Stk4 (serine/threonine kinase 4) - Rat Genome Database

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Gene: Stk4 (serine/threonine kinase 4) Mus musculus
Analyze
Symbol: Stk4
Name: serine/threonine kinase 4
RGD ID: 1323809
MGI Page MGI
Description: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in hippo signaling and positive regulation of substrate-dependent cell migration, cell attachment to substrate. Acts upstream of or within several processes, including animal organ development; epithelial tube morphogenesis; and regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in ovary; renal vasculature; and testis. Orthologous to human STK4 (serine/threonine kinase 4); PARTICIPATES IN mitogen activated protein kinase signaling pathway; non-small cell lung carcinoma pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI447339; AU020804; Kas; Kas-2; mammalian STE20-like protein kinase 1; Mst; MST-1; Mst1; serine/threonine-protein kinase 4; Sps1/Ste20-related kinase 3; STE20-like kinase MST1; sterile 20-like kinase 1; Yeast Sps1/Ste20-related kinase 3; Ysk; Ysk3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,916,033 - 163,997,444 (+)NCBIGRCm39mm39
GRCm39 Ensembl2163,912,242 - 163,997,444 (+)Ensembl
GRCm382164,074,113 - 164,155,524 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,070,322 - 164,155,524 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,899,914 - 163,981,257 (+)NCBIGRCm37mm9NCBIm37
MGSCv362163,765,619 - 163,846,962 (+)NCBImm8
Celera2170,004,346 - 170,087,071 (+)NCBICelera
Cytogenetic Map2H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IDA,ISO)
cytosol  (ISO)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IDA,ISO)
protein-containing complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal humoral immune response  (IEA)
abnormal immune system organ morphology  (IAGP)
abnormal leukocyte adhesion  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal liver sinusoid morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal lung development  (IAGP)
abnormal marginal zone B cell morphology  (IAGP)
abnormal memory T cell number  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal Peyer's patch germinal center morphology  (IAGP)
abnormal Peyer's patch T cell area morphology  (IAGP)
abnormal placenta development  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal placental transport  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
decreased B cell number  (IAGP)
decreased B-1 B cell number  (IEA)
decreased B-2 B cell number  (IEA)
decreased CD11b-high dendritic cell number  (IEA)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating aspartate transaminase level  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast apoptosis  (IAGP)
decreased hepatocyte apoptosis  (IAGP)
decreased IgD level  (IEA)
decreased IgG level  (IEA)
decreased length of long bones  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased myeloid dendritic cell number  (IAGP)
decreased sensitivity to induced cell death  (IAGP)
decreased sensitivity to induced morbidity/mortality  (IAGP)
decreased single-positive T cell number  (IEA)
decreased spleen white pulp amount  (IAGP)
decreased T cell number  (IAGP)
decreased trophoblast giant cell number  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
emphysema  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged pericardium  (IAGP)
enlarged spleen  (IAGP)
enlarged stomach  (IAGP)
failure of initiation of embryo turning  (IAGP)
impaired humoral immune response  (IEA)
incomplete embryo turning  (IAGP)
increased B-1b cell number  (IEA)
increased carcinoma incidence  (IAGP)
increased central memory CD4-positive, alpha-beta T cell number  (IEA)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased dendritic cell number  (IEA)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased embryonic tissue cell apoptosis  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased IgE level  (IEA)
increased IgM level  (IEA)
increased interferon-gamma secretion  (IAGP)
increased interleukin-2 secretion  (IAGP)
increased interleukin-4 secretion  (IAGP)
increased liver tumor incidence  (IAGP)
increased liver weight  (IAGP)
increased lung endothelial cell proliferation  (IAGP)
increased macrophage cell number  (IEA)
increased neutrophil cell number  (IEA)
increased NK cell number  (IEA)
increased placenta apoptosis  (IAGP)
increased single-positive T cell number  (IAGP)
increased T cell apoptosis  (IAGP)
increased T cell proliferation  (IAGP)
increased thymocyte number  (IAGP)
lethargy  (IAGP)
liver hyperplasia  (IAGP)
lung inflammation  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pale yolk sac  (IAGP)
postnatal lethality  (IAGP)
primary atelectasis  (IAGP)
pulmonary hyaline membrane formation  (IAGP)
short limbs  (IAGP)
small ectoplacental cone  (IAGP)
thymus hyperplasia  (IAGP)
References

Additional References at PubMed
PMID:7559398   PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11278283   PMID:11805089   PMID:11864565   PMID:12223493  
PMID:12384512   PMID:12477932   PMID:12520002   PMID:12750396   PMID:14610273   PMID:15345747   PMID:15489334   PMID:15741177   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16892067  
PMID:17395874   PMID:17708935   PMID:17967808   PMID:18287559   PMID:18369314   PMID:18799693   PMID:18942145   PMID:19073936   PMID:19339990   PMID:19692642   PMID:19786569   PMID:19822666  
PMID:19878874   PMID:19956688   PMID:19962960   PMID:20080598   PMID:20080689   PMID:20171103   PMID:21376238   PMID:21512031   PMID:21572393   PMID:21677750   PMID:21730291   PMID:21831922  
PMID:21873635   PMID:22042863   PMID:22292086   PMID:22412158   PMID:22926556   PMID:23033074   PMID:23071096   PMID:23085515   PMID:23374633   PMID:23454691   PMID:23555292   PMID:23620511  
PMID:23644383   PMID:23684612   PMID:23818595   PMID:24040101   PMID:24141421   PMID:24224013   PMID:24453252   PMID:24457600   PMID:24595170   PMID:24633305   PMID:24852423   PMID:24874741  
PMID:25133611   PMID:25225358   PMID:25544559   PMID:25667983   PMID:25695629   PMID:25772357   PMID:25787764   PMID:25912685   PMID:25986053   PMID:26039999   PMID:26056943   PMID:26131558  
PMID:26389641   PMID:26414765   PMID:26457732   PMID:26538370   PMID:26538561   PMID:26787462   PMID:26903296   PMID:26923596   PMID:27125670   PMID:27358050   PMID:27496379   PMID:27510910  
PMID:27535619   PMID:27701149   PMID:27869648   PMID:28087714   PMID:28137909   PMID:28145433   PMID:28210902   PMID:28378742   PMID:28457749   PMID:28486106   PMID:28527887   PMID:28681838  
PMID:28833175   PMID:29017029   PMID:29127009   PMID:29343826   PMID:29474739   PMID:29674007   PMID:29712669   PMID:29849151   PMID:29934496   PMID:29961191   PMID:30093562   PMID:30196744  
PMID:30251683   PMID:30338935   PMID:30386341   PMID:30413360   PMID:30478091   PMID:30537740   PMID:30651296   PMID:30765703   PMID:30771091   PMID:30783090   PMID:30912742   PMID:31117242  
PMID:31215035   PMID:31283035   PMID:31434702   PMID:31572367   PMID:31676778   PMID:31707227   PMID:31857346   PMID:32253273   PMID:32289155   PMID:32320827   PMID:32325033   PMID:32332916  
PMID:32376130   PMID:32468668   PMID:32470318   PMID:32510157   PMID:32627655   PMID:32687725   PMID:32730753   PMID:32929029   PMID:32975614   PMID:32987643   PMID:33086070  


Genomics

Comparative Map Data
Stk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,916,033 - 163,997,444 (+)NCBIGRCm39mm39
GRCm39 Ensembl2163,912,242 - 163,997,444 (+)Ensembl
GRCm382164,074,113 - 164,155,524 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,070,322 - 164,155,524 (+)EnsemblGRCm38mm10GRCm38
MGSCv372163,899,914 - 163,981,257 (+)NCBIGRCm37mm9NCBIm37
MGSCv362163,765,619 - 163,846,962 (+)NCBImm8
Celera2170,004,346 - 170,087,071 (+)NCBICelera
Cytogenetic Map2H3NCBI
STK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2044,966,479 - 45,080,021 (+)EnsemblGRCh38hg38GRCh38
GRCh382044,966,470 - 45,080,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372043,595,153 - 43,708,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,028,534 - 43,142,008 (+)NCBINCBI36hg18NCBI36
Build 342043,028,533 - 43,142,005NCBI
Celera2040,303,755 - 40,417,237 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2040,336,825 - 40,450,492 (+)NCBIHuRef
CHM1_12043,497,900 - 43,611,341 (+)NCBICHM1_1
Stk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23152,745,958 - 152,827,747 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3152,745,681 - 152,827,744 (+)Ensembl
Rnor_6.03160,467,552 - 160,546,540 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,467,552 - 160,546,540 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,652,145 - 166,731,213 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,014,941 - 155,095,272 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13154,920,949 - 154,998,005 (+)NCBI
Celera3151,397,134 - 151,475,844 (+)NCBICelera
Cytogenetic Map3q42NCBI
Stk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,308,285 - 12,399,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,308,285 - 12,399,012 (-)NCBIChiLan1.0ChiLan1.0
STK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12042,389,611 - 42,503,014 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,389,615 - 42,503,014 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02041,297,157 - 41,410,487 (+)NCBIMhudiblu_PPA_v0panPan3
STK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,375,630 - 32,463,848 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,375,189 - 32,521,042 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,021,037 - 32,109,251 (+)NCBI
ROS_Cfam_1.02433,086,419 - 33,174,685 (+)NCBI
UMICH_Zoey_3.12432,347,829 - 32,432,566 (+)NCBI
UNSW_CanFamBas_1.02432,462,830 - 32,551,067 (+)NCBI
UU_Cfam_GSD_1.02433,004,538 - 33,092,881 (+)NCBI
Stk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640192,233,117 - 192,331,335 (-)NCBI
SpeTri2.0NW_0049365147,686,760 - 7,784,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,376,115 - 47,475,718 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,387,594 - 47,475,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,912,419 - 52,932,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,737,484 - 18,844,610 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl218,742,162 - 18,844,647 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605067,388,889 - 67,493,337 (-)NCBIVero_WHO_p1.0
Stk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247909,415,172 - 9,521,103 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH136568  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382164,155,307 - 164,155,498UniSTSGRCm38
MGSCv372163,981,043 - 163,981,234UniSTSGRCm37
Celera2170,086,857 - 170,087,048UniSTS
Cytogenetic Map2H3UniSTS
MTH921  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382164,144,505 - 164,144,544UniSTSGRCm38
GRCm382164,144,436 - 164,144,544UniSTSGRCm38
MGSCv372163,970,172 - 163,970,280UniSTSGRCm37
MGSCv372163,970,241 - 163,970,280UniSTSGRCm37
Celera2170,076,055 - 170,076,094UniSTS
Celera2170,075,988 - 170,076,094UniSTS
Cytogenetic Map2H3UniSTS
Whitehead_YAC2 UniSTS
AI447339  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382164,155,313 - 164,155,476UniSTSGRCm38
MGSCv372163,981,049 - 163,981,212UniSTSGRCm37
Celera2170,086,863 - 170,087,026UniSTS
Cytogenetic Map2H3UniSTS
Whitehead/MRC_RH21876.64UniSTS
UniSTS:234596  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382164,154,556 - 164,154,682UniSTSGRCm38
MGSCv372163,980,292 - 163,980,418UniSTSGRCm37
Celera2170,086,106 - 170,086,232UniSTS
Cytogenetic Map2H3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163844614182113224Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145676855179677006Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132182239166182410Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162791700182113224Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152857301169276004Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145355029179355165Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142751556178800659Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145386799179386921Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162895006178800659Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135857301169857441Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162895006178800659Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2139124680173124809Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144673941181254801Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155982127182113224Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156354671182113224Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158236417178800659Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2150146982182113224Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151936377182113224Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163844614182113224Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150370301182113224Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143931525165823099Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149394987182113224Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143931525169276004Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148822973182113224Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135857301169857441Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135857301169857441Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135857301169857441Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151799021164277226Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150370301182113224Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142586427176586530Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150370301182113224Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148396284182113224Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133302991167303138Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133302991167303138Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151867353174547331Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152487900182113224Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
12801461Intim1_mintima modifier 1 (mouse)2142586427176586530Mouse
11353826Bdln10_mbody length 10 (mouse)2140599562174599562Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135590624173607823Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160769245169952882Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160769245169952882Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3019
Count of miRNA genes:762
Interacting mature miRNAs:996
Transcripts:ENSMUST00000018353, ENSMUST00000088291, ENSMUST00000134078, ENSMUST00000137866, ENSMUST00000153319
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000018353   ⟹   ENSMUSP00000018353
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2163,916,058 - 163,997,444 (+)Ensembl
GRCm38.p6 Ensembl2164,074,138 - 164,155,524 (+)Ensembl
RefSeq Acc Id: ENSMUST00000088291   ⟹   ENSMUSP00000085629
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2163,952,121 - 163,997,444 (+)Ensembl
GRCm38.p6 Ensembl2164,110,201 - 164,155,524 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134078   ⟹   ENSMUSP00000122440
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2163,912,242 - 163,928,511 (+)Ensembl
GRCm38.p6 Ensembl2164,070,322 - 164,086,591 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137866   ⟹   ENSMUSP00000116745
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2163,941,640 - 163,960,289 (+)Ensembl
GRCm38.p6 Ensembl2164,099,720 - 164,118,369 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153319
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2163,923,517 - 163,938,777 (+)Ensembl
GRCm38.p6 Ensembl2164,081,597 - 164,096,857 (+)Ensembl
RefSeq Acc Id: NM_021420   ⟹   NP_067395
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392163,916,058 - 163,997,444 (+)NCBI
GRCm382164,074,138 - 164,155,524 (+)NCBI
MGSCv372163,899,914 - 163,981,257 (+)RGD
Celera2170,004,346 - 170,087,071 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006499963   ⟹   XP_006500026
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392163,916,033 - 163,997,183 (+)NCBI
GRCm382164,074,116 - 164,155,519 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006499964   ⟹   XP_006500027
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392163,916,033 - 163,942,293 (+)NCBI
GRCm382164,074,113 - 164,100,380 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067395   ⟸   NM_021420
- Peptide Label: precursor
- UniProtKB: Q9JI11 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006500027   ⟸   XM_006499964
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006500026   ⟸   XM_006499963
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000085629   ⟸   ENSMUST00000088291
RefSeq Acc Id: ENSMUSP00000122440   ⟸   ENSMUST00000134078
RefSeq Acc Id: ENSMUSP00000116745   ⟸   ENSMUST00000137866
RefSeq Acc Id: ENSMUSP00000018353   ⟸   ENSMUST00000018353
Protein Domains
Protein kinase   SARAH

Promoters
RGD ID:6832875
Promoter ID:MM_KWN:32891
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000002310
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362163,899,729 - 163,900,229 (+)MPROMDB
RGD ID:6832876
Promoter ID:MM_KWN:32894
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000002311
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362163,924,551 - 163,925,552 (+)MPROMDB
RGD ID:6879606
Promoter ID:EPDNEW_M3254
Type:initiation region
Name:Stk4_1
Description:Mus musculus serine/threonine kinase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382164,074,146 - 164,074,206EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929004 AgrOrtholog
Ensembl Genes ENSMUSG00000018209 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000018353 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000085629 UniProtKB/TrEMBL
  ENSMUSP00000116745 UniProtKB/TrEMBL
  ENSMUSP00000122440 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018353 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000088291 UniProtKB/TrEMBL
  ENSMUST00000134078 UniProtKB/TrEMBL
  ENSMUST00000137866 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mst1_SARAH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58231 UniProtKB/Swiss-Prot
MGD MGI:1929004 ENTREZGENE
NCBI Gene 58231 ENTREZGENE
Pfam Mst1_SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stk4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A5M9_MOUSE UniProtKB/TrEMBL
  F7BYZ4_MOUSE UniProtKB/TrEMBL
  Q61156_MOUSE UniProtKB/TrEMBL
  Q8CDG4_MOUSE UniProtKB/TrEMBL
  Q9JI11 ENTREZGENE, UniProtKB/Swiss-Prot