Stk4 (serine/threonine kinase 4) - Rat Genome Database

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Gene: Stk4 (serine/threonine kinase 4) Heterocephalus glaber
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Symbol: Stk4
Name: serine/threonine kinase 4
RGD ID: 18928716
Description: ENCODES a protein that exhibits ATP binding (inferred); identical protein binding (inferred); kinase activity (inferred); INVOLVED IN apoptotic process (ortholog); branching involved in blood vessel morphogenesis (ortholog); canonical Wnt signaling pathway (ortholog); ASSOCIATED WITH bipolar disorder (ortholog); focal epilepsy (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,415,177 - 9,521,051 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,415,172 - 9,521,103 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation involved in embryonic placenta development  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
central nervous system development  (IEA,ISO)
endocardium development  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
hepatocyte apoptotic process  (IEA,ISO)
hippo signaling  (IEA,ISO)
intracellular signal transduction  (IEA)
keratinocyte differentiation  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of organ growth  (IEA,ISO)
neural tube formation  (IEA,ISO)
organ growth  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of hepatocyte apoptotic process  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of substrate-dependent cell migration, cell attachment to substrate  (IEA)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
primitive hemopoiesis  (IEA,ISO)
protein import into nucleus  (IEA)
protein stabilization  (IEA,ISO)
protein tetramerization  (IEA)
regulation of cell differentiation involved in embryonic placenta development  (IEA,ISO)
regulation of MAPK cascade  (IEA)
signal transduction  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Stk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247909,415,177 - 9,521,051 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247909,415,172 - 9,521,103 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
STK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,966,512 - 45,080,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2044,966,494 - 45,080,021 (+)EnsemblGRCh38hg38GRCh38
GRCh372043,595,153 - 43,708,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,028,534 - 43,142,008 (+)NCBINCBI36Build 36hg18NCBI36
Build 342043,028,533 - 43,142,005NCBI
Celera2040,303,755 - 40,417,237 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2040,336,825 - 40,450,492 (+)NCBIHuRef
CHM1_12043,497,900 - 43,611,341 (+)NCBICHM1_1
T2T-CHM13v2.02046,702,402 - 46,815,925 (+)NCBIT2T-CHM13v2.0
Stk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,916,033 - 163,997,444 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2163,912,242 - 163,997,444 (+)EnsemblGRCm39 Ensembl
GRCm382164,074,113 - 164,155,524 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,070,322 - 164,155,524 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,899,914 - 163,981,257 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362163,765,619 - 163,846,962 (+)NCBIMGSCv36mm8
Celera2170,004,346 - 170,087,071 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.6NCBI
Stk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,165,238 - 173,247,135 (+)NCBIGRCr8
mRatBN7.23152,745,958 - 152,827,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,745,681 - 152,827,744 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3156,556,038 - 156,635,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,054,974 - 165,134,178 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03162,798,706 - 162,878,517 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03160,467,552 - 160,546,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,467,552 - 160,546,540 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,652,145 - 166,731,213 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,014,941 - 155,095,272 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13154,920,949 - 154,998,005 (+)NCBI
Celera3151,397,134 - 151,475,844 (+)NCBICelera
Cytogenetic Map3q42NCBI
Stk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,308,285 - 12,399,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,308,285 - 12,399,012 (-)NCBIChiLan1.0ChiLan1.0
STK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,699,610 - 50,812,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12050,692,724 - 50,806,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02041,297,157 - 41,410,487 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12042,389,611 - 42,503,014 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,389,615 - 42,503,014 (+)Ensemblpanpan1.1panPan2
STK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,375,630 - 32,463,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,375,189 - 32,521,042 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,021,037 - 32,109,251 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,086,419 - 33,174,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,086,465 - 33,231,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12432,347,829 - 32,432,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02432,462,830 - 32,551,067 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,004,538 - 33,092,881 (+)NCBIUU_Cfam_GSD_1.0
Stk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,233,117 - 192,331,335 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,686,087 - 7,785,025 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,686,760 - 7,784,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,387,600 - 47,475,718 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,387,594 - 47,475,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,912,419 - 52,932,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,737,484 - 18,844,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,742,162 - 18,844,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605067,388,889 - 67,493,337 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: ENSHGLT00000008437   ⟹   ENSHGLP00000008348
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247909,415,177 - 9,521,051 (-)Ensembl
RefSeq Acc Id: XM_004858176   ⟹   XP_004858233
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247909,415,172 - 9,521,103 (-)NCBI
RefSeq Acc Id: XM_021238912   ⟹   XP_021094571
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247909,415,172 - 9,515,618 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004858233 (Get FASTA)   NCBI Sequence Viewer  
  XP_021094571 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000008348
  ENSHGLP00000054463
GenBank Protein JAO00865 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004858233   ⟸   XM_004858176
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JWM1 (UniProtKB/TrEMBL),   G5BB27 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094571   ⟸   XM_021238912
- Peptide Label: isoform X2
- UniProtKB: G5BB27 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000008348   ⟸   ENSHGLT00000008437


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000006041 Ensembl, ENTREZGENE
  ENSHGLG00000046460 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000008437 ENTREZGENE
  ENSHGLT00000047431 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.4270 UniProtKB/TrEMBL
  4.10.170.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Mst1_SARAH_domain UniProtKB/TrEMBL
  p53_tetramer_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SARAH_dom UniProtKB/TrEMBL
KEGG Report hgl:101704401 UniProtKB/TrEMBL
NCBI Gene Stk4 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE 4 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TAO UniProtKB/TrEMBL
Pfam Mst1_SARAH UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  SARAH UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6JWM1 ENTREZGENE, UniProtKB/TrEMBL
  G5BB27 ENTREZGENE, UniProtKB/TrEMBL