Tmem145 (transmembrane protein 145) - Rat Genome Database

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Gene: Tmem145 (transmembrane protein 145) Mus musculus
Analyze
Symbol: Tmem145
Name: transmembrane protein 145
RGD ID: 1621964
MGI Page MGI
Description: Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human TMEM145 (transmembrane protein 145).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B930076A02Rik
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,004,981 - 25,015,621 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,005,531 - 25,015,620 (+)EnsemblGRCm39 Ensembl
GRCm38725,305,500 - 25,316,196 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,306,106 - 25,316,195 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,091,127 - 26,101,214 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,014,868 - 25,024,955 (+)NCBIMGSCv36mm8
Celera719,921,152 - 19,931,476 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17114649   PMID:18799693  
PMID:21267068   PMID:27534441   PMID:32325033   PMID:38187761  


Genomics

Comparative Map Data
Tmem145
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,004,981 - 25,015,621 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,005,531 - 25,015,620 (+)EnsemblGRCm39 Ensembl
GRCm38725,305,500 - 25,316,196 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,306,106 - 25,316,195 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,091,127 - 26,101,214 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,014,868 - 25,024,955 (+)NCBIMGSCv36mm8
Celera719,921,152 - 19,931,476 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map713.74NCBI
TMEM145
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381942,313,309 - 42,325,064 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1942,313,309 - 42,325,064 (+)EnsemblGRCh38hg38GRCh38
GRCh371942,817,461 - 42,829,216 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,509,317 - 47,521,054 (+)NCBINCBI36Build 36hg18NCBI36
Celera1939,618,273 - 39,630,010 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1939,247,618 - 39,259,356 (+)NCBIHuRef
CHM1_11942,819,140 - 42,830,877 (+)NCBICHM1_1
T2T-CHM13v2.01945,132,694 - 45,144,449 (+)NCBIT2T-CHM13v2.0
Tmem145
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8190,019,727 - 90,029,432 (+)NCBIGRCr8
mRatBN7.2180,891,888 - 80,901,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,891,927 - 80,901,611 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0182,174,379 - 82,184,075 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,174,451 - 82,184,068 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,438,538 - 83,448,240 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,580,829 - 80,590,503 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera175,334,816 - 75,344,483 (+)NCBICelera
Cytogenetic Map1q21NCBI
Tmem145
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555592,940 - 602,902 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955555592,685 - 602,950 (-)NCBIChiLan1.0ChiLan1.0
TMEM145
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22048,418,281 - 48,430,006 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11950,286,901 - 50,298,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01939,201,037 - 39,212,761 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,793,267 - 47,804,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,793,267 - 47,804,526 (+)Ensemblpanpan1.1panPan2
TMEM145
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,063,552 - 112,072,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,063,551 - 112,072,244 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,489,936 - 111,498,385 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,676,390 - 112,684,840 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,676,511 - 112,684,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11112,230,630 - 112,239,046 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,866,316 - 111,875,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,793,094 - 112,801,544 (-)NCBIUU_Cfam_GSD_1.0
Tmem145
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,850,761 - 15,859,465 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706198,339 - 206,739 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706198,105 - 206,794 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM145
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,619,547 - 49,628,239 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,619,540 - 49,628,234 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2645,513,930 - 45,522,472 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM145
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,517,715 - 36,528,918 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl636,517,826 - 36,529,397 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607314,763,629 - 14,774,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem145
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624907438,968 - 448,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624907438,713 - 448,037 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem145
264 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:676
Count of miRNA genes:378
Interacting mature miRNAs:437
Transcripts:ENSMUST00000108409, ENSMUST00000119703, ENSMUST00000140016
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000108409   ⟹   ENSMUSP00000104046
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,005,533 - 25,015,620 (+)Ensembl
GRCm38.p6 Ensembl725,306,108 - 25,316,195 (+)Ensembl
RefSeq Acc Id: ENSMUST00000119703   ⟹   ENSMUSP00000112676
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,005,533 - 25,015,607 (+)Ensembl
GRCm38.p6 Ensembl725,306,108 - 25,316,182 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,005,531 - 25,008,251 (+)Ensembl
GRCm38.p6 Ensembl725,306,106 - 25,308,826 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205639   ⟹   ENSMUSP00000159059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl725,005,533 - 25,015,620 (+)Ensembl
GRCm38.p6 Ensembl725,306,108 - 25,316,195 (+)Ensembl
RefSeq Acc Id: NM_001403202   ⟹   NP_001390131
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,005,521 - 25,015,621 (+)NCBI
RefSeq Acc Id: NM_001403203   ⟹   NP_001390132
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,004,981 - 25,015,621 (+)NCBI
RefSeq Acc Id: NM_183311   ⟹   NP_899134
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,005,521 - 25,015,621 (+)NCBI
GRCm38725,306,108 - 25,316,195 (+)NCBI
MGSCv37726,091,127 - 26,101,214 (+)RGD
Celera719,921,152 - 19,931,476 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_175362
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,005,521 - 25,015,621 (+)NCBI
RefSeq Acc Id: NR_175363
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,005,521 - 25,015,621 (+)NCBI
RefSeq Acc Id: XM_006540114   ⟹   XP_006540177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,005,092 - 25,015,621 (+)NCBI
GRCm38725,305,667 - 25,316,196 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030242692   ⟹   XP_030098552
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39725,005,415 - 25,015,621 (+)NCBI
GRCm38725,305,991 - 25,316,196 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_899134   ⟸   NM_183311
- Peptide Label: isoform 2 precursor
- UniProtKB: E9PUE6 (UniProtKB/TrEMBL),   D3YU53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540177   ⟸   XM_006540114
- Peptide Label: isoform X1
- UniProtKB: A0A5F8MPQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030098552   ⟸   XM_030242692
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000112676   ⟸   ENSMUST00000119703
RefSeq Acc Id: ENSMUSP00000104046   ⟸   ENSMUST00000108409
RefSeq Acc Id: ENSMUSP00000159059   ⟸   ENSMUST00000205639
RefSeq Acc Id: NP_001390132   ⟸   NM_001403203
- Peptide Label: isoform 2 precursor
- UniProtKB: E9PUE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001390131   ⟸   NM_001403202
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A5F8MPQ2 (UniProtKB/TrEMBL)
Protein Domains
GPR180/TMEM145 transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C4U2-F1-model_v2 AlphaFold Q8C4U2 1-746 view protein structure

Promoters
RGD ID:6892272
Promoter ID:EPDNEW_M9583
Type:initiation region
Name:Tmem145_1
Description:Mus musculus transmembrane protein 145 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38725,306,098 - 25,306,158EPDNEW
RGD ID:6842204
Promoter ID:MM_KWN:49439
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:ENSMUST00000058863,   ENSMUST00000119703,   NM_183311,   OTTMUST00000079171
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36726,090,861 - 26,091,361 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3607779 AgrOrtholog
Ensembl Genes ENSMUSG00000043843 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000108409 ENTREZGENE
  ENSMUST00000108409.2 UniProtKB/TrEMBL
  ENSMUST00000119703.8 UniProtKB/TrEMBL
  ENSMUST00000205639 ENTREZGENE
  ENSMUST00000205639.3 UniProtKB/TrEMBL
InterPro GPR180/TMEM145 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Intimal_thickness-rel_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:330485 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3607779 ENTREZGENE
NCBI Gene 330485 ENTREZGENE
PANTHER INTIMAL THICKNESS RECEPTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 145 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GpcrRhopsn4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem145 PhenoGen
UniProt A0A5F8MPQ2 ENTREZGENE, UniProtKB/TrEMBL
  D3YU53 ENTREZGENE, UniProtKB/TrEMBL
  E9PUE6 ENTREZGENE, UniProtKB/TrEMBL
  Q8C4U2 ENTREZGENE, UniProtKB/Swiss-Prot