Plscr5 (phospholipid scramblase family, member 5) - Rat Genome Database

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Gene: Plscr5 (phospholipid scramblase family, member 5) Rattus norvegicus
Analyze
Symbol: Plscr5
Name: phospholipid scramblase family, member 5
RGD ID: 1564500
Description: Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. Orthologous to human PLSCR5 (phospholipid scramblase family member 5); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC501036; phospholipid scramblase family member 5; RGD1564500; similar to phospholipid scramblase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88101,597,207 - 101,618,571 (+)NCBIGRCr8
mRatBN7.2892,717,479 - 92,738,843 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl892,722,600 - 92,738,299 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx898,400,883 - 98,416,577 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0896,600,134 - 96,615,828 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0894,432,845 - 94,448,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0899,558,279 - 99,579,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl899,568,958 - 99,579,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0899,042,074 - 99,063,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4897,143,459 - 97,159,158 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera892,241,712 - 92,257,400 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plscr5Rat(+)-catechin multiple interactionsISOPLSCR5 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PLSCR5 mRNACTDPMID:24763279
Plscr5Rat1,2-dichloroethane decreases expressionISOPlscr5 (Mus musculus)6480464ethylene dichloride results in decreased expression of PLSCR5 mRNACTDPMID:28960355
Plscr5Rat6-propyl-2-thiouracil affects expressionEXP 6480464Propylthiouracil affects the expression of PLSCR5 mRNACTDPMID:24780913
Plscr5Rataflatoxin B1 decreases methylationISOPLSCR5 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of PLSCR5 geneCTDPMID:27153756
Plscr5Ratbenzo[a]pyrene decreases methylationISOPLSCR5 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of PLSCR5 5' UTRCTDPMID:27901495
Plscr5Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of PLSCR5 mRNACTDPMID:25181051 more ...
Plscr5RatCGP 52608 multiple interactionsISOPLSCR5 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to PLSCR5 gene]CTDPMID:28238834
Plscr5RatCuprizon decreases expressionEXP 6480464Cuprizone results in decreased expression of PLSCR5 mRNACTDPMID:27523638
Plscr5RatCuprizon increases expressionEXP 6480464Cuprizone results in increased expression of PLSCR5 mRNACTDPMID:26577399
Plscr5Rattitanium dioxide increases expressionISOPlscr5 (Mus musculus)6480464titanium dioxide results in increased expression of PLSCR5 mRNACTDPMID:35295148
Plscr5Rattriclosan decreases expressionISOPLSCR5 (Homo sapiens)6480464Triclosan results in decreased expression of PLSCR5 mRNACTDPMID:30510588

1 to 11 of 11 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plscr5Ratplasma membrane phospholipid scrambling involved_inIBAMGI:893575 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plscr5Ratplasma membrane phospholipid scrambling involved_inIEAInterPro:IPR0055521600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plscr5Ratplasma membrane is_active_inIBAMGI:893575 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Plscr5Ratphospholipid scramblase activity enablesIEAInterPro:IPR0055521600115GO_REF:0000002InterProGO_REF:0000002
Plscr5Ratphospholipid scramblase activity enablesIBAPANTHER:PTN000582979 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Plscr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88101,597,207 - 101,618,571 (+)NCBIGRCr8
mRatBN7.2892,717,479 - 92,738,843 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl892,722,600 - 92,738,299 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx898,400,883 - 98,416,577 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0896,600,134 - 96,615,828 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0894,432,845 - 94,448,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0899,558,279 - 99,579,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl899,568,958 - 99,579,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0899,042,074 - 99,063,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4897,143,459 - 97,159,158 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera892,241,712 - 92,257,400 (+)NCBICelera
Cytogenetic Map8q31NCBI
PLSCR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383146,576,555 - 146,605,346 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3146,576,555 - 146,605,346 (-)EnsemblGRCh38hg38GRCh38
GRCh373146,294,342 - 146,323,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363147,786,315 - 147,806,693 (-)NCBINCBI36Build 36hg18NCBI36
Celera3144,720,660 - 144,741,039 (-)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3143,680,464 - 143,700,842 (-)NCBIHuRef
CHM1_13146,266,683 - 146,287,061 (-)NCBICHM1_1
T2T-CHM13v2.03149,331,731 - 149,360,509 (-)NCBIT2T-CHM13v2.0
Plscr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39992,068,569 - 92,094,589 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl992,074,989 - 92,091,825 (+)EnsemblGRCm39 Ensembl
GRCm38992,186,516 - 92,212,536 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl992,192,936 - 92,209,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv37992,087,774 - 92,104,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36992,087,774 - 92,104,536 (+)NCBIMGSCv36mm8
Celera991,780,517 - 91,797,373 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map948.33NCBI
Plscr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547410,855,888 - 10,904,450 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547410,855,958 - 10,903,801 (+)NCBIChiLan1.0ChiLan1.0
PLSCR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22144,461,879 - 144,490,694 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13144,466,610 - 144,495,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03143,593,413 - 143,628,126 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13151,176,200 - 151,210,799 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3151,176,253 - 151,212,156 (-)Ensemblpanpan1.1panPan2
PLSCR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12341,709,662 - 41,739,638 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2341,681,017 - 41,733,150 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2341,574,886 - 41,604,840 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02342,327,939 - 42,357,931 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2342,331,540 - 42,357,955 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12341,915,765 - 41,945,917 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02341,990,888 - 42,021,009 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02342,234,122 - 42,264,264 (-)NCBIUU_Cfam_GSD_1.0
Plscr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560281,019,261 - 81,046,315 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365198,694,575 - 8,712,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365198,688,210 - 8,712,104 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLSCR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1386,928,254 - 86,949,019 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11386,920,326 - 86,954,257 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21394,560,866 - 94,587,178 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLSCR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11544,096,245 - 44,134,975 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1544,106,757 - 44,121,238 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604116,985,249 - 17,012,992 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plscr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473023,549,667 - 23,565,050 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473023,551,467 - 23,565,050 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Plscr5
138 total Variants

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:8
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000073400
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 43 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat

1 to 10 of 43 rows



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 3 85 12 15 5 13 5 29 17 84 3 19 10



Ensembl Acc Id: ENSRNOT00000073400   ⟹   ENSRNOP00000066419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl892,722,600 - 92,738,299 (+)Ensembl
Rnor_6.0 Ensembl899,568,958 - 99,579,255 (+)Ensembl
RefSeq Acc Id: NM_001191999   ⟹   NP_001178928
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88101,597,207 - 101,618,571 (+)NCBI
mRatBN7.2892,717,479 - 92,738,843 (+)NCBI
Rnor_6.0899,563,556 - 99,579,255 (+)NCBI
Rnor_5.0899,042,074 - 99,063,372 (+)NCBI
Celera892,241,712 - 92,257,400 (+)NCBI
Sequence:
Protein RefSeqs NP_001178928 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77540 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066419
  ENSRNOP00000066419.3
RefSeq Acc Id: NP_001178928   ⟸   NM_001191999
- UniProtKB: M0RA77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066419   ⟸   ENSRNOT00000073400

Name Modeler Protein Id AA Range Protein Structure
AF-M0RA77-F1-model_v2 AlphaFold M0RA77 1-275 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 15 of 15 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29559 BioCyc
Ensembl Genes ENSRNOG00000047917 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073400 ENTREZGENE
  ENSRNOT00000073400.3 UniProtKB/TrEMBL
InterPro Scramblase UniProtKB/TrEMBL
  Tubby_C-like UniProtKB/TrEMBL
KEGG Report rno:501036 UniProtKB/TrEMBL
NCBI Gene 501036 ENTREZGENE
PANTHER PHOSPHOLIPID SCRAMBLASE FAMILY MEMBER 5 UniProtKB/TrEMBL
  PTHR23248 UniProtKB/TrEMBL
Pfam Scramblase UniProtKB/TrEMBL
PhenoGen Plscr5 PhenoGen
RatGTEx ENSRNOG00000047917 RatGTEx
Superfamily-SCOP Tubby_C UniProtKB/TrEMBL
UniProt M0RA77 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Plscr5  phospholipid scramblase family, member 5  RGD1564500  similar to phospholipid scramblase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1564500  similar to phospholipid scramblase 1   RGD1564500_predicted  similar to phospholipid scramblase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564500_predicted  similar to phospholipid scramblase 1 (predicted)  LOC501036  similar to phospholipid scramblase 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501036  similar to phospholipid scramblase 1      Symbol and Name status set to provisional 70820 PROVISIONAL