Bco1 (beta-carotene oxygenase 1) - Rat Genome Database

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Gene: Bco1 (beta-carotene oxygenase 1) Heterocephalus glaber
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Symbol: Bco1
Name: beta-carotene oxygenase 1
RGD ID: 18933373
Description: ENCODES a protein that exhibits beta-carotene 15,15'-dioxygenase activity (ortholog); INVOLVED IN beta-carotene metabolic process (ortholog); retinal metabolic process (ortholog); retinoid metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH Hypercarotenemia and Vitamin A Deficiency, Autosomal Dominant (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Bcmo1; beta,beta-carotene 15,15'-dioxygenase; Beta,beta-carotene 15,15'-monooxygenase; beta-carotene 15,15'-monooxygenase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247466,143,892 - 6,180,408 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247466,146,338 - 6,181,020 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Bco1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247466,143,892 - 6,180,408 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247466,146,338 - 6,181,020 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
BCO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381681,238,689 - 81,291,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1681,238,576 - 81,291,226 (+)Ensemblhg38GRCh38
GRCh371681,272,294 - 81,324,747 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361679,829,797 - 79,882,248 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341679,829,796 - 79,882,248NCBI
Celera1665,569,740 - 65,622,032 (+)NCBICelera
Cytogenetic Map16q23.2NCBI
HuRef1667,027,575 - 67,079,925 (+)NCBIHuRef
CHM1_11682,683,655 - 82,736,052 (+)NCBICHM1_1
T2T-CHM13v2.01687,299,473 - 87,351,905 (+)NCBIT2T-CHM13v2.0
Bco1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398117,822,590 - 117,860,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8117,822,593 - 117,860,459 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388117,095,851 - 117,133,720 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,095,854 - 117,133,720 (+)Ensemblmm10GRCm38
MGSCv378119,619,765 - 119,657,620 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368119,981,842 - 120,019,458 (+)NCBIMGSCv36mm8
Celera8121,315,369 - 121,353,295 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map863.61NCBI
Bco1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81962,058,061 - 62,094,923 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1962,058,089 - 62,094,917 (+)EnsemblGRCr8
mRatBN7.21945,149,250 - 45,186,102 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,149,265 - 45,186,101 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1951,959,095 - 51,995,942 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,612,116 - 52,648,960 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,856,354 - 54,893,189 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1955,855,529 - 55,892,072 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1953,979,111 - 54,015,648 (+)NCBILyon_Normotensive
Lyon_Hypertensive1955,853,790 - 55,890,331 (+)NCBILyon_Hypertensive
F344_StmMcwi1953,573,316 - 53,610,153 (+)NCBIF344_StmMcwi
Rnor_6.01949,637,059 - 49,673,577 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,637,016 - 49,673,808 (+)Ensemblrn6Rnor6.0
Rnor_5.01960,424,580 - 60,460,636 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41947,202,955 - 47,239,225 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1944,421,345 - 44,457,802 (+)NCBICelera
RGSC_v3.11947,207,835 - 47,244,106 (+)NCBI
Cytogenetic Map19q12NCBI
Bco1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555223,985,266 - 4,018,886 (+)Ensembl
ChiLan1.0NW_0049555223,985,515 - 4,018,116 (+)NCBIChiLan1.0ChiLan1.0
BCO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21890,987,587 - 91,047,027 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11696,908,478 - 96,962,121 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01661,843,567 - 61,897,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11681,270,957 - 81,323,088 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,270,577 - 81,323,088 (+)EnsemblpanPan2panpan1.1
BCO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,598,743 - 70,637,273 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,599,284 - 70,637,017 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha570,547,948 - 70,586,427 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0570,903,713 - 70,942,206 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl570,903,715 - 70,942,392 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1570,846,152 - 70,884,642 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,681,343 - 70,719,822 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0571,159,198 - 71,197,682 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bco1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,698,707 - 30,729,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647528,859,318 - 28,889,934 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647528,859,222 - 28,890,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl67,012,332 - 7,055,305 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.167,008,330 - 7,054,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BCO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1566,681,756 - 66,730,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl566,681,513 - 66,733,604 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660479,105,596 - 9,155,354 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bco1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11736,750,709 - 36,786,831 (+)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000024958   ⟹   ENSHGLP00000024736
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247466,143,892 - 6,180,408 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000024959   ⟹   ENSHGLP00000024737
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247466,148,195 - 6,180,408 (-)Ensembl
RefSeq Acc Id: XM_004842798   ⟹   XP_004842855
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247466,146,338 - 6,181,020 (-)NCBI
RefSeq Acc Id: XM_021256670   ⟹   XP_021112329
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247466,146,338 - 6,180,325 (-)NCBI
RefSeq Acc Id: XM_021256671   ⟹   XP_021112330
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247466,146,338 - 6,180,325 (-)NCBI
RefSeq Acc Id: XM_021256672   ⟹   XP_021112331
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247466,146,338 - 6,181,019 (-)NCBI
RefSeq Acc Id: XM_021256673   ⟹   XP_021112332
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247466,146,338 - 6,180,330 (-)NCBI
RefSeq Acc Id: XM_021256674   ⟹   XP_021112333
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247466,146,338 - 6,180,327 (-)NCBI
RefSeq Acc Id: XP_004842855   ⟸   XM_004842798
- Peptide Label: isoform X3
- UniProtKB: G5B1X2 (UniProtKB/TrEMBL),   A0AAX6P3P7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112331   ⟸   XM_021256672
- Peptide Label: isoform X4
- UniProtKB: G5B1X2 (UniProtKB/TrEMBL),   A0AAX6SSG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112332   ⟸   XM_021256673
- Peptide Label: isoform X5
- UniProtKB: G5B1X2 (UniProtKB/TrEMBL),   A0AAX6SRI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112333   ⟸   XM_021256674
- Peptide Label: isoform X6
- UniProtKB: A0AAX6SX64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112330   ⟸   XM_021256671
- Peptide Label: isoform X2
- UniProtKB: G5B1X2 (UniProtKB/TrEMBL),   A0AAX6SX42 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112329   ⟸   XM_021256670
- Peptide Label: isoform X1
- UniProtKB: G5B1X2 (UniProtKB/TrEMBL),   A0AAX6STZ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000024736   ⟸   ENSHGLT00000024958
Ensembl Acc Id: ENSHGLP00000024737   ⟸   ENSHGLT00000024959


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017639 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024958 ENTREZGENE
InterPro Carotenoid_Oase UniProtKB/TrEMBL
KEGG Report hgl:101724039 UniProtKB/TrEMBL
NCBI Gene Bco1 ENTREZGENE
PANTHER BETA,BETA-CAROTENE 15,15'-DIOXYGENASE UniProtKB/TrEMBL
  BETA-CAROTENE DIOXYGENASE UniProtKB/TrEMBL
Pfam RPE65 UniProtKB/TrEMBL
UniProt A0AAX6P3P7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SRI1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SSG1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6STZ9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SX42 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SX64 ENTREZGENE, UniProtKB/TrEMBL
  G5B1X2 ENTREZGENE, UniProtKB/TrEMBL