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Gene: Tmem145 (transmembrane protein 145) Rattus norvegicus

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Symbol:

Tmem145

Name:

transmembrane protein 145

RGD ID:

1595911

Description:

Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Orthologous to human TMEM145 (transmembrane protein 145); INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC292722; similar to C15A7.2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM145 (transmembrane protein 145)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Tmem145 (transmembrane protein 145)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem145 (transmembrane protein 145)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM145 (transmembrane protein 145)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM145 (transmembrane protein 145)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem145 (transmembrane protein 145)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM145 (transmembrane protein 145)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM145 (transmembrane protein 145)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem145 (transmembrane protein 145)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	NOXO1 (NADPH oxidase organizer 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TMEM145 (transmembrane protein 145)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmem145 (transmembrane protein 145)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem145 (transmembrane protein 145)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C15A7.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9304	Alliance	DIOPT (OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	tmem145	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	90,019,727 - 90,029,432 (+)	NCBI		GRCr8
mRatBN7.2	1	80,891,888 - 80,901,615 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	80,891,927 - 80,901,611 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	82,174,379 - 82,184,075 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	82,174,451 - 82,184,068 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	83,438,538 - 83,448,240 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	80,580,829 - 80,590,503 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	75,334,816 - 75,344,483 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Carpenter Syndrome 2 (ISO)

congenital hypoplastic anemia (ISO)

craniosynostosis 1 (ISO)

Diamond-Blackfan anemia (ISO)

maple syrup urine disease (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butanal (ISO)

cisplatin (ISO)

D-glucose (ISO)

fructose (ISO)

glucose (ISO)

methimazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

paracetamol (EXP)

resveratrol (ISO)

rifampicin (ISO)

sulfadimethoxine (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IEA)

response to pheromone (IEA)

Cellular Component

membrane (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Tmem145
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	90,019,727 - 90,029,432 (+)	NCBI		GRCr8
mRatBN7.2	1	80,891,888 - 80,901,615 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	80,891,927 - 80,901,611 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	82,174,379 - 82,184,075 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	82,174,451 - 82,184,068 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	83,438,538 - 83,448,240 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	80,580,829 - 80,590,503 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	75,334,816 - 75,344,483 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

TMEM145
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	42,313,309 - 42,325,064 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	42,313,309 - 42,325,064 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	42,817,461 - 42,829,216 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	47,509,317 - 47,521,054 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	39,618,273 - 39,630,010 (+)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	39,247,618 - 39,259,356 (+)	NCBI		HuRef
CHM1_1	19	42,819,140 - 42,830,877 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	45,132,694 - 45,144,449 (+)	NCBI		T2T-CHM13v2.0

Tmem145
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	25,004,981 - 25,015,621 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	25,005,531 - 25,015,620 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	25,305,500 - 25,316,196 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	25,306,106 - 25,316,195 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	26,091,127 - 26,101,214 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	25,014,868 - 25,024,955 (+)	NCBI		MGSCv36	mm8
Celera	7	19,921,152 - 19,931,476 (+)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	13.74	NCBI

Tmem145
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	592,940 - 602,902 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955555	592,685 - 602,950 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM145
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	48,418,281 - 48,430,006 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	50,286,901 - 50,298,625 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	39,201,037 - 39,212,761 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	47,793,267 - 47,804,752 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	47,793,267 - 47,804,526 (+)	Ensembl	panpan1.1		panPan2

TMEM145
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	112,063,552 - 112,072,095 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	112,063,551 - 112,072,244 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	111,489,936 - 111,498,385 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	112,676,390 - 112,684,840 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	112,676,511 - 112,684,868 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	112,230,630 - 112,239,046 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	111,866,316 - 111,875,014 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	112,793,094 - 112,801,544 (-)	NCBI		UU_Cfam_GSD_1.0

Tmem145
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	15,850,761 - 15,859,465 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936706	198,339 - 206,739 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936706	198,105 - 206,794 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM145
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	49,619,547 - 49,628,239 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	49,619,540 - 49,628,234 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	45,513,930 - 45,522,472 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM145
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	36,517,715 - 36,528,918 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	36,517,826 - 36,529,397 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	14,763,629 - 14,774,920 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem145
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624907	438,968 - 448,005 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624907	438,713 - 448,037 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmem145
33 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	25
Interacting mature miRNAs:	25
Transcripts:	ENSRNOT00000027783
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	49393172	94393172	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	78479925	123479925	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	53895117	82174945	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	11481312	82174945	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat
2302059	Pia36	Pristane induced arthritis QTL 36	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	43333002	88333002	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	65789093	115540829	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	66023617	118608521	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	11481312	82174945	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	72197680	90508767	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	11481312	82174945	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	77876254	106047988	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
4889494	Scort2	Serum corticosterone level QTL 2	4.2		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	80592172	125592172	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	32737273	90665040	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	49361465	82174945	Rat
61344	Bp29	Blood pressure QTL 29	7.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	78350581	123350581	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	77494165	122494165	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	53863041	90532583	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	11481312	82174945	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	11481312	82174945	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	50343510	99980958	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	77857876	122857876	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	78430536	123430536	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	53895117	82174945	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	78430754	91209302	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	3	30	111	48	42	26	7	26	6	127	55	93	34	57	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001432082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_197264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002725549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002728703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027783 ⟹ ENSRNOP00000027783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	80,891,927 - 80,901,611 (+)	Ensembl
Rnor_6.0 Ensembl	1	82,174,451 - 82,184,068 (+)	Ensembl

RefSeq Acc Id:

XM_002728703 ⟹ XP_002728749

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	90,019,729 - 90,029,432 (+)	NCBI
mRatBN7.2	1	80,891,896 - 80,901,615 (+)	NCBI
Rnor_6.0	1	82,174,379 - 82,184,075 (+)	NCBI
Rnor_5.0	1	83,438,538 - 83,448,240 (+)	NCBI
RGSC_v3.4	1	80,580,829 - 80,590,503 (+)	RGD

Sequence:

show sequence

GCCTGCGCGCTCTCGCCTCCGTCACCGGGCCGGAGCGGGAGCCGGAGCCGTGCCGAGGCCAGAG
CGGGAGGAATGGAGCCTTCGCGCGCGCCCGCGCTGCGCCGCCTGCTGCCGCCACTGCTGCTCTT
GCTGCTGCCACTGTACCCCCGCACCCGGGCCAAGTACGTGCGGGGCAACCTCAGCTCCAAAGAG
GACTGGGTGTTCCTGACAAGATTTTGTTTCCTCTCGGATTATGGCCGACTGGACTTCCGATTCC
GATACCCTGAGGCCAAGTGCTGTCAGAACATCCTCCTCTATTTTGACGACCCATCTCAGTGGCC
AGCGGTGTACAAGGCAAGGGACAAGGACTGTTTGGCCAAGGAGTCGGTGATCAGGCCAGAGAAC
AACCAGGTCATCAATCTCACCACCCAGTACGCCTGGTCGGGCTGTCAGGTGGTGTCAGAGGAGG
GAACCCGCTACCTGAGCTGCTCCAGTGGCCGCAGCTTCCGCTCTGTGCGTGAACGATGGTGGTA
TATTGCGCTCAGCAAGTGTGGGGGAGATGGGCTACAGTTGGAATATGAGATGGTTCTTACCAAC
GGCAAGTCTTTCTGGACACGGCATTTCTCAGCTGATGAATTTGGGATCCTGGAGACAGATGTGA
CCTTTCTCCTCATCTTCACCCTCATCTTTGTCCTCTCTTGTTACTTTGGATACTTGCTGAAAGG
CCGTCAGCTACTCCACACAACTTACAAAATGTTCATGGCTGCAGCAGGAGTGGAGGTCCTGAGC
CTCCTGTTTTTCTGCATCTACTGGGGCCAGTACGCCACAGACGGCATCGGGAATGACAGCGTAA
AGATCTTGGCCAAGCTACTCTTCTCCTCCAGCTTCCTCATCTTCCTGCTCACACTCATCCTCCT
CGGGAAGGGATTCACGGTTACACGAGGCCGCATCAGCCACTCAGGCTCCGTGAAGTTGTCTGTG
TACATGACCCTGTACACCCTCACCCACGTGGTGTTGCTCATCTACGAGGCAGAATTCTTTGACC
CAGGCCAGGTACTATACACATACGAGTCTCCGGCTGGTTATGGACTCATCGGGCTGCAGGTGGC
GGCCTATGTGTGGTTCTGCTATGCAGTGCTGGTCTCCCTGCGGCACTATCCGGAGAAACAGCCC
TTTTATGTGCCCTTCTTTGCTGCCTATACCCTCTGGTTCTTTGCTGTCCCTGTCATGGCCCTGA
TCGCCAATTTTGGGATCCCGAAGTGGGCCCGAGAGAAGATCGTCAATGGTATCCAGCTGGGGAT
CCACCTGTATGCGCATGGCGTGTTTCTGATCATGACCCGCCCATCGGCGGCCAACAAGAACTTT
CCATACCACGTGCGAACTTCGCAGATCGCCTCCGCTGGGGTCCCTGCGCCCGGAGGGAGCCAAT
CCGCAGATAAGGCCTTCCCGCAGCACGTCTATGGAAACGTGACGTTCATCAGCGACTCGGTGCC
CAACTTCACGGAGCTCTTCTCCATCCCCCCGCCCACCTCCTCTGCCGGGAAGCAGGTGGAGGAG
ACAGCGGTGGCGGCGGCAGTGCCCCCAAGGGGTCGTGTGGTGACCATGGCCGAGCCGGGCGCAG
CCTCCCCACCCCCACCCGCTCGGTTCCCCAAGGCGGTCGACTCGGGCTGGGATGGCCCGACGCC
GTCCTACCAGCCGCTTGTGCCCCAGACGGCGGCGCCGCACACCGGCTTCACCGAATACTTCAGC
ATGCACACAGCCGGGGGCCCTGCACCCCCGGTCTGAGCATCCCTTTCCCGCCTCTGCCCCACAG
GCGGCGCACCGGGCCCCGGCTGGGCTCCGGAACCCCTTCTCTCTCCTGGCCCAAGGGCTCGGCC
TTGCCAGGCACCCCCACCCCACACACACACCCCGCGCCCACGTTGGGTGCGCTGCGTCCTGCCC
CTTTCCCTCTTGTGCCAAACGGTCCCGCGGGAGCCGTTCTCCGCGTCCCCTCCCTCAGCCCCTG
CCCCGAACGGCTCCGGAATCTGGACTCCCGCTGTTCCGTGATCTCCGCCCCCCTGACCCCCTCC
GAGACCTCTGACCCTGCTGGACTCCGGAACATCCGTGACGACCGCCTGGACCCTGCCTGTGACC
CTCCAGGACCCTGCGACCCTCGAGCCACTGTTCAGGGACGGATATTGTGAAGTTGGTCTCTACT
TTGAAACCCTCTCTGGGGTTTGTGACCTCGGACCTGTGCTTTGTCCGTCCATCTGCATGCCAAG
GACCTTCACATGGTCTCTGGCAGAAAGACGTTTTCTCTTCTTGCCAAAATAAAGAGGATTCGTT
GAGTTTTTAATCTA

hide sequence

RefSeq Acc Id:

XM_039093582 ⟹ XP_038949510

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	90,019,727 - 90,029,432 (+)	NCBI
mRatBN7.2	1	80,891,888 - 80,901,161 (+)	NCBI

RefSeq Acc Id:

XM_063277664 ⟹ XP_063133734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	90,020,077 - 90,029,432 (+)	NCBI

RefSeq Acc Id:

XM_063277665 ⟹ XP_063133735

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	90,020,463 - 90,029,432 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001419011	(Get FASTA)	NCBI Sequence Viewer
	XP_002728749	(Get FASTA)	NCBI Sequence Viewer
	XP_038949510	(Get FASTA)	NCBI Sequence Viewer
	XP_063133734	(Get FASTA)	NCBI Sequence Viewer
	XP_063133735	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027783.6

RefSeq Acc Id:

XP_002728749 ⟸ XM_002728703

- Peptide Label:

isoform X2

- Sequence:

show sequence

MEPSRAPALRRLLPPLLLLLLPLYPRTRAKYVRGNLSSKEDWVFLTRFCFLSDYGRLDFRFRYP
EAKCCQNILLYFDDPSQWPAVYKARDKDCLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTR
YLSCSSGRSFRSVRERWWYIALSKCGGDGLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFL
LIFTLIFVLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNDSVKIL
AKLLFSSSFLIFLLTLILLGKGFTVTRGRISHSGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQ
VLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLRHYPEKQPFYVPFFAAYTLWFFAVPVMALIAN
FGIPKWAREKIVNGIQLGIHLYAHGVFLIMTRPSAANKNFPYHVRTSQIASAGVPAPGGSQSAD
KAFPQHVYGNVTFISDSVPNFTELFSIPPPTSSAGKQVEETAVAAAVPPRGRVVTMAEPGAASP
PPPARFPKAVDSGWDGPTPSYQPLVPQTAAPHTGFTEYFSMHTAGGPAPPV

hide sequence

Ensembl Acc Id:

ENSRNOP00000027783 ⟸ ENSRNOT00000027783

RefSeq Acc Id:	XP_038949510 ⟸ XM_039093582
- Peptide Label:	isoform X1
- UniProtKB:	D3Z9I0 (UniProtKB/TrEMBL), A6J953 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133734 ⟸ XM_063277664
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063133735 ⟸ XM_063277665
- Peptide Label:	isoform X3

Protein Domains

GPR180-like N-terminal GPR180/TMEM145 transmembrane

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z9I0-F1-model_v2	AlphaFold	D3Z9I0	1-745	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1595911	AgrOrtholog
BioCyc Gene	G2FUF-60391	BioCyc
Ensembl Genes	ENSRNOG00000020489	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027783.6	UniProtKB/TrEMBL
InterPro	GPR180-like_N	UniProtKB/TrEMBL
	GPR180/TMEM145	UniProtKB/TrEMBL
	Intimal_thickness-rel_rcpt	UniProtKB/TrEMBL
NCBI Gene	292722	ENTREZGENE
PANTHER	INTIMAL THICKNESS RECEPTOR-RELATED	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 145	UniProtKB/TrEMBL
Pfam	GpcrRhopsn4	UniProtKB/TrEMBL
	TMEM145_N	UniProtKB/TrEMBL
PhenoGen	Tmem145	PhenoGen
RatGTEx	ENSRNOG00000020489	RatGTEx
UniProt	A6J953	ENTREZGENE, UniProtKB/TrEMBL
	D3Z9I0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-09-17	Tmem145	transmembrane protein 145	LOC292722	similar to C15A7.2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC292722	similar to C15A7.2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar