Bco1 (beta-carotene oxygenase 1) - Rat Genome Database

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Gene: Bco1 (beta-carotene oxygenase 1) Mus musculus
Analyze
Symbol: Bco1
Name: beta-carotene oxygenase 1
RGD ID: 1332399
MGI Page MGI
Description: Enables beta-carotene 15,15'-dioxygenase activity. Involved in carotene catabolic process and retinal metabolic process. Acts upstream of or within beta-carotene metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human BCO1 (beta-carotene oxygenase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Bcd; Bcdo; Bcdo1; Bcmo; Bcmo1; beta,beta-carotene 15,15'-dioxygenase; beta,beta-carotene 15,15'-monooxygenase; beta-C; beta-carotene 15, 15'-dioxygenase 1; beta-carotene 15,15' dioxygenase; beta-carotene 15,15'-monooxygenase; beta-carotene cleavage enzyme; beta-carotene dioxygenase 1; beta-CD; betaCM; betaCMOOX; carotenoid-15,15'-oxygenase; Cm; CMO1; Cmoi
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398117,822,590 - 117,860,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8117,822,593 - 117,860,459 (+)EnsemblGRCm39 Ensembl
GRCm388117,095,851 - 117,133,720 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,095,854 - 117,133,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv378119,619,765 - 119,657,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368119,981,842 - 120,019,458 (+)NCBIMGSCv36mm8
Celera8121,315,369 - 121,353,295 (+)NCBICelera
Cytogenetic Map8E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Harrison EH Biochim Biophys Acta. 2012 Jan;1821(1):70-7. Epub 2011 Jun 12.
2. Mammalian carotenoid-oxygenases: key players for carotenoid function and homeostasis. Lobo GP, etal., Biochim Biophys Acta. 2012 Jan;1821(1):78-87. Epub 2011 May 4.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Cloning and expression of beta,beta-carotene 15,15'-dioxygenase. Wyss A, etal., Biochem Biophys Res Commun 2000 May 10;271(2):334-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11092891   PMID:11217851   PMID:11237856   PMID:11401432   PMID:11418584   PMID:12466851   PMID:12477932   PMID:12668631   PMID:12759335  
PMID:12882399   PMID:14681479   PMID:15951442   PMID:16141072   PMID:16141073   PMID:17855355   PMID:18093975   PMID:18295589   PMID:19022959   PMID:19556237   PMID:20003456   PMID:20061533  
PMID:20372966   PMID:20470748   PMID:20472610   PMID:20820853   PMID:21125869   PMID:21183473   PMID:21285397   PMID:21673813   PMID:21677750   PMID:21873635   PMID:21935922   PMID:22911456  
PMID:22967998   PMID:23988655   PMID:24005908   PMID:24034573   PMID:24106281   PMID:24449471   PMID:25002123   PMID:25260612   PMID:25602705   PMID:25701869   PMID:27389691   PMID:27629887  
PMID:28286282   PMID:28448568   PMID:29742455   PMID:29892071   PMID:30006135   PMID:32433733   PMID:34742949   PMID:36150025   PMID:36400405  


Genomics

Comparative Map Data
Bco1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398117,822,590 - 117,860,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8117,822,593 - 117,860,459 (+)EnsemblGRCm39 Ensembl
GRCm388117,095,851 - 117,133,720 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8117,095,854 - 117,133,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv378119,619,765 - 119,657,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368119,981,842 - 120,019,458 (+)NCBIMGSCv36mm8
Celera8121,315,369 - 121,353,295 (+)NCBICelera
Cytogenetic Map8E1NCBI
BCO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381681,238,689 - 81,291,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1681,238,689 - 81,291,142 (+)EnsemblGRCh38hg38GRCh38
GRCh371681,272,294 - 81,324,747 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361679,829,797 - 79,882,248 (+)NCBINCBI36Build 36hg18NCBI36
Build 341679,829,796 - 79,882,248NCBI
Celera1665,569,740 - 65,622,032 (+)NCBICelera
Cytogenetic Map16q23.2NCBI
HuRef1667,027,575 - 67,079,925 (+)NCBIHuRef
CHM1_11682,683,655 - 82,736,052 (+)NCBICHM1_1
T2T-CHM13v2.01687,299,473 - 87,351,905 (+)NCBIT2T-CHM13v2.0
Bco1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21945,149,250 - 45,186,102 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,149,265 - 45,186,101 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1951,959,095 - 51,995,942 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01952,612,116 - 52,648,960 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01954,856,354 - 54,893,189 (+)NCBIRnor_WKY
Rnor_6.01949,637,059 - 49,673,577 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,637,016 - 49,673,808 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,424,580 - 60,460,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,202,955 - 47,239,225 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11947,207,835 - 47,244,106 (+)NCBI
Celera1944,421,345 - 44,457,802 (+)NCBICelera
Cytogenetic Map19q12NCBI
Bco1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555223,985,266 - 4,018,886 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555223,985,515 - 4,018,116 (+)NCBIChiLan1.0ChiLan1.0
BCO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11681,270,957 - 81,323,088 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1681,270,577 - 81,323,088 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01661,843,567 - 61,897,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BCO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,598,743 - 70,637,273 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,599,284 - 70,637,017 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha570,547,948 - 70,586,427 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0570,903,713 - 70,942,206 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl570,903,715 - 70,942,392 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1570,846,152 - 70,884,642 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,681,343 - 70,719,822 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0571,159,198 - 71,197,682 (-)NCBIUU_Cfam_GSD_1.0
Bco1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,698,707 - 30,729,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647528,859,318 - 28,889,934 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647528,859,222 - 28,890,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl67,012,332 - 7,055,305 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.167,008,330 - 7,054,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BCO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1566,681,756 - 66,730,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl566,681,513 - 66,733,604 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660479,105,596 - 9,155,354 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bco1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247466,143,892 - 6,180,408 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247466,146,338 - 6,181,020 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:320
Count of miRNA genes:217
Interacting mature miRNAs:243
Transcripts:ENSMUST00000034308, ENSMUST00000167370, ENSMUST00000176860
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8110415083130127694Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8110415083130127694Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8111481497130127694Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8111481497130127694Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined114439420126055880Mouse

Markers in Region
Bcmo1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8E1UniSTS
Bcmo1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8E1UniSTS
cM Map863.61UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034308   ⟹   ENSMUSP00000034308
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8117,822,593 - 117,860,459 (+)Ensembl
GRCm38.p6 Ensembl8117,095,854 - 117,133,720 (+)Ensembl
RefSeq Acc Id: ENSMUST00000167370   ⟹   ENSMUSP00000132042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8117,095,865 - 117,131,218 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176860   ⟹   ENSMUSP00000134815
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8117,822,737 - 117,860,055 (+)Ensembl
GRCm38.p6 Ensembl8117,095,998 - 117,133,316 (+)Ensembl
RefSeq Acc Id: NM_001163028   ⟹   NP_001156500
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398117,822,604 - 117,860,459 (+)NCBI
GRCm388117,095,865 - 117,133,720 (+)NCBI
MGSCv378119,619,765 - 119,657,620 (+)RGD
Celera8121,315,369 - 121,353,295 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_021486   ⟹   NP_067461
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398117,822,604 - 117,860,459 (+)NCBI
GRCm388117,095,865 - 117,133,720 (+)NCBI
MGSCv378119,619,765 - 119,657,620 (+)RGD
Celera8121,315,369 - 121,353,295 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011248481   ⟹   XP_011246783
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398117,822,590 - 117,859,693 (+)NCBI
GRCm388117,095,851 - 117,132,953 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067461   ⟸   NM_021486
- Peptide Label: isoform 1
- UniProtKB: Q9ERN9 (UniProtKB/Swiss-Prot),   Q9JJS6 (UniProtKB/Swiss-Prot),   Q05AC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001156500   ⟸   NM_001163028
- Peptide Label: isoform 2
- UniProtKB: E9Q321 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011246783   ⟸   XM_011248481
- Peptide Label: isoform X1
- UniProtKB: E9Q321 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034308   ⟸   ENSMUST00000034308
RefSeq Acc Id: ENSMUSP00000132042   ⟸   ENSMUST00000167370
RefSeq Acc Id: ENSMUSP00000134815   ⟸   ENSMUST00000176860

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJS6-F1-model_v2 AlphaFold Q9JJS6 1-566 view protein structure

Promoters
RGD ID:8668385
Promoter ID:EPDNEW_M12223
Type:single initiation site
Name:Bco1_1
Description:Mus musculus beta-carotene oxygenase 1 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388117,095,869 - 117,095,929EPDNEW
RGD ID:6842858
Promoter ID:MM_KWN:55865
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_001163028,   OTTMUST00000055544
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368119,619,546 - 119,620,046 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1926923 AgrOrtholog
Ensembl Genes ENSMUSG00000031845 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034308 ENTREZGENE
  ENSMUSP00000034308.9 UniProtKB/Swiss-Prot
  ENSMUSP00000134815 ENTREZGENE
  ENSMUSP00000134815.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034308 ENTREZGENE
  ENSMUST00000034308.16 UniProtKB/Swiss-Prot
  ENSMUST00000176860 ENTREZGENE
  ENSMUST00000176860.2 UniProtKB/TrEMBL
InterPro Carotenoid_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:63857 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1926923 ENTREZGENE
NCBI Gene 63857 ENTREZGENE
PANTHER BETA,BETA-CAROTENE 15,15'-DIOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10543 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RPE65 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bco1 PhenoGen
UniProt BCDO1_MOUSE UniProtKB/Swiss-Prot
  E9Q321 ENTREZGENE, UniProtKB/TrEMBL
  Q05AC0 ENTREZGENE, UniProtKB/TrEMBL
  Q9ERN9 ENTREZGENE
  Q9JJS6 ENTREZGENE
UniProt Secondary Q6K1L5 UniProtKB/Swiss-Prot
  Q8C6N5 UniProtKB/Swiss-Prot
  Q9ERN9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-12 Bco1  beta-carotene oxygenase 1  Bcmo1  beta-carotene 15,15'-monooxygenase  Symbol and/or name change 5135510 APPROVED
2011-08-17 Bcmo1  beta-carotene 15,15'-monooxygenase  Bcmo1  beta-carotene 15,15'-monooxygenase  Symbol and/or name change 5135510 APPROVED