Abcf3 (ATP binding cassette subfamily F member 3) - Rat Genome Database

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Gene: Abcf3 (ATP binding cassette subfamily F member 3) Rattus norvegicus
Analyze
Symbol: Abcf3
Name: ATP binding cassette subfamily F member 3
RGD ID: 1310468
Description: Predicted to enable ATP binding activity. Predicted to be involved in defense response to virus. Orthologous to human ABCF3 (ATP binding cassette subfamily F member 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family F member 3; ATP-binding cassette, sub-family F (GCN20), member 3; ATP-binding cassette, subfamily F (GCN20), member 3; LOC287982
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,844,863 - 93,856,595 (-)NCBIGRCr8
mRatBN7.21180,340,476 - 80,352,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,339,977 - 80,352,211 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,062,967 - 89,074,696 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,716,387 - 81,728,116 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,777,452 - 80,789,181 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,026,206 - 84,037,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,026,207 - 84,037,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,098,518 - 87,110,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,570,495 - 82,582,228 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,628,084 - 82,639,817 (-)NCBI
Celera1179,179,874 - 79,191,606 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:19946888   PMID:25468996  


Genomics

Comparative Map Data
Abcf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,844,863 - 93,856,595 (-)NCBIGRCr8
mRatBN7.21180,340,476 - 80,352,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,339,977 - 80,352,211 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,062,967 - 89,074,696 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,716,387 - 81,728,116 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,777,452 - 80,789,181 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,026,206 - 84,037,938 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,026,207 - 84,037,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,098,518 - 87,110,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,570,495 - 82,582,228 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,628,084 - 82,639,817 (-)NCBI
Celera1179,179,874 - 79,191,606 (-)NCBICelera
Cytogenetic Map11q23NCBI
ABCF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,186,199 - 184,194,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,186,095 - 184,194,012 (+)EnsemblGRCh38hg38GRCh38
GRCh373183,903,987 - 183,911,793 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,386,557 - 185,394,489 (+)NCBINCBI36Build 36hg18NCBI36
Build 343185,386,587 - 185,394,495NCBI
Celera3182,345,574 - 182,353,503 (+)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,310,757 - 181,318,688 (+)NCBIHuRef
CHM1_13183,868,268 - 183,876,199 (+)NCBICHM1_1
T2T-CHM13v2.03186,995,138 - 187,002,952 (+)NCBIT2T-CHM13v2.0
Abcf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,367,309 - 20,380,357 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,367,327 - 20,380,129 (+)EnsemblGRCm39 Ensembl
GRCm381620,548,556 - 20,561,603 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,548,577 - 20,561,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371620,548,676 - 20,561,676 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,462,205 - 20,474,363 (+)NCBIMGSCv36mm8
Celera1621,112,678 - 21,125,678 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.46NCBI
Abcf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,268,615 - 23,281,041 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,271,925 - 23,280,988 (-)NCBIChiLan1.0ChiLan1.0
ABCF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,057,454 - 182,065,326 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,062,171 - 182,070,043 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,221,309 - 181,229,662 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,704,188 - 189,712,143 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,704,188 - 189,712,143 (+)Ensemblpanpan1.1panPan2
ABCF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,082,911 - 17,089,942 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,082,987 - 17,089,911 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,170,094 - 21,181,250 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,990,979 - 17,002,135 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,990,997 - 17,002,133 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,028,322 - 17,039,479 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,024,247 - 17,035,405 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,254,475 - 17,265,633 (+)NCBIUU_Cfam_GSD_1.0
Abcf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,578,541 - 119,588,161 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,669,738 - 5,680,043 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,670,395 - 5,680,043 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,105,344 - 122,113,559 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,102,939 - 122,112,896 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,545,271 - 131,552,818 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,232,161 - 5,240,012 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,227,836 - 5,239,958 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606314,011,181 - 14,019,084 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,376,045 - 72,384,077 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,372,773 - 72,384,077 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcf3
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:144
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000002327
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
RH137176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,340,576 - 80,340,780 (+)MAPPERmRatBN7.2
Rnor_6.01184,026,307 - 84,026,510NCBIRnor6.0
Rnor_5.01187,098,619 - 87,098,822UniSTSRnor5.0
RGSC_v3.41182,570,596 - 82,570,799UniSTSRGSC3.4
Celera1179,179,975 - 79,180,178UniSTS
RH 3.4 Map11657.3UniSTS
Cytogenetic Map11q23UniSTS
BF390931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,340,097 - 80,340,295 (+)MAPPERmRatBN7.2
Rnor_6.01184,025,828 - 84,026,025NCBIRnor6.0
Rnor_5.01187,098,140 - 87,098,337UniSTSRnor5.0
RGSC_v3.41182,570,117 - 82,570,314UniSTSRGSC3.4
Celera1179,179,496 - 79,179,693UniSTS
RH 3.4 Map11655.7UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002327   ⟹   ENSRNOP00000002327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,340,477 - 80,352,211 (-)Ensembl
Rnor_6.0 Ensembl1184,026,207 - 84,037,938 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103652   ⟹   ENSRNOP00000076934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,339,977 - 80,352,152 (-)Ensembl
RefSeq Acc Id: NM_001011896   ⟹   NP_001011896
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,844,863 - 93,856,595 (-)NCBI
mRatBN7.21180,340,476 - 80,352,211 (-)NCBI
Rnor_6.01184,026,206 - 84,037,938 (-)NCBI
Rnor_5.01187,098,518 - 87,110,250 (-)NCBI
RGSC_v3.41182,570,495 - 82,582,228 (-)RGD
Celera1179,179,874 - 79,191,606 (-)RGD
Sequence:
RefSeq Acc Id: XM_063270329   ⟹   XP_063126399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,844,863 - 93,854,552 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001011896 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126399 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82042 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002327.5
  ENSRNOP00000076934.1
GenBank Protein Q66H39 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001011896   ⟸   NM_001011896
- UniProtKB: Q66H39 (UniProtKB/Swiss-Prot),   A6JSA8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002327   ⟸   ENSRNOT00000002327
Ensembl Acc Id: ENSRNOP00000076934   ⟸   ENSRNOT00000103652
RefSeq Acc Id: XP_063126399   ⟸   XM_063270329
- Peptide Label: isoform X1
Protein Domains
ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H39-F1-model_v2 AlphaFold Q66H39 1-709 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698277
Promoter ID:EPDNEW_R8802
Type:multiple initiation site
Name:Abcf3_1
Description:ATP binding cassette subfamily F member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,037,859 - 84,037,919EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310468 AgrOrtholog
BioCyc Gene G2FUF-20735 BioCyc
Ensembl Genes ENSRNOG00000001710 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002327.6 UniProtKB/TrEMBL
  ENSRNOT00000103652.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131554 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran_Xtn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like_CS UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ABCF_EF3_subfamily UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287982 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95186 IMAGE-MGC_LOAD
NCBI Gene 287982 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-BINDING TRANSPORT PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran_Xtn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abcf3 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001710 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0Z4_RAT UniProtKB/TrEMBL
  A0A8L2Q0F1_RAT UniProtKB/TrEMBL
  A6JSA8 ENTREZGENE, UniProtKB/TrEMBL
  ABCF3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcf3  ATP binding cassette subfamily F member 3  Abcf3  ATP-binding cassette, subfamily F (GCN20), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcf3  ATP-binding cassette, subfamily F (GCN20), member 3  Abcf3  ATP-binding cassette, sub-family F (GCN20), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Abcf3  ATP-binding cassette, sub-family F (GCN20), member 3  Abcf3_predicted  ATP-binding cassette, sub-family F (GCN20), member 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Abcf3_predicted  ATP-binding cassette, sub-family F (GCN20), member 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED