Gnb1 (G protein subunit beta 1) - Rat Genome Database

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Gene: Gnb1 (G protein subunit beta 1) Rattus norvegicus
Analyze
Symbol: Gnb1
Name: G protein subunit beta 1
RGD ID: 2718
Description: Enables alkylglycerophosphoethanolamine phosphodiesterase activity and spectrin binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of cytosolic calcium ion concentration. Acts upstream of or within cardiac muscle cell apoptotic process and cellular response to hypoxia. Located in several cellular components, including cell body; photoreceptor inner segment; and photoreceptor outer segment membrane. Part of heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1); PARTICIPATES IN G protein mediated signaling pathway via Galpha12/Galpha13 family; adenosine signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanine nucleotide binding protein (G protein), beta 1; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide binding protein, beta 1; Guanine nucleotide-binding protein beta 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; guanine nucleotide-binding protein, beta-1 subunit; transducin beta chain 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,357,778 - 171,424,489 (+)NCBIGRCr8
mRatBN7.25166,075,508 - 166,142,223 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,075,629 - 166,142,124 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,801,104 - 168,845,812 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,622,525 - 170,667,219 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,585,062 - 170,629,767 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,914,025 - 172,981,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,934,990 - 172,979,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,388,373 - 176,456,527 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,341,135 - 172,386,772 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,366,363 - 172,398,680 (+)NCBI
Celera5164,297,726 - 164,342,470 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP,ISO)
alendronic acid  (EXP)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
barium(0)  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
daidzein  (EXP)
decabromodiphenyl ether  (ISO)
delta8-THC  (ISO)
diazinon  (ISO)
dichlorine  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ivermectin  (ISO)
kojic acid  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
nickel atom  (ISO)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
pyrogallol  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have lysophospholipase D activity. Aoyama C, etal., Biochem J. 2011 Dec 1;440(2):241-50. doi: 10.1042/BJ20110545.
2. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
3. Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain. Betty M, etal., Neuroscience 1998 Jul;85(2):475-86.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. Kiefer KC, etal., ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28.
7. Immunohistochemical localization of G protein beta1, beta2, beta3, beta4, beta5, and gamma3 subunits in the adult rat brain. Liang JJ, etal., J Neurochem. 1998 Jul;71(1):345-55.
8. G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes. Macrez-Lepretre N, etal., J Biol Chem. 1997 Apr 11;272(15):10095-102.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The giant spectrin betaV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Papal S, etal., Hum Mol Genet. 2013 Sep 15;22(18):3773-88. doi: 10.1093/hmg/ddt228. Epub 2013 May 23.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). Sato M, etal., J Biol Chem. 2009 Nov 6;284(45):31431-40. doi: 10.1074/jbc.M109.014068. Epub 2009 Sep 1.
19. Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation. Sokolov M, etal., Neuron. 2002 Mar 28;34(1):95-106.
20. Identification and characterization of a G-protein regulatory motif in WAVE1. Song KS, etal., FEBS Lett. 2006 Apr 3;580(8):1993-8. Epub 2006 Mar 6.
21. rGbeta1: a psychostimulant-regulated gene essential for establishing cocaine sensitization. Wang XB, etal., J Neurosci 1997 Aug 1;17(15):5993-6000.
Additional References at PubMed
PMID:1543505   PMID:10570481   PMID:11567049   PMID:12477932   PMID:12486122   PMID:14712229   PMID:15489334   PMID:15953418   PMID:16009138   PMID:16221676   PMID:16854843   PMID:17493708  
PMID:17634366   PMID:17897319   PMID:18367617   PMID:18719114   PMID:19056867   PMID:19199708   PMID:19255495   PMID:20458337   PMID:21052544   PMID:22082260   PMID:23209302   PMID:23376485  
PMID:23533145   PMID:24769233   PMID:25002582   PMID:25941381   PMID:28259758   PMID:29476059   PMID:34012023  


Genomics

Comparative Map Data
Gnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85171,357,778 - 171,424,489 (+)NCBIGRCr8
mRatBN7.25166,075,508 - 166,142,223 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,075,629 - 166,142,124 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5168,801,104 - 168,845,812 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,622,525 - 170,667,219 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,585,062 - 170,629,767 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,914,025 - 172,981,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,934,990 - 172,979,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05176,388,373 - 176,456,527 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,341,135 - 172,386,772 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15172,366,363 - 172,398,680 (+)NCBI
Celera5164,297,726 - 164,342,470 (+)NCBICelera
Cytogenetic Map5q36NCBI
GNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,785,286 - 1,891,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,785,285 - 1,892,292 (-)EnsemblGRCh38hg38GRCh38
GRCh3711,716,725 - 1,822,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611,706,589 - 1,812,355 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411,748,891 - 1,854,657NCBI
Celera1824,442 - 878,396 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1993,370 - 1,099,481 (-)NCBIHuRef
CHM1_111,703,768 - 1,809,545 (-)NCBICHM1_1
T2T-CHM13v2.011,219,664 - 1,325,475 (-)NCBIT2T-CHM13v2.0
Gnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,575,514 - 155,643,726 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,575,818 - 155,643,726 (+)EnsemblGRCm39 Ensembl
GRCm384155,491,300 - 155,559,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4155,491,361 - 155,559,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv374154,865,470 - 154,933,378 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364154,335,170 - 154,401,618 (+)NCBIMGSCv36mm8
Celera4157,766,104 - 157,834,163 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.17NCBI
Gnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,165,850 - 9,193,066 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554869,165,850 - 9,192,306 (+)NCBIChiLan1.0ChiLan1.0
GNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,384,861 - 226,491,117 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,040,769 - 225,147,102 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01490,415 - 596,826 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111,647,764 - 1,753,106 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11,647,340 - 1,701,614 (-)Ensemblpanpan1.1panPan2
GNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,777,854 - 56,879,619 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,779,354 - 56,817,295 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,854,797 - 56,892,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,979,770 - 57,081,319 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,979,770 - 57,081,208 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,971,985 - 57,009,669 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,864,386 - 56,902,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,254,317 - 57,292,011 (-)NCBIUU_Cfam_GSD_1.0
Gnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,911,024 - 27,981,551 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,524,325 - 1,555,102 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367371,518,855 - 1,554,926 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,867,158 - 63,952,505 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,867,155 - 63,957,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,654,890 - 129,765,765 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,707,085 - 129,766,667 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605434,071,639 - 34,168,179 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,936,932 - 8,003,433 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248187,937,061 - 8,002,798 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnb1
214 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:35
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000041789
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
PMC197251P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2137,852,098 - 37,852,262 (+)MAPPERmRatBN7.2
Rnor_6.02157,011,700 - 157,011,863NCBIRnor6.0
Rnor_5.02176,377,567 - 176,377,730UniSTSRnor5.0
RGSC_v3.4132,051,165 - 32,051,328UniSTSRGSC3.4
Cytogenetic Map1p11UniSTS
Cytogenetic Map5q36UniSTS
RH127715  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1650,678,418 - 50,678,630UniSTS
Celera5164,343,501 - 164,343,713UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map16q12.1UniSTS
BE099765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,120,815 - 166,120,984 (+)MAPPERmRatBN7.2
Rnor_6.05172,959,990 - 172,960,158NCBIRnor6.0
Rnor_5.05176,435,113 - 176,435,281UniSTSRnor5.0
RGSC_v3.45172,366,782 - 172,366,950UniSTSRGSC3.4
Celera5164,322,483 - 164,322,651UniSTS
RH 3.4 Map51155.1UniSTS
Cytogenetic Map5q36UniSTS
RH140264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,121,425 - 166,121,615 (+)MAPPERmRatBN7.2
Rnor_6.05172,960,600 - 172,960,789NCBIRnor6.0
Rnor_5.05176,435,723 - 176,435,912UniSTSRnor5.0
RGSC_v3.45172,367,392 - 172,367,581UniSTSRGSC3.4
Celera5164,323,093 - 164,323,282UniSTS
RH 3.4 Map51155.5UniSTS
Cytogenetic Map5q36UniSTS
AA900898  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera5164,342,363 - 164,342,551UniSTS
Celera1650,677,236 - 50,677,425UniSTS
RH 3.4 Map8849.9UniSTS
Cytogenetic Map1p11UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map5q36UniSTS
RH124831  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02176,375,601 - 176,375,767NCBIRnor5.0
Rnor_5.05176,456,304 - 176,456,470NCBIRnor5.0
RGSC_v3.45172,387,965 - 172,388,130UniSTSRGSC3.4
RGSC_v3.4132,049,200 - 32,049,365UniSTSRGSC3.4
Celera5164,343,663 - 164,343,828UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:496680  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02176,377,830 - 176,378,105NCBIRnor5.0
Rnor_5.03151,876,035 - 151,876,320NCBIRnor5.0
Rnor_5.01656,527,453 - 56,527,738NCBIRnor5.0
RGSC_v3.4132,051,429 - 32,051,703UniSTSRGSC3.4
RGSC_v3.41656,334,152 - 56,334,436UniSTSRGSC3.4
Celera1650,676,178 - 50,676,462UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map1p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 37
Medium 3 43 57 41 19 41 8 11 37 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF022083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY552805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U88324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000041789   ⟹   ENSRNOP00000044340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,075,629 - 166,140,804 (+)Ensembl
Rnor_6.0 Ensembl5172,934,990 - 172,979,986 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116462   ⟹   ENSRNOP00000085954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,126,274 - 166,142,124 (+)Ensembl
RefSeq Acc Id: NM_030987   ⟹   NP_112249
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,378,363 - 171,423,074 (+)NCBI
mRatBN7.25166,096,088 - 166,140,807 (+)NCBI
Rnor_6.05172,934,990 - 172,979,988 (+)NCBI
Rnor_5.05176,388,373 - 176,456,527 (+)NCBI
RGSC_v3.45172,341,135 - 172,386,772 (+)RGD
Celera5164,297,726 - 164,342,470 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239517   ⟹   XP_006239579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,780 - 171,424,489 (+)NCBI
mRatBN7.25166,075,508 - 166,142,223 (+)NCBI
Rnor_6.05172,914,025 - 172,981,403 (+)NCBI
Rnor_5.05176,388,373 - 176,456,527 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764335   ⟹   XP_008762557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,778 - 171,424,489 (+)NCBI
mRatBN7.25166,075,508 - 166,142,223 (+)NCBI
Rnor_6.05172,914,025 - 172,981,403 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109260   ⟹   XP_038965188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,780 - 171,424,489 (+)NCBI
mRatBN7.25166,075,508 - 166,142,223 (+)NCBI
RefSeq Acc Id: XM_039109261   ⟹   XP_038965189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,780 - 171,424,489 (+)NCBI
mRatBN7.25166,075,508 - 166,142,223 (+)NCBI
RefSeq Acc Id: XM_039109262   ⟹   XP_038965190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,780 - 171,424,489 (+)NCBI
mRatBN7.25166,075,508 - 166,142,223 (+)NCBI
RefSeq Acc Id: XM_039109263   ⟹   XP_038965191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,780 - 171,424,489 (+)NCBI
mRatBN7.25166,075,508 - 166,142,223 (+)NCBI
RefSeq Acc Id: XM_063287153   ⟹   XP_063143223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,778 - 171,424,489 (+)NCBI
RefSeq Acc Id: XM_063287154   ⟹   XP_063143224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,778 - 171,424,489 (+)NCBI
RefSeq Acc Id: XM_063287155   ⟹   XP_063143225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,778 - 171,424,489 (+)NCBI
RefSeq Acc Id: XM_063287156   ⟹   XP_063143226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85171,357,778 - 171,424,489 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112249   ⟸   NM_030987
- UniProtKB: Q6Q8B1 (UniProtKB/Swiss-Prot),   Q9QWG8 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239579   ⟸   XM_006239517
- Peptide Label: isoform X1
- UniProtKB: Q6Q8B1 (UniProtKB/Swiss-Prot),   Q9QWG8 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762557   ⟸   XM_008764335
- Peptide Label: isoform X1
- UniProtKB: Q6Q8B1 (UniProtKB/Swiss-Prot),   Q9QWG8 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044340   ⟸   ENSRNOT00000041789
RefSeq Acc Id: XP_038965188   ⟸   XM_039109260
- Peptide Label: isoform X1
- UniProtKB: Q6Q8B1 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   Q9QWG8 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965189   ⟸   XM_039109261
- Peptide Label: isoform X1
- UniProtKB: Q6Q8B1 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   Q9QWG8 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965190   ⟸   XM_039109262
- Peptide Label: isoform X1
- UniProtKB: Q6Q8B1 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   Q9QWG8 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965191   ⟸   XM_039109263
- Peptide Label: isoform X1
- UniProtKB: Q6Q8B1 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   Q9QWG8 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085954   ⟸   ENSRNOT00000116462
RefSeq Acc Id: XP_063143223   ⟸   XM_063287153
- Peptide Label: isoform X1
- UniProtKB: Q9QWG8 (UniProtKB/Swiss-Prot),   Q6Q8B1 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143224   ⟸   XM_063287154
- Peptide Label: isoform X1
- UniProtKB: Q9QWG8 (UniProtKB/Swiss-Prot),   Q6Q8B1 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143225   ⟸   XM_063287155
- Peptide Label: isoform X1
- UniProtKB: Q9QWG8 (UniProtKB/Swiss-Prot),   Q6Q8B1 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143226   ⟸   XM_063287156
- Peptide Label: isoform X1
- UniProtKB: Q9QWG8 (UniProtKB/Swiss-Prot),   Q6Q8B1 (UniProtKB/Swiss-Prot),   P54311 (UniProtKB/Swiss-Prot),   A6IUQ6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54311-F1-model_v2 AlphaFold P54311 1-340 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2718 AgrOrtholog
BioCyc Gene G2FUF-38925 BioCyc
Ensembl Genes ENSRNOG00000016638 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015622 UniProtKB/Swiss-Prot
  ENSRNOG00060003955 UniProtKB/Swiss-Prot
  ENSRNOG00065009937 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041789 ENTREZGENE
  ENSRNOT00000041789.3 UniProtKB/Swiss-Prot
  ENSRNOT00000116462.1 UniProtKB/TrEMBL
  ENSRNOT00055026696 UniProtKB/Swiss-Prot
  ENSRNOT00060006655 UniProtKB/Swiss-Prot
  ENSRNOT00065015992 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123318 IMAGE-MGC_LOAD
InterPro G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanine_nucleotide-bd_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93395 IMAGE-MGC_LOAD
NCBI Gene 24400 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) SUBUNIT BETA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnb1 PhenoGen
PIRSF GN-bd_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GPROTEINB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016638 RatGTEx
  ENSRNOG00055015622 RatGTEx
  ENSRNOG00060003955 RatGTEx
  ENSRNOG00065009937 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GEG9_RAT UniProtKB/TrEMBL
  A6IUQ6 ENTREZGENE, UniProtKB/TrEMBL
  GBB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q45QL8_RAT UniProtKB/TrEMBL
  Q6Q8B1 ENTREZGENE
  Q9QWG8 ENTREZGENE
UniProt Secondary Q6Q8B1 UniProtKB/Swiss-Prot
  Q9QWG8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Gnb1  G protein subunit beta 1  Gnb1  guanine nucleotide binding protein (G protein), beta polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Gnb1  guanine nucleotide binding protein (G protein), beta polypeptide 1  Gnb1  guanine nucleotide binding protein (G protein), beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Gnb1  guanine nucleotide binding protein (G protein), beta 1  Gnb1  guanine nucleotide binding protein, beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gnb1  Guanine nucleotide-binding protein beta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in cortex, striatum, hippocampus, hypothalamus, thalamus and dorsal raphe 632972