Advanced Search (OLGA)

Gene: Stk4 (serine/threonine kinase 4) Rattus norvegicus

Analyze

Symbol:

Stk4

Name:

serine/threonine kinase 4

RGD ID:

1312035

Description:

Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in positive regulation of vascular associated smooth muscle cell apoptotic process. Predicted to be located in cytosol and nuclear body. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human STK4 (serine/threonine kinase 4); PARTICIPATES IN mitogen activated protein kinase signaling pathway; non-small cell lung carcinoma pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC311622; serine/threonine-protein kinase 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STK4 (serine/threonine kinase 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Stk4 (serine/threonine kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Stk4 (serine/threonine kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STK4 (serine/threonine kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STK4 (serine/threonine kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Stk4 (serine/threonine kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STK4 (serine/threonine kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STK4 (serine/threonine kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Stk4 (serine/threonine kinase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	STK4 (serine/threonine kinase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Stk4 (serine/threonine kinase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cst-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	hpo	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	stk4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	173,165,238 - 173,247,135 (+)	NCBI		GRCr8
mRatBN7.2	3	152,745,958 - 152,827,747 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	152,745,681 - 152,827,744 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	156,556,038 - 156,635,241 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,054,974 - 165,134,178 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	162,798,706 - 162,878,517 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	160,467,552 - 160,546,540 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	160,467,552 - 160,546,540 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	166,652,145 - 166,731,213 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,014,941 - 155,095,272 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	154,920,949 - 154,998,005 (+)	NCBI
Celera	3	151,397,134 - 151,475,844 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenosine deaminase deficiency (ISO)

bipolar disorder (ISO)

focal epilepsy (ISO)

genetic disease (ISO)

primary immunodeficiency disease (ISO)

severe combined immunodeficiency (ISO)

T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

(20S)-ginsenoside Rg3 (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

5-fluorouracil (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

alendronic acid (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

antirheumatic drug (ISO)

arsenic acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP)

bortezomib (ISO)

carbon nanotube (ISO)

chloroprene (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclophosphamide (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (ISO)

disodium selenite (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

folic acid (ISO)

FR900359 (ISO)

hydroxyurea (ISO)

irinotecan (ISO)

ivermectin (ISO)

leptomycin B (ISO)

Licochalcone A (ISO)

methidathion (ISO)

methimazole (EXP)

methoxychlor (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (EXP,ISO)

sunitinib (ISO)

T-2 toxin (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

torcetrapib (ISO)

Tributyltin oxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (ISO)

vincristine (ISO)

vitamin E (ISO)

XMU-MP-1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (ISO)

branching involved in blood vessel morphogenesis (ISO)

canonical Wnt signaling pathway (ISO)

cell differentiation involved in embryonic placenta development (ISO)

cell morphogenesis (ISO)

cell population proliferation (ISO)

central nervous system development (ISO)

chromatin remodeling (IEA)

endocardium development (ISO)

epithelial cell proliferation (ISO)

extrinsic apoptotic signaling pathway via death domain receptors (ISO)

hepatocyte apoptotic process (ISO)

hippo signaling (ISO)

intracellular signal transduction (IBA,ISO)

keratinocyte differentiation (ISO)

negative regulation of canonical Wnt signaling pathway (IBA,ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of epithelial cell proliferation (ISO)

negative regulation of organ growth (ISO)

neural tube formation (ISO)

organ growth (ISO)

peptidyl-serine phosphorylation (ISO)

positive regulation of apoptotic process (IBA,ISO)

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (ISO)

positive regulation of fat cell differentiation (ISO)

positive regulation of hepatocyte apoptotic process (ISO)

positive regulation of hippo signaling (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of substrate-dependent cell migration, cell attachment to substrate (ISO)

positive regulation of vascular associated smooth muscle cell apoptotic process (IMP)

primitive hemopoiesis (ISO)

protein autophosphorylation (ISO)

protein import into nucleus (ISO)

protein phosphorylation (ISO)

protein stabilization (ISO)

protein tetramerization (IEA)

regulation of cell differentiation involved in embryonic placenta development (ISO)

regulation of MAPK cascade (IBA)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

nuclear body (IEA,ISO)

nucleoplasm (ISO)

nucleus (ISO)

protein-containing complex (ISO)

Molecular Function

3-phosphoinositide-dependent protein kinase activity (IEA)

AMP-activated protein kinase activity (IEA)

ATP binding (ISO)

DNA-dependent protein kinase activity (IEA)

eukaryotic translation initiation factor 2alpha kinase activity (IEA)

histone H2AS1 kinase activity (IEA)

histone H2AS121 kinase activity (IEA)

histone H2AT120 kinase activity (IEA)

histone H2AXS139 kinase activity (IEA)

histone H2BS14 kinase activity (IEA)

histone H2BS36 kinase activity (IEA)

histone H3S10 kinase activity (IEA)

histone H3S28 kinase activity (IEA)

histone H3S57 kinase activity (IEA)

histone H3T11 kinase activity (IEA)

histone H3T3 kinase activity (IEA)

histone H3T45 kinase activity (IEA)

histone H3T6 kinase activity (IEA)

histone H4S1 kinase activity (IEA)

identical protein binding (ISO)

magnesium ion binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

protein kinase activity (ISO)

protein serine/threonine kinase activity (IBA,ISO)

Rho-dependent protein serine/threonine kinase activity (IEA)

ribosomal protein S6 kinase activity (IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

non-small cell lung carcinoma pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Immunohistochemical localization of apoptosome-related proteins in Lewy bodies in Parkinson's disease and dementia with Lewy bodies.	Kawamoto Y, etal., Brain Res. 2014 Jul 7;1571:39-48. doi: 10.1016/j.brainres.2014.05.007. Epub 2014 May 13.
4.	MicroRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mst1.	Li S, etal., Biochem J. 2013 Jun 1;452(2):281-91. doi: 10.1042/BJ20120680.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8566796	PMID:8702870	PMID:9545236	PMID:11278283	PMID:11805089	PMID:12384512	PMID:12477932	PMID:15109305	PMID:15688006	PMID:16751106	PMID:16930133	PMID:17517604
PMID:17932490	PMID:18328708	PMID:18369314	PMID:18986304	PMID:19073936	PMID:19525978	PMID:19786569	PMID:19962960	PMID:20080598	PMID:20080689	PMID:20412773	PMID:20562859
PMID:21212262	PMID:21512132	PMID:22292086	PMID:23386615	PMID:24595170	PMID:31847471	PMID:32240614	PMID:33568044	PMID:34217161	PMID:35395037	PMID:38430683

Genomics

Comparative Map Data

Stk4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	173,165,238 - 173,247,135 (+)	NCBI		GRCr8
mRatBN7.2	3	152,745,958 - 152,827,747 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	152,745,681 - 152,827,744 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	156,556,038 - 156,635,241 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,054,974 - 165,134,178 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	162,798,706 - 162,878,517 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	160,467,552 - 160,546,540 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	160,467,552 - 160,546,540 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	166,652,145 - 166,731,213 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,014,941 - 155,095,272 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	154,920,949 - 154,998,005 (+)	NCBI
Celera	3	151,397,134 - 151,475,844 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

STK4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	44,966,512 - 45,080,021 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	44,966,494 - 45,084,214 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	43,595,153 - 43,708,662 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	43,028,534 - 43,142,008 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	43,028,533 - 43,142,005	NCBI
Celera	20	40,303,755 - 40,417,237 (+)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	40,336,825 - 40,450,492 (+)	NCBI		HuRef
CHM1_1	20	43,497,900 - 43,611,341 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	46,702,402 - 46,815,925 (+)	NCBI		T2T-CHM13v2.0

Stk4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	163,916,033 - 163,997,444 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	163,912,242 - 163,997,444 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	164,074,113 - 164,155,524 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	164,070,322 - 164,155,524 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	163,899,914 - 163,981,257 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	163,765,619 - 163,846,962 (+)	NCBI		MGSCv36	mm8
Celera	2	170,004,346 - 170,087,071 (+)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	84.6	NCBI

Stk4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	12,308,285 - 12,399,012 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	12,308,285 - 12,399,012 (-)	NCBI	ChiLan1.0	ChiLan1.0

STK4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	50,699,610 - 50,812,920 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	50,692,724 - 50,806,027 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	41,297,157 - 41,410,487 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	42,389,611 - 42,503,014 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	42,389,615 - 42,503,014 (+)	Ensembl	panpan1.1		panPan2

STK4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	32,375,630 - 32,463,848 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	32,375,189 - 32,521,042 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	32,021,037 - 32,109,251 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	33,086,419 - 33,174,685 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	33,086,465 - 33,231,663 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	32,347,829 - 32,432,566 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	32,462,830 - 32,551,067 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	33,004,538 - 33,092,881 (+)	NCBI		UU_Cfam_GSD_1.0

Stk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	192,233,117 - 192,331,335 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	7,686,087 - 7,785,025 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	7,686,760 - 7,784,948 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STK4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	47,387,600 - 47,475,718 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	47,387,594 - 47,475,705 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	52,912,419 - 52,932,976 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STK4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	18,737,484 - 18,844,610 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	18,742,162 - 18,844,647 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	67,388,889 - 67,493,337 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stk4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	9,415,177 - 9,521,051 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624790	9,415,172 - 9,521,103 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Stk4
257 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	450
Count of miRNA genes:	234
Interacting mature miRNAs:	308
Transcripts:	ENSRNOT00000066657
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	145925360	166177555	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145925360	166177555	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145956084	157309487	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	145925360	166177555	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	145925360	166177555	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	145925360	166177555	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	145925360	166177555	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	145956084	161299569	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	149040888	168026850	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	145925360	166177555	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat

Markers in Region

RH142266

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	152,827,378 - 152,827,562 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	160,546,175 - 160,546,358	NCBI	Rnor6.0
Rnor_5.0	3	166,730,845 - 166,731,028	UniSTS	Rnor5.0
RGSC_v3.4	3	155,094,907 - 155,095,090	UniSTS	RGSC3.4
Celera	3	151,475,479 - 151,475,662	UniSTS
RH 3.4 Map	3	1422.2	UniSTS
Cytogenetic Map	3	q42	UniSTS

BF388103

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	152,810,385 - 152,810,583 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	160,529,214 - 160,529,411	NCBI	Rnor6.0
Rnor_5.0	3	166,713,884 - 166,714,081	UniSTS	Rnor5.0
RGSC_v3.4	3	155,077,946 - 155,078,143	UniSTS	RGSC3.4
Celera	3	151,458,518 - 151,458,715	UniSTS
RH 3.4 Map	3	1422.2	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC088330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066657 ⟹ ENSRNOP00000061873

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	152,753,508 - 152,827,744 (+)	Ensembl
Rnor_6.0 Ensembl	3	160,467,552 - 160,546,540 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098768 ⟹ ENSRNOP00000076920

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	152,753,173 - 152,827,744 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099516 ⟹ ENSRNOP00000078057

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	152,748,585 - 152,827,744 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118925 ⟹ ENSRNOP00000084019

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	152,745,681 - 152,827,744 (+)	Ensembl

RefSeq Acc Id:

NM_001107800 ⟹ NP_001101270

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	173,167,992 - 173,247,132 (+)	NCBI
mRatBN7.2	3	152,748,600 - 152,827,744 (+)	NCBI
Rnor_6.0	3	160,467,552 - 160,546,540 (+)	NCBI
Rnor_5.0	3	166,652,145 - 166,731,213 (+)	NCBI
RGSC_v3.4	3	155,014,941 - 155,095,272 (+)	RGD
Celera	3	151,397,134 - 151,475,844 (+)	RGD

Sequence:

show sequence

GGGCTCCCAGAGGATGGAGCATTGAGGCAGTCTGGGCGGCTGCTGGCAGCGCCATGGAGACCGT
GCAACTGAGGAACCCACCGCGCAGGCAGCTGAAAAAGTTGGATGAAGATAGTTTAACTAAACAG
CCAGAAGAAGTGTTTGATGTCTTAGAGAAACTTGGAGAAGGGTCTTATGGCAGCGTGTACAAGG
CGATTCACAAAGAGACCGGCCAGATTGTCGCCATCAAGCAGGTGCCCGTGGAGTCGGACCTGCA
GGAGATAATCAAGGAAATCTCGATAATGCAGCAGTGTGACAGCCCACATGTCGTCAAATACTAT
GGCAGCTACTTTAAGAACACGGACCTGTGGATTGTTATGGAGTACTGTGGGGCTGGTTCTGTAT
CCGATATTATTCGGCTCCGAAACAAGACGTTAACAGAAGATGAAATAGCTACAATATTACAATC
AACTCTTAAAGGATTAGAATACCTTCATTTTATGAGAAAAATACACCGAGATATCAAGGCGGGA
AATATTTTGCTAAACACAGAAGGCCATGCAAAGCTTGCAGACTTTGGAGTCGCAGGCCAACTTA
CAGATACCATGGCAAAGAGGAATACAGTGATAGGGACACCGTTTTGGATGGCTCCTGAAGTTAT
TCAGGAAATCGGGTACAACTGTGTGGCAGACATCTGGTCTCTGGGAATCACGGCCATAGAAATG
GCTGAAGGAAAGCCCCCATACGCTGACATCCATCCAATGAGGGCAATATTCATGATTCCTACAA
ACCCTCCTCCCACATTCCGTAAGCCCGAGGTGTGGTCGGACAACTTCATGGATTTCGTGAAGCA
GTGTCTGGTAAAAAGCCCGGAGCAGAGAGCCACAGCCACTCAGCTCCTCCAGCACCCGTTTGTT
AAGAGCGCCAAGGGAGCGGCCATACTGCGAGACTTAATTAACGAGGCCATGGACGTGAAACTGA
AGCGCCAGGAAGCCCAGCAGCGGGCAGTGGACCAGGACGACGATGAGAACTCAGAGGAGGATGA
AATGGACTCTGGCACGATGGTTCGAGCTGCGGGTGATGACATGGGCACTGTCCGAGTAGCCAGC
ACGATGAGCGGCGGAGCCAATACTATGATTGAGCACGGTGACACATTGCCATCCCAGCTGGGTA
CCATGGTGATCAACACGGAGGATGAGGAAGAGGAAGGAACCATGAAAAGGAGAGATGAGACCAT
GCAGCCTGCAAAACCGTCTTTTCTTGAATACTTTGAACAAAAAGAAAAGGAAAATCAGATCAAC
AGCTTTGGCAAGAATGTATCTGGCTCTCTGAAGAATTCTTCAGATTGGAAAATACCTCAGGATG
GAGACTACGAGTTTCTGAAGAGCTGGACTGTGGAGGACCTTCAGAAGCGGCTCTCTGCCCTCGA
CCCCATGATGGAGCAGGAAATGGAAGAGATCCGGCAGAAATACCGCTCCAAGCGGCAGCCAATC
CTGGATGCCATCGAAGCCAAGAAGAGGAGGCAACAGAACTTCTGATGACACCAGCCCAGCCTTT
GGTGGCTTCTGGGTTGCTAGACTCGTGTCTGTTAGCCAGCACTTCTGCTCTGTCATTTATCCAC
AGCACCTTTGTGAACTCAGGAATGCACGCCAGTGGGAAGGGCTACTCGACAGTCATTGTGCCAT
TTGGTGTGAGCATTTACACCAGCAAGGTGTATCTTGAAGGGTTTGTATTGGTGCTTTTAACTCA
GAAATTTAGACCCCAGGAGCAGAGACTCCTAGTTCAGTGACAGCTGGGACATTTTTTTTTTTTT
TTACATTGTTTCTTTTGTTTTCCTCCTAGTAATAGCTTTTGGTTGCTCGCCCTGGAATACTTTT
TAAAAATCTATAAATATGCATATATATAAATTATAAATAGACCCCCCACTCCGTGTGGGGGTAT
CTCTGTACAGGTACAGTTTCAAACACTTTGCCTCTTTCCTGTGAGATTATGGTACTGTGCAGCA
AGAGAGCAGAGGACACTGGGAGACTTAGCTTGTCACTGAATCCCAGGAGTCAGCGTCATCTGTT
ACAGAGCTGCATGGAGAAATTAGTCTTGGGATGGATGTGCTACCACAGTGACAAGCCTCGTGTG
GTCACCACTGGTCTCCAAAGCTGTCGGTGGCCGGGAAAAAGCCTGGAGAACTTGAGTTGGCTCC
TTGAGTCCCAGGAGAAGCCTTTGCTCTCCCAACGCCTTTCATGCATCCCCACCCTCCCAGCTGC
CTGCAGTCACACCTCAGATCCTGCCCAGTGCCTTAAGAGGAGACACATCTGTGAAAGGACAGGC
AACCAAGAACTCTCCAGCAAACAGGGCCCTCAGCAGTCCAAAAACCTCGCTGTTGATGGGGACT
CACACACGGCATTCATTCCTTCGATACAGGGTAAAGGGCACTGCTTTCATGGTCCACATTCAAA
TACGTGATTGTTTATTTTATTTTTTTCACTCACTGTGGAGGCTGTGACAAGGGTAAATTAATGC
CAGACTGAGGCTCACTCAGAATGGCAGAGCTGGAAGGGCCTGTGGCAGTCATTGGGTCCGACCT
TGTATTGTCCCAGTGGGAAAATGAGACTTAGAGGAGAGGTGACTTTGTCAATGTCACAAATCAA
GTTAGAAGCAGGGATGAGAATTCAGAGCCTTTGTTCTGGGCCACTGGACCAAGAACCTCTTCAC
TGAGAATGAAGAATTGTAGACCAGGTTGGCCCAGGAACCCCTGCTCGCTCTTTGCCTCTTTGGT
ACCCAAGCTGCTGTGGAAAGGCTCCCCAGGGCAGCCATGTCATTCTGTCTCAGCATACCAGCGG
TGTCTTACGGTGTCTCCCAGCTACAGACAGGCACTCACGAAAGGCCTGCAGCGGGGTGGAGGGC
TTTGCAAAGACAGTTACAGAGTCATCTCTGCGCCCTTAGCTCAAAACTGCAGCCAGAAGGAACT
GGGAAGGCAGTTGCCTTTTATTTCTTCCCCTTTCGTCCCTCTGATGGGGCTGCACCTGAGGACA
CGGAAACTCGACTCCTTTAATTGCCTTTGCTCCCTAACTGGAGAGTCGATAAAAAGGCAGGGGA
TGTTCTGTTCTGTGACCAGACTCTGTTCTTTGCAGTTAAAGCAAGCTTTAAAAAATGCAAGAGG
CAGCTGGTCTGCAGGACGCAGCCAGCAAAGCAACTGTGCAACAGAGAGGATTAGAGGACCGTTT
GAGGATCTTGCTGGGATGATAAATGGTGGCCAGCACTCTGGGTAGCAGGCGGCAGGCACTGAGC
AAGGTGTTCTACAGATTCATCGGGGTCCCCTGTGCTCGCTAACTAAGTTCTTTCTCATATGATG
AAATTGAGTTTGAAAGATTCCTCCCCACGACACCGTGGATCTGGATGCCTTGGCATCCTGTCAG
GCTAGCAGTCCCAGAAATCGGGAAGTCCAAAACGCTTAGAATGAAGTGACCGCGGCTTCTCACC
AAGTGTAAGTGGTATTTTTTTTTTTTTTTTTTTGGTTCTTTTTTTCGGAGCTGGGGACCGAACC
CAGGGCCTTGCACTTCCTAGGCAAGCGCTCTACCACTGAGCTAAATCCCCAACCCCAAGTGGTA
TTTTTTTTTTAAAGGTTAGAAACCAGATGAATTAATAGTCCTGTCCCCCAGTCAAATTAATAGT
CCTGTACCCCAATCAAGAAAGTTTTTAAAAACCCAAAACAGGGAGGACATGCGTAACATTTGCT
ATGCTTACTTGGTAACCCAGCCTCAGCTCTTTCCTCTTGAAGAAAAAGGATTTGGGCTTTGCCA
GACAGAAGGGAAAAGCCCATGACTCCCTTCTGAAGCAAGGTGGGAGTACCAGAAAGTGGTTCTC
CTGTGAGCCTCCATCCGAGTCTGTGGTTGCAAGTGTGTCTGTGAAGCCCTTTGCCAGAAGCCAG
TTGTTTGAGGTCCCTGGTGAGGAGCATGCGATGTTCAGTGACAGTCAGGGGAGCAAACCACTCT
TCCCCTGAGGACCGAGTCCCAGGAAGCTTCACTTCCCTGGAGCCTGAGCCCTTGAGACTCTGGC
CAGCCTCTCTGCTCCAAGACGCTGAGGCCTACACCTAAATTTTCTTTTCAACAAACAAACCTCA
TGCTCTCTTAAAAGTTTTGTAGTTTTGCTCCCATTCATAAATTTGAAGCACATTTCCAATTTTA
TTTCCTTTATATATTTTTTATTTTATAGAAGATTTTATATATAAGATTTTATACTCCCCAGTAG
ATTAGACAAGAATTTGACAGGCTGGGAGTGAGAAAGATGGTTGGGTTGTGTGGATGAACAGGGG
CAGCAATCGAAGCCTCAGGAGTTGAGTCTTACACTGTAGAGTAGAACCTGGCAACGCCAGAAAC
TTCCTTTACCATTTAAAACTCAATAGCCCTGTCTAATGTCAGGAAGGAGAAGGATGGCGCTGTA
GGCCCTGCAGATTCTCAGAGCCGTAATAACAGAGTATTATGAACAGCTTCATGCTGATACACTC
ACCAGCTAAAGTGAAGTGGACGGATACCCAGAAAATGTCAAAGGAACTAAGCTTACTCAGAGAC
AAAATGGGCAGTCGCAACAGCCCCCAGCCCCTTTCCTACCAGAACTCGGTAGCTCTGAGAGACA
CGGATATCTCTTCCTTCAAAGGATCTGACACTCTGGTAGCAACTGTTCCTCAAGGTCATGCCAG
CAGAGTGTGACAGAGTCTTACTCCACTGTCCTTCCCAGCATACCTTTTGGTCCCTAAAGACTGC
CATTCTTCATCTTGGAGGAAATTGTTCCCACTCAAACCACACCCCTCACCTCACCGTTCTCAGC
CTTTTCTAAGGACCGTGTTTGTATTTTTATTTGGATGACACGCATCGTTTTTGGAATCCATGCT
CTCTGTGTTTAGACGGGAGGTCTCTTCCACCAGCCTGCACTCAGACCAACTTGGAAAGAAAAAA
AAATCTGAAATGCTGTTGCTGATGTACAATTTAAAAAGAAAATGTGAAGTTTGTAGCTTTAATC
TTTTGTAACAAAAACTAATTAACACTGGCTTCAGTGCTGACCGGAAATGCTATTTTGTAAGGTT
TGGCTGTAAATAATAGAGCTCAGCTGTTTGTATATGTGTGAAACATAGCTTCCTCCACTGCCGT
GTTCTTTTAACTTGAGGTACCTCCTGTGTGCGTTTATGTTAGAGTTGTCCCCCCTCACCCCTCC
CCCAACACCTGTCACCCTTGCGTTAAATAAACTGTCCTTTAGACC

hide sequence

RefSeq Acc Id:

XM_039105129 ⟹ XP_038961057

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	173,165,238 - 173,247,135 (+)	NCBI
mRatBN7.2	3	152,745,958 - 152,827,747 (+)	NCBI

RefSeq Acc Id:

XM_039105130 ⟹ XP_038961058

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	173,189,153 - 173,247,135 (+)	NCBI
mRatBN7.2	3	152,769,736 - 152,827,747 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101270	(Get FASTA)	NCBI Sequence Viewer
	XP_038961057	(Get FASTA)	NCBI Sequence Viewer
	XP_038961058	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL96550	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061873.2
	ENSRNOP00000076920.1
	ENSRNOP00000078057.1
	ENSRNOP00000084019.1

RefSeq Acc Id:

NP_001101270 ⟸ NM_001107800

- UniProtKB:

A6JX59 (UniProtKB/TrEMBL), A0A8I6A0F8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE
SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIAT
ILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMA
PEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEVWSDNFMD
FVKQCLVKSPEQRATATQLLQHPFVKSAKGAAILRDLINEAMDVKLKRQEAQQRAVDQDDDENS
EEDEMDSGTMVRAAGDDMGTVRVASTMSGGANTMIEHGDTLPSQLGTMVINTEDEEEEGTMKRR
DETMQPAKPSFLEYFEQKEKENQINSFGKNVSGSLKNSSDWKIPQDGDYEFLKSWTVEDLQKRL
SALDPMMEQEMEEIRQKYRSKRQPILDAIEAKKRRQQNF

hide sequence

Ensembl Acc Id:

ENSRNOP00000061873 ⟸ ENSRNOT00000066657

RefSeq Acc Id:	XP_038961057 ⟸ XM_039105129
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5Y708 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961058 ⟸ XM_039105130
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000078057 ⟸ ENSRNOT00000099516

Ensembl Acc Id:

ENSRNOP00000076920 ⟸ ENSRNOT00000098768

Ensembl Acc Id:

ENSRNOP00000084019 ⟸ ENSRNOT00000118925

Protein Domains

Protein kinase SARAH

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A648-F1-model_v2	AlphaFold	D4A648	1-487	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692646

Promoter ID:

EPDNEW_R3169

Type:

initiation region

Name:

Stk4_1

Description:

serine/threonine kinase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	160,467,560 - 160,467,620	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1312035	AgrOrtholog
BioCyc Gene	G2FUF-46883	BioCyc
Ensembl Genes	ENSRNOG00000013529	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000066657.2	UniProtKB/TrEMBL
	ENSRNOT00000098768.1	UniProtKB/TrEMBL
	ENSRNOT00000099516.1	UniProtKB/TrEMBL
	ENSRNOT00000118925.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.4270	UniProtKB/TrEMBL
	4.10.170.10	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	p53_tetramer_sf	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	SARAH	UniProtKB/TrEMBL
	SARAH_domain	UniProtKB/TrEMBL
	STE20_Ser/Thr_kinase	UniProtKB/TrEMBL
KEGG Report	rno:311622	UniProtKB/TrEMBL
NCBI Gene	311622	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE 4	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE TAO	UniProtKB/TrEMBL
Pfam	Mst1_SARAH	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PhenoGen	Stk4	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	SARAH	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013529	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A8I5Y708	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZJB8_RAT	UniProtKB/TrEMBL
	A0A8I6A0F8	ENTREZGENE, UniProtKB/TrEMBL
	A6JX59	ENTREZGENE, UniProtKB/TrEMBL
	D4A648_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Stk4	serine/threonine kinase 4	Stk4_predicted	serine/threonine kinase 4 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Stk4_predicted	serine/threonine kinase 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)