCm39mm39
GRCm39 Ensembl1234,007,670 - 34,009,828 (+)Ensembl
GRCm381233,957,671 - 33,959,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1233,957,671 - 33,959,829 (+)EnsemblGRCm38mm10GRCm38
MGSCv371234,642,536 - 34,644,696 (+)NCBIGRCm37mm9NCBIm37
MGSCv361234,542,918 - 34,545,078 (+)NCBImm8
Celera1235,391,139 - 35,393,299 (+)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1214.81NCBI
Twist1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2650,674,910 - 50,676,904 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl653,401,109 - 53,403,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0653,401,241 - 53,403,235 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0663,023,523 - 63,025,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4652,605,869 - 52,607,863 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1652,609,172 - 52,609,784 (+)NCBI
Celera649,841,416 - 49,843,227 (+)NCBICelera
Cytogenetic Map6q16NCBI
Twist1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541022,003,981 - 22,005,483 (-)NCBIChiLan1.0ChiLan1.0
TWIST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1719,086,842 - 19,088,398 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0719,761,041 - 19,765,665 (-)NCBIMhudiblu_PPA_v0panPan3
TWIST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1432,910,643 - 32,912,659 (-)NCBI
ROS_Cfam_1.01433,303,139 - 33,305,160 (-)NCBI
UMICH_Zoey_3.11433,412,240 - 33,414,258 (-)NCBI
UNSW_CanFamBas_1.01433,113,407 - 33,115,426 (-)NCBI
UU_Cfam_GSD_1.01433,429,893 - 33,431,914 (-)NCBI
TWIST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1988,286,911 - 88,290,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2997,326,044 - 97,329,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWIST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12139,040,178 - 39,042,384 (+)NCBI
ChlSab1.1 Ensembl2139,040,547 - 39,041,146 (+)Ensembl
Vero_WHO_p1.0NW_02366604265,498,692 - 65,500,893 (-)NCBI
Twist1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473911,352,040 - 11,354,019 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005328806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005328806   ⟹   XP_005328863
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440511877,655,541 - 77,657,763 (-)NCBI
SpeTri2.0NW_0049365465,331,220 - 5,332,669 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005328863 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3277955 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005328863   ⟸   XM_005328806
- Sequence:
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
NCBI Gene Twist1 ENTREZGENE