Dhodh (dihydroorotate dehydrogenase (quinone)) - Rat Genome Database

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Gene: Dhodh (dihydroorotate dehydrogenase (quinone)) Heterocephalus glaber
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Symbol: Dhodh
Name: dihydroorotate dehydrogenase (quinone)
RGD ID: 18902352
Description: ENCODES a protein that exhibits dihydroorotase activity (ortholog); dihydroorotate dehydrogenase activity (ortholog); FMN binding (ortholog); INVOLVED IN 'de novo' pyrimidine nucleobase biosynthetic process (ortholog); female pregnancy (ortholog); lactation (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; de novo pyrimidine biosynthetic pathway; dihydropyrimidinase deficiency pathway; ASSOCIATED WITH beta thalassemia (ortholog); erythroleukemia (ortholog); Experimental Arthritis (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dihydroorotate dehydrogenase (quinone), mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474614,254,193 - 14,268,034 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dhodh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474614,254,193 - 14,268,034 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
DHODH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,008,744 - 72,027,659 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,008,588 - 72,027,664 (+)Ensemblhg38GRCh38
GRCh371672,042,643 - 72,061,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,600,144 - 70,616,456 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341670,600,163 - 70,616,456NCBI
Celera1656,356,753 - 56,373,075 (+)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,809,449 - 57,826,108 (+)NCBIHuRef
CHM1_11673,455,964 - 73,472,648 (+)NCBICHM1_1
T2T-CHM13v2.01677,826,803 - 77,845,694 (+)NCBIT2T-CHM13v2.0
Dhodh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,319,876 - 110,335,330 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,317,975 - 110,335,305 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388109,593,244 - 109,608,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,591,343 - 109,608,673 (-)Ensemblmm10GRCm38
MGSCv378112,117,148 - 112,132,573 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368112,482,377 - 112,497,802 (-)NCBIMGSCv36mm8
Celera8113,818,789 - 113,834,192 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.12NCBI
Dhodh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,460,636 - 54,483,049 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1954,468,690 - 54,514,496 (-)EnsemblGRCr8
mRatBN7.21937,551,858 - 37,573,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,558,177 - 37,591,654 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1944,372,421 - 44,386,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,025,749 - 45,039,726 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,335,351 - 47,349,222 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1948,253,910 - 48,267,887 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1946,377,403 - 46,391,380 (-)NCBILyon_Normotensive
Lyon_Hypertensive1948,252,107 - 48,266,084 (-)NCBILyon_Hypertensive
F344_StmMcwi1945,999,414 - 46,013,312 (-)NCBIF344_StmMcwi
Rnor_6.01942,066,103 - 42,087,906 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,066,351 - 42,082,012 (+)Ensemblrn6Rnor6.0
Rnor_5.01952,891,853 - 52,913,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41939,463,111 - 39,477,184 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1936,964,203 - 36,978,276 (-)NCBICelera
RGSC_v3.11939,467,991 - 39,482,059 (-)NCBI
Cytogenetic Map19q12NCBI
Dhodh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,699,722 - 4,713,466 (+)Ensembl
ChiLan1.0NW_0049554844,699,743 - 4,713,466 (+)NCBIChiLan1.0ChiLan1.0
DHODH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,126,469 - 82,142,783 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,054,928 - 88,070,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01652,977,879 - 52,994,496 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,854,238 - 71,870,673 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,854,238 - 71,870,673 (+)EnsemblpanPan2panpan1.1
DHODH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,756,411 - 77,766,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,756,407 - 77,774,090 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha577,718,144 - 77,727,932 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0578,195,768 - 78,205,557 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,195,854 - 78,239,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,015,829 - 78,025,617 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,838,711 - 77,848,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0578,337,853 - 78,347,642 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dhodh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,711,350 - 37,725,488 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,862,166 - 21,877,711 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,863,627 - 21,877,660 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHODH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,942,933 - 14,955,997 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1614,942,898 - 14,956,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,563,531 - 14,574,102 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHODH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,161,788 - 55,177,383 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,161,916 - 55,180,896 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604717,957,062 - 17,973,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhodh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11729,313,558 - 29,327,396 (-)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000018136   ⟹   ENSHGLP00000017959
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474614,254,193 - 14,268,034 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000018137   ⟹   ENSHGLP00000017960
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474614,254,956 - 14,267,719 (+)Ensembl
RefSeq Acc Id: XM_004842916   ⟹   XP_004842973
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474614,254,812 - 14,268,034 (+)NCBI
RefSeq Acc Id: XM_004842917   ⟹   XP_004842974
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBI
RefSeq Acc Id: XM_021256745   ⟹   XP_021112404
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474614,254,844 - 14,268,034 (+)NCBI
RefSeq Acc Id: XM_021256746   ⟹   XP_021112405
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474614,254,811 - 14,268,034 (+)NCBI
RefSeq Acc Id: XM_021256747   ⟹   XP_021112406
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474614,254,834 - 14,268,034 (+)NCBI
RefSeq Acc Id: XM_021256748   ⟹   XP_021112407
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474614,255,038 - 14,268,034 (+)NCBI
RefSeq Acc Id: XP_021112405   ⟸   XM_021256746
- Peptide Label: isoform X4
- UniProtKB: G5B5U5 (UniProtKB/TrEMBL),   A0AAX6SXD2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842974   ⟸   XM_004842917
- Peptide Label: isoform X2
- UniProtKB: A0AAX6P3Q3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842973   ⟸   XM_004842916
- Peptide Label: isoform X1
- UniProtKB: A0A0N8ETI6 (UniProtKB/TrEMBL),   G5B5U5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112406   ⟸   XM_021256747
- Peptide Label: isoform X5
- UniProtKB: G5B5U5 (UniProtKB/TrEMBL),   A0AAX6SSQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112404   ⟸   XM_021256745
- Peptide Label: isoform X3
- UniProtKB: G5B5U5 (UniProtKB/TrEMBL),   A0AAX6SU96 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112407   ⟸   XM_021256748
- Peptide Label: isoform X6
- UniProtKB: G5B5U5 (UniProtKB/TrEMBL),   A0AAX6SRV4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000017960   ⟸   ENSHGLT00000018137
Ensembl Acc Id: ENSHGLP00000017959   ⟸   ENSHGLT00000018136


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012868 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000018136 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  DHO_dehydrogenase UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/TrEMBL
  Dihydroorotate_DH_1_2 UniProtKB/TrEMBL
  Dihydroorotate_DH_2 UniProtKB/TrEMBL
  Dihydroorotate_DH_CS UniProtKB/TrEMBL
NCBI Gene Dhodh ENTREZGENE
PANTHER DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL UniProtKB/TrEMBL
  DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam DHO_dh UniProtKB/TrEMBL
PIRSF DHO_oxidase UniProtKB/TrEMBL
PROSITE DHODEHASE_1 UniProtKB/TrEMBL
  DHODEHASE_2 UniProtKB/TrEMBL
Superfamily-SCOP FMN-linked oxidoreductases UniProtKB/TrEMBL
UniProt A0A0N8ETI6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6P3Q3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SRV4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SSQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SU96 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SXD2 ENTREZGENE, UniProtKB/TrEMBL
  G5B5U5 ENTREZGENE, UniProtKB/TrEMBL