Mme (membrane metalloendopeptidase) - Rat Genome Database

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Gene: Mme (membrane metalloendopeptidase) Heterocephalus glaber
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Symbol: Mme
Name: membrane metalloendopeptidase
RGD ID: 18932282
Description: ENCODES a protein that exhibits cardiolipin binding (ortholog); endopeptidase activity (ortholog); exopeptidase activity (ortholog); INVOLVED IN amygdala development (ortholog); amyloid-beta clearance by cellular catabolic process (ortholog); amyloid-beta metabolic process (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; kallikrein-kinin cascade pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Breast Neoplasms (ortholog); cerebellar ataxia type 43 (ortholog); FOUND IN axon (ortholog); brush border (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Neprilysin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473032,601,488 - 32,689,080 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473032,601,835 - 32,691,368 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mme
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473032,601,488 - 32,689,080 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473032,601,835 - 32,691,368 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
MME
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383155,024,202 - 155,183,729 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3155,024,124 - 155,183,803 (+)Ensemblhg38GRCh38
GRCh373154,741,991 - 154,901,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363156,280,130 - 156,384,212 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343156,280,756 - 156,384,194NCBI
Celera3153,217,556 - 153,321,523 (+)NCBICelera
Cytogenetic Map3q25.2NCBI
HuRef3152,191,860 - 152,295,862 (+)NCBIHuRef
CHM1_13154,760,481 - 154,864,540 (+)NCBICHM1_1
T2T-CHM13v2.03157,798,155 - 157,957,709 (+)NCBIT2T-CHM13v2.0
Mme
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39363,202,632 - 63,291,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl363,148,958 - 63,293,451 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38363,295,211 - 63,383,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl363,241,537 - 63,386,030 (+)Ensemblmm10GRCm38
MGSCv37363,099,794 - 63,186,153 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36363,383,801 - 63,470,160 (+)NCBIMGSCv36mm8
Celera362,969,256 - 63,055,608 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map329.97NCBI
Mme
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82149,806,826 - 149,957,381 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2149,872,291 - 149,953,463 (+)EnsemblGRCr8
mRatBN7.22147,686,913 - 147,803,808 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2147,722,086 - 147,803,792 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2154,412,545 - 154,499,268 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02152,461,414 - 152,548,760 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02147,094,065 - 147,181,452 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2148,991,448 - 149,079,493 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive2149,310,747 - 149,398,794 (+)NCBILyon_Normotensive
Lyon_Hypertensive2148,938,994 - 149,027,031 (+)NCBILyon_Hypertensive
F344_StmMcwi2148,726,316 - 148,813,704 (+)NCBIF344_StmMcwi
Rnor_6.02153,799,203 - 153,880,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2153,803,349 - 153,880,738 (+)Ensemblrn6Rnor6.0
Rnor_5.02173,193,501 - 173,278,946 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42153,031,724 - 153,114,515 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2142,009,686 - 142,090,693 (+)NCBICelera
RGSC_v3.12152,981,686 - 153,064,477 (+)NCBI
RH 3.4 Map2955.0RGD
Cytogenetic Map2q31NCBI
Mme
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554486,226,059 - 6,314,949 (+)Ensembl
ChiLan1.0NW_0049554486,193,113 - 6,311,666 (+)NCBIChiLan1.0ChiLan1.0
MME
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22152,997,962 - 153,099,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13152,949,064 - 153,103,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03152,085,694 - 152,240,148 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13159,637,965 - 160,292,119 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3160,197,566 - 160,292,119 (+)EnsemblpanPan2panpan1.1
MME
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12348,966,222 - 49,059,919 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2348,971,066 - 49,059,919 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2348,843,474 - 48,934,858 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02349,596,559 - 49,692,908 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2349,593,076 - 49,694,136 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12349,187,708 - 49,279,020 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02349,238,095 - 49,328,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02349,521,230 - 49,612,145 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mme
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560287,138,054 - 87,220,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365192,513,704 - 2,595,971 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365192,513,896 - 2,595,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MME
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1395,019,081 - 95,126,045 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11395,018,395 - 95,122,977 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213103,025,551 - 103,128,284 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MME
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11535,577,460 - 35,681,730 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1535,580,714 - 35,633,914 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660418,227,922 - 8,338,216 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mme
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1391,838,915 - 91,949,210 (-)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000019698   ⟹   ENSHGLP00000019505
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473032,601,488 - 32,689,080 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000019699   ⟹   ENSHGLP00000019506
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473032,601,488 - 32,689,012 (+)Ensembl
RefSeq Acc Id: XM_004834486   ⟹   XP_004834543
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473032,602,468 - 32,691,368 (+)NCBI
RefSeq Acc Id: XM_004834487   ⟹   XP_004834544
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473032,601,835 - 32,691,368 (+)NCBI
RefSeq Acc Id: XM_004834488   ⟹   XP_004834545
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473032,606,495 - 32,691,368 (+)NCBI
RefSeq Acc Id: XM_004834489   ⟹   XP_004834546
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473032,604,361 - 32,691,368 (+)NCBI
RefSeq Acc Id: XM_021253347   ⟹   XP_021109006
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473032,602,224 - 32,691,368 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004834543 (Get FASTA)   NCBI Sequence Viewer  
  XP_004834544 (Get FASTA)   NCBI Sequence Viewer  
  XP_004834545 (Get FASTA)   NCBI Sequence Viewer  
  XP_004834546 (Get FASTA)   NCBI Sequence Viewer  
  XP_021109006 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB13482 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019506
GenBank Protein JAO01083 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004834544   ⟸   XM_004834487
- UniProtKB: G5BW21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109006   ⟸   XM_021253347
- UniProtKB: G5BW21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834543   ⟸   XM_004834486
- UniProtKB: G5BW21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834546   ⟸   XM_004834489
- UniProtKB: G5BW21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004834545   ⟸   XM_004834488
- UniProtKB: G5BW21 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000019506   ⟸   ENSHGLT00000019699
Ensembl Acc Id: ENSHGLP00000019505   ⟸   ENSHGLT00000019698


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013970 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000019699 ENTREZGENE
Gene3D-CATH 1.10.1380.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M13 UniProtKB/TrEMBL
  Peptidase_M13_C UniProtKB/TrEMBL
  Peptidase_M13_dom_2 UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/TrEMBL
KEGG Report hgl:101715828 UniProtKB/TrEMBL
NCBI Gene Mme ENTREZGENE
PANTHER PTHR11733 UniProtKB/TrEMBL
  PTHR11733:SF114 UniProtKB/TrEMBL
Pfam Peptidase_M13 UniProtKB/TrEMBL
  Peptidase_M13_N UniProtKB/TrEMBL
PRINTS NEPRILYSIN UniProtKB/TrEMBL
PROSITE NEPRILYSIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt G5BW21 ENTREZGENE, UniProtKB/TrEMBL