Rap1gap (Rap1 GTPase-activating protein) - Rat Genome Database

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Gene: Rap1gap (Rap1 GTPase-activating protein) Rattus norvegicus
Analyze
Symbol: Rap1gap
Name: Rap1 GTPase-activating protein
RGD ID: 1309908
Description: Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Involved in cellular response to glial cell derived neurotrophic factor; negative regulation of neuron differentiation; and negative regulation of thyroid gland epithelial cell proliferation. Located in several cellular components, including dendrite; early endosome; and neuronal cell body. Orthologous to human RAP1GAP (RAP1 GTPase activating protein); INTERACTS WITH 4,4'-sulfonyldiphenol; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313644; rap1 GTPase-activating protein 1; RAP1, GTPase activating protein 1; Rap1ga1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,157,511 - 155,222,622 (+)NCBIGRCr8
mRatBN7.25149,873,987 - 149,939,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,892,019 - 149,939,253 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,587,863 - 152,635,071 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,362,154 - 154,409,364 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,344,163 - 154,391,373 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,008,868 - 156,074,350 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,026,911 - 156,074,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,764,852 - 159,829,865 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,468,558 - 156,489,592 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,434,614 - 156,499,630 (+)NCBI
Celera5148,288,148 - 148,335,223 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folpet  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
propanal  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth. Jiao L, etal., Cell Res. 2011 Feb;21(2):327-37. doi: 10.1038/cr.2010.139. Epub 2010 Sep 28.
4. Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. Meng J and Casey PJ, J Biol Chem 2002 Nov 8;277(45):43417-24. Epub 2002 Aug 26.
5. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Nakatani N, etal., Hum Mol Genet. 2006 Jun 15;15(12):1949-62. Epub 2006 May 10.
6. Loss of Rap1GAP in papillary thyroid cancer. Nellore A, etal., J Clin Endocrinol Metab. 2009 Mar;94(3):1026-32. doi: 10.1210/jc.2008-1042. Epub 2008 Dec 9.
7. Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. Potla U, etal., J Clin Invest. 2014 Apr;124(4):1757-69. doi: 10.1172/JCI67846. Epub 2014 Mar 18.
8. Expression of Rap1GAP in human myeloid disease following microarray selection. Qi X, etal., Genet Mol Res. 2008 Apr 29;7(2):379-87.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Downregulation of Rap1GAP contributes to Ras transformation. Tsygankova OM, etal., Mol Cell Biol. 2007 Oct;27(19):6647-58. Epub 2007 Jul 23.
12. Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer. Zhang L, etal., Cancer Res. 2006 Jan 15;66(2):898-906.
13. Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Zheng H, etal., Cancer Res. 2009 Jan 15;69(2):449-57. doi: 10.1158/0008-5472.CAN-08-2399.
Additional References at PubMed
PMID:10476970   PMID:12477932   PMID:14660640   PMID:15141215   PMID:15308668   PMID:15691704   PMID:16076873   PMID:16236484   PMID:16301177   PMID:16627466   PMID:17003042   PMID:17822405  
PMID:18049479   PMID:18063584   PMID:18309292   PMID:18707003   PMID:19244230   PMID:22797597   PMID:24803656   PMID:27612188   PMID:28476918   PMID:32864822   PMID:38154105  


Genomics

Comparative Map Data
Rap1gap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,157,511 - 155,222,622 (+)NCBIGRCr8
mRatBN7.25149,873,987 - 149,939,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,892,019 - 149,939,253 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,587,863 - 152,635,071 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,362,154 - 154,409,364 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,344,163 - 154,391,373 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,008,868 - 156,074,350 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,026,911 - 156,074,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,764,852 - 159,829,865 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,468,558 - 156,489,592 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,434,614 - 156,499,630 (+)NCBI
Celera5148,288,148 - 148,335,223 (+)NCBICelera
Cytogenetic Map5q36NCBI
RAP1GAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,596,221 - 21,669,357 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,596,221 - 21,669,357 (-)EnsemblGRCh38hg38GRCh38
GRCh37121,922,714 - 21,995,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,795,302 - 21,868,386 (-)NCBINCBI36Build 36hg18NCBI36
Build 34121,668,020 - 21,741,105NCBI
Celera120,245,427 - 20,318,559 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,166,471 - 20,239,313 (-)NCBIHuRef
CHM1_1122,034,710 - 22,107,810 (-)NCBICHM1_1
T2T-CHM13v2.0121,420,130 - 21,493,311 (-)NCBIT2T-CHM13v2.0
Rap1gap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,391,549 - 137,457,172 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,392,037 - 137,457,172 (+)EnsemblGRCm39 Ensembl
GRCm384137,664,711 - 137,729,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,664,726 - 137,729,861 (+)EnsemblGRCm38mm10GRCm38
MGSCv374137,237,618 - 137,285,782 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,953,779 - 137,001,943 (+)NCBIMGSCv36mm8
Celera4135,889,498 - 135,937,347 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.02NCBI
Rap1gap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,886,557 - 1,933,977 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,886,557 - 1,950,942 (-)NCBIChiLan1.0ChiLan1.0
RAP1GAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21205,272,365 - 205,342,799 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11204,384,247 - 204,454,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0120,790,076 - 20,860,511 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,754,733 - 21,824,405 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,754,733 - 21,824,405 (-)Ensemblpanpan1.1panPan2
RAP1GAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,509,592 - 77,554,620 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,527,914 - 77,544,205 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha273,996,971 - 74,060,748 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,051,854 - 78,115,519 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,051,841 - 78,116,079 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,886,050 - 74,934,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,881,825 - 75,945,588 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,884,969 - 76,948,528 (+)NCBIUU_Cfam_GSD_1.0
Rap1gap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,417,746 - 41,459,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,242,824 - 7,284,395 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,242,528 - 7,284,342 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAP1GAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,664,485 - 79,735,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,664,486 - 79,735,361 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAP1GAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,967,457 - 111,040,940 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,987,308 - 111,040,947 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,248,535 - 5,322,289 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rap1gap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,460,230 - 6,506,741 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247646,460,230 - 6,521,693 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rap1gap
309 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:397
Count of miRNA genes:207
Interacting mature miRNAs:239
Transcripts:ENSRNOT00000046802
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat

Markers in Region
RH139790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,938,708 - 149,938,927 (+)MAPPERmRatBN7.2
Rnor_6.05156,073,805 - 156,074,023NCBIRnor6.0
Rnor_5.05159,829,320 - 159,829,538UniSTSRnor5.0
RGSC_v3.45156,538,159 - 156,538,377UniSTSRGSC3.4
RGSC_v3.45156,489,046 - 156,489,264UniSTSRGSC3.4
Celera5148,334,678 - 148,334,896UniSTS
RH 3.4 Map51014.5UniSTS
Cytogenetic Map5q36UniSTS
AU047836  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,919,621 - 149,919,764 (+)MAPPERmRatBN7.2
Rnor_6.05156,054,721 - 156,054,863NCBIRnor6.0
Rnor_5.05159,810,236 - 159,810,378UniSTSRnor5.0
RGSC_v3.45156,469,962 - 156,470,104UniSTSRGSC3.4
Celera5148,315,594 - 148,315,736UniSTS
Cytogenetic Map5q36UniSTS
BF387645  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.05156,826,807 - 156,826,982NCBIRnor5.0
Rnor_5.05159,777,022 - 159,777,197NCBIRnor5.0
Rnor_5.01873,067,573 - 73,067,748NCBIRnor5.0
RGSC_v3.45156,436,408 - 156,436,582UniSTSRGSC3.4
Celera5148,282,102 - 148,282,276UniSTS
RH 3.4 Map51015.5UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001100713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_354337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_354338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC119102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB581996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB732529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000046802   ⟹   ENSRNOP00000048749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,892,019 - 149,939,253 (+)Ensembl
Rnor_6.0 Ensembl5156,026,911 - 156,074,395 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098228   ⟹   ENSRNOP00000097348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,918,124 - 149,939,253 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116365   ⟹   ENSRNOP00000079431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5149,913,989 - 149,937,772 (+)Ensembl
RefSeq Acc Id: NM_001100713   ⟹   NP_001094183
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,175,300 - 155,222,622 (+)NCBI
mRatBN7.25149,891,934 - 149,939,254 (+)NCBI
Rnor_6.05156,026,899 - 156,074,350 (+)NCBI
Rnor_5.05159,764,852 - 159,829,865 (+)NCBI
Celera5148,288,148 - 148,335,223 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001415932   ⟹   NP_001402861
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,175,300 - 155,222,622 (+)NCBI
mRatBN7.25149,891,934 - 149,939,254 (+)NCBI
RefSeq Acc Id: NM_001415933   ⟹   NP_001402862
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,157,588 - 155,222,622 (+)NCBI
mRatBN7.25149,874,221 - 149,939,254 (+)NCBI
RefSeq Acc Id: XM_017593409   ⟹   XP_017448898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,175,318 - 155,222,622 (+)NCBI
mRatBN7.25149,891,954 - 149,939,254 (+)NCBI
Rnor_6.05156,026,854 - 156,074,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593410   ⟹   XP_017448899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,198,058 - 155,220,871 (+)NCBI
mRatBN7.25149,914,687 - 149,937,524 (+)NCBI
Rnor_6.05156,044,509 - 156,072,619 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593412   ⟹   XP_017448901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,201,579 - 155,222,622 (+)NCBI
mRatBN7.25149,918,206 - 149,939,254 (+)NCBI
Rnor_6.05156,053,303 - 156,074,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593413   ⟹   XP_017448902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,157,563 - 155,222,622 (+)NCBI
mRatBN7.25149,873,987 - 149,939,254 (+)NCBI
Rnor_6.05156,008,868 - 156,074,350 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110059   ⟹   XP_038965987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,201,579 - 155,222,622 (+)NCBI
mRatBN7.25149,918,218 - 149,939,254 (+)NCBI
RefSeq Acc Id: XM_063287777   ⟹   XP_063143847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,192,890 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287778   ⟹   XP_063143848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,175,348 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287779   ⟹   XP_063143849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,175,316 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287780   ⟹   XP_063143850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,192,571 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287781   ⟹   XP_063143851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,201,579 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287782   ⟹   XP_063143852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,192,571 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287783   ⟹   XP_063143853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,192,571 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287784   ⟹   XP_063143854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,175,320 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287785   ⟹   XP_063143855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,192,571 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287786   ⟹   XP_063143856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,192,685 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287787   ⟹   XP_063143857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,157,567 - 155,222,622 (+)NCBI
RefSeq Acc Id: XM_063287788   ⟹   XP_063143858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,157,511 - 155,222,622 (+)NCBI
RefSeq Acc Id: XR_354337
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,198,058 - 155,222,622 (+)NCBI
mRatBN7.25149,914,687 - 149,939,254 (+)NCBI
Rnor_6.05156,044,510 - 156,074,350 (+)NCBI
Rnor_5.05159,764,852 - 159,829,865 (+)NCBI
Sequence:
RefSeq Acc Id: XR_354338
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,198,058 - 155,222,622 (+)NCBI
mRatBN7.25149,914,687 - 149,939,254 (+)NCBI
Rnor_6.05156,044,513 - 156,074,350 (+)NCBI
Rnor_5.05159,764,852 - 159,829,865 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001094183   ⟸   NM_001100713
- Peptide Label: isoform 1
- UniProtKB: F1LV89 (UniProtKB/TrEMBL),   A6ITE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448902   ⟸   XM_017593413
- Peptide Label: isoform X14
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448898   ⟸   XM_017593409
- Peptide Label: isoform X5
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448899   ⟸   XM_017593410
- Peptide Label: isoform X7
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448901   ⟸   XM_017593412
- Peptide Label: isoform X9
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048749   ⟸   ENSRNOT00000046802
RefSeq Acc Id: XP_038965987   ⟸   XM_039110059
- Peptide Label: isoform X13
- UniProtKB: A0A8I6AU92 (UniProtKB/TrEMBL),   A6ITE6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079431   ⟸   ENSRNOT00000116365
Ensembl Acc Id: ENSRNOP00000097348   ⟸   ENSRNOT00000098228
RefSeq Acc Id: NP_001402862   ⟸   NM_001415933
- Peptide Label: isoform 3
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402861   ⟸   NM_001415932
- Peptide Label: isoform 2
- UniProtKB: A6ITE4 (UniProtKB/TrEMBL),   A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143858   ⟸   XM_063287788
- Peptide Label: isoform X16
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143857   ⟸   XM_063287787
- Peptide Label: isoform X15
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143849   ⟸   XM_063287779
- Peptide Label: isoform X3
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143854   ⟸   XM_063287784
- Peptide Label: isoform X11
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143848   ⟸   XM_063287778
- Peptide Label: isoform X2
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143850   ⟸   XM_063287780
- Peptide Label: isoform X4
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143852   ⟸   XM_063287782
- Peptide Label: isoform X8
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143853   ⟸   XM_063287783
- Peptide Label: isoform X10
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143855   ⟸   XM_063287785
- Peptide Label: isoform X12
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143856   ⟸   XM_063287786
- Peptide Label: isoform X14
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143847   ⟸   XM_063287777
- Peptide Label: isoform X1
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143851   ⟸   XM_063287781
- Peptide Label: isoform X6
- UniProtKB: A6ITE6 (UniProtKB/TrEMBL)
Protein Domains
Rap-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LV89-F1-model_v2 AlphaFold F1LV89 1-753 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309908 AgrOrtholog
BioCyc Gene G2FUF-39472 BioCyc
Ensembl Genes ENSRNOG00000013825 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046802.6 UniProtKB/TrEMBL
  ENSRNOT00000098228.1 UniProtKB/TrEMBL
  ENSRNOT00000116365.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11210 UniProtKB/TrEMBL
  6.10.140.210 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317741 IMAGE-MGC_LOAD
InterPro GoLoco_motif UniProtKB/TrEMBL
  Rap/Ran-GAP_sf UniProtKB/TrEMBL
  Rap1_Ran_GAP UniProtKB/TrEMBL
  Rap_GAP_dom UniProtKB/TrEMBL
KEGG Report rno:313644 UniProtKB/TrEMBL
MGC_CLONE MGC:109391 IMAGE-MGC_LOAD
NCBI Gene 313644 ENTREZGENE
PANTHER RAP GTPASE-ACTIVATING PROTEIN UniProtKB/TrEMBL
  RAP1 GTPASE-ACTIVATING PROTEIN 1 UniProtKB/TrEMBL
Pfam GoLoco UniProtKB/TrEMBL
  Rap-GAP_dimer UniProtKB/TrEMBL
  Rap_GAP UniProtKB/TrEMBL
PhenoGen Rap1gap PhenoGen
PROSITE GOLOCO UniProtKB/TrEMBL
  RAPGAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013825 RatGTEx
SMART GoLoco UniProtKB/TrEMBL
Superfamily-SCOP SSF111347 UniProtKB/TrEMBL
UniProt A0A8I5ZN32_RAT UniProtKB/TrEMBL
  A0A8I6AU92 ENTREZGENE, UniProtKB/TrEMBL
  A6ITE4 ENTREZGENE, UniProtKB/TrEMBL
  A6ITE6 ENTREZGENE, UniProtKB/TrEMBL
  F1LV89 ENTREZGENE, UniProtKB/TrEMBL
  Q5EB70_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Rap1gap  Rap1 GTPase-activating protein  Rap1ga1  RAP1, GTPase activating protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Rap1ga1  RAP1, GTPase activating protein 1  Rap1ga1_predicted  RAP1, GTPase activating protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rap1ga1_predicted  RAP1, GTPase activating protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED