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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1312035
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stk4
Name: serine/threonine kinase 4
Acc ID: CHEBI:44423
Term: hydroxyurea
Definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Chemical ID: MESH:D006918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stk4increases cleavageISOStk4 (Mus musculus)6480464CTDHydroxyurea results in increased cleavage of STK4 proteinPMID:29228353
Stk4multiple interactionsISOStk4 (Mus musculus)6480464CTDTRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased cleavage of STK4 protein]PMID:29228353
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