Kctd8 (potassium channel tetramerization domain containing 8) - Rat Genome Database

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Gene: Kctd8 (potassium channel tetramerization domain containing 8) Rattus norvegicus
Analyze
Symbol: Kctd8
Name: potassium channel tetramerization domain containing 8
RGD ID: 1312020
Description: Enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be part of receptor complex. Predicted to be active in postsynapse and presynaptic active zone membrane. Orthologous to human KCTD8 (potassium channel tetramerization domain containing 8); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BTB/POZ domain-containing protein KCTD8; LOC364148; potassium channel tetramerisation domain containing 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81439,127,210 - 39,372,118 (+)NCBIGRCr8
mRatBN7.21438,773,274 - 39,018,182 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1438,773,634 - 39,017,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1439,130,366 - 39,371,062 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01440,430,399 - 40,671,095 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01438,911,211 - 39,151,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01461,912,193 - 62,158,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01462,014,881 - 62,262,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41441,322,489 - 41,568,787 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11441,325,208 - 41,570,659 (+)NCBI
Celera1437,968,777 - 38,212,675 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Schwenk J, etal., Nature. 2010 May 13;465(7295):231-5. doi: 10.1038/nature08964. Epub 2010 Apr 18.

Genomics

Comparative Map Data
Kctd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81439,127,210 - 39,372,118 (+)NCBIGRCr8
mRatBN7.21438,773,274 - 39,018,182 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1438,773,634 - 39,017,554 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1439,130,366 - 39,371,062 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01440,430,399 - 40,671,095 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01438,911,211 - 39,151,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01461,912,193 - 62,158,730 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01462,014,881 - 62,262,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41441,322,489 - 41,568,787 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11441,325,208 - 41,570,659 (+)NCBI
Celera1437,968,777 - 38,212,675 (+)NCBICelera
Cytogenetic Map14p11NCBI
KCTD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38444,173,903 - 44,448,809 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl444,173,903 - 44,448,809 (-)EnsemblGRCh38hg38GRCh38
GRCh37444,175,920 - 44,450,826 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36443,871,030 - 44,145,581 (-)NCBINCBI36Build 36hg18NCBI36
Build 34444,017,200 - 44,291,752NCBI
Celera444,623,428 - 44,899,318 (-)NCBICelera
Cytogenetic Map4p13NCBI
HuRef443,497,191 - 43,773,162 (-)NCBIHuRef
CHM1_1444,175,030 - 44,449,969 (-)NCBICHM1_1
T2T-CHM13v2.0444,140,713 - 44,416,533 (-)NCBIT2T-CHM13v2.0
Kctd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39569,266,628 - 69,499,052 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl569,266,628 - 69,499,022 (-)EnsemblGRCm39 Ensembl
GRCm38569,109,285 - 69,341,709 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl569,109,285 - 69,341,679 (-)EnsemblGRCm38mm10GRCm38
MGSCv37569,500,524 - 69,732,948 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36569,388,420 - 69,620,844 (-)NCBIMGSCv36mm8
Celera566,398,651 - 66,630,271 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map537.01NCBI
Kctd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554433,605,922 - 3,835,852 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554433,605,845 - 3,836,717 (+)NCBIChiLan1.0ChiLan1.0
KCTD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2344,361,845 - 44,645,637 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1444,548,537 - 44,832,098 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0438,495,174 - 38,778,451 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1444,345,609 - 44,627,333 (-)NCBIpanpan1.1PanPan1.1panPan2
KCTD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11340,774,055 - 40,977,984 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1340,738,332 - 40,977,969 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1340,727,836 - 40,931,734 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01341,388,231 - 41,584,543 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1341,389,137 - 41,584,543 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11341,060,793 - 41,264,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01341,111,624 - 41,309,252 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01341,498,704 - 41,702,405 (-)NCBIUU_Cfam_GSD_1.0
Kctd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528535,117,451 - 35,356,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648210,942,514 - 11,180,486 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648210,941,599 - 11,180,776 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl834,746,458 - 35,005,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1834,745,209 - 35,005,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2836,222,599 - 36,223,960 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCTD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1275,838,643 - 6,116,080 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604751,984,808 - 52,292,949 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kctd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476122,524,242 - 22,780,475 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476122,523,933 - 22,781,345 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kctd8
1856 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:31
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000031329
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142216796767167967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
D14Got54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21438,898,197 - 38,898,470 (-)MAPPERmRatBN7.2
Rnor_6.01462,032,177 - 62,032,449NCBIRnor6.0
Rnor_5.01462,134,865 - 62,135,137UniSTSRnor5.0
RGSC_v3.41441,448,864 - 41,449,137RGDRGSC3.4
RGSC_v3.41441,448,865 - 41,449,137UniSTSRGSC3.4
RGSC_v3.11441,451,255 - 41,451,528RGD
Celera1438,092,719 - 38,092,991UniSTS
RH 2.0 Map14497.8RGD
Cytogenetic Map14p11UniSTS
D14Got57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21438,781,702 - 38,781,930 (-)MAPPERmRatBN7.2
Rnor_6.01462,149,100 - 62,149,327NCBIRnor6.0
Rnor_5.01462,253,499 - 62,253,726UniSTSRnor5.0
RGSC_v3.41441,331,013 - 41,331,241RGDRGSC3.4
RGSC_v3.41441,331,014 - 41,331,241UniSTSRGSC3.4
RGSC_v3.11441,333,404 - 41,333,632RGD
Celera1437,977,240 - 37,977,443UniSTS
Cytogenetic Map14p11UniSTS
D14Got56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21438,898,182 - 38,898,332 (-)MAPPERmRatBN7.2
Rnor_6.01462,032,315 - 62,032,464NCBIRnor6.0
Rnor_5.01462,135,003 - 62,135,152UniSTSRnor5.0
RGSC_v3.41441,448,849 - 41,448,999RGDRGSC3.4
RGSC_v3.41441,448,850 - 41,448,999UniSTSRGSC3.4
RGSC_v3.11441,451,240 - 41,451,390RGD
Celera1438,092,704 - 38,092,853UniSTS
Cytogenetic Map14p11UniSTS
AU046510  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01462,177,081 - 62,177,308NCBIRnor5.0
RGSC_v3.41441,409,041 - 41,409,300UniSTSRGSC3.4
Celera1438,053,030 - 38,053,290UniSTS
Cytogenetic Map14p11UniSTS
RH138038  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21439,017,855 - 39,018,007 (-)MAPPERmRatBN7.2
Rnor_6.01461,912,368 - 61,912,519NCBIRnor6.0
Rnor_5.01462,015,056 - 62,015,207UniSTSRnor5.0
RGSC_v3.41441,568,461 - 41,568,612UniSTSRGSC3.4
Celera1438,212,349 - 38,212,500UniSTS
Cytogenetic Map14p11UniSTS
RH138830  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01462,048,675 - 62,048,803NCBIRnor6.0
Celera1438,075,795 - 38,075,922UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000096772   ⟹   ENSRNOP00000082933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1438,773,634 - 39,017,554 (+)Ensembl
RefSeq Acc Id: NM_001100172   ⟹   NP_001093642
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81439,127,210 - 39,372,118 (+)NCBI
mRatBN7.21438,773,274 - 39,018,182 (+)NCBI
Rnor_6.01461,912,193 - 62,158,730 (-)NCBI
Rnor_5.01462,014,881 - 62,262,242 (-)NCBI
RGSC_v3.41441,322,489 - 41,568,787 (+)RGD
Celera1437,968,777 - 38,212,675 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001093642 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABM68628 (Get FASTA)   NCBI Sequence Viewer  
  EDL90016 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082933.1
RefSeq Acc Id: NP_001093642   ⟸   NM_001100172
- UniProtKB: A6Y7S3 (UniProtKB/TrEMBL),   A0A8I5ZVW6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000082933   ⟸   ENSRNOT00000096772
Protein Domains
BTB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312020 AgrOrtholog
BioCyc Gene G2FUF-15812 BioCyc
Ensembl Genes ENSRNOG00000063710 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000096772.1 UniProtKB/TrEMBL
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  H1_KCTD8 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv_tetra UniProtKB/TrEMBL
KEGG Report rno:364148 UniProtKB/TrEMBL
NCBI Gene 364148 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD8 UniProtKB/TrEMBL
  POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam K_tetra UniProtKB/TrEMBL
PhenoGen Kctd8 PhenoGen
RatGTEx ENSRNOG00000063710 RatGTEx
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
UniProt A0A8I5ZVW6 ENTREZGENE, UniProtKB/TrEMBL
  A6Y7S3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Kctd8  potassium channel tetramerization domain containing 8  Kctd8  potassium channel tetramerisation domain containing 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Kctd8  potassium channel tetramerisation domain containing 8   Kctd8_predicted  potassium channel tetramerisation domain containing 8 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kctd8_predicted  potassium channel tetramerisation domain containing 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED