Grxcr1 (glutaredoxin and cysteine rich domain containing 1) - Rat Genome Database

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Gene: Grxcr1 (glutaredoxin and cysteine rich domain containing 1) Rattus norvegicus
Analyze
Symbol: Grxcr1
Name: glutaredoxin and cysteine rich domain containing 1
RGD ID: 1564635
Description: Predicted to be involved in inner ear receptor cell stereocilium organization and vestibular receptor cell development. Predicted to act upstream of or within cochlea development; inner ear auditory receptor cell differentiation; and sensory perception of sound. Predicted to be active in kinocilium and stereocilium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 25. Orthologous to human GRXCR1 (glutaredoxin and cysteine rich domain containing 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: glutaredoxin domain-containing cysteine-rich protein 1; glutaredoxin domain-containing cysteine-rich protein 1-like; glutaredoxin, cysteine rich 1; LOC100910415; LOC498355; RGD1564635; similar to CG12206-PA, isoform A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81440,358,077 - 40,480,493 (-)NCBIGRCr8
mRatBN7.21440,004,169 - 40,126,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1440,004,169 - 40,126,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1440,344,095 - 40,473,189 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01441,644,157 - 41,773,245 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01440,124,980 - 40,254,066 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01441,663,688 - 41,787,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1441,663,688 - 41,786,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01441,461,233 - 41,583,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41442,605,908 - 42,728,503 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1439,172,879 - 39,287,730 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
kinocilium  (IBA,ISO)
stereocilium  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11276175   PMID:12405956   PMID:13336002   PMID:19389623   PMID:20137774   PMID:30380417  


Genomics

Comparative Map Data
Grxcr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81440,358,077 - 40,480,493 (-)NCBIGRCr8
mRatBN7.21440,004,169 - 40,126,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1440,004,169 - 40,126,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1440,344,095 - 40,473,189 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01441,644,157 - 41,773,245 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01440,124,980 - 40,254,066 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01441,663,688 - 41,787,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1441,663,688 - 41,786,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01441,461,233 - 41,583,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41442,605,908 - 42,728,503 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1439,172,879 - 39,287,730 (-)NCBICelera
Cytogenetic Map14p11NCBI
GRXCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38442,892,713 - 43,030,658 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl442,892,713 - 43,030,658 (+)EnsemblGRCh38hg38GRCh38
GRCh37442,894,730 - 43,032,675 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36442,590,041 - 42,727,432 (+)NCBINCBI36Build 36hg18NCBI36
Celera443,343,120 - 43,480,521 (+)NCBICelera
Cytogenetic Map4p13NCBI
HuRef442,217,707 - 42,355,084 (+)NCBIHuRef
CHM1_1442,888,840 - 43,025,561 (+)NCBICHM1_1
T2T-CHM13v2.0442,860,117 - 42,998,036 (+)NCBIT2T-CHM13v2.0
Grxcr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39568,189,122 - 68,323,741 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl568,189,178 - 68,323,741 (+)EnsemblGRCm39 Ensembl
GRCm38568,031,835 - 68,166,398 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl568,031,835 - 68,166,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv37568,423,074 - 68,557,637 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36568,310,970 - 68,445,533 (+)NCBIMGSCv36mm8
Celera565,324,488 - 65,457,756 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map536.59NCBI
Grxcr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554434,799,056 - 4,908,767 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554434,799,056 - 4,908,749 (-)NCBIChiLan1.0ChiLan1.0
GRXCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2343,076,351 - 43,214,026 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1443,267,251 - 43,404,932 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0437,214,515 - 37,352,195 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1443,063,313 - 43,200,436 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl443,063,313 - 43,200,436 (+)Ensemblpanpan1.1panPan2
GRXCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11339,766,910 - 39,882,076 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1339,766,919 - 39,882,086 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1339,743,589 - 39,859,095 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01340,257,733 - 40,373,036 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1340,257,742 - 40,373,011 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11339,946,417 - 40,061,416 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01340,058,617 - 40,173,778 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01340,523,758 - 40,638,982 (+)NCBIUU_Cfam_GSD_1.0
Grxcr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528536,211,010 - 36,317,310 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364829,981,356 - 10,087,222 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364829,981,410 - 10,087,222 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRXCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1277,300,259 - 7,436,241 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl277,300,376 - 7,435,093 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604753,573,360 - 53,714,687 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grxcr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476123,876,301 - 24,039,603 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476123,876,226 - 24,039,591 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grxcr1
1023 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:114
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000059439
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 5 1 56 6 6
Below cutoff 2 4 19 5 13 5 8 9 14 25 25 5 8

Sequence


RefSeq Acc Id: ENSRNOT00000059439   ⟹   ENSRNOP00000056195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1440,004,169 - 40,126,571 (-)Ensembl
Rnor_6.0 Ensembl1441,663,688 - 41,786,084 (-)Ensembl
RefSeq Acc Id: NM_001191935   ⟹   NP_001178864
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81440,358,077 - 40,480,493 (-)NCBI
mRatBN7.21440,004,169 - 40,126,571 (-)NCBI
Rnor_6.01441,663,688 - 41,786,084 (-)NCBI
Rnor_5.01441,461,233 - 41,583,874 (-)NCBI
Celera1439,172,879 - 39,287,730 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092286   ⟹   XP_038948214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81440,358,091 - 40,436,757 (-)NCBI
mRatBN7.21440,004,183 - 40,082,832 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178864 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948214 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90018 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056195
  ENSRNOP00000056195.3
RefSeq Acc Id: NP_001178864   ⟸   NM_001191935
- UniProtKB: D4A048 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056195   ⟸   ENSRNOT00000059439
RefSeq Acc Id: XP_038948214   ⟸   XM_039092286
- Peptide Label: isoform X1
Protein Domains
Glutaredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A048-F1-model_v2 AlphaFold D4A048 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564635 AgrOrtholog
BioCyc Gene G2FUF-15796 BioCyc
Ensembl Genes ENSRNOG00000038891 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059439 ENTREZGENE
  ENSRNOT00000059439.5 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro Glutaredoxin UniProtKB/TrEMBL
  GRXCR1 UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene 498355 ENTREZGENE
PANTHER GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN 1 UniProtKB/TrEMBL
  PTHR46990 UniProtKB/TrEMBL
Pfam Glutaredoxin UniProtKB/TrEMBL
PhenoGen Grxcr1 PhenoGen
PROSITE GLUTAREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038891 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/TrEMBL
UniProt D4A048 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Grxcr1  glutaredoxin and cysteine rich domain containing 1  LOC100910415  glutaredoxin domain-containing cysteine-rich protein 1-like  Data merged from RGD:6498588 737654 PROVISIONAL
2016-03-08 Grxcr1  glutaredoxin and cysteine rich domain containing 1  Grxcr1  glutaredoxin, cysteine rich 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910415  glutaredoxin domain-containing cysteine-rich protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Grxcr1  glutaredoxin, cysteine rich 1  RGD1564635  similar to CG12206-PA, isoform A   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564635  similar to CG12206-PA, isoform A   RGD1564635_predicted  similar to CG12206-PA, isoform A (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564635_predicted  similar to CG12206-PA, isoform A (predicted)  LOC498355  similar to CG12206-PA, isoform A  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498355  similar to CG12206-PA, isoform A      Symbol and Name status set to provisional 70820 PROVISIONAL