Symbol:
Flg
Name:
filaggrin
RGD ID:
2620
Description:
Predicted to enable keratin filament binding activity. Predicted to be a structural constituent of skin epidermis. Involved in epidermal cell differentiation. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cornified envelope and keratohyalin granule. Human ortholog(s) of this gene implicated in atopic dermatitis 2 and ichthyosis vulgaris. Orthologous to human FLG (filaggrin); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; acrylamide; ammonium chloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
Filaggrin (profilaggrin); LOC679174; Pflg; profilaggrin
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
FLG (filaggrin) RGD
RGD
Mus musculus (house mouse):
Flg (filaggrin) RGD
RGD
Pan paniscus (bonobo/pygmy chimpanzee):
FLG (filaggrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
FLG (filaggrin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
FLG (filaggrin)
Alliance
DIOPT (HGNC)
Latest Assembly:
GRCr8 - GRCr8 Assembly
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 2 181,583,801 - 181,596,464 (+) NCBI GRCr8 mRatBN7.2 2 178,884,793 - 178,912,986 (+) NCBI mRatBN7.2 mRatBN7.2 UTH_Rnor_SHR_Utx 2 186,449,517 - 186,478,945 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 2 184,429,834 - 184,448,291 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 2 179,092,619 - 179,122,045 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 2 193,565,401 - 193,574,297 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 2 211,289,344 - 211,294,588 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 186,307,359 - 186,311,549 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 2 186,259,903 - 186,260,929 (+) NCBI Celera 2 171,386,515 - 171,395,603 (-) NCBI Celera Cytogenetic Map 2 q34 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Flg Rat 1,3,5-trinitro-1,3,5-triazinane increases expression EXP 6480464 cyclonite results in increased expression of FLG mRNA CTD PMID:25559034 Flg Rat 17beta-estradiol increases expression ISO Flg (Mus musculus) 6480464 Estradiol results in increased expression of FLG mRNA CTD PMID:19484750 Flg Rat 17beta-estradiol decreases expression ISO FLG (Homo sapiens) 6480464 Estradiol results in decreased expression of FLG mRNA CTD PMID:28701262 Flg Rat 17beta-estradiol multiple interactions ISO FLG (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of FLG mRNA more ... CTD PMID:28701262 more ... Flg Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Flg (Mus musculus) 6480464 AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG protein] CTD PMID:12151643 Flg Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO FLG (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of FLG protein CTD PMID:24161567 Flg Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Flg (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of FLG protein CTD PMID:12151643 Flg Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO FLG (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of FLG mRNA and Tetrachlorodibenzodioxin results in increased expression of FLG protein CTD PMID:21835898 and PMID:23152189 Flg Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO FLG (Homo sapiens) 6480464 [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA] more ... CTD PMID:21835898 Flg Rat 2,4,5-trichlorophenol multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene mutant form affects the susceptibility to 2 more ... CTD PMID:30245359 Flg Rat 2,4,5-trichlorophenol affects response to substance ISO FLG (Homo sapiens) 6480464 FLG gene mutant form affects the susceptibility to 2 more ... CTD PMID:30245359 Flg Rat 2,4-D multiple interactions ISO Flg (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 Flg Rat 2,4-Dihydroxybenzophenone multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene mutant form affects the susceptibility to 2 more ... CTD PMID:30245359 Flg Rat 2,4-Dihydroxybenzophenone affects response to substance ISO FLG (Homo sapiens) 6480464 FLG gene mutant form affects the susceptibility to 2 and 4-dihydroxybenzophenone CTD PMID:30245359 Flg Rat 2,6-dimethoxyphenol multiple interactions ISO FLG (Homo sapiens) 6480464 [pyrogallol 1 more ... CTD PMID:38598786 Flg Rat 4-Hydroxybenzophenone multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in decreased secretion of FSHB protein and [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in increased secretion of Estradiol CTD PMID:30245359 Flg Rat 4-Hydroxybenzophenone affects response to substance ISO FLG (Homo sapiens) 6480464 FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone CTD PMID:30245359 Flg Rat 9-cis-retinoic acid decreases expression ISO FLG (Homo sapiens) 6480464 Alitretinoin results in decreased expression of FLG mRNA CTD PMID:15982314 Flg Rat acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of FLG mRNA CTD PMID:28959563 Flg Rat aflatoxin B1 decreases methylation ISO FLG (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of FLG gene CTD PMID:27153756 Flg Rat aldehydo-D-glucose multiple interactions ISO Flg (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 Flg Rat all-trans-4-oxoretinoic acid decreases expression ISO FLG (Homo sapiens) 6480464 4-oxoretinoic acid results in decreased expression of FLG mRNA CTD PMID:15982314 Flg Rat all-trans-retinoic acid increases expression ISO FLG (Homo sapiens) 6480464 Tretinoin metabolite results in increased expression of FLG mRNA CTD PMID:15982314 Flg Rat all-trans-retinoic acid decreases expression ISO Flg (Mus musculus) 6480464 Tretinoin results in decreased expression of FLG protein CTD PMID:25240866 Flg Rat all-trans-retinoic acid decreases expression ISO FLG (Homo sapiens) 6480464 Tretinoin results in decreased expression of FLG mRNA and Tretinoin results in decreased expression of FLG protein CTD PMID:15982314 and PMID:25240866 Flg Rat alpha-naphthoflavone multiple interactions ISO FLG (Homo sapiens) 6480464 [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA] CTD PMID:21835898 Flg Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of FLG mRNA CTD PMID:16483693 Flg Rat antimonite multiple interactions ISO FLG (Homo sapiens) 6480464 2-tert-butyl-9-fluoro-3 more ... CTD PMID:32076005 Flg Rat arsane multiple interactions ISO FLG (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of FLG mRNA CTD PMID:32525701 Flg Rat arsenic atom multiple interactions ISO FLG (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of FLG mRNA CTD PMID:32525701 Flg Rat arsenite(3-) multiple interactions ISO FLG (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of arsenite] which results in decreased expression of FLG mRNA and U 0126 inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which results in decreased expression of FLG mRNA] CTD PMID:32076005 Flg Rat avobenzone decreases expression ISO FLG (Homo sapiens) 6480464 avobenzone results in decreased expression of FLG mRNA CTD PMID:31016361 Flg Rat benzalkonium chloride increases expression ISO Flg (Mus musculus) 6480464 Benzalkonium Compounds results in increased expression of FLG mRNA CTD PMID:30171875 Flg Rat benzo[a]pyrene increases mutagenesis ISO FLG (Homo sapiens) 6480464 Benzo(a)pyrene results in increased mutagenesis of FLG gene CTD PMID:25435355 Flg Rat benzo[a]pyrene increases methylation ISO FLG (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of FLG 5' UTR and Benzo(a)pyrene results in increased methylation of FLG promoter CTD PMID:27901495 Flg Rat beta-damascenone increases expression ISO Flg (Mus musculus) 6480464 beta-damascenone results in increased expression of FLG mRNA and beta-damascenone results in increased expression of FLG protein CTD PMID:22982537 Flg Rat beta-naphthoflavone decreases expression ISO FLG (Homo sapiens) 6480464 beta-Naphthoflavone results in decreased expression of FLG protein CTD PMID:24161567 Flg Rat bis(2-ethylhexyl) phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of 2-ethyl-5-carboxypentyl phthalate more ... CTD PMID:24380925 Flg Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of FLG mRNA CTD PMID:25181051 Flg Rat bisphenol A affects response to substance ISO FLG (Homo sapiens) 6480464 FLG gene mutant form affects the susceptibility to bisphenol A CTD PMID:30245359 Flg Rat bisphenol A multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene mutant form affects the susceptibility to bisphenol A] which results in decreased secretion of FSHB protein more ... CTD PMID:28701262 and PMID:30245359 Flg Rat bisphenol A affects expression ISO FLG (Homo sapiens) 6480464 bisphenol A affects the expression of FLG mRNA CTD PMID:28701262 Flg Rat Butylbenzyl phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to butylbenzyl phthalate] which affects the abundance of mono-benzyl phthalate CTD PMID:24380925 Flg Rat C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of FLG mRNA CTD PMID:19167457 Flg Rat cadmium atom increases expression ISO FLG (Homo sapiens) 6480464 Cadmium results in increased expression of FLG mRNA CTD PMID:23369406 Flg Rat cadmium atom multiple interactions ISO FLG (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FLG mRNA CTD PMID:35301059 Flg Rat cadmium dichloride increases expression ISO FLG (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of FLG mRNA CTD PMID:38568856 Flg Rat cadmium dichloride multiple interactions ISO FLG (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FLG mRNA CTD PMID:35301059 Flg Rat calcipotriol decreases expression ISO FLG (Homo sapiens) 6480464 calcipotriene results in decreased expression of FLG protein CTD PMID:7508215 Flg Rat calcitriol decreases expression ISO FLG (Homo sapiens) 6480464 Calcitriol results in decreased expression of FLG protein CTD PMID:7508215 Flg Rat clofibrate multiple interactions ISO Flg (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of FLG mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FLG mRNA] CTD PMID:17585979 Flg Rat clofibrate increases expression ISO Flg (Mus musculus) 6480464 Clofibrate results in increased expression of FLG mRNA and Clofibrate results in increased expression of FLG protein CTD PMID:10951269 Flg Rat cortisol decreases expression ISO FLG (Homo sapiens) 6480464 Hydrocortisone results in decreased expression of FLG mRNA CTD PMID:32076005 Flg Rat cortisol multiple interactions ISO FLG (Homo sapiens) 6480464 Hydrocortisone inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of antimonite] which results in decreased expression of FLG mRNA] CTD PMID:32076005 Flg Rat D-glucose multiple interactions ISO Flg (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 Flg Rat dibutyl phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to Dibutyl Phthalate] which affects the abundance of monobutyl phthalate CTD PMID:24380925 Flg Rat diethyl phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to diethyl phthalate] which affects the abundance of monoethyl phthalate CTD PMID:24380925 Flg Rat diethylstilbestrol increases expression ISO Flg (Mus musculus) 6480464 Diethylstilbestrol results in increased expression of FLG mRNA CTD PMID:15171707 Flg Rat diisobutyl phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to diisobutyl phthalate] which affects the abundance of mono-isobutyl phthalate CTD PMID:24380925 Flg Rat diisononyl phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to diisononyl phthalate] which affects the abundance of monoisononylphthalate CTD PMID:24380925 Flg Rat dimethylarsinic acid increases expression ISO Flg (Mus musculus) 6480464 Cacodylic Acid results in increased expression of FLG mRNA CTD PMID:32052077 Flg Rat dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate decreases expression ISO FLG (Homo sapiens) 6480464 Antimony Potassium Tartrate results in decreased expression of FLG mRNA CTD PMID:28713220 Flg Rat dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate multiple interactions ISO FLG (Homo sapiens) 6480464 2-tert-butyl-9-fluoro-3 more ... CTD PMID:32076005 Flg Rat doxorubicin increases expression ISO FLG (Homo sapiens) 6480464 Doxorubicin results in increased expression of FLG mRNA CTD PMID:30031762 Flg Rat folic acid increases expression ISO FLG (Homo sapiens) 6480464 Folic Acid results in increased expression of FLG mRNA CTD PMID:21867686 Flg Rat folic acid increases expression ISO Flg (Mus musculus) 6480464 Folic Acid results in increased expression of FLG mRNA CTD PMID:25629700 Flg Rat fructose multiple interactions ISO Flg (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 Flg Rat fucoxanthin decreases expression ISO Flg (Mus musculus) 6480464 fucoxanthin results in decreased expression of FLG mRNA CTD PMID:27590588 Flg Rat fulvestrant multiple interactions ISO FLG (Homo sapiens) 6480464 fulvestrant affects the reaction [bisphenol A affects the expression of FLG mRNA] and fulvestrant inhibits the reaction [Estradiol results in decreased expression of FLG mRNA] CTD PMID:28701262 Flg Rat furfural multiple interactions ISO FLG (Homo sapiens) 6480464 [pyrogallol 1 more ... CTD PMID:38598786 Flg Rat glucose multiple interactions ISO Flg (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:37567420 Flg Rat hydroquinone increases expression ISO Flg (Mus musculus) 6480464 hydroquinone results in increased expression of FLG protein CTD PMID:25240866 Flg Rat hydroquinone increases expression ISO FLG (Homo sapiens) 6480464 hydroquinone results in increased expression of FLG mRNA and hydroquinone results in increased expression of FLG protein CTD PMID:25240866 Flg Rat indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FLG mRNA CTD PMID:22129741 Flg Rat iron dichloride decreases expression ISO FLG (Homo sapiens) 6480464 ferrous chloride results in decreased expression of FLG mRNA CTD PMID:35984750 Flg Rat isotretinoin decreases expression ISO FLG (Homo sapiens) 6480464 Isotretinoin results in decreased expression of FLG mRNA CTD PMID:15982314 Flg Rat lucanthone decreases expression ISO FLG (Homo sapiens) 6480464 Lucanthone results in decreased expression of FLG mRNA CTD PMID:21148553 Flg Rat LY294002 multiple interactions ISO Flg (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in decreased expression of FLG protein] CTD PMID:31884678 Flg Rat methylparaben multiple interactions ISO FLG (Homo sapiens) 6480464 FLG gene mutant form affects the abundance of and affects the susceptibility to methylparaben CTD PMID:28525834 Flg Rat mono(2-ethyl-5-hydroxyhexyl) phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-hydroxyhexyl) phthalate CTD PMID:24380925 Flg Rat mono(2-ethyl-5-oxohexyl) phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:24380925 Flg Rat mono(2-ethylhexyl) phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of mono-(2-ethylhexyl)phthalate CTD PMID:24380925 Flg Rat mono(5-carboxy-2-ethylpentyl) phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to Diethylhexyl Phthalate] which affects the abundance of 2-ethyl-5-carboxypentyl phthalate CTD PMID:24380925 Flg Rat monobenzyl phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to butylbenzyl phthalate] which affects the abundance of mono-benzyl phthalate CTD PMID:24380925 Flg Rat Monobutylphthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to Dibutyl Phthalate] which affects the abundance of monobutyl phthalate CTD PMID:24380925 Flg Rat monoethyl phthalate multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene polymorphism affects the susceptibility to diethyl phthalate] which affects the abundance of monoethyl phthalate CTD PMID:24380925 Flg Rat N-acetyl-L-cysteine multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FLG mRNA CTD PMID:22129741 Flg Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FLG mRNA CTD PMID:22129741 Flg Rat nickel atom affects response to substance ISO FLG (Homo sapiens) 6480464 FLG protein affects the susceptibility to Nickel CTD PMID:21166815 Flg Rat nickel sulfate decreases expression ISO FLG (Homo sapiens) 6480464 nickel sulfate results in decreased expression of FLG mRNA CTD PMID:22714537 Flg Rat NS-398 multiple interactions ISO Flg (Mus musculus) 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Particulate Matter results in decreased expression of FLG protein] CTD PMID:31884678 Flg Rat oxybenzone affects response to substance ISO FLG (Homo sapiens) 6480464 FLG gene mutant form affects the susceptibility to oxybenzone CTD PMID:30245359 Flg Rat oxybenzone multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein more ... CTD PMID:30245359 Flg Rat paracetamol multiple interactions ISO Flg (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of FLG mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FLG mRNA] CTD PMID:17585979 Flg Rat perfluoroheptanoic acid increases expression ISO Flg (Mus musculus) 6480464 perfluoro-n-heptanoic acid results in increased expression of FLG mRNA CTD PMID:36435305 Flg Rat perfluorohexanesulfonic acid increases expression ISO Flg (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of FLG mRNA CTD PMID:38458531 Flg Rat perfluorohexanoic acid increases expression ISO Flg (Mus musculus) 6480464 perfluorohexanoic acid results in increased expression of FLG mRNA CTD PMID:36435305 Flg Rat perfluoropentanoic acid increases expression ISO Flg (Mus musculus) 6480464 perfluoropentanoic acid results in increased expression of FLG mRNA CTD PMID:36435305 Flg Rat phenacetin increases expression EXP 6480464 Phenacetin results in increased expression of FLG mRNA CTD PMID:17082564 Flg Rat phenylhydrazine increases expression EXP 6480464 phenylhydrazine results in increased expression of FLG mRNA CTD PMID:17082564 Flg Rat pirinixic acid increases expression ISO Flg (Mus musculus) 6480464 pirinixic acid results in increased expression of FLG mRNA and pirinixic acid results in increased expression of FLG protein CTD PMID:10951269 and PMID:20813756 Flg Rat propylparaben multiple interactions ISO FLG (Homo sapiens) 6480464 FLG gene mutant form affects the abundance of and affects the susceptibility to propylparaben CTD PMID:28525834 Flg Rat quercitrin increases expression ISO FLG (Homo sapiens) 6480464 quercitrin results in increased expression of FLG mRNA CTD PMID:25193878 Flg Rat sodium arsenate multiple interactions ISO FLG (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of FLG mRNA CTD PMID:32525701 Flg Rat sodium arsenate decreases expression ISO FLG (Homo sapiens) 6480464 sodium arsenate results in decreased expression of FLG mRNA CTD PMID:11485391 and PMID:12727804 Flg Rat sodium arsenite decreases expression ISO FLG (Homo sapiens) 6480464 sodium arsenite results in decreased expression of FLG mRNA CTD PMID:11485391 more ... Flg Rat sodium arsenite multiple interactions ISO FLG (Homo sapiens) 6480464 [sodium arsenite results in increased abundance of arsenite] which results in decreased expression of FLG mRNA and U 0126 inhibits the reaction [[sodium arsenite results in increased abundance of arsenite] which results in decreased expression of FLG mRNA] CTD PMID:32076005 Flg Rat sodium arsenite increases expression ISO FLG (Homo sapiens) 6480464 sodium arsenite results in increased expression of FLG mRNA and sodium arsenite results in increased expression of FLG protein CTD PMID:19524636 Flg Rat sodium chloride multiple interactions ISO FLG (Homo sapiens) 6480464 [Sodium Chloride co-treated with Furaldehyde] results in increased expression of and affects the localization of FLG protein more ... CTD PMID:38598786 Flg Rat sodium dodecyl sulfate increases expression ISO FLG (Homo sapiens) 6480464 Sodium Dodecyl Sulfate results in increased expression of FLG mRNA and Sodium Dodecyl Sulfate results in increased expression of FLG protein CTD PMID:25240866 Flg Rat temozolomide increases expression ISO FLG (Homo sapiens) 6480464 Temozolomide results in increased expression of FLG mRNA CTD PMID:31758290 Flg Rat testosterone multiple interactions ISO FLG (Homo sapiens) 6480464 [FLG gene mutant form affects the susceptibility to 2 more ... CTD PMID:30245359 Flg Rat trans-urocanic acid decreases abundance ISO FLG (Homo sapiens) 6480464 FLG mutant form results in decreased abundance of Urocanic Acid CTD PMID:24061166 Flg Rat triclosan increases expression ISO Flg (Mus musculus) 6480464 Triclosan results in increased expression of FLG mRNA and Triclosan results in increased expression of FLG protein CTD PMID:34515797 Flg Rat triptonide increases expression ISO Flg (Mus musculus) 6480464 triptonide results in increased expression of FLG mRNA CTD PMID:33045310 Flg Rat urocanic acid decreases abundance ISO FLG (Homo sapiens) 6480464 FLG mutant form results in decreased abundance of Urocanic Acid CTD PMID:24061166
1,3,5-trinitro-1,3,5-triazinane (EXP) 17beta-estradiol (ISO) 2,3,7,8-tetrachlorodibenzodioxine (ISO) 2,4,5-trichlorophenol (ISO) 2,4-D (ISO) 2,4-Dihydroxybenzophenone (ISO) 2,6-dimethoxyphenol (ISO) 4-Hydroxybenzophenone (ISO) 9-cis-retinoic acid (ISO) acrylamide (EXP) aflatoxin B1 (ISO) aldehydo-D-glucose (ISO) all-trans-4-oxoretinoic acid (ISO) all-trans-retinoic acid (ISO) alpha-naphthoflavone (ISO) ammonium chloride (EXP) antimonite (ISO) arsane (ISO) arsenic atom (ISO) arsenite(3-) (ISO) avobenzone (ISO) benzalkonium chloride (ISO) benzo[a]pyrene (ISO) beta-damascenone (ISO) beta-naphthoflavone (ISO) bis(2-ethylhexyl) phthalate (ISO) bisphenol A (EXP,ISO) Butylbenzyl phthalate (ISO) C60 fullerene (EXP) cadmium atom (ISO) cadmium dichloride (ISO) calcipotriol (ISO) calcitriol (ISO) clofibrate (ISO) cortisol (ISO) D-glucose (ISO) dibutyl phthalate (ISO) diethyl phthalate (ISO) diethylstilbestrol (ISO) diisobutyl phthalate (ISO) diisononyl phthalate (ISO) dimethylarsinic acid (ISO) dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO) doxorubicin (ISO) folic acid (ISO) fructose (ISO) fucoxanthin (ISO) fulvestrant (ISO) furfural (ISO) glucose (ISO) hydroquinone (ISO) indole-3-methanol (EXP) iron dichloride (ISO) isotretinoin (ISO) lucanthone (ISO) LY294002 (ISO) methylparaben (ISO) mono(2-ethyl-5-hydroxyhexyl) phthalate (ISO) mono(2-ethyl-5-oxohexyl) phthalate (ISO) mono(2-ethylhexyl) phthalate (ISO) mono(5-carboxy-2-ethylpentyl) phthalate (ISO) monobenzyl phthalate (ISO) Monobutylphthalate (ISO) monoethyl phthalate (ISO) N-acetyl-L-cysteine (EXP) N-nitrosodiethylamine (EXP) nickel atom (ISO) nickel sulfate (ISO) NS-398 (ISO) oxybenzone (ISO) paracetamol (ISO) perfluoroheptanoic acid (ISO) perfluorohexanesulfonic acid (ISO) perfluorohexanoic acid (ISO) perfluoropentanoic acid (ISO) phenacetin (EXP) phenylhydrazine (EXP) pirinixic acid (ISO) propylparaben (ISO) quercitrin (ISO) sodium arsenate (ISO) sodium arsenite (ISO) sodium chloride (ISO) sodium dodecyl sulfate (ISO) temozolomide (ISO) testosterone (ISO) trans-urocanic acid (ISO) triclosan (ISO) triptonide (ISO) urocanic acid (ISO)
1.
Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
2.
Filaggrin, an intermediate filament-associated protein: structural and functional implications from the sequence of a cDNA from rat.
Haydock PV and Dale BA, DNA Cell Biol 1990 May;9(4):251-61.
3.
Antisense profilaggrin RNA delays and decreases profilaggrin expression and alters in vitro differentiation of rat epidermal keratinocytes.
Haydock PV, etal., J Invest Dermatol. 1993 Aug;101(2):118-26.
4.
Induction of selected lipid metabolic enzymes and differentiation-linked structural proteins by air exposure in fetal rat skin explants.
Komuves LG, etal., J Invest Dermatol. 1999 Mar;112(3):303-9.
5.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
6.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
8.
Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution.
Pearton DJ, etal., J Invest Dermatol. 2002 Sep;119(3):661-9.
9.
GOA pipeline
RGD automated data pipeline
10.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
12.
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.
Smith FJ, etal., Nat Genet. 2006 Mar;38(3):337-42. Epub 2006 Jan 29.
Flg Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 2 181,583,801 - 181,596,464 (+) NCBI GRCr8 mRatBN7.2 2 178,884,793 - 178,912,986 (+) NCBI mRatBN7.2 mRatBN7.2 UTH_Rnor_SHR_Utx 2 186,449,517 - 186,478,945 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 2 184,429,834 - 184,448,291 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 2 179,092,619 - 179,122,045 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 2 193,565,401 - 193,574,297 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 2 211,289,344 - 211,294,588 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 186,307,359 - 186,311,549 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 2 186,259,903 - 186,260,929 (+) NCBI Celera 2 171,386,515 - 171,395,603 (-) NCBI Celera Cytogenetic Map 2 q34 NCBI
FLG Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 1 152,302,165 - 152,325,239 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 1 152,302,165 - 152,325,239 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 1 152,274,641 - 152,297,715 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 1 150,541,275 - 150,564,303 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 1 125,386,606 - 125,408,667 (-) NCBI Celera Cytogenetic Map 1 q21.3 NCBI HuRef 1 123,649,333 - 123,671,391 (-) NCBI HuRef CHM1_1 1 153,670,002 - 153,693,030 (-) NCBI CHM1_1 T2T-CHM13v2.0 1 151,437,741 - 151,461,789 (-) NCBI T2T-CHM13v2.0
Flg Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 3 93,180,853 - 93,200,996 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 3 93,180,830 - 93,200,993 (+) Ensembl GRCm39 Ensembl GRCm38 3 93,273,546 - 93,293,689 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 3 93,273,523 - 93,293,686 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 3 93,089,108 - 93,097,615 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 3 93,367,872 - 93,379,097 (+) NCBI MGSCv36 mm8 Celera 3 93,804,333 - 93,822,603 (-) NCBI Celera Cytogenetic Map 3 F2.1 NCBI cM Map 3 40.16 NCBI
FLG Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 1 97,536,576 - 97,547,401 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 1 97,286,770 - 97,298,567 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 1 127,634,416 - 127,649,659 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 1 131,276,648 - 131,285,336 (-) NCBI panpan1.1 PanPan1.1 panPan2
FLG Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 17 61,217,915 - 61,233,068 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 17 60,662,290 - 60,679,224 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 17 62,238,036 - 62,255,220 (-) NCBI ROS_Cfam_1.0 UMICH_Zoey_3.1 17 61,075,602 - 61,083,175 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 17 61,151,018 - 61,170,965 (-) NCBI UNSW_CanFamBas_1.0
.
1578648 Bss11 Bone structure and strength QTL 11 4.7 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 2 114837527 211674221 Rat 1358356 Srcrt1 Stress Responsive Cort QTL1 3.66 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 2 161699179 222436696 Rat 1331734 Bp204 Blood pressure QTL 204 3.61192 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 2 168358098 223265385 Rat 1298074 Bp164 Blood pressure QTL 164 0.003 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 42804607 202447032 Rat 1354648 Bp239 Blood pressure QTL 239 0.001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 66118463 226797303 Rat 1354649 Kidm17 Kidney mass QTL 17 2.9 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) 2 81754530 227146641 Rat 10755499 Bp389 Blood pressure QTL 389 2.61 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 2 18960362 228801039 Rat 1298076 Bp166 Blood pressure QTL 166 0.0009 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 136445150 202447032 Rat 152025245 Scl81 Serum cholesterol level QTL 81 3.49 blood cholesterol amount (VT:0000180) 2 122609194 206936711 Rat 70162 Bp63 Blood pressure QTL 63 5.64 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 2 169745596 214745596 Rat 1554319 Bmd2 Bone mineral density QTL 2 13.4 0.0001 lumbar vertebra area (VT:0010570) lumbar vertebra cross-sectional area (CMO:0001689) 2 114837675 212549332 Rat 12879836 Kidm61 Kidney mass QTL 61 0.001 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 2 152413072 185122374 Rat 1581569 Uae32 Urinary albumin excretion QTL 32 0.0001 urine protein amount (VT:0005160) urine albumin excretion rate (CMO:0000757) 2 78665619 219826953 Rat 10043136 Iddm54 Insulin dependent diabetes mellitus QTL 54 3.4 0.0001 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) 2 143657411 190602963 Rat 12879837 Am2 Aortic mass QTL 2 0.001 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 2 152413072 185122374 Rat 12879838 Cm86 Cardiac mass QTL 86 0.002 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 2 152413072 185122374 Rat 1302793 Bw16 Body weight QTL 16 5 0.0001 body mass (VT:0001259) body weight (CMO:0000012) 2 157142209 202446871 Rat 61467 Bp14 Blood pressure QTL 14 2.2 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 43154682 202446871 Rat 12879839 Cm85 Cardiac mass QTL 85 0.001 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) 2 152413072 185122374 Rat 61469 Bp16 Blood pressure QTL 16 5.64 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 2 169745596 214745596 Rat 70175 BpQTLCluster3 Blood pressure QTL cluster 3 4.128 arterial blood pressure trait (VT:2000000) absolute change in systolic blood pressure (CMO:0000607) 2 135552573 202446871 Rat 1549833 Bp257 Blood pressure QTL 257 0.003 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 2 168354880 185122374 Rat 1358900 Bw48 Body weight QTL 48 4.88 body mass (VT:0001259) body weight (CMO:0000012) 2 157142078 211086598 Rat 1359030 Bp277 Blood pressure QTL 277 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 2 114837527 185876470 Rat 1331760 Bp206 Blood pressure QTL 206 3.62454 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 2 56043031 202447032 Rat 12879840 Bw179 Body weight QTL 179 0.005 body mass (VT:0001259) body weight (CMO:0000012) 2 152413072 185122374 Rat 1581502 Esta3 Estrogen-induced thymic atrophy QTL 3 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 2 136916935 189599348 Rat 1359032 Hrtrt18 Heart rate QTL 18 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 2 157142078 192625452 Rat 2301966 Bp322 Blood pressure QTL 322 3.58 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 150540301 202447032 Rat 1298080 Bp163 Blood pressure QTL 163 0.02 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 66118275 202447032 Rat 8662832 Vetf7 Vascular elastic tissue fragility QTL 7 3.5 aorta elastin amount (VT:0003905) aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002) 2 81689826 221035911 Rat 1298085 Bp165 Blood pressure QTL 165 0.0006 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 42804607 202447032 Rat 1359022 Ppulsi1 Prepulse inhibition QTL 1 3.63 prepulse inhibition trait (VT:0003088) acoustic startle response measurement (CMO:0001519) 2 136916935 213594495 Rat 1641891 Alcrsp17 Alcohol response QTL 17 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 2 149559561 249053267 Rat 724534 Uae6 Urinary albumin excretion QTL 6 10 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 2 78665619 249053267 Rat 61374 Edpm2 Estrogen-dependent pituitary mass QTL 2 4.42 0.86 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) 2 76539322 202447032 Rat 8662843 Vetf9 Vascular elastic tissue fragility QTL 9 2.05 thoracic aorta molecular composition trait (VT:0010568) aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003) 2 157142078 226277316 Rat 631501 Bp101 Blood pressure QTL 101 2.4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 150341684 202446871 Rat 2307174 Activ3 Activity QTL 3 4.83 0.000058 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 2 168594495 213594495 Rat 1331794 Bp202 Blood pressure QTL 202 3.66819 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 141194931 223265385 Rat 71113 Cari2 Carrageenan-induced inflammation QTL 2 2.7 0.009 hypodermis integrity trait (VT:0010550) inflammatory exudate volume (CMO:0001429) 2 141596551 202447032 Rat 1331805 Cm29 Cardiac mass QTL 29 3.50746 heart mass (VT:0007028) heart wet weight (CMO:0000069) 2 141194931 223265385 Rat 634308 Sach6 Saccharin preference QTL 6 4.9 taste sensitivity trait (VT:0001986) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) 2 112456140 212696837 Rat 1598805 Memor8 Memory QTL 8 3 exploratory behavior trait (VT:0010471) average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674) 2 150341585 189039377 Rat 1358917 Cm42 Cardiac mass QTL 42 2.82 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 2 25413423 203928301 Rat 724568 Uae13 Urinary albumin excretion QTL 13 4.4 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 2 143157029 210020885 Rat 1358913 Cm41 Cardiac mass QTL 41 2.73 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 2 25413423 203928301 Rat 1300165 Rf9 Renal function QTL 9 3.28 kidney glomerulus integrity trait (VT:0010546) index of glomerular damage (CMO:0001135) 2 133914684 202447032 Rat 61401 Niddm2 Non-insulin dependent diabetes mellitus QTL 2 4.54 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 2 144599348 189599348 Rat 631507 Bp105 Blood pressure QTL 105 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 2 112456140 212696837 Rat 1641925 Alcrsp2 Alcohol response QTL 2 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 2 149559561 221167075 Rat 1354609 Niddm62 Non-insulin dependent diabetes mellitus QTL 62 4.72 0.000006 insulin secretion trait (VT:0003564) plasma insulin level (CMO:0000342) 2 150540301 202447032 Rat 1598833 Bp295 Blood pressure QTL 295 3.5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 147798556 192798556 Rat 1354622 Kidm16 Kidney mass QTL 16 3 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 2 81754530 222436696 Rat 631266 Bp132 Blood pressure QTL 132 0.0005 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 46123260 202447032 Rat 631522 Bp74 Blood pressure QTL 74 0.05 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 172710921 184114403 Rat 7488927 Bp365 Blood pressure QTL 365 0.008 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 2 162765032 207765032 Rat 1598838 Bp290 Blood pressure QTL 290 1.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 166539266 211539266 Rat 7488925 Bp364 Blood pressure QTL 364 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 2 160564068 205564068 Rat 2293843 Kiddil6 Kidney dilation QTL 6 3.1 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 2 42804607 182042367 Rat 2306901 Bp337 Blood pressure QTL 337 0.01 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 2 164073756 227146641 Rat 1354605 Rf48 Renal function QTL 48 2.9 blood creatinine amount (VT:0005328) plasma creatinine level (CMO:0000537) 2 74786664 206665859 Rat 6903312 Bw112 Body weight QTL 112 3.2 0.0013 body mass (VT:0001259) body weight (CMO:0000012) 2 143657569 184114274 Rat 1354601 Slep1 Serum leptin concentration QTL 1 5.39 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 2 43171017 184114403 Rat 2293084 Iddm26 Insulin dependent diabetes mellitus QTL 26 2.9 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 2 174930955 213594495 Rat
Flg
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 2 178,909,027 - 178,909,309 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,891,975 - 178,892,257 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,893,193 - 178,893,475 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,899,283 - 178,899,565 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,900,501 - 178,900,783 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,904,155 - 178,904,437 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,905,373 - 178,905,655 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,906,591 - 178,906,873 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,907,809 - 178,908,091 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,890,757 - 178,891,039 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,910,245 - 178,910,527 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,911,463 - 178,911,745 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,898,065 - 178,898,347 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,896,847 - 178,897,129 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,895,629 - 178,895,911 (+) MAPPER mRatBN7.2 mRatBN7.2 2 178,894,411 - 178,894,693 (+) MAPPER mRatBN7.2 Rnor_6.0 2 193,572,763 - 193,573,044 NCBI Rnor6.0 Rnor_5.0 2 211,292,237 - 211,292,518 UniSTS Rnor5.0 Cytogenetic Map 2 q34 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
RefSeq Acc Id:
NM_001393766 ⟹ NP_001380695
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 2 181,583,801 - 181,596,464 (+) NCBI mRatBN7.2 2 178,884,793 - 178,912,986 (+) NCBI
RefSeq Acc Id:
NP_001380695 ⟸ NM_001393766
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2013-03-29
Flg
filaggrin
LOC679174
similar to filaggrin
Data merged from RGD:1591824
737654 PROVISIONAL
2006-11-20
LOC679174
similar to filaggrin
Symbol and Name status set to provisional
70820 PROVISIONAL
2002-11-06
Flg
filaggrin
Filaggrin (profilaggrin)
Name updated
625702 APPROVED
2002-06-10
Flg
Filaggrin (profilaggrin)
Symbol and Name status set to approved
70586 APPROVED
Note Type
Note
Reference
gene_domains
contains two repeats of 406 amino acid with a filaggrin domain in each repeat
632675
gene_expression
expressed in fully cornified cells of the mammalian epidermis, mRNA highly expressed only in keratinizing epithelia
632675
gene_process
responsible for epidermal differentiation
632675
gene_transcript
cDNA is 2,314 bp long and has a 1,875 bp long coding region ending with an A-T rich 3' noncoding region
632675
