Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Riok3 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RIOK3 mRNA] | CTD | PMID:31150632 | Riok3 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RIOK3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RIOK3 mRNA | CTD | PMID:22079256 | Riok3 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Riok3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RIOK3 mRNA | CTD | PMID:22206623 | Riok3 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Riok3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of RIOK3 mRNA | CTD | PMID:22206623 | Riok3 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Riok3 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of RIOK3 mRNA | CTD | PMID:17555576 | Riok3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RIOK3 mRNA | CTD | PMID:22298810 | Riok3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RIOK3 mRNA | CTD | PMID:33387578 | Riok3 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Riok3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RIOK3 mRNA | CTD | PMID:21570461 | Riok3 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of RIOK3 mRNA | CTD | PMID:21346803 | Riok3 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of RIOK3 mRNA | CTD | PMID:21346803 | Riok3 | Rat | 2-hydroxypropanoic acid | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of RIOK3 mRNA | CTD | PMID:30851411 | Riok3 | Rat | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of RIOK3 mRNA | CTD | PMID:21346803 | Riok3 | Rat | 4-hydroxynon-2-enal | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in increased expression of RIOK3 mRNA | CTD | PMID:19191707 | Riok3 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of RIOK3 mRNA | CTD | PMID:28959563 | Riok3 | Rat | acrylamide | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of RIOK3 mRNA | CTD | PMID:32763439 | Riok3 | Rat | aflatoxin B1 | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of RIOK3 mRNA | CTD | PMID:21641981 | Riok3 | Rat | all-trans-retinoic acid | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of RIOK3 mRNA | CTD | PMID:33167477 | Riok3 | Rat | antirheumatic drug | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of RIOK3 mRNA | CTD | PMID:24449571 | Riok3 | Rat | aristolochic acid A | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of RIOK3 protein | CTD | PMID:33212167 | Riok3 | Rat | arsane | affects methylation | ISO | RIOK3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of RIOK3 gene | CTD | PMID:25304211 | Riok3 | Rat | arsenic atom | affects methylation | ISO | RIOK3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of RIOK3 gene | CTD | PMID:25304211 | Riok3 | Rat | benzo[a]pyrene | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of RIOK3 mRNA | CTD | PMID:19770486 and PMID:22228805 | Riok3 | Rat | benzo[a]pyrene | decreases methylation | ISO | Riok3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased methylation of RIOK3 3' UTR more ... | CTD | PMID:27901495 | Riok3 | Rat | benzo[a]pyrene | increases methylation | ISO | RIOK3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of RIOK3 promoter | CTD | PMID:27901495 | Riok3 | Rat | benzo[a]pyrene | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of RIOK3 mRNA | CTD | PMID:26238291 | Riok3 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | Riok3 | Rat | bisphenol A | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of RIOK3 mRNA | CTD | PMID:22576693 and PMID:29275510 | Riok3 | Rat | bisphenol A | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of RIOK3 mRNA | CTD | PMID:33221593 | Riok3 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RIOK3 mRNA | CTD | PMID:30816183 more ... | Riok3 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of RIOK3 mRNA | CTD | PMID:25181051 | Riok3 | Rat | bisphenol A | increases methylation | ISO | RIOK3 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of RIOK3 gene | CTD | PMID:22576693 | Riok3 | Rat | butanal | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of RIOK3 mRNA | CTD | PMID:26079696 | Riok3 | Rat | cadmium atom | multiple interactions | ISO | RIOK3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RIOK3 mRNA | CTD | PMID:35301059 | Riok3 | Rat | cadmium dichloride | affects expression | EXP | | 6480464 | Cadmium Chloride affects the expression of RIOK3 mRNA | CTD | PMID:22110744 | Riok3 | Rat | cadmium dichloride | multiple interactions | ISO | RIOK3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RIOK3 mRNA | CTD | PMID:35301059 | Riok3 | Rat | cadmium dichloride | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of RIOK3 mRNA | CTD | PMID:26472689 and PMID:38568856 | Riok3 | Rat | caffeine | increases phosphorylation | ISO | RIOK3 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of RIOK3 protein | CTD | PMID:35688186 | Riok3 | Rat | carbamazepine | affects expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of RIOK3 mRNA | CTD | PMID:25979313 | Riok3 | Rat | carbon nanotube | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Riok3 | Rat | cobalt dichloride | multiple interactions | ISO | RIOK3 (Homo sapiens) | 6480464 | zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RIOK3 mRNA] | CTD | PMID:22202117 | Riok3 | Rat | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of RIOK3 mRNA | CTD | PMID:24386269 | Riok3 | Rat | cobalt dichloride | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of RIOK3 mRNA | CTD | PMID:19320972 more ... | Riok3 | Rat | copper atom | decreases expression | ISO | Riok3 (Mus musculus) | 6480464 | Copper results in decreased expression of RIOK3 mRNA | CTD | PMID:17205981 | Riok3 | Rat | copper(0) | decreases expression | ISO | Riok3 (Mus musculus) | 6480464 | Copper results in decreased expression of RIOK3 mRNA | CTD | PMID:17205981 | Riok3 | Rat | copper(II) sulfate | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of RIOK3 mRNA | CTD | PMID:19549813 | Riok3 | Rat | corosolic acid | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | corosolic acid results in increased expression of RIOK3 mRNA | CTD | PMID:37939859 | Riok3 | Rat | crocidolite asbestos | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of RIOK3 mRNA | CTD | PMID:18687144 | Riok3 | Rat | CU-O LINKAGE | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | cupric oxide results in increased expression of RIOK3 mRNA | CTD | PMID:22077320 | Riok3 | Rat | cyclosporin A | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of RIOK3 mRNA | CTD | PMID:25562108 | Riok3 | Rat | dibutyl phthalate | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of RIOK3 mRNA | CTD | PMID:21266533 | Riok3 | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of RIOK3 mRNA | CTD | PMID:21266533 | Riok3 | Rat | dicrotophos | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of RIOK3 mRNA | CTD | PMID:28302478 | Riok3 | Rat | dimethylarsinous acid | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | dimethylarsinous acid results in increased expression of RIOK3 mRNA | CTD | PMID:23487506 | Riok3 | Rat | doxorubicin | multiple interactions | ISO | Riok3 (Mus musculus) | 6480464 | [[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of RIOK3 mRNA | CTD | PMID:21040762 | Riok3 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of RIOK3 mRNA | CTD | PMID:29391264 | Riok3 | Rat | ethanol | affects expression | ISO | Riok3 (Mus musculus) | 6480464 | Ethanol affects the expression of RIOK3 mRNA | CTD | PMID:30319688 | Riok3 | Rat | ethyl methanesulfonate | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of RIOK3 mRNA | CTD | PMID:23649840 | Riok3 | Rat | fenthion | decreases expression | ISO | Riok3 (Mus musculus) | 6480464 | Fenthion results in decreased expression of RIOK3 mRNA | CTD | PMID:34813904 | Riok3 | Rat | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of RIOK3 mRNA | CTD | PMID:34044035 | Riok3 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of RIOK3 mRNA | CTD | PMID:24136188 | Riok3 | Rat | folic acid | multiple interactions | ISO | Riok3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RIOK3 mRNA | CTD | PMID:22206623 | Riok3 | Rat | formaldehyde | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of RIOK3 mRNA | CTD | PMID:23649840 | Riok3 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of RIOK3 mRNA | CTD | PMID:22061828 | Riok3 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of RIOK3 mRNA | CTD | PMID:33387578 | Riok3 | Rat | hydrogen peroxide | affects expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of RIOK3 mRNA | CTD | PMID:20044591 | Riok3 | Rat | hydrogen peroxide | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Hydrogen Peroxide results in decreased expression of RIOK3 mRNA | CTD | PMID:18951874 | Riok3 | Rat | hypochlorous acid | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | Hypochlorous Acid results in increased expression of RIOK3 mRNA | CTD | PMID:19376150 | Riok3 | Rat | lead diacetate | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | lead acetate results in increased expression of RIOK3 mRNA | CTD | PMID:25270620 | Riok3 | Rat | leflunomide | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | leflunomide results in increased expression of RIOK3 mRNA | CTD | PMID:28988120 | Riok3 | Rat | mercury dichloride | increases expression | EXP | | 6480464 | Mercuric Chloride results in increased expression of RIOK3 mRNA | CTD | PMID:16507785 | Riok3 | Rat | methidathion | decreases expression | ISO | Riok3 (Mus musculus) | 6480464 | methidathion results in decreased expression of RIOK3 mRNA | CTD | PMID:34813904 | Riok3 | Rat | methyl methanesulfonate | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of RIOK3 mRNA | CTD | PMID:23649840 | Riok3 | Rat | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of RIOK3 mRNA | CTD | PMID:28801915 | Riok3 | Rat | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of RIOK3 mRNA | CTD | PMID:24136188 | Riok3 | Rat | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of RIOK3 mRNA | CTD | PMID:22110744 | Riok3 | Rat | paracetamol | affects expression | ISO | Riok3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of RIOK3 mRNA | CTD | PMID:17562736 | Riok3 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of RIOK3 mRNA | CTD | PMID:33387578 | Riok3 | Rat | paracetamol | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of RIOK3 mRNA | CTD | PMID:21420995 | Riok3 | Rat | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of RIOK3 mRNA | CTD | PMID:32680482 | Riok3 | Rat | pirinixic acid | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of RIOK3 mRNA | CTD | PMID:23811191 | Riok3 | Rat | potassium chromate | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of RIOK3 mRNA | CTD | PMID:22079256 | Riok3 | Rat | potassium chromate | multiple interactions | ISO | RIOK3 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RIOK3 mRNA | CTD | PMID:22079256 | Riok3 | Rat | pyrimidines | decreases splicing | ISO | RIOK3 (Homo sapiens) | 6480464 | Pyrimidines results in decreased splicing of RIOK3 mRNA | CTD | PMID:25281741 | Riok3 | Rat | quinazolines | decreases splicing | ISO | RIOK3 (Homo sapiens) | 6480464 | Quinazolines results in decreased splicing of RIOK3 mRNA | CTD | PMID:25281741 | Riok3 | Rat | rac-lactic acid | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of RIOK3 mRNA | CTD | PMID:30851411 | Riok3 | Rat | resveratrol | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | resveratrol results in decreased expression of RIOK3 mRNA | CTD | PMID:19167446 | Riok3 | Rat | silver atom | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Silver results in increased expression of RIOK3 mRNA | CTD | PMID:26014281 | Riok3 | Rat | silver(0) | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Silver results in increased expression of RIOK3 mRNA | CTD | PMID:26014281 | Riok3 | Rat | sodium arsenite | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of RIOK3 mRNA | CTD | PMID:28595984 and PMID:34032870 | Riok3 | Rat | sodium arsenite | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of RIOK3 mRNA | CTD | PMID:38568856 | Riok3 | Rat | sunitinib | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of RIOK3 mRNA | CTD | PMID:31533062 | Riok3 | Rat | testosterone | decreases expression | ISO | Riok3 (Mus musculus) | 6480464 | Testosterone deficiency results in decreased expression of RIOK3 mRNA | CTD | PMID:33848595 | Riok3 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of RIOK3 mRNA | CTD | PMID:31150632 | Riok3 | Rat | tetrachloromethane | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of RIOK3 mRNA | CTD | PMID:31919559 | Riok3 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RIOK3 mRNA] | CTD | PMID:31150632 | Riok3 | Rat | theophylline | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Theophylline results in decreased expression of RIOK3 mRNA | CTD | PMID:16083514 | Riok3 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of RIOK3 mRNA | CTD | PMID:34492290 | Riok3 | Rat | thiram | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Thiram results in increased expression of RIOK3 mRNA | CTD | PMID:38568856 | Riok3 | Rat | titanium dioxide | increases expression | ISO | Riok3 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of RIOK3 mRNA | CTD | PMID:27760801 | Riok3 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of RIOK3 mRNA | CTD | PMID:33387578 | Riok3 | Rat | trichostatin A | affects expression | ISO | RIOK3 (Homo sapiens) | 6480464 | trichostatin A affects the expression of RIOK3 mRNA | CTD | PMID:28542535 | Riok3 | Rat | triphenyl phosphate | affects expression | ISO | RIOK3 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of RIOK3 mRNA | CTD | PMID:37042841 | Riok3 | Rat | urethane | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Urethane results in increased expression of RIOK3 mRNA | CTD | PMID:28818685 | Riok3 | Rat | valproic acid | affects expression | ISO | Riok3 (Mus musculus) | 6480464 | Valproic Acid affects the expression of RIOK3 mRNA | CTD | PMID:17292431 | Riok3 | Rat | valproic acid | affects expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of RIOK3 mRNA | CTD | PMID:25979313 | Riok3 | Rat | valproic acid | increases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of RIOK3 mRNA | CTD | PMID:23179753 and PMID:28001369 | Riok3 | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of RIOK3 mRNA | CTD | PMID:19015723 | Riok3 | Rat | vitamin E | decreases expression | ISO | RIOK3 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of RIOK3 mRNA | CTD | PMID:19244175 | Riok3 | Rat | zinc atom | multiple interactions | ISO | RIOK3 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of RIOK3 mRNA | CTD | PMID:18593933 | Riok3 | Rat | zinc dichloride | multiple interactions | ISO | RIOK3 (Homo sapiens) | 6480464 | zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of RIOK3 mRNA] | CTD | PMID:22202117 | Riok3 | Rat | zinc(0) | multiple interactions | ISO | RIOK3 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of RIOK3 mRNA | CTD | PMID:18593933 | |