Fcgbpl1 (Fc fragment of IgG binding protein-like 1) - Rat Genome Database

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Gene: Fcgbpl1 (Fc fragment of IgG binding protein-like 1) Rattus norvegicus
Analyze
Symbol: Fcgbpl1
Name: Fc fragment of IgG binding protein-like 1
RGD ID: 1311906
Description: Predicted to be active in extracellular matrix and extracellular space. Orthologous to human FCGBP (Fc gamma binding protein); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fc fragment of IgG binding protein-like; IgG Fc binding protein; LOC292746; RGD1311906; similar to Fc fragment of IgG binding protein
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,552,363 - 92,590,377 (+)NCBIGRCr8
mRatBN7.2183,424,788 - 83,462,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,424,788 - 83,462,799 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,835,057 - 88,873,042 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,293,291 - 97,331,283 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,590,920 - 90,628,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,058,541 - 85,096,492 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,058,548 - 85,096,346 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,274,837 - 86,312,788 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,226,922 - 83,264,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera177,824,833 - 77,862,724 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin. Chu Q, etal., Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. doi: 10.1111/j.1442-9071.2010.02437.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Fcgbpl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,552,363 - 92,590,377 (+)NCBIGRCr8
mRatBN7.2183,424,788 - 83,462,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,424,788 - 83,462,799 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,835,057 - 88,873,042 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,293,291 - 97,331,283 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,590,920 - 90,628,905 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,058,541 - 85,096,492 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,058,548 - 85,096,346 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,274,837 - 86,312,788 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,226,922 - 83,264,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera177,824,833 - 77,862,724 (+)NCBICelera
Cytogenetic Map1q21NCBI
Fcgbpl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,828,891 - 27,864,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,828,891 - 27,864,236 (+)EnsemblGRCm39 Ensembl
GRCm38728,129,466 - 28,164,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,129,466 - 28,164,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,914,485 - 28,949,830 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,838,226 - 27,852,398 (+)NCBIMGSCv36mm8
Celera722,690,689 - 22,726,036 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.54NCBI

Variants

.
Variants in Fcgbpl1
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:57
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000057120
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat

Markers in Region
AA955367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,412,974 - 83,413,066 (+)MAPPERmRatBN7.2
mRatBN7.2183,462,694 - 83,462,786 (+)MAPPERmRatBN7.2
Rnor_6.0185,096,385 - 85,096,476NCBIRnor6.0
Rnor_6.0185,046,732 - 85,046,823NCBIRnor6.0
Rnor_5.0186,312,681 - 86,312,772UniSTSRnor5.0
Rnor_5.0186,263,028 - 86,263,119UniSTSRnor5.0
RGSC_v3.4183,215,160 - 83,215,251UniSTSRGSC3.4
RGSC_v3.4183,264,829 - 83,264,920UniSTSRGSC3.4
Celera177,862,617 - 77,862,708UniSTS
Celera177,813,024 - 77,813,115UniSTS
RH 3.4 Map1828.9UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 2 4
Below cutoff 1 18 3 2 3 4 51 21 27 9 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057120   ⟹   ENSRNOP00000053948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,424,788 - 83,462,799 (+)Ensembl
Rnor_6.0 Ensembl185,058,548 - 85,096,346 (+)Ensembl
RefSeq Acc Id: NM_001164656   ⟹   NP_001158128
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,552,363 - 92,590,377 (+)NCBI
mRatBN7.2183,424,788 - 83,462,802 (+)NCBI
Rnor_6.0185,058,541 - 85,096,492 (+)NCBI
Rnor_5.0186,274,837 - 86,312,788 (+)NCBI
RGSC_v3.4183,226,922 - 83,264,936 (+)RGD
Celera177,824,833 - 77,862,724 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001158128 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99756 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053948
  ENSRNOP00000053948.3
Reference Protein Sequences
RefSeq Acc Id: NP_001158128   ⟸   NM_001164656
- Peptide Label: precursor
- UniProtKB: F7EZQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000053948   ⟸   ENSRNOT00000057120
Protein Domains
VWFD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7EZQ4-F1-model_v2 AlphaFold F7EZQ4 1-2537 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689862
Promoter ID:EPDNEW_R387
Type:single initiation site
Name:Fcgbpl1_1
Description:Fc fragment of IgG binding protein-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0185,058,531 - 85,058,591EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311906 AgrOrtholog
BioCyc Gene G2FUF-60263 BioCyc
Ensembl Genes ENSRNOG00000042899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057120 ENTREZGENE
  ENSRNOT00000057120.4 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623759 IMAGE-MGC_LOAD
InterPro Conserved-cysteine-rich_domain UniProtKB/TrEMBL
  Fol_N UniProtKB/TrEMBL
  Prot_Inh_CR_TIL UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TILa_dom UniProtKB/TrEMBL
  von_Willebrand_fac_D UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
KEGG Report rno:292746 UniProtKB/TrEMBL
MGC_CLONE MGC:124882 IMAGE-MGC_LOAD
NCBI Gene 292746 ENTREZGENE
PANTHER ALPHA-TECTORIN-RELATED UniProtKB/TrEMBL
  EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/TrEMBL
  RIKEN CDNA 9530053A07 GENE UniProtKB/TrEMBL
  VWFD DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  TILa UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PhenoGen Fcgbpl1 PhenoGen
PROSITE VWFD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042899 RatGTEx
SMART FOLN UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP Cysrich_TIL UniProtKB/TrEMBL
UniProt F7EZQ4 ENTREZGENE, UniProtKB/TrEMBL
  Q499U7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-23 Fcgbpl1  Fc fragment of IgG binding protein-like 1  RGD1311906  similar to Fc fragment of IgG binding protein; IgG Fc binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1311906  similar to Fc fragment of IgG binding protein; IgG Fc binding protein  RGD1311906_predicted  similar to Fc fragment of IgG binding protein; IgG Fc binding protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311906_predicted  similar to Fc fragment of IgG binding protein; IgG Fc binding protein (predicted)  LOC292746_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC292746_predicted  similar to Fc fragment of IgG binding protein; IgG Fc binding protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL