Mdh1b (malate dehydrogenase 1B) - Rat Genome Database

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Gene: Mdh1b (malate dehydrogenase 1B) Rattus norvegicus
Analyze
Symbol: Mdh1b
Name: malate dehydrogenase 1B
RGD ID: 1307874
Description: Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Orthologous to human MDH1B (malate dehydrogenase 1B); INTERACTS WITH bisphenol A; bromobenzene; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC316444; malate dehydrogenase 1B, NAD (soluble); putative malate dehydrogenase 1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,614,185 - 72,661,820 (-)NCBIGRCr8
mRatBN7.2965,120,370 - 65,168,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,119,029 - 65,167,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx973,617,360 - 73,674,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0978,770,729 - 78,818,072 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,162,001 - 77,209,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0970,403,612 - 70,450,204 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl970,404,093 - 70,450,170 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0972,123,041 - 72,169,621 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4962,368,173 - 62,418,212 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1962,555,822 - 62,565,152 (-)NCBI
Celera962,531,570 - 62,578,420 (-)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Mdh1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8972,614,185 - 72,661,820 (-)NCBIGRCr8
mRatBN7.2965,120,370 - 65,168,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,119,029 - 65,167,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx973,617,360 - 73,674,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0978,770,729 - 78,818,072 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,162,001 - 77,209,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0970,403,612 - 70,450,204 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl970,404,093 - 70,450,170 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0972,123,041 - 72,169,621 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4962,368,173 - 62,418,212 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1962,555,822 - 62,565,152 (-)NCBI
Celera962,531,570 - 62,578,420 (-)NCBICelera
Cytogenetic Map9q32NCBI
MDH1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382206,737,763 - 206,765,328 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2206,737,763 - 206,765,328 (-)EnsemblGRCh38hg38GRCh38
GRCh372207,602,487 - 207,630,052 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362207,310,732 - 207,338,295 (-)NCBINCBI36Build 36hg18NCBI36
Celera2201,363,918 - 201,391,481 (-)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2199,451,956 - 199,479,592 (-)NCBIHuRef
CHM1_12207,608,333 - 207,635,912 (-)NCBICHM1_1
T2T-CHM13v2.02207,219,869 - 207,247,441 (-)NCBIT2T-CHM13v2.0
Mdh1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39163,726,732 - 63,769,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl163,737,978 - 63,769,477 (-)EnsemblGRCm39 Ensembl
GRCm38163,698,827 - 63,730,318 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl163,698,819 - 63,730,318 (-)EnsemblGRCm38mm10GRCm38
MGSCv37163,745,401 - 63,776,892 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36163,633,103 - 63,664,594 (-)NCBIMGSCv36mm8
Celera164,225,205 - 64,256,797 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.31NCBI
Mdh1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554578,212,523 - 8,243,877 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554578,213,271 - 8,268,350 (+)NCBIChiLan1.0ChiLan1.0
MDH1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213109,346,030 - 109,373,975 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B109,361,035 - 109,388,954 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B93,972,114 - 93,999,996 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B212,100,285 - 212,128,079 (-)NCBIpanpan1.1PanPan1.1panPan2
MDH1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13715,255,894 - 15,287,374 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3715,256,507 - 15,287,341 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3716,139,898 - 16,171,502 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03715,192,510 - 15,224,134 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3715,193,125 - 15,224,083 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13715,144,755 - 15,170,047 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03715,117,799 - 15,143,071 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03715,121,968 - 15,147,265 (-)NCBIUU_Cfam_GSD_1.0
Mdh1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303163,415,512 - 163,439,578 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366313,057,345 - 3,074,350 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366313,050,689 - 3,074,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDH1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15109,990,050 - 110,021,416 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115109,989,095 - 110,021,237 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215121,598,070 - 121,617,709 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MDH1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11092,511,706 - 92,550,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1092,510,429 - 92,550,598 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040106,813,216 - 106,851,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdh1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247659,209,923 - 9,247,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247659,209,653 - 9,247,651 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mdh1b
419 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000017207
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
1578659Tspe1Trichinella spiralis expulsion QTL 14.8parasite quantity (VT:0010441)logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)96138143465691299Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat

Markers in Region
D1Mit466  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2965,106,068 - 65,106,285 (+)MAPPERmRatBN7.2
Rnor_6.0970,389,799 - 70,390,015NCBIRnor6.0
Rnor_5.0972,183,229 - 72,183,445UniSTSRnor5.0
RGSC_v3.4962,352,255 - 62,352,471UniSTSRGSC3.4
Celera962,517,680 - 62,517,896UniSTS
Cytogenetic Map9q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 4 17 113 91 90 59 25 59 6 177 61 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001432733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017207   ⟹   ENSRNOP00000017207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,120,375 - 65,167,933 (-)Ensembl
Rnor_6.0 Ensembl970,404,093 - 70,450,170 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086391   ⟹   ENSRNOP00000069626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,119,029 - 65,167,933 (-)Ensembl
Rnor_6.0 Ensembl970,404,094 - 70,449,796 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097252   ⟹   ENSRNOP00000077547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,119,029 - 65,167,933 (-)Ensembl
RefSeq Acc Id: NM_001108221   ⟹   NP_001101691
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,195 - 72,661,745 (-)NCBI
mRatBN7.2965,120,375 - 65,167,933 (-)NCBI
Rnor_6.0970,404,093 - 70,450,170 (-)NCBI
Rnor_5.0972,123,041 - 72,169,621 (+)NCBI
RGSC_v3.4962,368,173 - 62,418,212 (-)RGD
Celera962,531,570 - 62,578,420 (-)RGD
Sequence:
RefSeq Acc Id: XM_017596470   ⟹   XP_017451959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,723 (-)NCBI
mRatBN7.2965,120,370 - 65,167,610 (-)NCBI
Rnor_6.0970,403,614 - 70,449,042 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596471   ⟹   XP_017451960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,805 (-)NCBI
mRatBN7.2965,120,370 - 65,168,008 (-)NCBI
Rnor_6.0970,403,614 - 70,450,204 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596472   ⟹   XP_017451961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,736 (-)NCBI
mRatBN7.2965,120,370 - 65,167,914 (-)NCBI
Rnor_6.0970,403,614 - 70,450,175 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039083649   ⟹   XP_038939577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,659,852 (-)NCBI
mRatBN7.2965,120,370 - 65,165,206 (-)NCBI
RefSeq Acc Id: XM_039083650   ⟹   XP_038939578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,742 (-)NCBI
mRatBN7.2965,120,370 - 65,167,936 (-)NCBI
RefSeq Acc Id: XM_039083652   ⟹   XP_038939580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,658,693 (-)NCBI
mRatBN7.2965,120,370 - 65,164,880 (-)NCBI
RefSeq Acc Id: XM_039083653   ⟹   XP_038939581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,805 (-)NCBI
mRatBN7.2965,120,370 - 65,167,997 (-)NCBI
RefSeq Acc Id: XM_039083654   ⟹   XP_038939582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,420 (-)NCBI
mRatBN7.2965,120,370 - 65,167,610 (-)NCBI
RefSeq Acc Id: XM_039083655   ⟹   XP_038939583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,658,661 (-)NCBI
mRatBN7.2965,120,370 - 65,164,840 (-)NCBI
RefSeq Acc Id: XM_039083657   ⟹   XP_038939585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,658,704 (-)NCBI
mRatBN7.2965,120,370 - 65,164,903 (-)NCBI
RefSeq Acc Id: XM_039083658   ⟹   XP_038939586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,647,717 - 72,658,704 (-)NCBI
mRatBN7.2965,153,926 - 65,164,903 (-)NCBI
RefSeq Acc Id: XM_063267213   ⟹   XP_063123283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,466 (-)NCBI
RefSeq Acc Id: XM_063267214   ⟹   XP_063123284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,659,852 (-)NCBI
RefSeq Acc Id: XM_063267215   ⟹   XP_063123285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,659,852 (-)NCBI
RefSeq Acc Id: XM_063267216   ⟹   XP_063123286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,783 (-)NCBI
RefSeq Acc Id: XM_063267217   ⟹   XP_063123287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,614,185 - 72,661,820 (-)NCBI
RefSeq Acc Id: XR_005488912
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8972,643,603 - 72,658,704 (-)NCBI
mRatBN7.2965,149,787 - 65,164,903 (-)NCBI
RefSeq Acc Id: NP_001101691   ⟸   NM_001108221
- UniProtKB: A0A0G2JVU8 (UniProtKB/TrEMBL),   A0A8I5XW88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451960   ⟸   XM_017596471
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017451961   ⟸   XM_017596472
- Peptide Label: isoform X7
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451959   ⟸   XM_017596470
- Peptide Label: isoform X4
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017207   ⟸   ENSRNOT00000017207
Ensembl Acc Id: ENSRNOP00000069626   ⟸   ENSRNOT00000086391
RefSeq Acc Id: XP_038939581   ⟸   XM_039083653
- Peptide Label: isoform X6
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939578   ⟸   XM_039083650
- Peptide Label: isoform X3
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939582   ⟸   XM_039083654
- Peptide Label: isoform X6
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939577   ⟸   XM_039083649
- Peptide Label: isoform X1
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939585   ⟸   XM_039083657
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038939580   ⟸   XM_039083652
- Peptide Label: isoform X6
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939583   ⟸   XM_039083655
- Peptide Label: isoform X6
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939586   ⟸   XM_039083658
- Peptide Label: isoform X10
Ensembl Acc Id: ENSRNOP00000077547   ⟸   ENSRNOT00000097252
RefSeq Acc Id: XP_063123287   ⟸   XM_063267217
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063123286   ⟸   XM_063267216
- Peptide Label: isoform X6
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123283   ⟸   XM_063267213
- Peptide Label: isoform X2
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123284   ⟸   XM_063267214
- Peptide Label: isoform X3
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123285   ⟸   XM_063267215
- Peptide Label: isoform X6
- UniProtKB: A0A8I5XW88 (UniProtKB/TrEMBL)
Protein Domains
Lactate/malate dehydrogenase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVU8-F1-model_v2 AlphaFold A0A0G2JVU8 1-533 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696714
Promoter ID:EPDNEW_R7238
Type:single initiation site
Name:Mdh1b_1
Description:malate dehydrogenase 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0970,450,146 - 70,450,206EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307874 AgrOrtholog
BioCyc Gene G2FUF-27339 BioCyc
BioCyc Pathway MALATE-ASPARTATE-SHUTTLE-PWY [malate/L-aspartate shuttle pathway] BioCyc
  PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image MALATE-ASPARTATE-SHUTTLE-PWY BioCyc
  PWY-5690 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000012891 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017207.6 UniProtKB/TrEMBL
  ENSRNOT00000086391.2 UniProtKB/TrEMBL
  ENSRNOT00000097252.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.110.10 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Lactate/malate_DH_C UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/TrEMBL
  Malate_DH_SF1 UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
KEGG Report rno:316444 UniProtKB/TrEMBL
NCBI Gene 316444 ENTREZGENE
PANTHER MALATE DEHYDROGENASE 1B-RELATED UniProtKB/TrEMBL
  MDH_SF1 UniProtKB/TrEMBL
Pfam Ldh_1_C UniProtKB/TrEMBL
PhenoGen Mdh1b PhenoGen
RatGTEx ENSRNOG00000012891 RatGTEx
Superfamily-SCOP Lactate_DH/Glyco_hydro_4_C UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A0G2JVU8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5XW88 ENTREZGENE, UniProtKB/TrEMBL
  A6IPG9_RAT UniProtKB/TrEMBL
  D3Z861_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-19 Mdh1b  malate dehydrogenase 1B  Mdh1b  malate dehydrogenase 1B, NAD (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mdh1b  malate dehydrogenase 1B, NAD (soluble)   Mdh1b_predicted  malate dehydrogenase 1B, NAD (soluble) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mdh1b_predicted  malate dehydrogenase 1B, NAD (soluble) (predicted)      Symbol and Name status set to approved 70820 APPROVED