Iglc1 (immunoglobulin lambda constant 1) - Rat Genome Database

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Gene: Iglc1 (immunoglobulin lambda constant 1) Rattus norvegicus
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Symbol: Iglc1
Name: immunoglobulin lambda constant 1
RGD ID: 2319568
Description: Predicted to be located in external side of plasma membrane. Predicted to be part of B cell receptor complex. Orthologous to several human genes including IGLC2 (immunoglobulin lambda constant 2); IGLC3 (immunoglobulin lambda constant 3 (Kern-Oz+ marker)); and IGLC6 (immunoglobulin lambda constant 6); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; acrylamide.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ig lambda-1 chain C region-like; Ig lambda-2 chain C region; lambda-chain C1-region-like; LOC100361706
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,452,233 - 95,454,185 (+)NCBIGRCr8
mRatBN7.21181,947,966 - 81,949,822 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,947,934 - 81,949,822 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01186,094,822 - 86,096,399 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,094,567 - 86,096,397 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,196,933 - 89,198,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,198,234 - 84,199,868 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1180,730,236 - 80,731,679 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1373499   PMID:3114047  


Genomics

Comparative Map Data
Iglc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,452,233 - 95,454,185 (+)NCBIGRCr8
mRatBN7.21181,947,966 - 81,949,822 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,947,934 - 81,949,822 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01186,094,822 - 86,096,399 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,094,567 - 86,096,397 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,196,933 - 89,198,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,198,234 - 84,199,868 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1180,730,236 - 80,731,679 (+)NCBICelera
Cytogenetic Map11q23NCBI
IGLC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,895,375 - 22,895,694 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2222,895,375 - 22,895,834 (+)EnsemblGRCh38hg38GRCh38
GRCh372223,237,555 - 23,237,874 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,567,557 - 21,567,874NCBINCBI36Build 36hg18NCBI36
Celera227,052,136 - 7,052,455 (+)NCBICelera
Cytogenetic Map22q11.22NCBI
HuRef226,205,404 - 6,205,723 (+)NCBIHuRef
CHM1_12223,249,845 - 23,250,164 (+)NCBICHM1_1
T2T-CHM13v2.02223,318,284 - 23,318,603 (+)NCBIT2T-CHM13v2.0
Iglc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,880,502 - 18,880,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,880,368 - 18,880,821 (-)EnsemblGRCm39 Ensembl
GRCm381619,061,752 - 19,062,071 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1619,061,618 - 19,062,071 (-)EnsemblGRCm38mm10GRCm38
MGSCv371619,061,845 - 19,062,164 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361618,975,315 - 18,975,634 (-)NCBIMGSCv36mm8
Celera1619,635,804 - 19,636,123 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.8NCBI

Variants

.
Variants in Iglc1
3 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
RH130450  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,915,116 - 81,915,322 (+)MAPPERmRatBN7.2
mRatBN7.21181,949,523 - 81,949,729 (+)MAPPERmRatBN7.2
Rnor_6.01186,096,101 - 86,096,306NCBIRnor6.0
Rnor_5.01189,198,067 - 89,198,272UniSTSRnor5.0
RGSC_v3.41184,199,570 - 84,199,775UniSTSRGSC3.4
Celera1180,731,381 - 80,731,586UniSTS
Celera1180,698,007 - 80,698,212UniSTS
RH 3.4 Map11714.3UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 27 31 73 75 46 25 46 1 157 65 18 31 35 29

Sequence


Ensembl Acc Id: ENSRNOT00000086514   ⟹   ENSRNOP00000074645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,947,934 - 81,949,822 (+)Ensembl
Rnor_6.0 Ensembl1186,094,567 - 86,096,397 (+)Ensembl
RefSeq Acc Id: XM_006248649   ⟹   XP_006248711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,452,621 - 95,454,185 (+)NCBI
mRatBN7.21181,948,258 - 81,949,822 (+)NCBI
Rnor_6.01186,094,822 - 86,096,399 (+)NCBI
Rnor_5.01189,196,933 - 89,198,358 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088979   ⟹   XP_038944907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,452,233 - 95,454,185 (+)NCBI
mRatBN7.21181,947,966 - 81,949,822 (+)NCBI
Protein Sequences
Protein RefSeqs XP_006248711 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944907 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054780.5
  ENSRNOP00000074645.1
RefSeq Acc Id: XP_006248711   ⟸   XM_006248649
- Peptide Label: isoform X1
- UniProtKB: P20766 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074645   ⟸   ENSRNOT00000086514
RefSeq Acc Id: XP_038944907   ⟸   XM_039088979
- Peptide Label: isoform X2
- UniProtKB: P20766 (UniProtKB/Swiss-Prot),   A0A0G2K8K8 (UniProtKB/TrEMBL)
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8K8-F1-model_v2 AlphaFold A0A0G2K8K8 1-121 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319568 AgrOrtholog
BioCyc Gene G2FUF-20679 BioCyc
Ensembl Genes ENSRNOG00000050000 UniProtKB/Swiss-Prot
  ENSRNOG00000058590 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057971.5 UniProtKB/Swiss-Prot
  ENSRNOT00000086514.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC/Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 100361706 ENTREZGENE
PANTHER IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC CLASS II-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Iglc1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050000 RatGTEx
  ENSRNOG00000058590 RatGTEx
SMART IGc1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K8K8 ENTREZGENE, UniProtKB/TrEMBL
  LAC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-27 Iglc1  immunoglobulin lambda constant 1  LOC100361706  lambda-chain C1-region-like  Name and Symbol changed 629549 APPROVED
2010-05-05 LOC100361706  lambda-chain C1-region-like      Symbol and Name status set to provisional 70820 PROVISIONAL